SG11202101853PA - Humanized anti-c5 antibodies and uses thereof - Google Patents

Humanized anti-c5 antibodies and uses thereof

Info

Publication number
SG11202101853PA
SG11202101853PA SG11202101853PA SG11202101853PA SG11202101853PA SG 11202101853P A SG11202101853P A SG 11202101853PA SG 11202101853P A SG11202101853P A SG 11202101853PA SG 11202101853P A SG11202101853P A SG 11202101853PA SG 11202101853P A SG11202101853P A SG 11202101853PA
Authority
SG
Singapore
Prior art keywords
antibodies
humanized anti
humanized
Prior art date
Application number
SG11202101853PA
Other languages
English (en)
Inventor
Wenchao Song
Takashi Miwa
Damodar Gullipalli
Ping Tsui
Sayaka Sato
Original Assignee
Univ Pennsylvania
Kira Pharmaceuticals Us Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania, Kira Pharmaceuticals Us Llc filed Critical Univ Pennsylvania
Publication of SG11202101853PA publication Critical patent/SG11202101853PA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • A01K2227/105Murine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/03Animal model, e.g. for test or diseases
    • A01K2267/0393Animal model comprising a reporter system for screening tests
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C12N2015/8527Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic for producing animal models, e.g. for tests or diseases
    • C12N2015/859Animal models comprising reporter system for screening tests

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
SG11202101853PA 2018-09-06 2019-09-06 Humanized anti-c5 antibodies and uses thereof SG11202101853PA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862727666P 2018-09-06 2018-09-06
US201962837833P 2019-04-24 2019-04-24
PCT/US2019/049890 WO2020051418A1 (en) 2018-09-06 2019-09-06 Humanized anti-c5 antibodies and uses thereof

Publications (1)

Publication Number Publication Date
SG11202101853PA true SG11202101853PA (en) 2021-03-30

Family

ID=69723287

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202101853PA SG11202101853PA (en) 2018-09-06 2019-09-06 Humanized anti-c5 antibodies and uses thereof

Country Status (12)

Country Link
US (1) US20220177556A1 (zh)
EP (1) EP3846850A4 (zh)
JP (1) JP2021536509A (zh)
KR (1) KR20210055742A (zh)
CN (1) CN113038967A (zh)
AU (1) AU2019336214A1 (zh)
BR (1) BR112021004141A2 (zh)
CA (1) CA3111396A1 (zh)
IL (1) IL281272A (zh)
MX (1) MX2021002710A (zh)
SG (1) SG11202101853PA (zh)
WO (1) WO2020051418A1 (zh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018165062A1 (en) * 2017-03-06 2018-09-13 The Trustees Of The University Of Pensylvania Anti-c5 antibodies and uses thereof
US20220204602A1 (en) * 2019-04-24 2022-06-30 The Trustees Of The University Of Pennsylvania Bi-functional humanized anti-c5 antibodies and factor h fusion proteins and uses thereof
CN113563467A (zh) * 2020-04-28 2021-10-29 上海普铭生物科技有限公司 针对人补体蛋白c5的抗体及其应用
CN114149501B (zh) * 2020-12-11 2023-05-26 天士力生物医药股份有限公司 抗c5抗体及其应用
WO2023050233A1 (en) * 2021-09-29 2023-04-06 The Trustees Of The University Of Pennsylvania Humanized anti-c5a antibodies and uses thereof
WO2024097441A1 (en) 2022-11-02 2024-05-10 Kira Pharmaceuticals (Us) Llc Anti-c5 antibody fused to factor h for use in the treatment of complement-mediated diseases
WO2024097796A1 (en) 2022-11-02 2024-05-10 Kira Pharmaceuticals (Us) Llc Anti-c5 antibody fused to factor h for use in the treatment of complement-mediated diseases

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8410251B2 (en) * 2008-06-20 2013-04-02 National University Corporation Okayama University Antibody against calcified globule and use of the same
JP6505079B2 (ja) * 2013-03-29 2019-04-24 アレクシオン ファーマシューティカルズ, インコーポレイテッド 補体c5を標的とする治療薬の血清半減期を増加させるための組成物及び方法
NZ711451A (en) * 2014-03-07 2016-05-27 Alexion Pharma Inc Anti-c5 antibodies having improved pharmacokinetics
EA201791366A1 (ru) * 2014-12-19 2018-02-28 Чугаи Сейяку Кабусики Кайся Антитела к c5 и способы их применения
AU2017285763B2 (en) * 2016-06-17 2024-02-01 Chugai Seiyaku Kabushiki Kaisha Anti-C5 antibodies and methods of use
WO2018165062A1 (en) * 2017-03-06 2018-09-13 The Trustees Of The University Of Pensylvania Anti-c5 antibodies and uses thereof
US20220204602A1 (en) * 2019-04-24 2022-06-30 The Trustees Of The University Of Pennsylvania Bi-functional humanized anti-c5 antibodies and factor h fusion proteins and uses thereof

Also Published As

Publication number Publication date
IL281272A (en) 2021-04-29
EP3846850A4 (en) 2022-06-15
US20220177556A1 (en) 2022-06-09
WO2020051418A1 (en) 2020-03-12
CA3111396A1 (en) 2020-03-12
EP3846850A1 (en) 2021-07-14
MX2021002710A (es) 2021-09-23
CN113038967A (zh) 2021-06-25
BR112021004141A2 (pt) 2021-05-25
KR20210055742A (ko) 2021-05-17
JP2021536509A (ja) 2021-12-27
AU2019336214A1 (en) 2021-04-29

Similar Documents

Publication Publication Date Title
ZA202004494B (en) Anti-tmprss2 antibodies and antigen-binding fragments
IL269593A (en) Anti-ILT4 antibodies and antigen-binding fragments
IL262092B (en) Anti-pacap antibodies from humans and their use
IL263481A (en) Antibodies against c5 and their uses
IL269122A (en) Antibodies against C5 and their uses
IL281272A (en) Humanized antibodies against C5 and their uses
IL283812B (en) Humanized antibody against human pd–1
ZA201701920B (en) Anti-human il-17 monoclonal antibodies and use thereof
IL275734B (en) Anti-pd-l1 antibodies and uses thereof
IL282756A (en) Humanized antibodies against SIRPα
SI3445785T1 (sl) Humanizirana protitelesa proti CLEVER-1 in njihova uporaba
IL275264A (en) Anti-C5 antibody combinations and their uses
SG11202103095RA (en) Anti-human vsig4 antibodies and uses thereof
IL281608A (en) Antibodies against human CD45RC and their use
ZA202004784B (en) Humanized and de-immunized antibodies
ZA202101668B (en) Humanized anti-vegfr2 single-chain antibody and use thereof
IL277296A (en) Antibodies against PFRH5 and their antigen-binding fragments
GB201911211D0 (en) Monoclonal antibodies against ambra-1
GB201918103D0 (en) Epitopes and antibodies
GB201918104D0 (en) Epitopes and antibodies