SG11202011685QA - 2,3-dihydro-1h-pyrrolizine-7-formamide derivative and application thereof - Google Patents

2,3-dihydro-1h-pyrrolizine-7-formamide derivative and application thereof

Info

Publication number
SG11202011685QA
SG11202011685QA SG11202011685QA SG11202011685QA SG11202011685QA SG 11202011685Q A SG11202011685Q A SG 11202011685QA SG 11202011685Q A SG11202011685Q A SG 11202011685QA SG 11202011685Q A SG11202011685Q A SG 11202011685QA SG 11202011685Q A SG11202011685Q A SG 11202011685QA
Authority
SG
Singapore
Prior art keywords
pyrrolizine
dihydro
application
formamide derivative
formamide
Prior art date
Application number
SG11202011685QA
Other languages
English (en)
Inventor
Haiying He
Jianhua Xia
Zhen Gong
Jian Li
Shuhui Chen
Original Assignee
Chia Tai Tianqing Pharmaceutical Group Co Ltd
Medshine Discovery Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chia Tai Tianqing Pharmaceutical Group Co Ltd, Medshine Discovery Inc filed Critical Chia Tai Tianqing Pharmaceutical Group Co Ltd
Publication of SG11202011685QA publication Critical patent/SG11202011685QA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
SG11202011685QA 2018-05-25 2019-05-24 2,3-dihydro-1h-pyrrolizine-7-formamide derivative and application thereof SG11202011685QA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN201810528259 2018-05-25
CN201810843225 2018-07-27
CN201811189801 2018-10-12
PCT/CN2019/088376 WO2019223791A1 (zh) 2018-05-25 2019-05-24 2,3-二氢-1h-吡咯嗪-7-甲酰胺类衍生物及其应用

Publications (1)

Publication Number Publication Date
SG11202011685QA true SG11202011685QA (en) 2020-12-30

Family

ID=68616574

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202011685QA SG11202011685QA (en) 2018-05-25 2019-05-24 2,3-dihydro-1h-pyrrolizine-7-formamide derivative and application thereof

Country Status (10)

Country Link
US (1) US11891398B2 (zh)
EP (1) EP3805223A4 (zh)
JP (1) JP7333342B2 (zh)
KR (1) KR20210016402A (zh)
CN (2) CN113549079A (zh)
AU (1) AU2019272481B2 (zh)
CA (1) CA3101373A1 (zh)
PH (1) PH12020552017A1 (zh)
SG (1) SG11202011685QA (zh)
WO (1) WO2019223791A1 (zh)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2686740C2 (ru) 2014-06-11 2019-04-30 Венаторкс Фармасьютикалс, Инк. Ингибиторы бета-лактамазы
US11332485B2 (en) 2017-05-26 2022-05-17 VenatoRx Pharmaceuticals, Inc. Penicillin-binding protein inhibitors
WO2018218154A1 (en) 2017-05-26 2018-11-29 VenatoRx Pharmaceuticals, Inc. Penicillin-binding protein inhibitors
US11247965B2 (en) 2017-12-11 2022-02-15 VenatoRx Pharmaceuticals, Inc. Hepatitis B capsid assembly modulators
KR20200136994A (ko) 2018-03-30 2020-12-08 치아타이 티안큉 파마수티컬 그룹 주식회사 N-헤테로시클릭 5-원 고리-함유 캡시드 단백질 조립 억제제, 그의 약학적 조성물, 및 그의 용도
EP3807246A4 (en) 2018-06-11 2022-03-02 Venatorx Pharmaceuticals, Inc. HEPATITIS B CAPSID ASSEMBLY MODULATORS
CN113365999B (zh) * 2019-01-31 2023-04-14 正大天晴药业集团股份有限公司 含有吡咯并杂环的衣壳蛋白装配抑制剂
AU2020385518A1 (en) * 2019-11-22 2022-06-09 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Crystal form of nucleoprotein inhibitor and use thereof
US20230234968A1 (en) * 2020-06-10 2023-07-27 Medshine Discovery Inc. Methyl-substituted benzobisoxazole compound and use thereof
WO2022095950A1 (zh) 2020-11-05 2022-05-12 正大天晴药业集团股份有限公司 包含衣壳蛋白抑制剂和核苷类似物的药物组合

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060040945A1 (en) 2002-05-17 2006-02-23 Merckle Gmbh Annellated pyrrole compounds as proton pump inhibitors for treating ulcer
UA77812C2 (en) 2002-05-17 2007-01-15 Merckle Gmbh Anelated pyrrol substances as proton pump inhibitors for treating gastric ulcer
GB0710121D0 (en) 2007-05-25 2007-07-04 F2G Ltd Antifungal agents
EP2159224B1 (en) 2007-06-18 2012-08-01 Sunshine Lake Pharma Co., Ltd Bromo-phenyl substituted thiazolyl dihydropyrimidines
AU2017231817B2 (en) 2016-03-09 2021-02-25 Emory University Elimination of hepatitis B virus with antiviral agents
JOP20190024A1 (ar) * 2016-08-26 2019-02-19 Gilead Sciences Inc مركبات بيروليزين بها استبدال واستخداماتها
JP7123429B2 (ja) 2017-05-04 2022-08-23 シャンハイ ロングウッド バイオファルマシューティカルズ カンパニー リミテッド 二環式縮合環系ヌクレオカプシド阻害剤および薬物としてｂ型肝炎を治療するためのその使用
KR102526964B1 (ko) * 2018-02-26 2023-04-28 길리애드 사이언시즈, 인코포레이티드 Hbv 복제 억제제로서의 치환된 피롤리진 화합물
KR20200136994A (ko) 2018-03-30 2020-12-08 치아타이 티안큉 파마수티컬 그룹 주식회사 N-헤테로시클릭 5-원 고리-함유 캡시드 단백질 조립 억제제, 그의 약학적 조성물, 및 그의 용도
EP3807246A4 (en) * 2018-06-11 2022-03-02 Venatorx Pharmaceuticals, Inc. HEPATITIS B CAPSID ASSEMBLY MODULATORS
EA202092159A1 (ru) 2019-01-25 2020-12-15 Чиа Тай Тянцин Фармасьютикал Груп Ко., Лтд. Содержащий n-гетероциклическое пятичленное кольцо ингибитор сборки капсидного белка, его фармацевтическая композиция и их применение

Also Published As

Publication number Publication date
KR20210016402A (ko) 2021-02-15
US11891398B2 (en) 2024-02-06
WO2019223791A1 (zh) 2019-11-28
CN111247151B (zh) 2021-08-10
JP2021525267A (ja) 2021-09-24
CN111247151A (zh) 2020-06-05
CN113549079A (zh) 2021-10-26
EP3805223A4 (en) 2021-12-22
EP3805223A1 (en) 2021-04-14
AU2019272481B2 (en) 2024-03-21
US20220204510A1 (en) 2022-06-30
CA3101373A1 (en) 2019-11-28
AU2019272481A1 (en) 2020-12-17
JP7333342B2 (ja) 2023-08-24
PH12020552017A1 (en) 2021-06-28

Similar Documents

Publication Publication Date Title
SG11202011685QA (en) 2,3-dihydro-1h-pyrrolizine-7-formamide derivative and application thereof
HK1254654A1 (zh) 4，6-亞嘧啶基衍生物及其用途
IL278877B1 (en) Amino-pyrazinecarboxamide compounds, conjugates and their uses
IL276952A (en) History of 4,2-diaminoquinazolines and their medicinal uses
IL272055A (en) 8,1-naphthyridinone compounds and their uses
EP3680331A4 (en) MODIFIED CAS9 PROTEIN AND USING IT
ZA202103259B (en) Modified cas9 protein, and use thereof
IL277502A (en) Compounds and uses for them
IL276753A (en) Epibrotic compounds, their devices and uses
EP3845532A4 (en) QUINOLINO-PYRROLIDIN-2-ONE DERIVATIVE AND RELATED APPLICATION
GB2576614B (en) Compositions, uses and methods
SG11202008543RA (en) Pyrrolidineamide derivatives and uses thereof
IL284765A (en) 8,1-naphthyridinone compounds and their uses
IL279483A (en) Cyanotriazole compounds and their uses
GB201804163D0 (en) Uses, compositions and methods
PT3796975T (pt) Derivados de sulfonilaminobenzamida
SG11202002422WA (en) Novel phenylpyridine derivative and pharmaceutical composition comprising the same
EP3715344A4 (en) 1,4-BENZODIAZAPINE-2-ON DERIVATIVES AND THEIR USES
IL282999A (en) 4,3,1-oxadiazolone compound and drug
IL280369A (en) Myokines and their uses
IL276125A (en) Dihydroindolizinone derivative compounds, preparations containing them and their uses
EP3904347A4 (en) 2,4-DIAMINOPYRIMIDINE DERIVATIVE AND ITS APPLICATION
EP3634406C0 (en) 3,4,5-TRISUBSTITUTED-1,2,4-TRIAZOLES AND 3,4,5-TRISUBSTITUTED-3-THIO-1,2,4-TRIAZOLES AND USES THEREOF
IL287503A (en) Thio-semicarbazide compounds and their use
GB201819687D0 (en) Mrbr.5