US4419446A
(en)
|
1980-12-31 |
1983-12-06 |
The United States Of America As Represented By The Department Of Health And Human Services |
Recombinant DNA process utilizing a papilloma virus DNA as a vector
|
US4601978A
(en)
|
1982-11-24 |
1986-07-22 |
The Regents Of The University Of California |
Mammalian metallothionein promoter system
|
US4560655A
(en)
|
1982-12-16 |
1985-12-24 |
Immunex Corporation |
Serum-free cell culture medium and process for making same
|
US4657866A
(en)
|
1982-12-21 |
1987-04-14 |
Sudhir Kumar |
Serum-free, synthetic, completely chemically defined tissue culture media
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
US4767704A
(en)
|
1983-10-07 |
1988-08-30 |
Columbia University In The City Of New York |
Protein-free culture medium
|
US4965199A
(en)
|
1984-04-20 |
1990-10-23 |
Genentech, Inc. |
Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
|
GB8516415D0
(en)
|
1985-06-28 |
1985-07-31 |
Celltech Ltd |
Culture of animal cells
|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
GB8601597D0
(en)
|
1986-01-23 |
1986-02-26 |
Wilson R H |
Nucleotide sequences
|
US4927762A
(en)
|
1986-04-01 |
1990-05-22 |
Cell Enterprises, Inc. |
Cell culture medium with antioxidant
|
WO1988007089A1
(en)
|
1987-03-18 |
1988-09-22 |
Medical Research Council |
Altered antibodies
|
US5606040A
(en)
|
1987-10-30 |
1997-02-25 |
American Cyanamid Company |
Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group
|
US5770701A
(en)
|
1987-10-30 |
1998-06-23 |
American Cyanamid Company |
Process for preparing targeted forms of methyltrithio antitumor agents
|
EP0435911B1
(en)
|
1988-09-23 |
1996-03-13 |
Cetus Oncology Corporation |
Cell culture medium for enhanced cell growth, culture longevity and product expression
|
WO1990005144A1
(en)
|
1988-11-11 |
1990-05-17 |
Medical Research Council |
Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
|
US5089261A
(en)
|
1989-01-23 |
1992-02-18 |
Cetus Corporation |
Preparation of a polymer/interleukin-2 conjugate
|
SE509359C2
(en)
|
1989-08-01 |
1999-01-18 |
Cemu Bioteknik Ab |
Use of stabilized protein or peptide conjugates for the preparation of a drug
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
US6673986B1
(en)
|
1990-01-12 |
2004-01-06 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
US6150584A
(en)
|
1990-01-12 |
2000-11-21 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
US6075181A
(en)
|
1990-01-12 |
2000-06-13 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
EP1690935A3
(en)
|
1990-01-12 |
2008-07-30 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
US5891693A
(en)
|
1990-01-25 |
1999-04-06 |
Alusuisse Holdings A.G. |
Recombinant DNA methods vectors and host cells
|
CA2090105A1
(en)
|
1990-08-29 |
1992-03-01 |
Jean-Paul Soulillou |
Protein polyligands joined to a stable protein core
|
US5122469A
(en)
|
1990-10-03 |
1992-06-16 |
Genentech, Inc. |
Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
|
US5650150A
(en)
|
1990-11-09 |
1997-07-22 |
Gillies; Stephen D. |
Recombinant antibody cytokine fusion proteins
|
US5508192A
(en)
|
1990-11-09 |
1996-04-16 |
Board Of Regents, The University Of Texas System |
Bacterial host strains for producing proteolytically sensitive polypeptides
|
US5264365A
(en)
|
1990-11-09 |
1993-11-23 |
Board Of Regents, The University Of Texas System |
Protease-deficient bacterial strains for production of proteolytically sensitive polypeptides
|
US5571894A
(en)
|
1991-02-05 |
1996-11-05 |
Ciba-Geigy Corporation |
Recombinant antibodies specific for a growth factor receptor
|
WO1993006217A1
(en)
|
1991-09-19 |
1993-04-01 |
Genentech, Inc. |
EXPRESSION IN E. COLI OF ANTIBODY FRAGMENTS HAVING AT LEAST A CYSTEINE PRESENT AS A FREE THIOL, USE FOR THE PRODUCTION OF BIFUNCTIONAL F(ab')2 ANTIBODIES
|
US5587458A
(en)
|
1991-10-07 |
1996-12-24 |
Aronex Pharmaceuticals, Inc. |
Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof
|
WO1993008829A1
(en)
|
1991-11-04 |
1993-05-13 |
The Regents Of The University Of California |
Compositions that mediate killing of hiv-infected cells
|
EP0625200B1
(en)
|
1992-02-06 |
2005-05-11 |
Chiron Corporation |
Biosynthetic binding protein for cancer marker
|
WO1993022332A2
(en)
|
1992-04-24 |
1993-11-11 |
Board Of Regents, The University Of Texas System |
Recombinant production of immunoglobulin-like domains in prokaryotic cells
|
ATE196606T1
(en)
|
1992-11-13 |
2000-10-15 |
Idec Pharma Corp |
THERAPEUTIC USE OF CHIMERIC AND LABELED ANTIBODIES DIRECTED AGAINST A DIFFERENTIATION ANTIGEN WHICH EXPRESSION IS RESTRICTED TO HUMAN B LYMPHOCYTES, FOR THE TREATMENT OF B-CELL LYMPHOMA
|
US5635483A
(en)
|
1992-12-03 |
1997-06-03 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Tumor inhibiting tetrapeptide bearing modified phenethyl amides
|
US5780588A
(en)
|
1993-01-26 |
1998-07-14 |
Arizona Board Of Regents |
Elucidation and synthesis of selected pentapeptides
|
EP0714409A1
(en)
|
1993-06-16 |
1996-06-05 |
Celltech Therapeutics Limited |
Antibodies
|
US5773001A
(en)
|
1994-06-03 |
1998-06-30 |
American Cyanamid Company |
Conjugates of methyltrithio antitumor agents and intermediates for their synthesis
|
US5639635A
(en)
|
1994-11-03 |
1997-06-17 |
Genentech, Inc. |
Process for bacterial production of polypeptides
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
US5641870A
(en)
|
1995-04-20 |
1997-06-24 |
Genentech, Inc. |
Low pH hydrophobic interaction chromatography for antibody purification
|
US5739277A
(en)
|
1995-04-14 |
1998-04-14 |
Genentech Inc. |
Altered polypeptides with increased half-life
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
US5714586A
(en)
|
1995-06-07 |
1998-02-03 |
American Cyanamid Company |
Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
|
US5712374A
(en)
|
1995-06-07 |
1998-01-27 |
American Cyanamid Company |
Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
|
GB9603256D0
(en)
|
1996-02-16 |
1996-04-17 |
Wellcome Found |
Antibodies
|
WO1997038123A1
(en)
|
1996-04-05 |
1997-10-16 |
Board Of Regents, The University Of Texas System |
Methods for producing soluble, biologically-active disulfide bond-containing eukaryotic proteins in bacterial cells
|
US5834597A
(en)
|
1996-05-20 |
1998-11-10 |
Protein Design Labs, Inc. |
Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same
|
DE19701141C1
(en)
*
|
1997-01-16 |
1998-04-09 |
Hoechst Ag |
Gene construct for treatment of disease involving protease, particularly tumours and inflammation
|
US6277375B1
(en)
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
US6083715A
(en)
|
1997-06-09 |
2000-07-04 |
Board Of Regents, The University Of Texas System |
Methods for producing heterologous disulfide bond-containing polypeptides in bacterial cells
|
EP0994903B1
(en)
|
1997-06-24 |
2005-05-25 |
Genentech, Inc. |
Methods and compositions for galactosylated glycoproteins
|
WO1999022764A1
(en)
|
1997-10-31 |
1999-05-14 |
Genentech, Inc. |
Methods and compositions comprising glycoprotein glycoforms
|
IL138608A0
(en)
|
1998-04-02 |
2001-10-31 |
Genentech Inc |
Antibody variants and fragments thereof
|
WO1999054342A1
(en)
|
1998-04-20 |
1999-10-28 |
Pablo Umana |
Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity
|
ES2420835T3
(en)
|
1999-04-09 |
2013-08-27 |
Kyowa Hakko Kirin Co., Ltd. |
Procedure to control the activity of immunofunctional molecules
|
IT1306736B1
(en)
|
1999-10-29 |
2001-10-02 |
Benito Salmi |
CONTAINMENT AND DISTRIBUTION DEVICE FOR BALLS FOR ALVOLO SHOOTS.
|
US6399219B1
(en)
|
1999-12-23 |
2002-06-04 |
Vapor Technologies, Inc. |
Article having a decorative and protective coating thereon
|
ES2274823T3
(en)
|
1999-12-29 |
2007-06-01 |
Immunogen, Inc. |
COTOTOXIC AGENTS THAT INCLUDE DOXORRUBICINAS AND DAUNORRUBICINAS AND ITS THERAPEUTIC USE.
|
JP2003530838A
(en)
|
2000-04-12 |
2003-10-21 |
ヒューマン ゲノム サイエンシズ インコーポレイテッド |
Albumin fusion protein
|
US20040014652A1
(en)
|
2000-06-01 |
2004-01-22 |
Andre Trouet |
Tumor activated prodrug compounds and methods of making and using the same
|
DE10045592A1
(en)
|
2000-09-15 |
2002-03-28 |
Klaus Pfizenmaier |
An antibody-TNF-TNF inhibitor fusion protein (TNF selectokine) as a target-specific procytokine for tumor therapy
|
US7064191B2
(en)
|
2000-10-06 |
2006-06-20 |
Kyowa Hakko Kogyo Co., Ltd. |
Process for purifying antibody
|
AU3942202A
(en)
|
2000-11-30 |
2002-06-11 |
Medarex Inc |
Transgenic transchromosomal rodents for making human antibodies
|
EP1355919B1
(en)
|
2000-12-12 |
2010-11-24 |
MedImmune, LLC |
Molecules with extended half-lives, compositions and uses thereof
|
GB0100551D0
(en)
|
2001-01-09 |
2001-02-21 |
Queen Mary & Westfield College |
Protein
|
JP4336771B2
(en)
|
2001-03-09 |
2009-09-30 |
モルフォシス アーゲー |
Serum albumin binding moiety
|
AU2002339845B2
(en)
|
2001-08-03 |
2009-03-26 |
Roche Glycart Ag |
Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity
|
WO2003015697A2
(en)
|
2001-08-13 |
2003-02-27 |
University Of Southern California |
Interleukin-2 mutants with reduced toxicity
|
WO2003030821A2
(en)
|
2001-10-05 |
2003-04-17 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
MXPA04003798A
(en)
|
2001-10-25 |
2004-07-30 |
Genentech Inc |
Glycoprotein compositions.
|
CA2471363C
(en)
|
2001-12-21 |
2014-02-11 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
CA2484556A1
(en)
|
2001-12-21 |
2003-07-24 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
KR101271635B1
(en)
*
|
2001-12-21 |
2013-06-12 |
휴먼 게놈 사이언시즈, 인코포레이티드 |
Albumin fusion proteins
|
US20040093621A1
(en)
|
2001-12-25 |
2004-05-13 |
Kyowa Hakko Kogyo Co., Ltd |
Antibody composition which specifically binds to CD20
|
US7691568B2
(en)
|
2002-04-09 |
2010-04-06 |
Kyowa Hakko Kirin Co., Ltd |
Antibody composition-containing medicament
|
CA2481658A1
(en)
|
2002-04-09 |
2003-10-16 |
Kyowa Hakko Kogyo Co., Ltd. |
Method of enhancing of binding activity of antibody composition to fcy receptor iiia
|
AU2003236019A1
(en)
|
2002-04-09 |
2003-10-20 |
Kyowa Hakko Kirin Co., Ltd. |
Drug containing antibody composition appropriate for patient suffering from Fc Gamma RIIIa polymorphism
|
ATE503829T1
(en)
|
2002-04-09 |
2011-04-15 |
Kyowa Hakko Kirin Co Ltd |
CELL WITH REDUCED OR DELETED ACTIVITY OF A PROTEIN INVOLVED IN GDP-FUCOSE TRANSPORT
|
WO2003085118A1
(en)
|
2002-04-09 |
2003-10-16 |
Kyowa Hakko Kogyo Co., Ltd. |
Process for producing antibody composition
|
US20040081647A1
(en)
*
|
2002-08-27 |
2004-04-29 |
Afeyan Noubar B. |
Adzymes and uses thereof
|
AU2003265866A1
(en)
|
2002-09-03 |
2004-03-29 |
Vit Lauermann |
Targeted release
|
US20060236411A1
(en)
|
2002-10-14 |
2006-10-19 |
Ingeborg Dreher |
Antagonists il-15
|
US7361740B2
(en)
|
2002-10-15 |
2008-04-22 |
Pdl Biopharma, Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
WO2004041862A2
(en)
|
2002-11-08 |
2004-05-21 |
Ablynx N.V. |
Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor
|
SI1572744T1
(en)
|
2002-12-16 |
2010-09-30 |
Genentech Inc |
Immunoglobulin variants and uses thereof
|
US20040136952A1
(en)
|
2002-12-26 |
2004-07-15 |
Mountain View Pharmaceuticals, Inc. |
Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity
|
UA90654C2
(en)
*
|
2002-12-26 |
2010-05-25 |
Маунтин Вью Фармасьютикалз, Инк. |
Polymer conjugates of interferon-beta with enhanced biological potency
|
WO2004090135A2
(en)
|
2003-04-09 |
2004-10-21 |
Asterion Limited |
Cytokine polypeptides and antibodies containing a signal sequence for the attachement of glycosylphosphatidylinositol
|
US7569215B2
(en)
|
2003-07-18 |
2009-08-04 |
Massachusetts Institute Of Technology |
Mutant interleukin-2 (IL-2) polypeptides
|
AU2004279742A1
(en)
|
2003-10-08 |
2005-04-21 |
Kyowa Hakko Kirin Co., Ltd. |
Fused protein composition
|
US20070134759A1
(en)
|
2003-10-09 |
2007-06-14 |
Harue Nishiya |
Process for producing antibody composition by using rna inhibiting the function of alpha1,6-fucosyltransferase
|
DK1725249T3
(en)
|
2003-11-06 |
2014-03-17 |
Seattle Genetics Inc |
Monomethylvaline compounds capable of conjugating to ligands.
|
JPWO2005053742A1
(en)
|
2003-12-04 |
2007-06-28 |
協和醗酵工業株式会社 |
Medicament containing antibody composition
|
NZ548612A
(en)
|
2004-02-09 |
2009-11-27 |
Human Genome Sciences Inc |
Albumin fusion proteins comprising tandem GLP-1
|
JP5620626B2
(en)
|
2005-03-31 |
2014-11-05 |
中外製薬株式会社 |
Polypeptide production method by association control
|
WO2006110728A2
(en)
|
2005-04-12 |
2006-10-19 |
The Uab Research Foundation |
Immunogenic cmv tegument aggregates
|
US20070269422A1
(en)
|
2006-05-17 |
2007-11-22 |
Ablynx N.V. |
Serum albumin binding proteins with long half-lives
|
WO2007146038A2
(en)
|
2006-06-07 |
2007-12-21 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
EP1867660A1
(en)
*
|
2006-06-14 |
2007-12-19 |
CSL Behring GmbH |
Proteolytically cleavable fusion protein comprising a blood coagulation factor
|
US20100254944A1
(en)
|
2006-09-14 |
2010-10-07 |
Mani Subramanian |
Albumin Fusion Proteins
|
CN101557817A
(en)
*
|
2006-09-14 |
2009-10-14 |
人类基因科学公司 |
Albumin fusion proteins
|
EP2150350B1
(en)
|
2007-05-24 |
2012-04-25 |
The Regents of the University of California |
Integrated fluidics devices with magnetic sorting
|
KR20100058541A
(en)
*
|
2007-08-15 |
2010-06-03 |
아뮤닉스 인코포레이티드 |
Compositions and methods for modifying properties of biologically active polypeptides
|
CA3128656A1
(en)
*
|
2007-08-22 |
2009-02-26 |
The Regents Of The University Of California |
Activatable binding polypeptides and methods of identification and use thereof
|
WO2009103965A1
(en)
|
2008-02-19 |
2009-08-27 |
Asterion Limited |
Modified linkers
|
WO2010014258A2
(en)
|
2008-08-01 |
2010-02-04 |
Nektar Therapeutics Al, Corporation |
Conjugates having a releasable linkage
|
GB0815216D0
(en)
|
2008-08-21 |
2008-09-24 |
Asterion Ltd |
Interleukin
|
JP5851842B2
(en)
|
2009-01-12 |
2016-02-03 |
サイトムエックス セラピューティクス, インク.CytomX Therapeutics, Inc. |
Modified antibody composition and methods of making and using the same
|
AU2010215761B2
(en)
|
2009-02-23 |
2017-04-06 |
Cytomx Therapeutics, Inc |
Proproteins and methods of use thereof
|
WO2011011797A2
(en)
|
2009-07-24 |
2011-01-27 |
The Board Of Trustees Of The Leland Stanford Junior University |
Cytokine compositions and methods of use thereof
|
CN102648002A
(en)
|
2009-10-10 |
2012-08-22 |
斯坦福大学托管董事会 |
IL-17 family cytokine compositions and uses
|
US8734774B2
(en)
|
2010-04-02 |
2014-05-27 |
University Of Rochester |
Protease activated cytokines
|
JP5969458B2
(en)
|
2010-04-09 |
2016-08-17 |
アルブミディクス アクティーゼルスカブ |
Albumin derivatives and variants
|
WO2012054929A2
(en)
|
2010-10-22 |
2012-04-26 |
Protox Therapeutics Corp. |
Use of human serum albumin to decrease antigenicity of therapeutic proteins
|
EP2635598A1
(en)
|
2010-11-01 |
2013-09-11 |
Novozymes Biopharma DK A/S |
Albumin variants
|
KR102472497B1
(en)
|
2010-11-12 |
2022-11-29 |
넥타르 테라퓨틱스 |
Conjugates of an il-2 moiety and a polymer
|
CU23923B1
(en)
|
2010-11-12 |
2013-07-31 |
Ct De Inmunología Molecular |
POLYPEPTIDES DERIVED FROM IL-2 WITH AGONIST ACTIVITY
|
EP2654792A4
(en)
*
|
2010-12-22 |
2016-05-11 |
Abbvie Inc |
Half immunoglobulin binding proteins and uses thereof
|
WO2013163631A2
(en)
|
2012-04-27 |
2013-10-31 |
Cytomx Therapeutics, Inc. |
Activatable antibodies that bind epidermal growth factor receptor and methods of use thereof
|
MX341569B
(en)
|
2012-05-18 |
2016-08-25 |
Nippon Steel & Sumikin Texeng Co Ltd |
Separating mechanism for separating circular blade and/or spacer, handling robot, storage stand, and separating method.
|
PE20150643A1
(en)
|
2012-06-22 |
2015-05-29 |
Cytomx Therapeutics Inc |
ANTI-JAGGED 1 / JAGGED 2 CROSS-REACTIVE ANTIBODIES ACTIVABLE ANTI-JAGGED ANTIBODIES AND METHODS OF USE OF THEM
|
US9856314B2
(en)
|
2012-06-22 |
2018-01-02 |
Cytomx Therapeutics, Inc. |
Activatable antibodies having non-binding steric moieties and methods of using the same
|
CN110615835A
(en)
|
2012-08-09 |
2019-12-27 |
利兰斯坦福初级大学董事会 |
Methods of selectively manipulating cellular responses in target cells to ligands recognized by two or more shared receptor polypeptides
|
US9309510B2
(en)
|
2012-08-10 |
2016-04-12 |
Cytomx Therapeutics, Inc. |
Protease-resistant systems for polypeptide display and methods of making and using thereof
|
WO2014052462A2
(en)
|
2012-09-25 |
2014-04-03 |
Cytomx Therapeutics, Inc. |
Activatable antibodies that bind interleukin-6 receptor and methods of use thereof
|
WO2014100014A1
(en)
|
2012-12-17 |
2014-06-26 |
The Board Of Trustees Of The Leland Stanford Junior University |
Super-2 complexes with antibody to augment il-2 therapy
|
WO2014094799A1
(en)
*
|
2012-12-19 |
2014-06-26 |
Scil-Proteins-Gmbh |
Ubiquitin moieties as a means for prolonging serum half-life
|
RU2015132436A
(en)
|
2013-01-04 |
2017-02-09 |
Сайтомкс Терапьютикс, Инк. |
METHODS FOR DETECTING PROTEASE ACTIVITY IN BIOLOGICAL SYSTEMS AND COMPOSITIONS FOR THEIR IMPLEMENTATION
|
US9255155B2
(en)
|
2013-01-31 |
2016-02-09 |
The Regents Of The University Of California |
Antibodies specific for urokinase-type plasminogen activator and methods of treating cancer
|
WO2014165093A2
(en)
|
2013-03-13 |
2014-10-09 |
Bristol-Myers Squibb Company |
Fibronectin based scaffold domains linked to serum albumin or a moiety binding thereto
|
CA2913732A1
(en)
|
2013-06-04 |
2014-12-11 |
Cytomx Therapeutics, Inc. |
Compositions and methods for conjugating activatable antibodies
|
EP4067383A1
(en)
|
2013-07-25 |
2022-10-05 |
Cytomx Therapeutics Inc. |
Multispecific antibodies, multispecific activatable antibodies and methods of using the same
|
KR20230011497A
(en)
|
2013-09-25 |
2023-01-20 |
싸이톰스 테라퓨틱스, 인크. |
Matrix metalloproteinase substrates and other cleavable moieties and methods of use thereof
|
US9540440B2
(en)
|
2013-10-30 |
2017-01-10 |
Cytomx Therapeutics, Inc. |
Activatable antibodies that bind epidermal growth factor receptor and methods of use thereof
|
US9737623B2
(en)
|
2013-12-11 |
2017-08-22 |
Cytomx Therapeutics, Inc. |
Antibodies that bind activatable antibodies and methods of use thereof
|
CN114106099B
(en)
|
2014-01-31 |
2024-05-24 |
西托姆克斯治疗公司 |
Substrates and other cleavable moieties for proteolytic enzymes and U-shaped plasminogen activators and methods of use thereof
|
RS61661B1
(en)
|
2014-02-21 |
2021-04-29 |
Nektar Therapeutics India Pvt Ltd |
Il-2rbeta-selective agonists in combination with an anti-ctla-4 antibody or an an anti-pd-1 antibody
|
KR102472862B1
(en)
*
|
2014-03-20 |
2022-12-05 |
브리스톨-마이어스 스큅 컴퍼니 |
Serum albumin-binding fibronectin type iii domains
|
EP3134102B1
(en)
|
2014-04-24 |
2019-07-03 |
The Board of Trustees of The Leland Stanford Junior University |
Superagonists, partial agonists and antagonists of interleukin-2
|
CN107108738A
(en)
|
2014-07-25 |
2017-08-29 |
西托姆克斯治疗公司 |
Anti-cd 3 antibodies, it anti-cd 3 antibodies, polyspecific anti-cd 3 antibodies, polyspecific can be activated can activate anti-cd 3 antibodies and its application method
|
MA41374A
(en)
|
2015-01-20 |
2017-11-28 |
Cytomx Therapeutics Inc |
MATRIX METALLOPROTEASE CLIVABLE AND SERINE PROTEASE CLIVABLE SUBSTRATES AND METHODS OF USE THEREOF
|
MA42971A
(en)
|
2015-03-13 |
2018-08-15 |
Cytomx Therapeutics Inc |
ANTI-PDL1 ANTIBODIES, ACTIVABLE ANTI-PLD1 ANTIBODIES, AND METHODS OF USE THEREOF
|
AU2016246152A1
(en)
*
|
2015-04-10 |
2017-11-02 |
Amgen Inc. |
Interleukin-2 muteins for the expansion of T-regulatory cells
|
DK3326641T3
(en)
*
|
2015-04-22 |
2019-09-30 |
Curevac Ag |
RNA-Containing Composition for the Treatment of Tumor Diseases
|
TWI726879B
(en)
|
2015-05-04 |
2021-05-11 |
美商Cytomx生物製藥公司 |
Anti-cd71 antibodies, activatable anti-cd71 antibodies, and methods of use thereof
|
AU2016258988A1
(en)
|
2015-05-04 |
2017-12-07 |
Cytomx Therapeutics, Inc |
Anti-ITGa3 antibodies, activatable anti-ITGa3 antibodies, and methods of use thereof
|
PT3292150T
(en)
|
2015-05-04 |
2020-06-01 |
Cytomx Therapeutics Inc |
Anti-cd166 antibodies, activatable anti-cd166 antibodies, and methods of use thereof
|
EP3297672B1
(en)
|
2015-05-21 |
2021-09-01 |
Harpoon Therapeutics, Inc. |
Trispecific binding proteins and methods of use
|
WO2016200645A1
(en)
|
2015-06-12 |
2016-12-15 |
Tianxin Wang |
Methods for protein modification in pharmaceutical applications
|
AU2016294440B2
(en)
|
2015-07-13 |
2022-10-13 |
Cytomx Therapeutics, Inc |
Anti-PD-1 antibodies, activatable anti-PD-1 antibodies, and methods of use thereof
|
TW201808990A
(en)
|
2016-03-08 |
2018-03-16 |
馬弗瑞克療法公司 |
Inducible binding proteins and methods of use
|
JP7101621B2
(en)
|
2016-05-20 |
2022-07-15 |
ハープーン セラピューティクス,インク. |
Single domain serum albumin binding protein
|
ES2951552T3
(en)
*
|
2016-07-29 |
2023-10-23 |
Juno Therapeutics Inc |
Immunomodulatory polypeptides and related compositions and methods
|
CN107759696A
(en)
*
|
2016-08-19 |
2018-03-06 |
安源医药科技(上海)有限公司 |
Fusion protein of human interleukin 7 and preparation method thereof
|
WO2018071777A1
(en)
|
2016-10-14 |
2018-04-19 |
Harpoon Therapeutics, Inc. |
Innate immune cell trispecific binding proteins and methods of use
|
WO2018071919A1
(en)
|
2016-10-14 |
2018-04-19 |
Xencor, Inc. |
IL15/IL15Rα HETERODIMERIC FC-FUSION PROTEINS
|
US11117968B2
(en)
|
2016-11-03 |
2021-09-14 |
Bristol-Myers Squibb Company |
Activatable anti-CTLA-4 antibodies and uses thereof
|
WO2018136725A1
(en)
|
2017-01-19 |
2018-07-26 |
Harpoon Therapeutics, Inc. |
Innate immune cell inducible binding proteins and methods of use
|
US11535668B2
(en)
|
2017-02-28 |
2022-12-27 |
Harpoon Therapeutics, Inc. |
Inducible monovalent antigen binding protein
|
AU2018227810A1
(en)
|
2017-03-01 |
2019-08-29 |
Nektar Therapeutics |
Immunotherapeutic tumor treatment method using an interleukin-2 receptor alpha, beta-selective agonist in combination with adoptive cell transfer therapy
|
JP2020511130A
(en)
|
2017-03-09 |
2020-04-16 |
サイトメックス セラピューティクス インコーポレイテッド |
CD147 antibody, activatable CD147 antibody, and methods of making and using same
|
CA3062291A1
(en)
|
2017-05-02 |
2018-11-08 |
Nektar Therapeutics |
Immunotherapeutic tumor treatment method
|
CN111093688A
(en)
|
2017-05-15 |
2020-05-01 |
尼克塔治疗公司 |
Long-acting interleukin-15 receptor agonists and related immunotherapeutic compositions and methods
|
JP2020522486A
(en)
|
2017-06-01 |
2020-07-30 |
サイトメックス セラピューティクス インコーポレイテッド |
Activatable anti-PDL1 antibody and method of using the same
|
US20200123227A1
(en)
|
2017-06-20 |
2020-04-23 |
The Board Of Regents Of The University Of Texas System |
Interferon prodrug for the treatment of cancer
|
EP3652210A1
(en)
|
2017-07-14 |
2020-05-20 |
CytomX Therapeutics, Inc. |
Anti-cd166 antibodies and uses thereof
|
WO2019018828A1
(en)
|
2017-07-20 |
2019-01-24 |
Cytomx Therapeutics, Inc. |
Methods of qualitatively and/or quantitatively analyzing properties of activatable antibodies and uses thereof
|
AU2018316694A1
(en)
|
2017-08-17 |
2020-02-13 |
Nektar Therapeutics |
Immunotherapeutic tumor treatment method
|
AU2018324097A1
(en)
|
2017-08-30 |
2020-03-12 |
Cytomx Therapeutics, Inc. |
Activatable anti-CD166 antibodies and methods of use thereof
|
KR20200064096A
(en)
|
2017-10-14 |
2020-06-05 |
싸이톰스 테라퓨틱스, 인크. |
Antibodies, activatable antibodies, bispecific antibodies and bispecific activatable antibodies and methods of using them
|
US20210154277A1
(en)
|
2017-11-07 |
2021-05-27 |
Nektar Therapeutics |
Immunotherapeutic combination for treating cancer
|
US20210260163A1
(en)
|
2018-03-09 |
2021-08-26 |
AskGene Pharma, Inc. |
Novel cytokine prodrugs
|
CU24554B1
(en)
|
2018-05-07 |
2021-11-04 |
Ct Inmunologia Molecular |
FUSION PROTEINS COMPOSED OF INTERLEUKIN 2 MUTEIN AND TYPE 1 INTERFERON
|
BR112020023167A2
(en)
*
|
2018-05-14 |
2021-02-09 |
Werewolf Therapeutics, Inc. |
activatable cytokine polypeptides and methods of using these
|
EP3794024B1
(en)
*
|
2018-05-14 |
2023-05-10 |
Werewolf Therapeutics, Inc. |
Activatable interleukin-2 polypeptides and methods of use thereof
|
AU2019288484A1
(en)
|
2018-06-22 |
2021-01-21 |
Cugene Inc. |
Cytokine-based bioactivatable drugs and methods of uses thereof
|
JP7479383B2
(en)
|
2018-09-27 |
2024-05-08 |
エクシリオ デベロップメント, インコーポレイテッド |
Masked cytokine polypeptides
|
KR20220020879A
(en)
|
2019-06-12 |
2022-02-21 |
에스크진 파마, 아이엔씨. |
New IL-15 prodrugs and how to use them
|
EP4004026A4
(en)
|
2019-07-25 |
2023-11-15 |
Trutino Biosciences Inc. |
Il-2 cytokine prodrugs comprising a cleavable linker
|
AU2020329216A1
(en)
|
2019-08-12 |
2022-02-24 |
AskGene Pharma, Inc. |
IL-2 fusion proteins that preferentially bind ILl-2ralpha
|
CN115867568A
(en)
|
2020-04-01 |
2023-03-28 |
西里欧发展公司 |
Masked IL-15 cytokines and cleavage products thereof
|
CA3172649A1
(en)
|
2020-04-01 |
2021-10-07 |
Raphael Rozenfeld |
Masked il-2 cytokines and their cleavage products
|
MX2022012312A
(en)
|
2020-04-01 |
2023-02-09 |
Xilio Dev Inc |
Masked il-12 cytokines and their cleavage products.
|