SG11202009527PA - Camptothecin peptide conjugates - Google Patents
Camptothecin peptide conjugatesInfo
- Publication number
- SG11202009527PA SG11202009527PA SG11202009527PA SG11202009527PA SG11202009527PA SG 11202009527P A SG11202009527P A SG 11202009527PA SG 11202009527P A SG11202009527P A SG 11202009527PA SG 11202009527P A SG11202009527P A SG 11202009527PA SG 11202009527P A SG11202009527P A SG 11202009527PA
- Authority
- SG
- Singapore
- Prior art keywords
- peptide conjugates
- camptothecin
- camptothecin peptide
- conjugates
- peptide
- Prior art date
Links
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 title 1
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 title 1
- 229940127093 camptothecin Drugs 0.000 title 1
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 title 1
- 239000000863 peptide conjugate Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/68037—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a camptothecin [CPT] or derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Cell Biology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862653961P | 2018-04-06 | 2018-04-06 | |
PCT/US2019/025968 WO2019195665A1 (fr) | 2018-04-06 | 2019-04-05 | Conjugués peptidiques de camptothécine |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202009527PA true SG11202009527PA (en) | 2020-10-29 |
Family
ID=68101237
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202009527PA SG11202009527PA (en) | 2018-04-06 | 2019-04-05 | Camptothecin peptide conjugates |
Country Status (16)
Country | Link |
---|---|
US (2) | US20190343828A1 (fr) |
EP (1) | EP3773736A4 (fr) |
JP (2) | JP7430643B2 (fr) |
KR (1) | KR20210006362A (fr) |
CN (1) | CN111936169A (fr) |
AR (1) | AR114473A1 (fr) |
AU (1) | AU2019247434A1 (fr) |
BR (1) | BR112020020466A2 (fr) |
CA (1) | CA3094313A1 (fr) |
EA (1) | EA202092410A1 (fr) |
IL (2) | IL310391A (fr) |
MA (1) | MA52669A (fr) |
MX (1) | MX2020010458A (fr) |
SG (1) | SG11202009527PA (fr) |
TW (1) | TW202010498A (fr) |
WO (1) | WO2019195665A1 (fr) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7330101B2 (ja) | 2016-11-08 | 2023-08-21 | レゲネロン ファーマシューティカルス,インコーポレーテッド | ステロイド及びそのタンパク質コンジュゲート |
CN110590796B (zh) * | 2018-06-12 | 2022-07-15 | 青岛海洋生物医药研究院股份有限公司 | 喜树碱衍生物及其制备方法和应用 |
DK3958977T3 (en) * | 2019-04-26 | 2023-12-11 | Immunogen Inc | Camptothecinderivater |
CN112125915A (zh) * | 2019-09-18 | 2020-12-25 | 四川百利药业有限责任公司 | 一种喜树碱衍生物及其偶联物 |
CN114929284A (zh) * | 2019-10-04 | 2022-08-19 | 西根公司 | 喜树碱肽缀合物 |
WO2021067820A1 (fr) * | 2019-10-04 | 2021-04-08 | Seagen Inc. | Formulation de conjugué anticorps-médicament |
CN115052632A (zh) * | 2020-01-15 | 2022-09-13 | 北京海步医药科技有限公司 | 靶向多肽-药物缀合物及其用途 |
CN113274507A (zh) * | 2020-02-20 | 2021-08-20 | 亚飞(上海)生物医药科技有限公司 | 靶向递送和激活的免疫刺激性偶联复合物的制备和用途 |
TW202146055A (zh) * | 2020-02-25 | 2021-12-16 | 美商麥迪波士頓股份有限公司 | 喜樹鹼衍生物及其結合物 |
MX2022014225A (es) | 2020-05-13 | 2023-02-09 | Seagen Inc | Metodos para tratar cancer utilizando una combinacion de conjugados de farmaco-anticuerpo anti-cd30. |
WO2022093800A2 (fr) | 2020-10-27 | 2022-05-05 | Elucida Oncology, Inc. | Conjugués particule vecteur-médicament lieurs auto-immolateurs et leurs utilisations |
EP4277629A1 (fr) * | 2021-01-15 | 2023-11-22 | R.P. Scherer Technologies, LLC | Conjugués anticorps-médicament de camptothécine et leurs méthodes d'utilisation |
CA3209426A1 (fr) * | 2021-02-05 | 2022-08-11 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Compose camptothecine, son procede de preparation et son application |
TW202241521A (zh) * | 2021-02-09 | 2022-11-01 | 大陸商蘇州宜聯生物醫藥有限公司 | 生物活性物偶聯物及其製備方法和用途 |
WO2022194257A1 (fr) * | 2021-03-17 | 2022-09-22 | 江苏恒瑞医药股份有限公司 | Procédé de préparation d'un dérivé de camptothécine |
AR125473A1 (es) * | 2021-04-29 | 2023-07-19 | Abbvie Inc | Conjugados de anticuerpo anti-c-met y fármaco |
CN113527418B (zh) * | 2021-07-16 | 2022-05-03 | 成都普康唯新生物科技有限公司 | 一种ADC linker的制备方法 |
US11806405B1 (en) | 2021-07-19 | 2023-11-07 | Zeno Management, Inc. | Immunoconjugates and methods |
CA3228345A1 (fr) * | 2021-08-19 | 2023-02-23 | Zhen Li | Derive de camptothecine, composition pharmaceutique et leur utilisation |
CA3233254A1 (fr) | 2021-09-27 | 2023-03-30 | Evopoint Biosciences Co., Ltd. | Anticorps, conjugue anticorps-medicament de celui-ci et utilisation associee |
CA3237379A1 (fr) * | 2021-11-09 | 2023-05-19 | Marc-Andre Kasper | Conjugues comprenant un phosphore (v) et un fragment de camptothecine |
WO2023143208A1 (fr) * | 2022-01-26 | 2023-08-03 | 苏州宜联生物医药有限公司 | Procédé de préparation d'un conjugué médicament-lieur |
US20230381321A1 (en) | 2022-03-17 | 2023-11-30 | Seagan Inc., | Camptothecin conjugates |
TW202345904A (zh) * | 2022-04-14 | 2023-12-01 | 瑞士商德彪製藥研究暨製造股份有限公司 | 具有改良之藥物動力學及藥物釋放特性之配體藥物結合物 |
KR20230149752A (ko) * | 2022-04-20 | 2023-10-27 | 주식회사 피노바이오 | Ddx5 단백질에 결합하는 캄토테신 유도체 및 이의 프로드럭 |
WO2023214849A1 (fr) * | 2022-05-04 | 2023-11-09 | 주식회사 피노바이오 | Conjugué de médicament à base de camptothécine se liant à la protéine ddx5 lié à un lieur sensible à l'acide et immunoconjugué l'utilisant |
WO2023231988A1 (fr) * | 2022-05-30 | 2023-12-07 | 苏州宜联生物医药有限公司 | Méthode de préparation d'un conjugué lieur-médicament et d'un intermédiaire de celui-ci |
CN116789733A (zh) * | 2022-07-05 | 2023-09-22 | 上海药明合联生物技术有限公司 | 偶联连接子 |
WO2024013723A1 (fr) * | 2022-07-15 | 2024-01-18 | Pheon Therapeutics Ltd | Conjugués anticorps-médicament qui se lient à cdcp1 et leurs utilisations |
WO2024054089A1 (fr) * | 2022-09-08 | 2024-03-14 | 주식회사 피노바이오 | Nouveaux dérivés de camptothécine et conjugué véhicule-médicament les comprenant |
WO2024073610A2 (fr) * | 2022-09-28 | 2024-04-04 | Solve Therapeutics, Inc. | Compositions et leurs utilisations |
WO2024078586A1 (fr) | 2022-10-14 | 2024-04-18 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Conjugué anticorps-médicament se liant au ptk7 humain et son procédé de préparation et d'utilisation |
WO2024082051A1 (fr) * | 2022-10-18 | 2024-04-25 | Zymeworks Bc Inc. | Conjugués anticorps-médicament ciblant le glypicane 3 et procédés d'utilisation |
CN118105508A (zh) * | 2022-11-29 | 2024-05-31 | 四川科伦博泰生物医药股份有限公司 | 药物连接子化合物及其制备方法和用途 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0540099B1 (fr) | 1991-10-29 | 1996-04-17 | Glaxo Wellcome Inc. | Dérivés de camptothécine solubles dans l'eau |
JPH06228141A (ja) * | 1992-01-24 | 1994-08-16 | Takeda Chem Ind Ltd | 縮合複素環誘導体、その塩、その製造法および用途 |
US5496830A (en) * | 1994-09-14 | 1996-03-05 | Johns Hopkins University | Inhibition of hemoflagellates by camptothecin compounds |
SG88737A1 (en) * | 1996-10-30 | 2002-05-21 | Tanabe Seiyaku Co | S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof |
EE200100603A (et) * | 1999-05-14 | 2003-02-17 | Imclone Systems Incorporated | Inimese refraktaarsete kasvajate ravi epidermaalse kasvufaktori retseptori antagonistidega |
US6629995B1 (en) * | 2000-03-31 | 2003-10-07 | Super Gen, Inc. | Camptothecin conjugates |
US6825206B1 (en) * | 2000-11-16 | 2004-11-30 | Research Triangle Institute | Camptothecin compounds with a thioether group |
US8877901B2 (en) | 2002-12-13 | 2014-11-04 | Immunomedics, Inc. | Camptothecin-binding moiety conjugates |
US7591994B2 (en) * | 2002-12-13 | 2009-09-22 | Immunomedics, Inc. | Camptothecin-binding moiety conjugates |
EA020696B1 (ru) * | 2007-10-12 | 2015-01-30 | Сиэтл Дженетикс, Инк. | Способ лечения лимфомы ходжкина с использованием комбинации гемцитабина и конъюгата антитела против cd30 с ауристатином |
KR102442906B1 (ko) | 2013-12-19 | 2022-09-14 | 씨젠 인크. | 표적화된-약물 컨쥬게이트와 함께 사용되는 메틸렌 카바메이트 링커 |
JP7244987B2 (ja) * | 2016-12-14 | 2023-03-23 | シージェン インコーポレイテッド | 多剤抗体薬物コンジュゲート |
TW202015740A (zh) * | 2018-06-07 | 2020-05-01 | 美商西雅圖遺傳學公司 | 喜樹鹼結合物 |
-
2019
- 2019-04-05 EA EA202092410A patent/EA202092410A1/ru unknown
- 2019-04-05 WO PCT/US2019/025968 patent/WO2019195665A1/fr active Application Filing
- 2019-04-05 US US16/376,302 patent/US20190343828A1/en not_active Abandoned
- 2019-04-05 SG SG11202009527PA patent/SG11202009527PA/en unknown
- 2019-04-05 IL IL310391A patent/IL310391A/en unknown
- 2019-04-05 MA MA052669A patent/MA52669A/fr unknown
- 2019-04-05 CN CN201980024331.XA patent/CN111936169A/zh active Pending
- 2019-04-05 AR ARP190100908A patent/AR114473A1/es unknown
- 2019-04-05 IL IL277748A patent/IL277748B1/en unknown
- 2019-04-05 BR BR112020020466-8A patent/BR112020020466A2/pt unknown
- 2019-04-05 EP EP19781578.0A patent/EP3773736A4/fr active Pending
- 2019-04-05 KR KR1020207031963A patent/KR20210006362A/ko unknown
- 2019-04-05 JP JP2020554542A patent/JP7430643B2/ja active Active
- 2019-04-05 CA CA3094313A patent/CA3094313A1/fr active Pending
- 2019-04-05 MX MX2020010458A patent/MX2020010458A/es unknown
- 2019-04-05 AU AU2019247434A patent/AU2019247434A1/en active Pending
- 2019-04-08 TW TW108112067A patent/TW202010498A/zh unknown
-
2021
- 2021-10-27 US US17/452,516 patent/US20220193069A1/en not_active Abandoned
-
2024
- 2024-01-31 JP JP2024012728A patent/JP2024042054A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
MA52669A (fr) | 2021-02-17 |
IL310391A (en) | 2024-03-01 |
CA3094313A1 (fr) | 2019-10-10 |
US20220193069A1 (en) | 2022-06-23 |
EP3773736A4 (fr) | 2022-01-05 |
US20190343828A1 (en) | 2019-11-14 |
JP7430643B2 (ja) | 2024-02-13 |
JP2021521111A (ja) | 2021-08-26 |
EA202092410A1 (ru) | 2021-02-09 |
JP2024042054A (ja) | 2024-03-27 |
IL277748A (en) | 2020-11-30 |
MX2020010458A (es) | 2021-01-29 |
WO2019195665A1 (fr) | 2019-10-10 |
AU2019247434A1 (en) | 2020-10-08 |
BR112020020466A2 (pt) | 2021-01-12 |
KR20210006362A (ko) | 2021-01-18 |
CN111936169A (zh) | 2020-11-13 |
IL277748B1 (en) | 2024-03-01 |
TW202010498A (zh) | 2020-03-16 |
EP3773736A1 (fr) | 2021-02-17 |
AR114473A1 (es) | 2020-09-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL277748A (en) | Camptothecin peptide conjugates | |
IL278990A (en) | Captures of camptothecin | |
IL291686A (en) | Camptothecin peptide conjugates | |
ZA201904269B (en) | Pyrrolobenzodiazepine-antibody conjugates | |
SI3592393T1 (sl) | Sprostljivi konjugati | |
SI3544636T1 (sl) | Konjugati pirolobenzodiazepin-protitelo | |
GB201702031D0 (en) | Pyrrolobenzodiazepine-antibody conjugates | |
IL283942A (en) | Tubulysins and protein-tubulysin conjugation | |
GB201820626D0 (en) | Conjugates | |
GB201713700D0 (en) | Peptide conjugates | |
EP3609527A4 (fr) | Conjugués de protéines | |
IL288681A (en) | Pyrrolobenzodiazepine-antibody conjugates | |
GB201817486D0 (en) | Peptides and conjugates | |
GB201811332D0 (en) | Pyrroloobenzodiazepine-antibody conjugates | |
GB201811335D0 (en) | Pyrrolobenzodiazepine-antibody conjugates | |
GB201805306D0 (en) | Peptides and conjugates | |
GB201906997D0 (en) | Conjugates | |
GB201900735D0 (en) | Conjugates | |
GB201817088D0 (en) | Pyrrolobenzodiazepine conjugates | |
GB201817110D0 (en) | Pyrrolobenzodiazepine conjugates | |
GB201815723D0 (en) | Bycyclic peptide ligand drug conjugates | |
GB201721290D0 (en) | Conjugates | |
GB201719906D0 (en) | Pyrrolobenzodiazepine-antibody conjugates | |
GB201719398D0 (en) | Pyrrolobenzodiazepine-antibody conjugates | |
GB201719393D0 (en) | Pyrrolobenzodiazepine-antibody conjugates |