SG11202008652VA - Process for the preparation of polymorph form b of treprostinil diethanolamine salt - Google Patents
Process for the preparation of polymorph form b of treprostinil diethanolamine saltInfo
- Publication number
- SG11202008652VA SG11202008652VA SG11202008652VA SG11202008652VA SG11202008652VA SG 11202008652V A SG11202008652V A SG 11202008652VA SG 11202008652V A SG11202008652V A SG 11202008652VA SG 11202008652V A SG11202008652V A SG 11202008652VA SG 11202008652V A SG11202008652V A SG 11202008652VA
- Authority
- SG
- Singapore
- Prior art keywords
- preparation
- polymorph form
- diethanolamine salt
- treprostinil diethanolamine
- treprostinil
- Prior art date
Links
- RHWRWEUCEXUUAV-ZSESPEEFSA-N 2-[[(1r,2r,3as,9as)-2-hydroxy-1-[(3s)-3-hydroxyoctyl]-2,3,3a,4,9,9a-hexahydro-1h-cyclopenta[g]naphthalen-5-yl]oxy]acetic acid;2-(2-hydroxyethylamino)ethanol Chemical class OCCNCCO.C1=CC=C(OCC(O)=O)C2=C1C[C@@H]1[C@@H](CC[C@@H](O)CCCCC)[C@H](O)C[C@@H]1C2 RHWRWEUCEXUUAV-ZSESPEEFSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/54—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings and other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
- C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
- C07C215/10—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with one amino group and at least two hydroxy groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/72—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings and other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
- C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
- C07C65/26—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Crystallography & Structural Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU1800089A HU231296B1 (hu) | 2018-03-09 | 2018-03-09 | Eljárás treprostinil-dietanol-amin só B polimorf formájának előállítására |
| PCT/HU2019/050007 WO2019171093A2 (en) | 2018-03-09 | 2019-03-07 | Process for the preparation of polymorph form b of treprostinil diethanolamine salt |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202008652VA true SG11202008652VA (en) | 2020-10-29 |
Family
ID=89992650
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202008652VA SG11202008652VA (en) | 2018-03-09 | 2019-03-07 | Process for the preparation of polymorph form b of treprostinil diethanolamine salt |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US11319274B2 (ja) |
| EP (1) | EP3762358B1 (ja) |
| JP (1) | JP7340534B2 (ja) |
| KR (1) | KR20200130717A (ja) |
| CN (1) | CN111801313B (ja) |
| AU (1) | AU2019229778B2 (ja) |
| CA (1) | CA3093183A1 (ja) |
| ES (1) | ES2939465T3 (ja) |
| HU (2) | HU231296B1 (ja) |
| IL (1) | IL277153B2 (ja) |
| MX (1) | MX2020009387A (ja) |
| SG (1) | SG11202008652VA (ja) |
| TW (1) | TWI825076B (ja) |
| WO (1) | WO2019171093A2 (ja) |
| ZA (1) | ZA202004936B (ja) |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102697790A (zh) | 2003-05-22 | 2012-10-03 | 联合治疗公司 | 化合物和释放前列环素类似物的方法 |
| KR101898407B1 (ko) | 2007-12-17 | 2018-09-12 | 유나이티드 세러퓨틱스 코오포레이션 | 레모둘린®의 활성 성분인 트레프로스티닐의 개선된 제조 방법 |
| ES2790859T3 (es) * | 2010-03-15 | 2020-10-29 | United Therapeutics Corp | Tratamiento para hipertensión pulmonar |
| CA2726599C (en) * | 2010-12-30 | 2017-07-25 | Alphora Research Inc. | Process for treprostinil salt preparation |
| CA2893604A1 (en) | 2012-12-07 | 2014-06-12 | Cayman Chemical Company Incorporated | Methods of synthesizing a prostacyclin analog |
| KR102347340B1 (ko) * | 2013-03-14 | 2022-01-06 | 유나이티드 세러퓨틱스 코오포레이션 | 트레프로스티닐의 고체 형태 |
| KR102238501B1 (ko) | 2013-03-25 | 2021-04-08 | 유나이티드 세러퓨틱스 코오포레이션 | 링커 티올 및 peg화된 형태를 갖는 프로스타시클린 화합물의 제조 방법 |
| US20160045470A1 (en) | 2014-08-12 | 2016-02-18 | Dr. Reddy's Laboratories Limited | Amorphous solid dispersion of treprostinil diethanolamine |
| WO2016038532A1 (en) | 2014-09-09 | 2016-03-17 | Mylan Laboratories Limited | Amorphous treprostinil diethanolamine |
| HU231186B1 (hu) * | 2014-10-08 | 2021-06-28 | CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. | Új eljárás treprostinil és sói előállítására |
| TWI540121B (zh) * | 2014-12-01 | 2016-07-01 | 臺灣永光化學工業股份有限公司 | 曲前列環素二乙醇胺之合成方法及新穎中間體 |
-
2018
- 2018-03-09 HU HU1800089A patent/HU231296B1/hu unknown
-
2019
- 2019-03-07 CA CA3093183A patent/CA3093183A1/en active Pending
- 2019-03-07 MX MX2020009387A patent/MX2020009387A/es unknown
- 2019-03-07 US US16/978,391 patent/US11319274B2/en active Active
- 2019-03-07 TW TW108107554A patent/TWI825076B/zh active
- 2019-03-07 KR KR1020207028753A patent/KR20200130717A/ko not_active Application Discontinuation
- 2019-03-07 JP JP2020547125A patent/JP7340534B2/ja active Active
- 2019-03-07 SG SG11202008652VA patent/SG11202008652VA/en unknown
- 2019-03-07 HU HUE19721005A patent/HUE061357T2/hu unknown
- 2019-03-07 IL IL277153A patent/IL277153B2/en unknown
- 2019-03-07 WO PCT/HU2019/050007 patent/WO2019171093A2/en active Application Filing
- 2019-03-07 CN CN201980016871.3A patent/CN111801313B/zh active Active
- 2019-03-07 ES ES19721005T patent/ES2939465T3/es active Active
- 2019-03-07 AU AU2019229778A patent/AU2019229778B2/en active Active
- 2019-03-07 EP EP19721005.7A patent/EP3762358B1/en active Active
-
2020
- 2020-08-11 ZA ZA2020/04936A patent/ZA202004936B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2019171093A2 (en) | 2019-09-12 |
| AU2019229778A1 (en) | 2020-10-22 |
| MX2020009387A (es) | 2020-10-28 |
| CA3093183A1 (en) | 2019-09-12 |
| CN111801313B (zh) | 2023-08-29 |
| IL277153B1 (en) | 2023-09-01 |
| JP2021517138A (ja) | 2021-07-15 |
| IL277153B2 (en) | 2024-01-01 |
| WO2019171093A3 (en) | 2019-11-14 |
| KR20200130717A (ko) | 2020-11-19 |
| BR112020018096A2 (pt) | 2020-12-22 |
| EP3762358A2 (en) | 2021-01-13 |
| TW202003441A (zh) | 2020-01-16 |
| RU2020133081A3 (ja) | 2022-04-12 |
| IL277153A (en) | 2020-10-29 |
| JP7340534B2 (ja) | 2023-09-07 |
| EP3762358B1 (en) | 2022-11-30 |
| US20210053901A1 (en) | 2021-02-25 |
| RU2020133081A (ru) | 2022-04-12 |
| HU231296B1 (hu) | 2022-09-28 |
| ZA202004936B (en) | 2024-04-24 |
| AU2019229778B2 (en) | 2023-11-02 |
| CN111801313A (zh) | 2020-10-20 |
| ES2939465T3 (es) | 2023-04-24 |
| TWI825076B (zh) | 2023-12-11 |
| US11319274B2 (en) | 2022-05-03 |
| HUP1800089A2 (en) | 2019-09-30 |
| HUE061357T2 (hu) | 2023-06-28 |
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