IL277956B1 - Process for the preparation of iloprost - Google Patents

Process for the preparation of iloprost

Info

Publication number
IL277956B1
IL277956B1 IL277956A IL27795620A IL277956B1 IL 277956 B1 IL277956 B1 IL 277956B1 IL 277956 A IL277956 A IL 277956A IL 27795620 A IL27795620 A IL 27795620A IL 277956 B1 IL277956 B1 IL 277956B1
Authority
IL
Israel
Prior art keywords
iloprost
preparation
Prior art date
Application number
IL277956A
Other languages
Hebrew (he)
Other versions
IL277956A (en
IL277956B2 (en
Original Assignee
Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Zrt
Publication of IL277956A publication Critical patent/IL277956A/en
Publication of IL277956B1 publication Critical patent/IL277956B1/en
Publication of IL277956B2 publication Critical patent/IL277956B2/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/557Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C13/00Cyclic hydrocarbons containing rings other than, or in addition to, six-membered aromatic rings
    • C07C13/28Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof
    • C07C13/32Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings
    • C07C13/44Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings with a bicyclo ring system containing eight carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/30Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/31Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/48Separation; Purification; Stabilisation; Use of additives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10Oxygen atoms
    • C07D309/12Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14All rings being cycloaliphatic
    • C07C2602/22All rings being cycloaliphatic the ring system containing eight carbon atoms, e.g. pentalene
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/42Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/46Unsaturated compounds containing hydroxy or O-metal groups containing rings other than six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/608Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a ring other than a six-membered aromatic ring in the acid moiety

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
IL277956A 2018-04-16 2019-04-16 Process for the preparation of iloprost IL277956B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU1800125A HU231212B1 (en) 2018-04-16 2018-04-16 Process for production of iloprost
PCT/HU2019/050016 WO2019202345A2 (en) 2018-04-16 2019-04-16 Process for the preparation of iloprost

Publications (3)

Publication Number Publication Date
IL277956A IL277956A (en) 2020-11-30
IL277956B1 true IL277956B1 (en) 2023-05-01
IL277956B2 IL277956B2 (en) 2023-09-01

Family

ID=90001691

Family Applications (1)

Application Number Title Priority Date Filing Date
IL277956A IL277956B2 (en) 2018-04-16 2019-04-16 Process for the preparation of iloprost

Country Status (16)

Country Link
US (2) US11535580B2 (en)
EP (2) EP3781544B1 (en)
JP (2) JP7368376B2 (en)
KR (1) KR20210005627A (en)
CN (1) CN112218847B (en)
AU (2) AU2019256800B2 (en)
BR (1) BR112020020909B1 (en)
CA (1) CA3096969A1 (en)
ES (1) ES2969135T3 (en)
HU (2) HU231212B1 (en)
IL (1) IL277956B2 (en)
MX (1) MX2020010985A (en)
SG (1) SG11202010200RA (en)
TW (1) TW201945332A (en)
WO (1) WO2019202345A2 (en)
ZA (1) ZA202006181B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11884613B2 (en) 2022-05-05 2024-01-30 Chirogate International Inc. Processes and intermediates for the preparation of carbaprostacyclin analogues

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4841968A (en) * 1986-09-26 1989-06-27 Southern Research Institute Antithrombotic/thrombolytic suture and methods of making and using the same

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1201712A (en) 1980-02-28 1986-03-11 Paul A. Aristoff Carbacyclin analogs
US4420632A (en) 1980-04-15 1983-12-13 The Upjohn Company Composition and process
JPS59134787A (en) * 1983-01-19 1984-08-02 Toray Ind Inc Preparation of 5,6,7-trinor-4,8-inter-m-phenylene pgi2 derivative
JPS60166644A (en) * 1984-02-10 1985-08-29 Sagami Chem Res Center Preparation of cis-bicyclo(3.3.0)octylidene derivative
DE3608088C2 (en) * 1986-03-07 1995-11-16 Schering Ag Pharmaceutical preparations containing cyclodextrin clathrates of carbacyclin derivatives
US4879285A (en) * 1986-08-22 1989-11-07 Royal North Shore Hospital And Area Health Service Fertility control
DE3816801A1 (en) 1988-05-13 1989-11-23 Schering Ag Process for the preparation of carbacyclines
US5425853A (en) * 1994-06-30 1995-06-20 Lloyd Berg Separation of propylene glycol from ethylene glycol by azeotropic distillation
HU227157B1 (en) 2001-07-30 2010-09-28 Chinoin Gyogyszer Es Vegyeszet Production of beraprost ester by selective oxidation
US20120270934A1 (en) * 2009-07-03 2012-10-25 Concert Pharmaceuticals, Inc. Prostacyclin derivatives
US8754516B2 (en) 2010-08-26 2014-06-17 Intel Corporation Bumpless build-up layer package with pre-stacked microelectronic devices
CN103102256A (en) 2013-01-24 2013-05-15 复旦大学 Preparation method of optical-activity 7-substituted oxy-6-hydroxyhept-3-ethylene-2-ketone
CN107324986B (en) * 2017-01-06 2021-04-30 常州博海威医药科技股份有限公司 Preparation method and application of 16(S) -iloprost

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4841968A (en) * 1986-09-26 1989-06-27 Southern Research Institute Antithrombotic/thrombolytic suture and methods of making and using the same

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
NORTH AMERICA ET AL:, LLOPROST.- CERTIFICATE OF ANALYSIS- TOCRIS, 14 December 2016 (2016-12-14) *
STEINER T ET AL:, A SIDE CHAIN OF DIASTEREOMERIC ILOPROST PROTRUDES FROM THE CAGE IN THE COMPLEX WITH CYCLOMALTOHEPTAOSE (@B-CYCLODEXTRIN): CRYSTAL STRUCTURE OF (@B-CYCLODEXTRIN)" 2 ILOPROST.20.5 H" 2O, 23 October 1989 (1989-10-23) *

Also Published As

Publication number Publication date
US11535580B2 (en) 2022-12-27
IL277956A (en) 2020-11-30
US11958798B2 (en) 2024-04-16
AU2019256800B2 (en) 2024-03-14
HU231212B1 (en) 2021-11-29
US20210147329A1 (en) 2021-05-20
MX2020010985A (en) 2021-01-08
EP3781544A2 (en) 2021-02-24
IL277956B2 (en) 2023-09-01
HUE065549T2 (en) 2024-06-28
WO2019202345A3 (en) 2020-01-09
AU2019256800A1 (en) 2020-12-03
JP2024009928A (en) 2024-01-23
EP4296256A3 (en) 2024-04-03
EP3781544C0 (en) 2023-11-08
SG11202010200RA (en) 2020-11-27
JP7368376B2 (en) 2023-10-24
CA3096969A1 (en) 2019-10-24
BR112020020909A2 (en) 2021-01-26
EP4296256A2 (en) 2023-12-27
WO2019202345A2 (en) 2019-10-24
HUP1800125A2 (en) 2019-10-28
ES2969135T3 (en) 2024-05-16
CN112218847B (en) 2024-03-08
BR112020020909B1 (en) 2023-12-19
EP3781544B1 (en) 2023-11-08
TW201945332A (en) 2019-12-01
JP2021521229A (en) 2021-08-26
US20230115500A1 (en) 2023-04-13
CN112218847A (en) 2021-01-12
AU2024204020A1 (en) 2024-07-04
ZA202006181B (en) 2024-05-30
KR20210005627A (en) 2021-01-14

Similar Documents

Publication Publication Date Title
IL276917A (en) Process for the preparation of elobixibat
GB2593352B (en) Process for the preparation of 3alpha-hydroxy-5alpha-pregnan-20-one (brexanolone)
SG11202005382YA (en) Process for the preparation of microcapsules
PL3765440T3 (en) Process for the preparation of n-alkyl-nitratoethylnitramines
IL276483B1 (en) Continuous process for the preparation of trazodone
SG11202005889WA (en) Process for the preparation of methyl mercaptan
IL289904A (en) Process for the preparation of biphenylamines
IL268835B (en) Process for the preparation of 2-cyanoimidazole compounds
IL281254A (en) Process for the preparation of lenvatinib
IL275480A (en) Process for the preparation of pyrimidinyl-4-aminopyrazole compounds
EP3802627A4 (en) Processes for the preparation of sugammadex
IL277956A (en) Process for the preparation of iloprost
EP3877361C0 (en) Process for the preparation of arylsulfonylpropenenitriles
PL3599256T3 (en) Process for the preparation of polyorganosiloaxnes
GB2572385B (en) Process for the preparation of glycidol
HUP1800278A2 (en) Process for the preparation of boc-linagliptin
GB2573115B (en) Process for the preparation of oxamyl
IL281635A (en) Synthetic method for the preparation of an alkoxymethylene-benzoylacetonitrile
IL276557A (en) Process for the preparation of metformin
PL3604272T3 (en) Process for the preparation of gabapentin
HK1246812A1 (en) Method for the preparation of immunoglobulins