SG11202006741WA - Oligonucleotide and nucleic acid synthesis - Google Patents

Oligonucleotide and nucleic acid synthesis

Info

Publication number
SG11202006741WA
SG11202006741WA SG11202006741WA SG11202006741WA SG11202006741WA SG 11202006741W A SG11202006741W A SG 11202006741WA SG 11202006741W A SG11202006741W A SG 11202006741WA SG 11202006741W A SG11202006741W A SG 11202006741WA SG 11202006741W A SG11202006741W A SG 11202006741WA
Authority
SG
Singapore
Prior art keywords
oligonucleotide
nucleic acid
acid synthesis
synthesis
nucleic
Prior art date
Application number
SG11202006741WA
Other languages
English (en)
Inventor
Stuart Crosby
Mathew Jenison
Joseph Brennan
Iain Barlow
Pascal Lang
Matthew Hayes
Catherine Fitzpatrick
Daniel Bygrave
Original Assignee
Evonetix Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evonetix Ltd filed Critical Evonetix Ltd
Publication of SG11202006741WA publication Critical patent/SG11202006741WA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00Processes for the preparation of sugar derivatives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • C07H19/073Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C12N15/1006Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811Selection methods for production or design of target specific oligonucleotides or binding molecules

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Immunology (AREA)
  • Saccharide Compounds (AREA)
SG11202006741WA 2018-01-24 2019-01-23 Oligonucleotide and nucleic acid synthesis SG11202006741WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1801182.5A GB201801182D0 (en) 2018-01-24 2018-01-24 Oligonucleotide and nucleic acid synthesis
PCT/GB2019/050192 WO2019145713A1 (en) 2018-01-24 2019-01-23 Oligonucleotide and nucleic acid synthesis

Publications (1)

Publication Number Publication Date
SG11202006741WA true SG11202006741WA (en) 2020-08-28

Family

ID=61283585

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202006741WA SG11202006741WA (en) 2018-01-24 2019-01-23 Oligonucleotide and nucleic acid synthesis

Country Status (11)

Country Link
US (2) US20210047361A1 (https=)
EP (1) EP3743433A1 (https=)
JP (2) JP7493452B2 (https=)
KR (1) KR20200115561A (https=)
CN (1) CN111770928A (https=)
AU (1) AU2019213203B2 (https=)
CA (1) CA3088583A1 (https=)
GB (1) GB201801182D0 (https=)
IL (1) IL276149B (https=)
SG (1) SG11202006741WA (https=)
WO (1) WO2019145713A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11970696B1 (en) 2019-08-27 2024-04-30 Leidos, Inc. Optical methods and systems for DNA assembly for computer data storage
WO2022183121A1 (en) 2021-02-26 2022-09-01 Avery Digital Data, Inc. Semiconductor chip devices and methods for polynucleotide synthesis
CN113004360A (zh) * 2021-03-03 2021-06-22 通用生物系统(安徽)有限公司 一种用于膜杂交检测的氨基修饰引物的生产方法
CN114621307B (zh) * 2022-04-12 2024-12-13 中国科学院苏州生物医学工程技术研究所 一种寡核苷酸空间坐标编码方法及其微流控装置
GB202300626D0 (en) 2023-01-16 2023-03-01 Evonetix Ltd Hybridisation detection
CN116333006A (zh) * 2023-04-07 2023-06-27 苏州欧利生物医药科技有限公司 一种带有荧光标记物的寡核苷酸的固相合成方法
US20250206769A1 (en) 2023-12-22 2025-06-26 Imec Vzw Synthesizing a Nucleic Acid or Nucleic Acid Analogue
WO2025163199A1 (en) 2024-02-01 2025-08-07 Analog Devices International Unlimited Company Methods of amplifying target nucleic acids in a sample
WO2025165064A1 (ko) * 2024-02-02 2025-08-07 에스티팜 주식회사 올리고뉴클레오티드 합성을 위한 개선된 방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6270391A (ja) * 1985-09-25 1987-03-31 Nippon Zeon Co Ltd 保護されたオリゴヌクレオチドの製造法
US5419874A (en) * 1992-07-06 1995-05-30 Beckman Instruments, Inc. Synthesis reaction column
US7135565B2 (en) * 2000-07-28 2006-11-14 Agilent Technologies, Inc. Synthesis of polynucleotides using combined oxidation/deprotection chemistry
WO2004101582A2 (en) * 2003-05-09 2004-11-25 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Thermolabile hydroxyl protecting groups and methods of use
US8138330B2 (en) * 2006-09-11 2012-03-20 Sigma-Aldrich Co. Llc Process for the synthesis of oligonucleotides
JP2010248084A (ja) 2009-04-10 2010-11-04 Invitrogen Japan Kk 新規洗浄溶媒を用いるオリゴヌクレオチド合成法

Also Published As

Publication number Publication date
IL276149B (en) 2022-08-01
JP7493452B2 (ja) 2024-05-31
AU2019213203A1 (en) 2020-08-06
GB201801182D0 (en) 2018-03-07
JP2024023388A (ja) 2024-02-21
US20240199681A1 (en) 2024-06-20
WO2019145713A9 (en) 2020-08-06
IL276149A (en) 2020-09-30
CN111770928A (zh) 2020-10-13
EP3743433A1 (en) 2020-12-02
AU2019213203A9 (en) 2020-08-27
AU2019213203B2 (en) 2023-02-23
US20210047361A1 (en) 2021-02-18
JP2021510716A (ja) 2021-04-30
WO2019145713A1 (en) 2019-08-01
KR20200115561A (ko) 2020-10-07
CA3088583A1 (en) 2019-08-01

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