SG11202006311SA - Novel processes and intermediates for the preparation of soluble guanylate cyclase stimulators - Google Patents
Novel processes and intermediates for the preparation of soluble guanylate cyclase stimulatorsInfo
- Publication number
- SG11202006311SA SG11202006311SA SG11202006311SA SG11202006311SA SG11202006311SA SG 11202006311S A SG11202006311S A SG 11202006311SA SG 11202006311S A SG11202006311S A SG 11202006311SA SG 11202006311S A SG11202006311S A SG 11202006311SA SG 11202006311S A SG11202006311S A SG 11202006311SA
- Authority
- SG
- Singapore
- Prior art keywords
- intermediates
- preparation
- guanylate cyclase
- soluble guanylate
- novel processes
- Prior art date
Links
- 102000007637 Soluble Guanylyl Cyclase Human genes 0.000 title 1
- 108010007205 Soluble Guanylyl Cyclase Proteins 0.000 title 1
- 239000003119 guanylate cyclase activator Substances 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862615678P | 2018-01-10 | 2018-01-10 | |
| PCT/CN2018/076982 WO2019161534A1 (fr) | 2018-02-22 | 2018-02-22 | Nouveaux procédés et intermédiaires pour la préparation de stimulateurs de guanylate cyclase soluble |
| PCT/US2019/013060 WO2019140095A1 (fr) | 2018-01-10 | 2019-01-10 | Nouveaux procédés et intermédiaires pour la préparation de stimulateurs de la guanylate cyclase soluble |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202006311SA true SG11202006311SA (en) | 2020-07-29 |
Family
ID=65279655
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202006311SA SG11202006311SA (en) | 2018-01-10 | 2019-01-10 | Novel processes and intermediates for the preparation of soluble guanylate cyclase stimulators |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US11274096B2 (fr) |
| EP (2) | EP4249469A3 (fr) |
| JP (2) | JP7357621B2 (fr) |
| KR (1) | KR20200106920A (fr) |
| CN (2) | CN118184645A (fr) |
| AU (2) | AU2019206560B2 (fr) |
| BR (1) | BR112020013985A2 (fr) |
| CA (1) | CA3087943A1 (fr) |
| CL (3) | CL2020001814A1 (fr) |
| ES (1) | ES2963447T3 (fr) |
| IL (1) | IL275748A (fr) |
| JO (1) | JOP20200165A1 (fr) |
| MA (1) | MA51565A (fr) |
| MX (3) | MX2020007364A (fr) |
| SG (1) | SG11202006311SA (fr) |
| TW (2) | TWI821237B (fr) |
| WO (1) | WO2019140095A1 (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2017291827B2 (en) * | 2016-07-07 | 2021-10-21 | Cyclerion Therapeutics, Inc. | Novel processes for preparation of soluble guanylate cyclase stimulators |
| US11274096B2 (en) | 2018-01-10 | 2022-03-15 | Cyclerion Therapeutics, Inc. | Processes and intermediates for the preparation of soluble guanylate cyclase stimulators |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR088020A1 (es) * | 2010-06-30 | 2014-05-07 | Ironwood Pharmaceuticals Inc | Compuestos heterociclicos como estimuladores de sgc |
| ES2774295T3 (es) * | 2013-03-15 | 2020-07-20 | Cyclerion Therapeutics Inc | Estimuladores de sGC |
| EP3094327A1 (fr) * | 2014-01-13 | 2016-11-23 | Ironwood Pharmaceuticals, Inc. | Utilisation de stimulateurs de la sgc pour le traitement de troubles neuromusculaires |
| AU2015317818A1 (en) * | 2014-09-17 | 2017-03-23 | Ironwood Pharmaceuticals, Inc. | SGC stimulators |
| CN107406422B (zh) * | 2014-09-17 | 2022-02-01 | 赛科理音医疗有限公司 | 作为sGC刺激剂的吡唑衍生物 |
| AU2016364976B2 (en) * | 2015-11-30 | 2022-08-25 | Cyclerion Therapeutics, Inc. | Solid dispersions comprising a sGC stimulator |
| AU2017292811B2 (en) | 2016-07-07 | 2021-10-21 | Cyclerion Therapeutics, Inc. | Novel processes for preparation of soluble guanylate cyclase stimulators |
| AU2017291827B2 (en) | 2016-07-07 | 2021-10-21 | Cyclerion Therapeutics, Inc. | Novel processes for preparation of soluble guanylate cyclase stimulators |
| US11274096B2 (en) | 2018-01-10 | 2022-03-15 | Cyclerion Therapeutics, Inc. | Processes and intermediates for the preparation of soluble guanylate cyclase stimulators |
-
2019
- 2019-01-10 US US16/961,109 patent/US11274096B2/en active Active
- 2019-01-10 ES ES19703440T patent/ES2963447T3/es active Active
- 2019-01-10 MA MA051565A patent/MA51565A/fr unknown
- 2019-01-10 JO JOP/2020/0165A patent/JOP20200165A1/ar unknown
- 2019-01-10 TW TW108101044A patent/TWI821237B/zh active
- 2019-01-10 KR KR1020207022640A patent/KR20200106920A/ko not_active Application Discontinuation
- 2019-01-10 WO PCT/US2019/013060 patent/WO2019140095A1/fr active Application Filing
- 2019-01-10 EP EP23187776.2A patent/EP4249469A3/fr active Pending
- 2019-01-10 CN CN202410363182.2A patent/CN118184645A/zh active Pending
- 2019-01-10 AU AU2019206560A patent/AU2019206560B2/en active Active
- 2019-01-10 EP EP19703440.8A patent/EP3737679B1/fr active Active
- 2019-01-10 JP JP2020538535A patent/JP7357621B2/ja active Active
- 2019-01-10 CN CN201980017700.2A patent/CN111902410B/zh active Active
- 2019-01-10 SG SG11202006311SA patent/SG11202006311SA/en unknown
- 2019-01-10 TW TW112138274A patent/TW202402741A/zh unknown
- 2019-01-10 BR BR112020013985-8A patent/BR112020013985A2/pt unknown
- 2019-01-10 CA CA3087943A patent/CA3087943A1/fr active Pending
- 2019-01-10 MX MX2020007364A patent/MX2020007364A/es unknown
-
2020
- 2020-06-30 IL IL275748A patent/IL275748A/en unknown
- 2020-07-07 CL CL2020001814A patent/CL2020001814A1/es unknown
- 2020-07-13 MX MX2023000045A patent/MX2023000045A/es unknown
- 2020-07-13 MX MX2023000044A patent/MX2023000044A/es unknown
-
2021
- 2021-10-08 US US17/497,352 patent/US11708361B2/en active Active
-
2022
- 2022-04-08 CL CL2022000907A patent/CL2022000907A1/es unknown
- 2022-04-08 CL CL2022000904A patent/CL2022000904A1/es unknown
-
2023
- 2023-04-28 US US18/140,966 patent/US20230339928A1/en active Pending
- 2023-09-26 JP JP2023162922A patent/JP2023182647A/ja active Pending
- 2023-11-22 AU AU2023270260A patent/AU2023270260A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP3402787A4 (fr) | Procédés de préparation d'acide 2,5-furandicarboxylique et des intermédiaires et dérivés correspondants | |
| GB202106894D0 (en) | Process for the preparation of 3alpha-hydroxy-5#LPHA-Pregnan-20-one (brexanolone) | |
| IL263995B (en) | State-of-the-art processes for the preparation of soluble guanylate cyclase stimulators | |
| ZA202101214B (en) | Process and intermediates for the preparation of bilastine | |
| IL260665B (en) | Improved process for the preparation of osimertinib (azd9291) or its salt and "azd9291 aniline" or its salt | |
| ZA202003590B (en) | Process for the preparation of opicapone and intermediates thereof | |
| IL275748A (en) | PROCESSES AND INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF SOLUBLE GIONLIGHT CYCLAS FANS | |
| HUE062956T2 (hu) | Eljárások niraparib és köztitermékei elõállítására | |
| IL263994B (en) | State-of-the-art processes for the preparation of soluble guanylate cyclase stimulators | |
| IL289904A (en) | A process for preparing biphenylamines | |
| EP3837239A4 (fr) | Procédé de préparation de solriamfétol et sel de celui-ci | |
| PL3737685T3 (pl) | Sposób wytwarzania kryzaborolu i jego związków pośrednich | |
| ZA202107053B (en) | Novel process for the preparation of filgotinib and intermediates thereof | |
| IL278549B2 (en) | Intermediates and processes for the preparation of linagliptin and its salts | |
| IL276852A (en) | A process for making soluble guinelate cyclase beads | |
| IL272837A (en) | A process for preparing tubolysins and their intermediates | |
| EP3877361C0 (fr) | Procédé de préparation d'arylsulfonylpropènenitriles | |
| FI4073051T3 (fi) | Menetelmä ja välituote oksetan-2-yylimetanamiinin valmistamiseksi | |
| IL281090A (en) | Alternative processes for the preparation of tubolysins and their intermediates | |
| PT3969459T (pt) | Processo e intermediários para a preparação de eldecalcitol | |
| HUE058725T2 (hu) | Eljárás aminok elõállítására | |
| HUP1800397A2 (en) | Process for the preparation of lumateperone and salts thereof | |
| HUP1800407A2 (en) | Coating composition and process for the preparation thereof | |
| HUP1500451A2 (en) | Processes for the preparation of 1,4,7-triaza-cyclononane derivatives and intermediates |