SG11202006087UA - Heterocyclylamino-substituted triazoles as modulators of rho-associated protein kinase - Google Patents

Heterocyclylamino-substituted triazoles as modulators of rho-associated protein kinase

Info

Publication number
SG11202006087UA
SG11202006087UA SG11202006087UA SG11202006087UA SG11202006087UA SG 11202006087U A SG11202006087U A SG 11202006087UA SG 11202006087U A SG11202006087U A SG 11202006087UA SG 11202006087U A SG11202006087U A SG 11202006087UA SG 11202006087U A SG11202006087U A SG 11202006087UA
Authority
SG
Singapore
Prior art keywords
heterocyclylamino
rho
modulators
protein kinase
associated protein
Prior art date
Application number
SG11202006087UA
Other languages
English (en)
Inventor
Clifford Jones
Peter Bunyard
Gary Pitt
Liam Byrne
Thomas Pesnot
Nicolas Guisot
Original Assignee
Redx Pharma Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Redx Pharma Plc filed Critical Redx Pharma Plc
Publication of SG11202006087UA publication Critical patent/SG11202006087UA/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/5381,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41961,2,4-Triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
SG11202006087UA 2018-01-25 2019-01-25 Heterocyclylamino-substituted triazoles as modulators of rho-associated protein kinase SG11202006087UA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1801226.0A GB201801226D0 (en) 2018-01-25 2018-01-25 Modulators of Rho-associated protein kinase
PCT/GB2019/050215 WO2019145729A1 (en) 2018-01-25 2019-01-25 Heterocyclylamino-substituted triazoles as modulators of rho-associated protein kinase

Publications (1)

Publication Number Publication Date
SG11202006087UA true SG11202006087UA (en) 2020-08-28

Family

ID=61558335

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202006087UA SG11202006087UA (en) 2018-01-25 2019-01-25 Heterocyclylamino-substituted triazoles as modulators of rho-associated protein kinase

Country Status (25)

Country Link
US (3) US11497751B2 (hu)
EP (2) EP3743420B1 (hu)
JP (2) JP7518324B2 (hu)
KR (1) KR20200113216A (hu)
CN (1) CN111655681B (hu)
AU (1) AU2019213214B2 (hu)
BR (1) BR112020013759A2 (hu)
CA (1) CA3088330A1 (hu)
CY (1) CY1125017T1 (hu)
DK (1) DK3743420T3 (hu)
EA (1) EA202091711A1 (hu)
ES (1) ES2907833T3 (hu)
GB (1) GB201801226D0 (hu)
HR (1) HRP20220269T8 (hu)
HU (1) HUE058940T2 (hu)
IL (1) IL275988B2 (hu)
LT (1) LT3743420T (hu)
MX (1) MX2020007898A (hu)
PH (1) PH12020550986A1 (hu)
PL (1) PL3743420T3 (hu)
PT (1) PT3743420T (hu)
SG (1) SG11202006087UA (hu)
SI (1) SI3743420T1 (hu)
WO (1) WO2019145729A1 (hu)
ZA (1) ZA202003983B (hu)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201801226D0 (en) 2018-01-25 2018-03-14 Redx Pharma Plc Modulators of Rho-associated protein kinase
CN111718310B (zh) * 2019-08-19 2021-06-11 中国药科大学 苯基取代的五元杂环类化合物及其制备方法、用途和药物组合物
CN110845410B (zh) * 2019-10-29 2021-02-26 暨明医药科技(苏州)有限公司 一种一锅法制备6,7-二甲氧基-3,4-二氢异喹啉盐酸盐的方法
IL310209A (en) * 2021-07-26 2024-03-01 Harvard College ROCK2 inhibitors and their uses
CN113999211B (zh) * 2021-11-23 2022-11-29 郑州大学 一类特异性抗前列腺癌活性的含1,2,3-三氮唑的吲唑骨架衍生物
GB202200735D0 (en) * 2022-01-20 2022-03-09 Redx Pharma Plc Compounds
WO2023182856A1 (ko) * 2022-03-24 2023-09-28 서울대학교산학협력단 로-키나제 억제제를 포함하는 켈로이드 등 피부 섬유화 질환의 예방 또는 치료용 약학적 조성물 및 그의 용도
CN115124558B (zh) * 2022-07-08 2024-08-13 闽都创新实验室 一种芳基硼酸酯类化合物的制备方法及其应用
WO2024123129A1 (ko) * 2022-12-08 2024-06-13 한국과학기술원 파브리병의 예방 또는 치료용 조성물
CN116891460A (zh) * 2023-07-12 2023-10-17 浙江大学 一种吲唑类衍生物或其药用盐及应用

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GB9207396D0 (en) 1992-04-03 1992-05-13 Merck Sharp & Dohme Therapeutic agents
CN100355750C (zh) * 2000-09-15 2007-12-19 沃泰克斯药物股份有限公司 可用作蛋白激酶抑制剂的吡唑化合物
CL2003002353A1 (es) * 2002-11-15 2005-02-04 Vertex Pharma Compuestos derivados de diaminotriazoles, inhibidores d ela proteina quinasa; composicion farmaceutica; procedimiento de preparacion; y su uso del compuesto en el tratamiento de enfermedades de desordenes alergicos, proliferacion, autoinmunes, condic
WO2004052280A2 (en) * 2002-12-10 2004-06-24 Imclone Systems Incorporated Anti-angiogenic compounds and their use in cancer treatment
US20050288347A1 (en) * 2004-03-26 2005-12-29 Hodge Carl N Certain triazole-based compounds, compositions, and uses thereof
WO2006135383A2 (en) * 2004-08-04 2006-12-21 Myriad Genetics, Inc. Indazoles
EP2035396B1 (en) 2006-05-25 2014-05-14 Synta Pharmaceuticals Corp. Triazole compounds that modulate hsp90 activity
DE102007022565A1 (de) * 2007-05-14 2008-11-20 Merck Patent Gmbh Heterocyclische Indazolderivate
US8344144B2 (en) * 2008-06-18 2013-01-01 Merck Sharp & Dohme Corp. Inhibitors of Janus kinases
EP2550266B1 (en) * 2010-03-24 2018-05-09 Amitech Therapeutics Solutions, Inc. Heterocyclic compounds useful for kinase inhibition
US9061966B2 (en) 2010-10-08 2015-06-23 Oryzon Genomics S.A. Cyclopropylamine inhibitors of oxidases
WO2012084704A1 (en) * 2010-12-20 2012-06-28 Merck Serono S.A. Indazolyl triazole derivatives as irak inhibitors
US20150011751A1 (en) * 2012-03-09 2015-01-08 Carna Biosciences, Inc. Novel triazine derivative
EP3262041A4 (en) 2015-02-27 2018-08-01 Lycera Corporation Indazolyl thiadiazolamines and related compounds for inhibition of rho-associated protein kinase and the treatment of disease
CN114591242A (zh) 2015-12-16 2022-06-07 洛克索肿瘤学股份有限公司 可用作激酶抑制剂的化合物
CN110582491B (zh) * 2017-06-30 2023-09-29 北京泰德制药股份有限公司 Rho相关蛋白激酶抑制剂、包含其的药物组合物及其制备方法和用途
GB201801226D0 (en) 2018-01-25 2018-03-14 Redx Pharma Plc Modulators of Rho-associated protein kinase

Also Published As

Publication number Publication date
WO2019145729A1 (en) 2019-08-01
BR112020013759A2 (pt) 2020-12-01
WO2019145729A9 (en) 2020-07-30
IL275988B2 (en) 2023-07-01
EP3743420A1 (en) 2020-12-02
SI3743420T1 (sl) 2022-06-30
PT3743420T (pt) 2022-02-04
HRP20220269T8 (hr) 2022-12-09
US20210038606A1 (en) 2021-02-11
CN111655681B (zh) 2024-01-05
US20240216386A1 (en) 2024-07-04
EA202091711A1 (ru) 2020-10-20
PL3743420T3 (pl) 2022-03-21
KR20200113216A (ko) 2020-10-06
CA3088330A1 (en) 2019-08-01
US20230021916A1 (en) 2023-01-26
GB201801226D0 (en) 2018-03-14
CN111655681A (zh) 2020-09-11
EP4026834A1 (en) 2022-07-13
LT3743420T (lt) 2022-02-25
HRP20220269T1 (hr) 2022-05-13
US11497751B2 (en) 2022-11-15
ES2907833T3 (es) 2022-04-26
JP7518324B2 (ja) 2024-07-18
CY1125017T1 (el) 2023-03-24
IL275988B1 (en) 2023-03-01
DK3743420T3 (da) 2022-03-07
EP3743420B1 (en) 2021-12-15
AU2019213214B2 (en) 2023-06-29
ZA202003983B (en) 2023-07-26
US11878020B2 (en) 2024-01-23
IL275988A (en) 2020-08-31
JP2024026193A (ja) 2024-02-28
MX2020007898A (es) 2020-09-07
HUE058940T2 (hu) 2022-09-28
JP2021512158A (ja) 2021-05-13
PH12020550986A1 (en) 2021-03-22
AU2019213214A1 (en) 2020-07-09

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