SG11202005005YA - Bcma-targeting chimeric antigen receptor, and uses thereof - Google Patents

Bcma-targeting chimeric antigen receptor, and uses thereof

Info

Publication number
SG11202005005YA
SG11202005005YA SG11202005005YA SG11202005005YA SG11202005005YA SG 11202005005Y A SG11202005005Y A SG 11202005005YA SG 11202005005Y A SG11202005005Y A SG 11202005005YA SG 11202005005Y A SG11202005005Y A SG 11202005005YA SG 11202005005Y A SG11202005005Y A SG 11202005005YA
Authority
SG
Singapore
Prior art keywords
bcma
antigen receptor
chimeric antigen
targeting chimeric
targeting
Prior art date
Application number
SG11202005005YA
Other languages
English (en)
Inventor
Iulian Pruteanu-Malinici
Keith Mansfield
Boris Engels
Jan Melenhorst
Adam Cohen
Edward Stadtmauer
Alfred Garfall
Michael Milone
Joseph Fraietta
Original Assignee
Novartis Ag
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Univ Pennsylvania filed Critical Novartis Ag
Publication of SG11202005005YA publication Critical patent/SG11202005005YA/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
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    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
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    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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  • Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
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  • Mycology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
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SG11202005005YA 2017-11-30 2018-11-30 Bcma-targeting chimeric antigen receptor, and uses thereof SG11202005005YA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762593043P 2017-11-30 2017-11-30
US201862752010P 2018-10-29 2018-10-29
PCT/US2018/063255 WO2019108900A1 (fr) 2017-11-30 2018-11-30 Récepteur d'antigène chimérique ciblant le bcma et ses utilisations

Publications (1)

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SG11202005005YA true SG11202005005YA (en) 2020-06-29

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Country Status (14)

Country Link
US (1) US20200371091A1 (fr)
EP (1) EP3717907A1 (fr)
JP (1) JP2021509009A (fr)
KR (1) KR20200096253A (fr)
CN (1) CN111727373A (fr)
AU (1) AU2018375738A1 (fr)
BR (1) BR112020010579A2 (fr)
CA (1) CA3083949A1 (fr)
IL (1) IL274921A (fr)
MX (1) MX2020005651A (fr)
RU (1) RU2020121458A (fr)
SG (1) SG11202005005YA (fr)
TW (1) TW201925782A (fr)
WO (1) WO2019108900A1 (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2708032C2 (ru) 2013-02-20 2019-12-03 Новартис Аг ЛЕЧЕНИЕ РАКА С ИСПОЛЬЗОВАНИЕМ ХИМЕРНОГО АНТИГЕНСПЕЦИФИЧЕСКОГО РЕЦЕПТОРА НА ОСНОВЕ ГУМАНИЗИРОВАННОГО АНТИТЕЛА ПРОТИВ EGFRvIII
EP2970426B1 (fr) 2013-03-15 2019-08-28 Michael C. Milone Ciblage de cellules cytotoxiques par des récepteurs chimériques pour une immunothérapie adoptive
EP3087101B1 (fr) 2013-12-20 2024-06-05 Novartis AG Récepteur d'antigène chimérique régulable
MY181834A (en) 2014-07-21 2021-01-08 Novartis Ag Treatment of cancer using humanized anti-bcma chimeric antigen receptor
PL3183268T3 (pl) 2014-08-19 2020-09-07 Novartis Ag Chimeryczny receptor antygenowy (CAR) anty-CD123 do zastosowania w leczeniu nowotworu złośliwego
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RU2020121458A (ru) 2021-12-30
AU2018375738A1 (en) 2020-06-11
CA3083949A1 (fr) 2020-06-06
JP2021509009A (ja) 2021-03-18
KR20200096253A (ko) 2020-08-11
IL274921A (en) 2020-07-30
CN111727373A (zh) 2020-09-29
US20200371091A1 (en) 2020-11-26
BR112020010579A2 (pt) 2020-11-10
MX2020005651A (es) 2020-10-28

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