SG11202003664TA - Nucleic acid-binding photoprobes and uses thereof - Google Patents

Nucleic acid-binding photoprobes and uses thereof

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Publication number
SG11202003664TA
SG11202003664TA SG11202003664TA SG11202003664TA SG11202003664TA SG 11202003664T A SG11202003664T A SG 11202003664TA SG 11202003664T A SG11202003664T A SG 11202003664TA SG 11202003664T A SG11202003664T A SG 11202003664TA SG 11202003664T A SG11202003664T A SG 11202003664TA
Authority
SG
Singapore
Prior art keywords
photoprobes
binding
nucleic acid
nucleic
acid
Prior art date
Application number
SG11202003664TA
Other languages
English (en)
Inventor
Gnanasambandam Kumaravel
Jennifer C Petter
Jonathan Craig Blain
Donovan Noel Chin
Chao Fang
Herschel Mukherjee
Neil Kubica
Original Assignee
Arrakis Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arrakis Therapeutics Inc filed Critical Arrakis Therapeutics Inc
Publication of SG11202003664TA publication Critical patent/SG11202003664TA/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
    • A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C07C247/16—Compounds containing azido groups with azido groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C247/18—Compounds containing azido groups with azido groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00—Reactions characterised by treatment of reaction samples
    • C12Q2523/10—Characterised by chemical treatment
    • C12Q2523/101—Crosslinking agents, e.g. psoralen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/205—Aptamer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/30—Oligonucleotides characterised by their secondary structure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/107—Nucleic acid detection characterized by the use of physical, structural and functional properties fluorescence

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physiology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
SG11202003664TA 2017-11-30 2018-11-30 Nucleic acid-binding photoprobes and uses thereof SG11202003664TA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762593175P 2017-11-30 2017-11-30
PCT/US2018/063490 WO2019109046A1 (en) 2017-11-30 2018-11-30 Nucleic acid-binding photoprobes and uses thereof

Publications (1)

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SG11202003664TA true SG11202003664TA (en) 2020-05-28

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SG11202003664TA SG11202003664TA (en) 2017-11-30 2018-11-30 Nucleic acid-binding photoprobes and uses thereof

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US (2) US11807623B2 (he)
EP (1) EP3717009A4 (he)
JP (2) JP2021505132A (he)
CN (1) CN111386127A (he)
AU (1) AU2018374389A1 (he)
CA (1) CA3078540A1 (he)
IL (2) IL297543A (he)
MX (1) MX2020003695A (he)
RU (1) RU2020112854A (he)
SG (1) SG11202003664TA (he)
WO (1) WO2019109046A1 (he)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10357493B2 (en) 2017-03-10 2019-07-23 Selenity Therapeutics (Bermuda), Ltd. Metalloenzyme inhibitor compounds
WO2020264572A1 (en) * 2019-06-27 2020-12-30 The Scripps Research Institute Fragment-based screening to identify small molecules that selectively bind rna
WO2021188978A1 (en) * 2020-03-20 2021-09-23 Academia Sinica Photoreactive and cleavable probes for tagging biomolecules

Family Cites Families (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB288885A (en) 1927-08-17 1928-04-19 John Robert English A new or improved three-way or four-way junction box or connector for electric conductors
LU55777A1 (he) 1967-04-14 1968-06-16
FR2540122B1 (fr) * 1983-01-27 1985-11-29 Centre Nat Rech Scient Nouveaux composes comportant une sequence d'oligonucleotide liee a un agent d'intercalation, leur procede de synthese et leur application
IL93682A (he) 1989-03-16 1996-06-18 Yeda Res & Dev תרכובות פוליציקליות בעלות פעילות אנטינגיפית שימושן בייצור תרופות ותכשירי רוקחות המכילים אותן
US5514786A (en) 1990-01-11 1996-05-07 Isis Pharmaceuticals, Inc. Compositions for inhibiting RNA activity
US5534408A (en) 1993-09-24 1996-07-09 University Of Massachusetts Medical Center 2-deoxystreptamine aminoglycoside inhibition of HIV RRE/Rev binding
WO1994009792A1 (en) 1992-10-23 1994-05-11 University Of Massachusetts Medical Center Small molecule inhibition of rna/ligand binding
US5639600A (en) 1994-08-05 1997-06-17 The Regents Of The University Of California Diagnosis and treatment of cell proliferative disease having clonal macrophage involvement
US5585069A (en) 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
CA2221318C (en) 1995-06-02 2012-01-24 Nexstar Pharmaceuticals, Inc. High affinity oligonucleotide ligands to growth factors
US6229002B1 (en) 1995-06-07 2001-05-08 Nexstar Pharmaceuticlas, Inc. Platelet derived growth factor (PDGF) nucleic acid ligand complexes
US7087648B1 (en) 1997-10-27 2006-08-08 The Regents Of The University Of California Methods for modulating macrophage proliferation using polyamine analogs
WO2000075306A2 (en) 1999-04-30 2000-12-14 Cyclops Genome Sciences Limited Method for producing double stranded polynucleotides
ES2383332T3 (es) 1999-07-27 2012-06-20 Bristol-Myers Squibb Company Procedimiento de ligación de aceptores de péptidos
US7303867B2 (en) 1999-12-16 2007-12-04 Katayanagi Institute Method for detecting target nucleotide sequences
DE10012823A1 (de) * 2000-03-16 2001-09-20 Bayer Ag Arzneimittel gegen virale Erkrankungen
AU2001296775A1 (en) 2000-10-06 2002-04-15 Kansas State University Research Foundation Triptycene analogs
US6822001B2 (en) 2000-11-03 2004-11-23 Tularik Inc. Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents
HU230382B1 (hu) 2001-02-24 2016-03-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Xantinszármazékok, előállításuk és alkalmazásuk gyógyszerként
CA2516091C (en) 2002-03-11 2016-03-08 Simon Fraser University Dna and rna conformational switches as sensitive electronic sensors of analytes
US20030198966A1 (en) 2002-04-19 2003-10-23 Stojanovic Milan N. Displacement assay for detection of small molecules
US7285285B2 (en) 2002-05-13 2007-10-23 L'oreal Photoactivatable diazirine-active agent compounds, compositions comprising them and uses thereof
WO2004006850A2 (en) 2002-07-12 2004-01-22 Paratek Pharmaceuticals, Inc 3, 10, AND 12a SUBSTITUTED TETRACYCLINE COMPOUNDS
US7964722B2 (en) 2002-08-31 2011-06-21 Board Of Regents Of The Nevada System Of Higher Education, On Behalf Of The University Of Nevada, Reno Light-driven rotary molecular motors
US20040121337A1 (en) 2002-12-19 2004-06-24 Nomadics, Inc. Luminescent polymers and methods of use thereof
US7700366B2 (en) 2003-12-04 2010-04-20 Massachusetts Institute Of Technology Fluorescent, semi-conductive polymers, and devices comprising them
US7759127B2 (en) 2003-12-05 2010-07-20 Massachusetts Institute Of Technology Organic materials able to detect analytes
US7687146B1 (en) 2004-02-11 2010-03-30 Zyvex Labs, Llc Simple tool for positional diamond mechanosynthesis, and its method of manufacture
CA2500938A1 (en) 2004-03-24 2005-09-24 Rohm And Haas Company Memory devices based on electric field programmable films
WO2005106035A2 (en) 2004-04-09 2005-11-10 Cornell Research Foundation, Inc. Modular design and construction of nucleic acid molecules, aptamer-derived nucleic acid constructs, rna scaffolds, their expression, and methods of use
US7723498B2 (en) 2004-06-04 2010-05-25 University Of Connecticut Directed evolution of recombinant monooxygenase nucleic acids and related polypeptides and methods of use
US7745614B2 (en) 2004-09-03 2010-06-29 The Board Of Trustees Of The Leland Stanford Junior University Universal linker compositions for the release or transfer of chemical agents from a polynucleotide
US8617819B2 (en) 2004-09-17 2013-12-31 Massachusetts Institute Of Technology Polymers for analyte detection
EP2284150A3 (en) 2004-10-25 2011-09-21 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
KR101411361B1 (ko) 2004-11-08 2014-06-25 비퍼겐 에이피에스 구조적 핵산에 의해 가이드되는 화학적 합성
ATE464381T1 (de) 2004-12-23 2010-04-15 Ge Healthcare Bio Sciences Rna-amplifikation auf ligationsbasis
WO2006074162A2 (en) 2005-01-04 2006-07-13 Hitachi Chemical Company, Ltd. Primer generation rolling circle amplification
WO2006089083A2 (en) 2005-02-18 2006-08-24 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Low-loss filter and frequency multiplexer
US20070009201A1 (en) 2005-07-08 2007-01-11 Rohm And Haas Electronic Materials Llc Electric field programmable films and memory devices based thereon
WO2007059226A2 (en) * 2005-11-15 2007-05-24 The General Hospital Corporation Photoactivatable antimicrobial agents
CN101438288A (zh) 2006-03-15 2009-05-20 Csir公司 谷氨酰胺合成酶的磷酰基转移酶活性的调节
EP2021470A1 (en) 2006-05-03 2009-02-11 Vipergen APS A method for preparing compounds by nucleic acid directed synthesis
US8318424B2 (en) 2006-06-05 2012-11-27 The University Of North Carolina At Chapel Hill High-throughput RNA structure analysis
US9719191B2 (en) 2006-11-29 2017-08-01 The Research Foundation For The State University Of New York Methods for identifying ligands that target nucleic acid molecules and nucleic acid structural motifs
US8715635B2 (en) 2007-02-06 2014-05-06 Technion Research & Development Foundation Limited Frictionless molecular rotary motors
US20100170796A1 (en) 2007-02-08 2010-07-08 Massachusetts Institute Of Technology In Vitro Microfluidic Model of Microcirculatory Diseases, and Methods of Use Thereof
AU2008218939B2 (en) * 2007-02-23 2014-05-08 The Research Foundation Of State University Of New York RNA targeting compounds and methods for making and using same
WO2009009591A2 (en) 2007-07-09 2009-01-15 Kansas State University Research Foundation Use of cells to facilitate targeted delivery of nanoparticle therapies
US9029524B2 (en) 2007-12-10 2015-05-12 California Institute Of Technology Signal activated RNA interference
WO2009077173A2 (en) 2007-12-19 2009-06-25 Philochem Ag Dna-encoded chemical libraries
JP2009263435A (ja) 2008-04-23 2009-11-12 Fujifilm Corp 光硬化性コーティング組成物、オーバープリント及びその製造方法
WO2009157938A1 (en) 2008-06-26 2009-12-30 Cv Therapeutics, Inc. A2b adenosine receptor antagonists for treating cancer
US8313424B2 (en) 2008-10-02 2012-11-20 Pericles Gabrielidis Sex toy
WO2010135716A1 (en) 2009-05-22 2010-11-25 The Research Foundation Of State University Of New York Trans-acting rna switches
WO2010148085A1 (en) 2009-06-16 2010-12-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Rna nanoparticles and methods of use
CN102639526B (zh) 2009-09-14 2014-06-04 苏文生命科学有限公司 作为5-ht4受体配体的1,2-二氢-2-氧代喹啉化合物
US9677125B2 (en) 2009-10-21 2017-06-13 General Electric Company Detection of plurality of targets in biological samples
WO2012024592A2 (en) 2010-08-19 2012-02-23 Massachusetts Institute Of Technology Compositions, methods, and systems comprising fluorous-soluble polymers
US8783281B2 (en) 2010-09-13 2014-07-22 GM Global Technology Operations LLC Fuel tank temperature and pressure management via selective extraction of liquid fuel and fuel vapor
DK2622073T5 (en) 2010-09-27 2019-02-25 Vipergen Method of Preparing an Enriched Library
FR2968302B1 (fr) 2010-12-06 2012-11-30 Biomerieux Sa Procedes de fonctionalisation et reactifs utilises dans de tels procedes utilisant un anhydride isatoique ou un de ses derives, molecules biologiques ainsi traitees et kits
US20130338178A1 (en) 2011-02-02 2013-12-19 The Trustees Of Princeton University Sirtuin modulators as inhibitors of cytomegalovirus
US9757497B2 (en) * 2011-05-20 2017-09-12 Surmodics, Inc. Delivery of coated hydrophobic active agent particles
US9487534B2 (en) 2011-08-02 2016-11-08 Scripps Research Institute, A Not-For-Profit Public Benefit Corporation Of California Modulators of virus assembly as antiviral agents
US10294478B2 (en) 2011-08-16 2019-05-21 The Research Foundation For The State University Of New York Aptamer modulators of estrogen receptors
AU2013288738A1 (en) * 2012-07-10 2015-01-29 Baseclick Gmbh Anandamide-modified nucleic acid molecules
CA2878837C (en) 2012-07-10 2019-07-30 Georgia State University Research Foundation, Inc. Anthraquinone analogs and methods of making and using thereof
EP2688093B1 (en) 2012-07-19 2018-07-18 Technische Universität Ilmenau Method of and apparatus for fluidic self-assembly of components on a substrate
FR2994184B1 (fr) 2012-08-02 2017-12-08 Biomerieux Sa Procedes de fonctionalisation et reactifs utilises dans de tels procedes utilisant un anhydride aza-isatoique ou un de ses derives, molecules biologiques ainsi traitees et kits
US9340538B2 (en) * 2012-08-24 2016-05-17 Sunshine Lake Pharma Co., Ltd. Dihydropyrimidine compounds and their application in pharmaceuticals
CA2883320A1 (en) 2012-08-30 2014-03-06 The Scripps Research Institute Small molecules targeting repeat r(cgg) sequences
JP2016502519A (ja) * 2012-11-09 2016-01-28 インディアナ・ユニバーシティ・リサーチ・アンド・テクノロジー・コーポレーション Ｈｂｖ集合エフェクターの代替的使用
US20140145673A1 (en) 2012-11-29 2014-05-29 Joseph Heilbrun System for Simultaneously Charging Multiple Portable Electronic Devices
TWI499552B (zh) 2012-12-07 2015-09-11 Univ Nat Cheng Kung 液滴產生方法及裝置
US10597650B2 (en) 2012-12-21 2020-03-24 New England Biolabs, Inc. Ligase activity
US20140212869A1 (en) 2013-01-25 2014-07-31 Agilent Technologies, Inc. Nucleic Acid Proximity Assay Involving the Formation of a Three-way junction
WO2014117161A1 (en) 2013-01-28 2014-07-31 Massachusetts Institute Of Technology Electromechanical device
WO2014145620A2 (en) 2013-03-15 2014-09-18 The Broad Institute, Inc. Novel hybridization probes and uses thereof
AU2014235957A1 (en) 2013-03-20 2015-10-01 Indiana University Research And Technology Corporation Fluorescent-HAP: a diagnostic stain for HBV cores in cells
GB201306097D0 (en) 2013-04-04 2013-05-22 Isis Innovation Sensor
CN105143890B (zh) 2013-04-22 2017-08-29 株式会社日立高新技术 自动分析装置
EP3022219B1 (en) 2013-07-15 2020-01-15 The Scripps Research Institute Specific targeting of rna expanded repeat sequences
US20150020944A1 (en) 2013-07-17 2015-01-22 The Goodyear Tire & Rubber Company Pneumatic tire having a single carcass ply reinforced with polyester cords
SG11201600278XA (en) 2013-08-02 2016-02-26 Gilead Meroz A spiral ring full road interchange system
US10157261B2 (en) 2013-08-09 2018-12-18 The Scripps Research Institute Transcriptome-wide design of selective, bioactive small molecules targeting RNA
WO2015021990A1 (en) 2013-08-16 2015-02-19 University Of Copenhagen Rna probing method and reagents
US9795687B2 (en) 2013-08-29 2017-10-24 The Scripps Research Institute Modularly assembled small molecules for the treatment of myotonic dystrophy type 1
EP3041785A1 (en) 2013-09-06 2016-07-13 Massachusetts Institute of Technology Devices and methods including a preconcentrator material for detection of analytes
WO2015042184A2 (en) 2013-09-17 2015-03-26 Hocuslocus, Llc Methods of using structurally interacting rna
CN105593610B (zh) 2013-09-30 2017-09-08 三菱重工业株式会社 热泵系统及热泵式供热水机
CN103479384B (zh) 2013-09-30 2015-11-18 无锡市凯顺医疗器械制造有限公司 一种导音管、导音管制备方法及模具
ES2791873T3 (es) 2013-10-07 2020-11-06 Univ North Carolina Chapel Hill Detección de modificaciones químicas en ácidos nucleicos
JP6448544B2 (ja) 2013-11-01 2019-01-09 株式会社Ｆｕｊｉ フィーダ
CA2839771A1 (en) 2013-11-29 2015-05-29 The Governors Of The University Of Alberta Binding-induced formation of dna three-way junctions
WO2015094958A1 (en) 2013-12-18 2015-06-25 Albert Einstein College Of Medicine Of Yeshiva University Method of rapid isolation of aptamer beacons
GB201402646D0 (en) 2014-02-14 2014-04-02 Eth Z Rich Polymers
WO2015180901A1 (en) 2014-05-29 2015-12-03 Siemens Aktiengesellschaft Bi-nuclear main group metal phosphorescent emitter
JP6461306B2 (ja) 2014-07-18 2019-01-30 ザ スクリプス リサーチ インスティテュート インサイチュで自己組織化した、毒性のあるｒｎａ阻害剤
US11046721B2 (en) 2014-08-04 2021-06-29 The Trustees Of The University Of Pennsylvania Ruthenium-based photolinkers and methods of use
KR102494171B1 (ko) 2014-08-20 2023-02-02 알닐람 파마슈티칼스 인코포레이티드 변형 이중-가닥 rna 제제
US10570463B2 (en) 2014-10-29 2020-02-25 Biotium, Inc. Nucleic acid modifying agents and uses thereof
WO2016085659A1 (en) * 2014-11-24 2016-06-02 Battelle Memorial Institute Chromatin activity precipitation method and system
US20180265911A1 (en) 2015-09-24 2018-09-20 The Trustees Of The University Of Pennsylvania Triptycene derivatives for nucleic acid junction stabilization
WO2017064156A1 (en) 2015-10-16 2017-04-20 F. Hoffmann-La Roche Ag Novel 6-fused and 2-heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
CA3012700A1 (en) 2016-02-01 2017-08-10 Arrakis Therapeutics, Inc. Compounds and methods of treating rna-mediated diseases
WO2017136403A1 (en) * 2016-02-02 2017-08-10 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
AU2017290894A1 (en) 2016-07-01 2019-01-17 Arrakis Therapeutics, Inc. Compounds and methods for modulating RNA function

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