SG11202002130WA - Artificial genome manipulation for gene expression regulation - Google Patents
Artificial genome manipulation for gene expression regulationInfo
- Publication number
- SG11202002130WA SG11202002130WA SG11202002130WA SG11202002130WA SG11202002130WA SG 11202002130W A SG11202002130W A SG 11202002130WA SG 11202002130W A SG11202002130W A SG 11202002130WA SG 11202002130W A SG11202002130W A SG 11202002130WA SG 11202002130W A SG11202002130W A SG 11202002130WA
- Authority
- SG
- Singapore
- Prior art keywords
- gene expression
- expression regulation
- genome manipulation
- artificial genome
- artificial
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/10—Applications; Uses in screening processes
- C12N2320/11—Applications; Uses in screening processes for the determination of target sites, i.e. of active nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/34—Allele or polymorphism specific uses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/106—Plasmid DNA for vertebrates
- C12N2800/107—Plasmid DNA for vertebrates for mammalian
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762564478P | 2017-09-28 | 2017-09-28 | |
US201762565868P | 2017-09-29 | 2017-09-29 | |
PCT/KR2018/011424 WO2019066490A2 (ko) | 2017-09-28 | 2018-09-27 | 유전자 발현 조절을 위한 인위적인 게놈 조작 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202002130WA true SG11202002130WA (en) | 2020-04-29 |
Family
ID=65902054
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202002130WA SG11202002130WA (en) | 2017-09-28 | 2018-09-27 | Artificial genome manipulation for gene expression regulation |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP3690047A4 (ru) |
JP (2) | JP2020536501A (ru) |
CN (1) | CN111527208B (ru) |
AU (1) | AU2018339164B2 (ru) |
BR (1) | BR112020006428A2 (ru) |
CA (1) | CA3077153A1 (ru) |
RU (2) | RU2767201C2 (ru) |
SG (1) | SG11202002130WA (ru) |
WO (1) | WO2019066490A2 (ru) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110577970B (zh) * | 2019-08-08 | 2022-11-18 | 复旦大学 | CRISPR/Sa-SlutCas9基因编辑系统及其应用 |
CN110577969B (zh) * | 2019-08-08 | 2022-07-22 | 复旦大学 | CRISPR/Sa-SlugCas9基因编辑系统及其应用 |
CN110577972B (zh) * | 2019-08-08 | 2022-10-11 | 复旦大学 | CRISPR/Sa-ShaCas9基因编辑系统及其应用 |
KR20230134477A (ko) * | 2020-12-01 | 2023-09-21 | 더 리서치 인스티튜트 앳 네이션와이드 칠드런스 하스피탈 | 말초 미엘린 단백질-22의 발현 억제를 위한 생성물및 방법 |
WO2022167421A1 (en) * | 2021-02-02 | 2022-08-11 | Limagrain Europe | Linkage of a distal promoter to a gene of interest by gene editing to modify gene expression |
CN114426982B (zh) * | 2022-02-22 | 2024-03-22 | 上海交通大学 | 一种细胞代谢重编程的方法及其应用 |
CN116536357A (zh) * | 2023-04-17 | 2023-08-04 | 中国医学科学院输血研究所 | 构建CRISPR/Cas12a中sgRNA剪切活性筛选系统的方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN116064533A (zh) * | 2012-10-23 | 2023-05-05 | 基因工具股份有限公司 | 用于切割靶dna的组合物及其用途 |
ES2553782T3 (es) * | 2012-12-12 | 2015-12-11 | The Broad Institute, Inc. | Ingeniería de sistemas, métodos y composiciones de guía optimizadas para manipulación de secuencias |
PT3456831T (pt) * | 2013-04-16 | 2021-09-10 | Regeneron Pharma | Modificação alvejada do genoma de rato |
US9388430B2 (en) * | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
WO2015048577A2 (en) * | 2013-09-27 | 2015-04-02 | Editas Medicine, Inc. | Crispr-related methods and compositions |
CN111269902A (zh) * | 2013-12-12 | 2020-06-12 | 布罗德研究所有限公司 | Crispr-cas系统和组合物的递送及用途 |
JP6905755B2 (ja) * | 2015-08-25 | 2021-07-21 | デューク ユニバーシティ | Rnaガイド型エンドヌクレアーゼを使用してゲノム工学における特異性を改善する組成物および方法 |
KR20180120670A (ko) * | 2015-11-13 | 2018-11-06 | 아벨리노 랩 유에스에이, 인크. | 각막 이상증의 치료 방법 |
CN110248957B (zh) * | 2016-11-14 | 2023-12-19 | 株式会社图尔金 | 经人工操纵的sc功能控制系统 |
CN110249051A (zh) * | 2016-12-08 | 2019-09-17 | 凯斯西储大学 | 增强功能性髓鞘产生的方法和组合物 |
-
2018
- 2018-09-27 CN CN201880076752.2A patent/CN111527208B/zh active Active
- 2018-09-27 BR BR112020006428-9A patent/BR112020006428A2/pt unknown
- 2018-09-27 SG SG11202002130WA patent/SG11202002130WA/en unknown
- 2018-09-27 RU RU2020114785A patent/RU2767201C2/ru active
- 2018-09-27 CA CA3077153A patent/CA3077153A1/en active Pending
- 2018-09-27 WO PCT/KR2018/011424 patent/WO2019066490A2/ko unknown
- 2018-09-27 EP EP18862957.0A patent/EP3690047A4/en active Pending
- 2018-09-27 RU RU2022103641A patent/RU2022103641A/ru unknown
- 2018-09-27 AU AU2018339164A patent/AU2018339164B2/en active Active
- 2018-09-27 JP JP2020513755A patent/JP2020536501A/ja active Pending
-
2021
- 2021-10-18 JP JP2021170086A patent/JP7440043B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
JP7440043B2 (ja) | 2024-02-28 |
BR112020006428A2 (pt) | 2020-09-24 |
EP3690047A2 (en) | 2020-08-05 |
EP3690047A4 (en) | 2021-11-03 |
AU2018339164A1 (en) | 2020-04-09 |
RU2767201C2 (ru) | 2022-03-16 |
CN111527208B (zh) | 2024-05-14 |
WO2019066490A2 (ko) | 2019-04-04 |
KR20190037145A (ko) | 2019-04-05 |
WO2019066490A3 (ko) | 2019-06-27 |
RU2020114785A3 (ru) | 2021-10-28 |
CN111527208A (zh) | 2020-08-11 |
RU2020114785A (ru) | 2021-10-28 |
CA3077153A1 (en) | 2019-04-04 |
JP2020536501A (ja) | 2020-12-17 |
JP2022023144A (ja) | 2022-02-07 |
AU2018339164B2 (en) | 2022-06-16 |
RU2022103641A (ru) | 2022-03-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL287033A (en) | Regulation of nuclease-mediated gene expression | |
ZA201900765B (en) | Regulation of gene expression using engineered nucleases | |
SG11202002130WA (en) | Artificial genome manipulation for gene expression regulation | |
IL268788A (en) | Preparations and methods for increased gene expression | |
GB2537899B (en) | Control of digits for artificial hand | |
HK1257078A1 (zh) | 優化的因子viii基因 | |
GB2546023B (en) | Feedback for providing artificial bone flap | |
EP3237017A4 (en) | Systems and methods for genome modification and regulation | |
EP3222728A4 (en) | Method for regulating gene expression using cas9 protein expressed from two vectors | |
EP3126506A4 (en) | Gene expression system and regulation thereof | |
HK1244032A1 (zh) | 控制基因表達的天然型mirna及其用途 | |
EP3158067A4 (en) | Compositions and methods for regulating gene expression via rna interference | |
GB201705484D0 (en) | Genetic construct | |
GB201708385D0 (en) | Genetic construct | |
GB201707212D0 (en) | Gene therapy for ciliopathies | |
GB201805865D0 (en) | Genes | |
GB201608907D0 (en) | Means for modulating gene expression | |
GB201803398D0 (en) | Methods for controlling gene expression | |
IL262067A (en) | Biomass genes | |
GB201605369D0 (en) | TALEN-based genetic manipulation | |
GB201605367D0 (en) | TALEN-based genetic manipulation |