SG11202001549UA - Dynamic human antibody light chain libraries - Google Patents

Dynamic human antibody light chain libraries

Info

Publication number
SG11202001549UA
SG11202001549UA SG11202001549UA SG11202001549UA SG11202001549UA SG 11202001549U A SG11202001549U A SG 11202001549UA SG 11202001549U A SG11202001549U A SG 11202001549UA SG 11202001549U A SG11202001549U A SG 11202001549UA SG 11202001549U A SG11202001549U A SG 11202001549UA
Authority
SG
Singapore
Prior art keywords
light chain
human antibody
antibody light
dynamic human
chain libraries
Prior art date
Application number
SG11202001549UA
Other languages
English (en)
Inventor
Yan Li
Fangyong Du
Peter Peizhi Luo
Original Assignee
Adagene Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adagene Inc filed Critical Adagene Inc
Publication of SG11202001549UA publication Critical patent/SG11202001549UA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
SG11202001549UA 2017-08-21 2017-08-21 Dynamic human antibody light chain libraries SG11202001549UA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2017/098333 WO2019036856A1 (en) 2017-08-21 2017-08-21 DYNAMIC BANKS OF LIGHT CHAIN OF HUMAN ANTIBODY

Publications (1)

Publication Number Publication Date
SG11202001549UA true SG11202001549UA (en) 2020-03-30

Family

ID=65439735

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202001549UA SG11202001549UA (en) 2017-08-21 2017-08-21 Dynamic human antibody light chain libraries

Country Status (11)

Country Link
US (2) US11585014B2 (pt)
EP (1) EP3673100A4 (pt)
JP (2) JP7324744B2 (pt)
KR (2) KR20200054209A (pt)
CN (1) CN111566262A (pt)
AU (1) AU2017428934B2 (pt)
BR (1) BR112020003459A2 (pt)
CA (1) CA3072111A1 (pt)
IL (1) IL272699A (pt)
SG (1) SG11202001549UA (pt)
WO (1) WO2019036856A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2017428737B2 (en) 2017-08-21 2024-02-15 Adagene Inc. Dynamic human heavy chain antibody libraries
WO2019036855A1 (en) 2017-08-21 2019-02-28 Adagene Inc. ANTI-CD137 MOLECULES AND THEIR USE
WO2019148445A1 (en) 2018-02-02 2019-08-08 Adagene Inc. Precision/context-dependent activatable antibodies, and methods of making and using the same
WO2019148444A1 (en) 2018-02-02 2019-08-08 Adagene Inc. Anti-ctla4 antibodies and methods of making and using the same

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US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
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CA2219361C (en) 1995-04-27 2012-02-28 Abgenix, Inc. Human antibodies derived from immunized xenomice
EP0823941A4 (en) 1995-04-28 2001-09-19 Abgenix Inc HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES
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AU2006245734C1 (en) * 2005-05-12 2012-05-24 Crucell Holland B.V. Host cell specific binding molecules capable of neutralizing viruses and uses thereof
WO2007056441A2 (en) * 2005-11-07 2007-05-18 Genentech, Inc. Binding polypeptides with diversified and consensus vh/vl hypervariable sequences
AU2009228158B2 (en) 2008-03-27 2014-02-27 Zymogenetics, Inc. Compositions and methods for inhibiting PDGFRbeta and VEGF-A
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WO2014139130A1 (en) * 2013-03-14 2014-09-18 Adagene Inc. An integrated system for library construction, affinity binder screening and expression thereof
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AU2017428737B2 (en) 2017-08-21 2024-02-15 Adagene Inc. Dynamic human heavy chain antibody libraries

Also Published As

Publication number Publication date
KR20230119260A (ko) 2023-08-16
WO2019036856A1 (en) 2019-02-28
AU2017428934A1 (en) 2020-03-05
KR20200054209A (ko) 2020-05-19
AU2017428934A8 (en) 2020-03-12
JP7324744B2 (ja) 2023-08-10
EP3673100A4 (en) 2021-04-21
AU2017428934B2 (en) 2023-07-20
JP2022033762A (ja) 2022-03-02
BR112020003459A2 (pt) 2020-08-25
US20200362019A1 (en) 2020-11-19
US20230287597A1 (en) 2023-09-14
IL272699A (en) 2020-04-30
CA3072111A1 (en) 2019-02-28
CN111566262A (zh) 2020-08-21
JP2020537633A (ja) 2020-12-24
US11585014B2 (en) 2023-02-21
EP3673100A1 (en) 2020-07-01

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