SG11202000941YA - Glp-1/glucagon receptor agonists in the treatment of fatty liver disease and steatohepatitis - Google Patents
Glp-1/glucagon receptor agonists in the treatment of fatty liver disease and steatohepatitisInfo
- Publication number
- SG11202000941YA SG11202000941YA SG11202000941YA SG11202000941YA SG11202000941YA SG 11202000941Y A SG11202000941Y A SG 11202000941YA SG 11202000941Y A SG11202000941Y A SG 11202000941YA SG 11202000941Y A SG11202000941Y A SG 11202000941YA SG 11202000941Y A SG11202000941Y A SG 11202000941YA
- Authority
- SG
- Singapore
- Prior art keywords
- steatohepatitis
- glp
- treatment
- liver disease
- receptor agonists
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2278—Vasoactive intestinal peptide [VIP]; Related peptides (e.g. Exendin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17306059 | 2017-08-09 | ||
PCT/EP2018/071478 WO2019030268A1 (en) | 2017-08-09 | 2018-08-08 | GLP-1 / GLUCAGON RECEPTOR AGONISTS FOR THE TREATMENT OF HEPATIC STEATOSIS AND STÉATOHÉPATITE |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202000941YA true SG11202000941YA (en) | 2020-02-27 |
Family
ID=59761892
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202000941YA SG11202000941YA (en) | 2017-08-09 | 2018-08-08 | Glp-1/glucagon receptor agonists in the treatment of fatty liver disease and steatohepatitis |
Country Status (15)
Country | Link |
---|---|
US (1) | US11352405B2 (ko) |
EP (1) | EP3664833B1 (ko) |
JP (1) | JP7230002B2 (ko) |
KR (1) | KR20200037358A (ko) |
CN (1) | CN111032071A (ko) |
AU (1) | AU2018314773A1 (ko) |
BR (1) | BR112020002503A2 (ko) |
CA (1) | CA3072118A1 (ko) |
ES (1) | ES2953631T3 (ko) |
IL (1) | IL272457A (ko) |
MX (1) | MX2020001590A (ko) |
RU (1) | RU2020109881A (ko) |
SG (1) | SG11202000941YA (ko) |
TW (1) | TW201920240A (ko) |
WO (1) | WO2019030268A1 (ko) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112442114A (zh) * | 2019-08-29 | 2021-03-05 | 渥太华Hdl药物研发公司 | 一种多肽及其应用 |
WO2021204755A1 (en) | 2020-04-06 | 2021-10-14 | Poxel | Pharmaceutical combination for the treatment of liver diseases |
US11813312B2 (en) * | 2020-04-24 | 2023-11-14 | Boehringer Ingelheim International Gmbh | Glucagon analogues as long-acting GLP-1/glucagon receptor agonists in the treatment of fatty liver disease and steatohepatitis |
US11478533B2 (en) | 2020-04-27 | 2022-10-25 | Novo Nordisk A/S | Semaglutide for use in medicine |
CN112472794A (zh) * | 2020-11-17 | 2021-03-12 | 深圳市图微安创科技开发有限公司 | 双靶点激动剂多肽治疗anit介导的pbc及其相关的肝纤维化 |
KR20240043778A (ko) * | 2021-07-30 | 2024-04-03 | 베링거 인겔하임 인터내셔날 게엠베하 | 장시간-작용하는 glp1/글루카곤 수용체 작용제를 위한 용량 용법 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2286837A3 (en) * | 2004-11-01 | 2013-09-04 | Amylin Pharmaceuticals, LLC | Treatment of obesity and obesity related diseases |
KR101968344B1 (ko) * | 2012-07-25 | 2019-04-12 | 한미약품 주식회사 | 옥신토모듈린 유도체를 포함하는 고지혈증 치료용 조성물 |
UA116217C2 (uk) * | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
MA38276B1 (fr) | 2012-12-21 | 2018-03-30 | Sanofi Sa | Dérivés de l'exendine 4 pour l’utilisation dans le traitement des troubles du syndrome metabolique, y compris le diabete et l'obesite, ainsi que la reduction de l'apport alimentaire excessif. |
TW201625668A (zh) * | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重glp-1/昇糖素受體激動劑之艾塞那肽-4衍生物 |
US10413593B2 (en) * | 2014-10-24 | 2019-09-17 | Merck Sharp & Dohme Corp. | Co-agonists of the glucagon and GLP-1 receptors |
CN107614695B (zh) * | 2015-04-02 | 2022-01-25 | 瑞美德生物医药科技有限公司 | 用胰高血糖素受体拮抗性抗体治疗肥胖症和非酒精性脂肪肝病或非酒精性脂肪性肝炎的方法 |
WO2016198628A1 (en) * | 2015-06-12 | 2016-12-15 | Sanofi | Non-acylated exendin-4 derivatives as dual glp-1/glucagon receptor agonists |
WO2016198624A1 (en) | 2015-06-12 | 2016-12-15 | Sanofi | Exendin-4 derivatives as trigonal glp-1/glucagon/gip receptor agonists |
TWI622596B (zh) * | 2015-10-26 | 2018-05-01 | 美國禮來大藥廠 | 升糖素受體促效劑 |
CN106046145B (zh) * | 2016-04-22 | 2022-11-04 | 深圳市图微安创科技开发有限公司 | Glp-1r/gcgr双靶点激动剂多肽治疗脂肪肝病、高脂血症和动脉硬化 |
AR110299A1 (es) | 2016-12-02 | 2019-03-13 | Sanofi Sa | Conjugados que comprenden un agonista dual de glp-1 / glucagón, un conector y ácido hialurónico |
-
2018
- 2018-08-08 US US16/637,517 patent/US11352405B2/en active Active
- 2018-08-08 CN CN201880051577.1A patent/CN111032071A/zh active Pending
- 2018-08-08 RU RU2020109881A patent/RU2020109881A/ru not_active Application Discontinuation
- 2018-08-08 CA CA3072118A patent/CA3072118A1/en active Pending
- 2018-08-08 EP EP18749805.0A patent/EP3664833B1/en active Active
- 2018-08-08 SG SG11202000941YA patent/SG11202000941YA/en unknown
- 2018-08-08 KR KR1020207006505A patent/KR20200037358A/ko active IP Right Grant
- 2018-08-08 MX MX2020001590A patent/MX2020001590A/es unknown
- 2018-08-08 WO PCT/EP2018/071478 patent/WO2019030268A1/en active Search and Examination
- 2018-08-08 BR BR112020002503-8A patent/BR112020002503A2/pt not_active Application Discontinuation
- 2018-08-08 AU AU2018314773A patent/AU2018314773A1/en not_active Abandoned
- 2018-08-08 JP JP2020506879A patent/JP7230002B2/ja active Active
- 2018-08-08 TW TW107127569A patent/TW201920240A/zh unknown
- 2018-08-08 ES ES18749805T patent/ES2953631T3/es active Active
-
2020
- 2020-02-04 IL IL272457A patent/IL272457A/en unknown
Also Published As
Publication number | Publication date |
---|---|
CA3072118A1 (en) | 2019-02-14 |
RU2020109881A3 (ko) | 2021-12-15 |
JP2020530017A (ja) | 2020-10-15 |
WO2019030268A1 (en) | 2019-02-14 |
EP3664833B1 (en) | 2023-05-31 |
IL272457A (en) | 2020-03-31 |
CN111032071A (zh) | 2020-04-17 |
MX2020001590A (es) | 2020-03-20 |
AU2018314773A1 (en) | 2020-03-26 |
JP7230002B2 (ja) | 2023-02-28 |
ES2953631T3 (es) | 2023-11-14 |
KR20200037358A (ko) | 2020-04-08 |
TW201920240A (zh) | 2019-06-01 |
BR112020002503A2 (pt) | 2020-08-18 |
US20200216510A1 (en) | 2020-07-09 |
EP3664833A1 (en) | 2020-06-17 |
US11352405B2 (en) | 2022-06-07 |
RU2020109881A (ru) | 2021-09-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL272457A (en) | GLP-1/Glucagon agonist receptors in the treatment of fatty liver disease and steatohepatitis | |
IL268702B (en) | Use of a long-acting dual glp-1/glucagon receptor agonist for the treatment of non-alcoholic fatty liver disease | |
IL279224A (en) | 1-GLP agonist receptors and their use | |
ZA201904616B (en) | Glp-1 receptor agonists and uses thereof | |
HUE063074T2 (hu) | GLP-1 receptor agonisták és alkalmazásuk | |
IL252596A0 (en) | History of azabicyclooctane as fxr agonists for use in the treatment of liver and gastrointestinal diseases | |
IL251741A0 (en) | Co-agonists for glucagon and 1- glp receptors | |
ZA201806637B (en) | Glucagon and glp-1 co-agonists for the treatment of obesity | |
HK1256909A1 (zh) | Glp-1和其在用於治療代謝疾病的組合物中的用途 | |
EP3277830A4 (en) | Methods for treating obesity and nonalcoholic fatty liver disease or nonalcoholic steatohepatitis using glucagon receptor antagonistic antibodies | |
IL274578A (en) | Pharmaceutical compounds and preparations thereof for use in the treatment of leiftic diseases | |
ZA201702813B (en) | Fatty liver disease treatment using glucocorticoid and mineralocorticoid receptor antagonists | |
GB201811757D0 (en) | Composition comprising GLP-1 receptor agonist and glucagon receptor agonist and application thereof | |
IL274747A (en) | FXR agonists for the treatment of liver diseases | |
IL272495A (en) | Pharmaceutical compounds and preparations thereof for use in the treatment of leiftic diseases | |
IL253943A0 (en) | Blockers of the growth hormone receptor in the prevention and treatment of disease | |
IL251024A0 (en) | Antibodies against eutaxin 2 for use in the treatment of liver diseases | |
GB201718838D0 (en) | Compounds and pharmaceutical compositions thereof for use in the treatment of fibrotic diseases | |
GB201712742D0 (en) | Compounds and pharmaceutical compositions thereof for use in the treatment of fibrotic diseases |