SG11202000747VA - Anti-cd137 antibodies - Google Patents

Anti-cd137 antibodies

Info

Publication number
SG11202000747VA
SG11202000747VA SG11202000747VA SG11202000747VA SG11202000747VA SG 11202000747V A SG11202000747V A SG 11202000747VA SG 11202000747V A SG11202000747V A SG 11202000747VA SG 11202000747V A SG11202000747V A SG 11202000747VA SG 11202000747V A SG11202000747V A SG 11202000747VA
Authority
SG
Singapore
Prior art keywords
antibodies
Prior art date
Application number
SG11202000747VA
Other languages
English (en)
Inventor
Christopher Carl Frye
Michael Dewain Kalos
Helen Kotanides
Stephanie Lynn Sandefur
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of SG11202000747VA publication Critical patent/SG11202000747VA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • C07K2317/524CH2 domain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • C07K2317/526CH3 domain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71Decreased effector function due to an Fc-modification
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75Agonist effect on antigen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SG11202000747VA 2017-08-01 2018-07-25 Anti-cd137 antibodies SG11202000747VA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762539687P 2017-08-01 2017-08-01
PCT/US2018/043632 WO2019027754A1 (en) 2017-08-01 2018-07-25 ANTI-CD137 ANTIBODIES

Publications (1)

Publication Number Publication Date
SG11202000747VA true SG11202000747VA (en) 2020-02-27

Family

ID=63165504

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202000747VA SG11202000747VA (en) 2017-08-01 2018-07-25 Anti-cd137 antibodies

Country Status (25)

Country Link
US (1) US10906983B2 (enrdf_load_stackoverflow)
EP (2) EP4070811A1 (enrdf_load_stackoverflow)
JP (2) JP6743320B1 (enrdf_load_stackoverflow)
KR (2) KR20210158420A (enrdf_load_stackoverflow)
CN (1) CN111182919B (enrdf_load_stackoverflow)
AU (2) AU2018311804B2 (enrdf_load_stackoverflow)
BR (1) BR112020001441A2 (enrdf_load_stackoverflow)
CA (2) CA3146758A1 (enrdf_load_stackoverflow)
CL (1) CL2020000233A1 (enrdf_load_stackoverflow)
CO (1) CO2020001050A2 (enrdf_load_stackoverflow)
CR (1) CR20200042A (enrdf_load_stackoverflow)
DO (1) DOP2020000020A (enrdf_load_stackoverflow)
EA (1) EA202090204A1 (enrdf_load_stackoverflow)
EC (1) ECSP20007663A (enrdf_load_stackoverflow)
ES (1) ES2912651T3 (enrdf_load_stackoverflow)
IL (1) IL272349B2 (enrdf_load_stackoverflow)
JO (1) JOP20200016B1 (enrdf_load_stackoverflow)
MA (1) MA49749A (enrdf_load_stackoverflow)
MX (1) MX2020001351A (enrdf_load_stackoverflow)
PE (1) PE20200839A1 (enrdf_load_stackoverflow)
PH (1) PH12020500225A1 (enrdf_load_stackoverflow)
SA (1) SA520411186B1 (enrdf_load_stackoverflow)
SG (1) SG11202000747VA (enrdf_load_stackoverflow)
UA (1) UA128388C2 (enrdf_load_stackoverflow)
WO (1) WO2019027754A1 (enrdf_load_stackoverflow)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11512134B2 (en) 2017-08-01 2022-11-29 Eli Lilly And Company Anti-CD137 antibodies
AU2018301393B2 (en) 2017-07-11 2025-02-27 Compass Therapeutics Llc Agonist antibodies that bind human CD137 and uses thereof
SG11202000747VA (en) * 2017-08-01 2020-02-27 Lilly Co Eli Anti-cd137 antibodies
WO2019089753A2 (en) 2017-10-31 2019-05-09 Compass Therapeutics Llc Cd137 antibodies and pd-1 antagonists and uses thereof
WO2019100052A2 (en) 2017-11-20 2019-05-23 Compass Therapeutics Llc Cd137 antibodies and tumor antigen-targeting antibodies and uses thereof
AU2019239194B2 (en) * 2018-03-23 2023-09-14 Eli Lilly And Company Anti-CD137 antibodies for combination with anti-PD-L1 antibodies
AU2019237977A1 (en) * 2018-03-23 2022-01-20 Eli Lilly And Company Anti-CD137 antibodies for combination with anti-PD-1 antibodies
JP7090204B2 (ja) * 2018-07-19 2022-06-23 イーライ リリー アンド カンパニー 免疫チェックポイントを標的とする二重特異性抗体
WO2020023556A1 (en) 2018-07-23 2020-01-30 Magenta Therapeutics, Inc. Use of anti-cd137 antibody drug conjugate (adc) in allogeneic cell therapy
SG11202003531WA (en) 2018-08-10 2020-05-28 Chugai Pharmaceutical Co Ltd Anti-cd137 antigen-binding molecule and utilization thereof
KR20220003572A (ko) 2019-04-24 2022-01-10 하이델베르크 파마 리서치 게엠베하 아마톡신 항체-약물 결합체 및 이의 용도
AU2020308463A1 (en) 2019-06-26 2022-02-17 Ap Biosciences, Inc. Antibodies for T-cell activation
CR20220451A (es) * 2020-02-12 2022-10-31 Chugai Pharmaceutical Co Ltd Moléculas de unión a antígeno anti-cd137 para su administración en el tratamiento contra el cáncer
KR20230135571A (ko) 2020-11-25 2023-09-25 상하이 준셀 테라퓨틱스 컴퍼니 리미티드 종양 침윤 림프구 배지 및 이의 응용
KR20250104655A (ko) 2023-12-29 2025-07-08 쿠팡 주식회사 옵션 피커 화면 제공 방법 및 그 장치
KR20250104669A (ko) 2023-12-29 2025-07-08 쿠팡 주식회사 옵션 선택 가이드 정보 제공 방법 및 그 장치

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1434596B1 (en) * 2001-10-09 2009-07-08 Mayo Foundation For Medical Education And Research Enhancement of immune responses by agonist 4-1bb-antibodies
US7288638B2 (en) 2003-10-10 2007-10-30 Bristol-Myers Squibb Company Fully human antibodies against human 4-1BB
MX374682B (es) 2010-09-09 2025-03-06 Pfizer Moléculas de unión a 4-1bb.
WO2016134358A1 (en) * 2015-02-22 2016-08-25 Sorrento Therapeutics, Inc. Antibody therapeutics that bind cd137
GB201619648D0 (en) * 2016-11-21 2017-01-04 Alligator Bioscience Ab Novel antibodies and uses thereof
SG11202000747VA (en) * 2017-08-01 2020-02-27 Lilly Co Eli Anti-cd137 antibodies

Also Published As

Publication number Publication date
US20200377607A1 (en) 2020-12-03
EA202090204A1 (ru) 2020-05-22
CO2020001050A2 (es) 2020-02-18
PE20200839A1 (es) 2020-08-13
CN111182919A (zh) 2020-05-19
IL272349B1 (en) 2024-05-01
EP3661544B1 (en) 2022-04-13
IL272349A (en) 2020-03-31
JOP20200016B1 (ar) 2022-10-30
JP2020527356A (ja) 2020-09-10
JP6743320B1 (ja) 2020-08-19
BR112020001441A2 (pt) 2020-08-04
EP3661544A1 (en) 2020-06-10
MX2020001351A (es) 2020-03-09
MA49749A (fr) 2021-03-24
CA3071383A1 (en) 2019-02-07
US10906983B2 (en) 2021-02-02
ECSP20007663A (es) 2020-06-30
CA3071383C (en) 2022-04-12
JOP20200016A1 (ar) 2020-01-28
EP4070811A1 (en) 2022-10-12
KR20200023439A (ko) 2020-03-04
ES2912651T3 (es) 2022-05-26
AU2021277707A1 (en) 2021-12-23
JP7257364B2 (ja) 2023-04-13
DOP2020000020A (es) 2020-02-28
IL272349B2 (en) 2024-09-01
CL2020000233A1 (es) 2020-07-31
PH12020500225A1 (en) 2020-11-09
CR20200042A (es) 2020-03-03
SA520411186B1 (ar) 2025-06-29
AU2018311804A1 (en) 2020-02-13
KR20210158420A (ko) 2021-12-30
UA128388C2 (uk) 2024-07-03
CA3146758A1 (en) 2019-02-07
JP2020182492A (ja) 2020-11-12
KR102344620B1 (ko) 2022-01-03
WO2019027754A1 (en) 2019-02-07
AU2018311804B2 (en) 2021-09-02
NZ761548A (en) 2024-07-05
CN111182919B (zh) 2023-07-07

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