EA202090204A1 - Анти-cd137 антитела - Google Patents
Анти-cd137 антителаInfo
- Publication number
- EA202090204A1 EA202090204A1 EA202090204A EA202090204A EA202090204A1 EA 202090204 A1 EA202090204 A1 EA 202090204A1 EA 202090204 A EA202090204 A EA 202090204A EA 202090204 A EA202090204 A EA 202090204A EA 202090204 A1 EA202090204 A1 EA 202090204A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- antibodies
- monotherapy
- chemotherapy
- bind
- human
- Prior art date
Links
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000001270 agonistic effect Effects 0.000 abstract 1
- 238000002512 chemotherapy Methods 0.000 abstract 1
- 201000005787 hematologic cancer Diseases 0.000 abstract 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 abstract 1
- 102000050327 human TNFRSF9 Human genes 0.000 abstract 1
- 230000005865 ionizing radiation Effects 0.000 abstract 1
- 238000009097 single-agent therapy Methods 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762539687P | 2017-08-01 | 2017-08-01 | |
| PCT/US2018/043632 WO2019027754A1 (en) | 2017-08-01 | 2018-07-25 | ANTI-CD137 ANTIBODIES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA202090204A1 true EA202090204A1 (ru) | 2020-05-22 |
Family
ID=63165504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA202090204A EA202090204A1 (ru) | 2017-08-01 | 2018-07-25 | Анти-cd137 антитела |
Country Status (25)
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11512134B2 (en) | 2017-08-01 | 2022-11-29 | Eli Lilly And Company | Anti-CD137 antibodies |
| AU2018301393B2 (en) | 2017-07-11 | 2025-02-27 | Compass Therapeutics Llc | Agonist antibodies that bind human CD137 and uses thereof |
| SG11202000747VA (en) * | 2017-08-01 | 2020-02-27 | Lilly Co Eli | Anti-cd137 antibodies |
| WO2019089753A2 (en) | 2017-10-31 | 2019-05-09 | Compass Therapeutics Llc | Cd137 antibodies and pd-1 antagonists and uses thereof |
| WO2019100052A2 (en) | 2017-11-20 | 2019-05-23 | Compass Therapeutics Llc | Cd137 antibodies and tumor antigen-targeting antibodies and uses thereof |
| AU2019239194B2 (en) * | 2018-03-23 | 2023-09-14 | Eli Lilly And Company | Anti-CD137 antibodies for combination with anti-PD-L1 antibodies |
| AU2019237977A1 (en) * | 2018-03-23 | 2022-01-20 | Eli Lilly And Company | Anti-CD137 antibodies for combination with anti-PD-1 antibodies |
| JP7090204B2 (ja) * | 2018-07-19 | 2022-06-23 | イーライ リリー アンド カンパニー | 免疫チェックポイントを標的とする二重特異性抗体 |
| WO2020023556A1 (en) | 2018-07-23 | 2020-01-30 | Magenta Therapeutics, Inc. | Use of anti-cd137 antibody drug conjugate (adc) in allogeneic cell therapy |
| SG11202003531WA (en) | 2018-08-10 | 2020-05-28 | Chugai Pharmaceutical Co Ltd | Anti-cd137 antigen-binding molecule and utilization thereof |
| KR20220003572A (ko) | 2019-04-24 | 2022-01-10 | 하이델베르크 파마 리서치 게엠베하 | 아마톡신 항체-약물 결합체 및 이의 용도 |
| AU2020308463A1 (en) | 2019-06-26 | 2022-02-17 | Ap Biosciences, Inc. | Antibodies for T-cell activation |
| CR20220451A (es) * | 2020-02-12 | 2022-10-31 | Chugai Pharmaceutical Co Ltd | Moléculas de unión a antígeno anti-cd137 para su administración en el tratamiento contra el cáncer |
| KR20230135571A (ko) | 2020-11-25 | 2023-09-25 | 상하이 준셀 테라퓨틱스 컴퍼니 리미티드 | 종양 침윤 림프구 배지 및 이의 응용 |
| KR20250104655A (ko) | 2023-12-29 | 2025-07-08 | 쿠팡 주식회사 | 옵션 피커 화면 제공 방법 및 그 장치 |
| KR20250104669A (ko) | 2023-12-29 | 2025-07-08 | 쿠팡 주식회사 | 옵션 선택 가이드 정보 제공 방법 및 그 장치 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1434596B1 (en) * | 2001-10-09 | 2009-07-08 | Mayo Foundation For Medical Education And Research | Enhancement of immune responses by agonist 4-1bb-antibodies |
| US7288638B2 (en) | 2003-10-10 | 2007-10-30 | Bristol-Myers Squibb Company | Fully human antibodies against human 4-1BB |
| MX374682B (es) | 2010-09-09 | 2025-03-06 | Pfizer | Moléculas de unión a 4-1bb. |
| WO2016134358A1 (en) * | 2015-02-22 | 2016-08-25 | Sorrento Therapeutics, Inc. | Antibody therapeutics that bind cd137 |
| GB201619648D0 (en) * | 2016-11-21 | 2017-01-04 | Alligator Bioscience Ab | Novel antibodies and uses thereof |
| SG11202000747VA (en) * | 2017-08-01 | 2020-02-27 | Lilly Co Eli | Anti-cd137 antibodies |
-
2018
- 2018-07-25 SG SG11202000747VA patent/SG11202000747VA/en unknown
- 2018-07-25 EP EP22159268.6A patent/EP4070811A1/en not_active Withdrawn
- 2018-07-25 MA MA049749A patent/MA49749A/fr unknown
- 2018-07-25 CN CN201880064332.2A patent/CN111182919B/zh active Active
- 2018-07-25 BR BR112020001441-9A patent/BR112020001441A2/pt unknown
- 2018-07-25 CA CA3146758A patent/CA3146758A1/en active Pending
- 2018-07-25 CA CA3071383A patent/CA3071383C/en active Active
- 2018-07-25 US US16/497,493 patent/US10906983B2/en active Active
- 2018-07-25 UA UAA202000367A patent/UA128388C2/uk unknown
- 2018-07-25 JO JOP/2020/0016A patent/JOP20200016B1/ar active
- 2018-07-25 ES ES18752950T patent/ES2912651T3/es active Active
- 2018-07-25 EA EA202090204A patent/EA202090204A1/ru unknown
- 2018-07-25 KR KR1020217041897A patent/KR20210158420A/ko not_active Ceased
- 2018-07-25 EP EP18752950.8A patent/EP3661544B1/en active Active
- 2018-07-25 KR KR1020207002814A patent/KR102344620B1/ko active Active
- 2018-07-25 JP JP2020505392A patent/JP6743320B1/ja active Active
- 2018-07-25 AU AU2018311804A patent/AU2018311804B2/en active Active
- 2018-07-25 IL IL272349A patent/IL272349B2/en unknown
- 2018-07-25 CR CR20200042A patent/CR20200042A/es unknown
- 2018-07-25 PE PE2020000155A patent/PE20200839A1/es unknown
- 2018-07-25 MX MX2020001351A patent/MX2020001351A/es unknown
- 2018-07-25 WO PCT/US2018/043632 patent/WO2019027754A1/en active Application Filing
-
2020
- 2020-01-29 CO CONC2020/0001050A patent/CO2020001050A2/es unknown
- 2020-01-29 CL CL2020000233A patent/CL2020000233A1/es unknown
- 2020-01-29 SA SA520411186A patent/SA520411186B1/ar unknown
- 2020-01-30 PH PH12020500225A patent/PH12020500225A1/en unknown
- 2020-01-31 EC ECSENADI20207663A patent/ECSP20007663A/es unknown
- 2020-01-31 DO DO2020000020A patent/DOP2020000020A/es unknown
- 2020-07-29 JP JP2020128427A patent/JP7257364B2/ja active Active
-
2021
- 2021-12-02 AU AU2021277707A patent/AU2021277707A1/en not_active Abandoned
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