SG11201913968VA - Proteins binding nkg2d, cd16 and a tumor-associated antigen - Google Patents
Proteins binding nkg2d, cd16 and a tumor-associated antigenInfo
- Publication number
- SG11201913968VA SG11201913968VA SG11201913968VA SG11201913968VA SG11201913968VA SG 11201913968V A SG11201913968V A SG 11201913968VA SG 11201913968V A SG11201913968V A SG 11201913968VA SG 11201913968V A SG11201913968V A SG 11201913968VA SG 11201913968V A SG11201913968V A SG 11201913968VA
- Authority
- SG
- Singapore
- Prior art keywords
- tumor
- associated antigen
- proteins binding
- binding nkg2d
- nkg2d
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 239000000427 antigen Substances 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762549201P | 2017-08-23 | 2017-08-23 | |
US201762558510P | 2017-09-14 | 2017-09-14 | |
US201762558509P | 2017-09-14 | 2017-09-14 | |
US201762558514P | 2017-09-14 | 2017-09-14 | |
US201762558511P | 2017-09-14 | 2017-09-14 | |
US201762566828P | 2017-10-02 | 2017-10-02 | |
US201762581357P | 2017-11-03 | 2017-11-03 | |
US201762608384P | 2017-12-20 | 2017-12-20 | |
PCT/US2018/047714 WO2019040727A1 (en) | 2017-08-23 | 2018-08-23 | BINDING PROTEINS FOR NKG2D, CD16 AND ANTIGEN ASSOCIATED WITH A TUMOR |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201913968VA true SG11201913968VA (en) | 2020-01-30 |
Family
ID=65439284
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201913968VA SG11201913968VA (en) | 2017-08-23 | 2018-08-23 | Proteins binding nkg2d, cd16 and a tumor-associated antigen |
Country Status (13)
Country | Link |
---|---|
US (1) | US20200231679A1 (zh) |
EP (1) | EP3672993A4 (zh) |
JP (2) | JP2020531525A (zh) |
KR (1) | KR20200038530A (zh) |
CN (1) | CN111315778A (zh) |
AU (1) | AU2018322178A1 (zh) |
BR (1) | BR112020003654A2 (zh) |
CA (1) | CA3072919A1 (zh) |
IL (2) | IL311488A (zh) |
MX (1) | MX2020002036A (zh) |
RU (1) | RU2020111554A (zh) |
SG (1) | SG11201913968VA (zh) |
WO (1) | WO2019040727A1 (zh) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2018219887A1 (en) | 2017-02-08 | 2019-08-22 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer |
BR112019017197A2 (pt) | 2017-02-20 | 2020-04-14 | Dragonfly Therapeutics Inc | proteínas que se ligam a her2, nkg2d e cd16 |
JP2021512630A (ja) | 2018-02-08 | 2021-05-20 | ドラゴンフライ セラピューティクス, インコーポレイテッド | Nkg2d受容体を標的とする抗体可変ドメイン |
WO2021150598A1 (en) * | 2020-01-20 | 2021-07-29 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Affinity peptide conjugated with antioxidant for protection of proteins from oxidation |
CN114437214B (zh) * | 2020-11-03 | 2023-06-02 | 南京北恒生物科技有限公司 | 靶向lir1的抗体及其用途 |
EP4273161A1 (en) * | 2020-12-31 | 2023-11-08 | Innovent Biologics (Suzhou) Co., Ltd. | Protein containing heterodimer antibody fc, and preparation method therefor |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL358215A1 (en) * | 2000-03-24 | 2004-08-09 | Micromet Ag | Multifunctional polypeptides comprising a binding site to an epitope of the nkg2d receptor complex |
US20070071759A1 (en) * | 2005-06-29 | 2007-03-29 | University Of Miami | Antibody-immune cell ligand fusion protein for cancer therapy |
WO2007044756A2 (en) * | 2005-10-11 | 2007-04-19 | Icos Corporation | Monoclonal antibodies recognizing human ccr8 |
EP2418223A3 (en) * | 2006-06-12 | 2013-01-16 | Emergent Product Development Seattle, LLC | Single-chain multivalent binding proteins with effector function |
CA2982321C (en) * | 2007-12-14 | 2021-01-05 | Novo Nordisk A/S | Antibodies against human nkg2d and uses thereof |
WO2010017103A2 (en) * | 2008-08-04 | 2010-02-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic | Fully human anti-human nkg2d monoclonal antibodies |
UY32808A (es) * | 2009-07-29 | 2011-02-28 | Abbott Lab | Inmunoglobulinas como dominio variable dual y usos de las mismas |
LT2951203T (lt) * | 2013-03-15 | 2019-09-10 | Xencor, Inc. | Heterodimeriniai baltymai |
DE102013019352A1 (de) * | 2013-11-13 | 2015-09-17 | Elke Pogge Von Strandmann | Tri-spezifische rekombinante Antikörperderivate zur Behandlung von malignen Erkrankungen durch Aktivierung einer NK-Zell-basierten Immunantwort |
EP3125934B1 (en) * | 2014-03-05 | 2019-10-23 | UCL Business Plc. | Chimeric antigen receptor (car) with antigen binding domains to the t cell receptor beta constant region |
AU2016206707A1 (en) * | 2015-01-14 | 2017-08-10 | Compass Therapeutics Llc | Multispecific immunomodulatory antigen-binding constructs |
KR102606190B1 (ko) * | 2015-02-20 | 2023-11-23 | 오하이오 스테이트 이노베이션 파운데이션 | Nkg2d 및 종양 연관 항원에 대해 유도된 이가 항체 |
AU2016284866B2 (en) * | 2015-06-23 | 2022-09-29 | Innate Pharma | Multispecific antigen binding proteins |
EP3374389A1 (en) * | 2015-11-13 | 2018-09-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anti- nkg2d single domain antibodies and uses thereof |
BR112018014368A2 (pt) * | 2016-01-13 | 2019-02-05 | Compass Therapeutics Llc | polipeptídeo de construto de ligação ao antígeno imunomodulador multiespecífico, conjugado, composição farmacêutica, método para tratar um indivíduo com câncer, método para inibir ou reduzir o crescimento de câncer, composição, célula, método de fazer um polipeptídeo de construto de ligação ao antígeno imunomodulador multiespecífico, vetor ou conjunto de vetores e kit |
EP3579866A4 (en) * | 2017-02-08 | 2020-12-09 | Dragonfly Therapeutics, Inc. | HEAVY CHAIN VARIABLE ANTIBODY DOMAINS WITH NKG2D RECEPTOR AIMING |
KR20190115469A (ko) * | 2017-02-10 | 2019-10-11 | 드래곤플라이 쎄라퓨틱스, 인크. | Bcma, nkg2d 및 cd16에 결합하는 단백질 |
-
2018
- 2018-08-23 CN CN201880054953.2A patent/CN111315778A/zh active Pending
- 2018-08-23 MX MX2020002036A patent/MX2020002036A/es unknown
- 2018-08-23 JP JP2020511319A patent/JP2020531525A/ja not_active Ceased
- 2018-08-23 EP EP18848423.2A patent/EP3672993A4/en active Pending
- 2018-08-23 RU RU2020111554A patent/RU2020111554A/ru unknown
- 2018-08-23 IL IL311488A patent/IL311488A/en unknown
- 2018-08-23 US US16/639,150 patent/US20200231679A1/en not_active Abandoned
- 2018-08-23 CA CA3072919A patent/CA3072919A1/en active Pending
- 2018-08-23 WO PCT/US2018/047714 patent/WO2019040727A1/en active Application Filing
- 2018-08-23 BR BR112020003654-4A patent/BR112020003654A2/pt unknown
- 2018-08-23 SG SG11201913968VA patent/SG11201913968VA/en unknown
- 2018-08-23 AU AU2018322178A patent/AU2018322178A1/en active Pending
- 2018-08-23 KR KR1020207007908A patent/KR20200038530A/ko not_active Application Discontinuation
-
2020
- 2020-02-16 IL IL272706A patent/IL272706A/en unknown
-
2023
- 2023-02-24 JP JP2023027219A patent/JP2023062184A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2019040727A1 (en) | 2019-02-28 |
JP2020531525A (ja) | 2020-11-05 |
US20200231679A1 (en) | 2020-07-23 |
EP3672993A1 (en) | 2020-07-01 |
MX2020002036A (es) | 2020-03-24 |
IL272706A (en) | 2020-04-30 |
IL311488A (en) | 2024-05-01 |
JP2023062184A (ja) | 2023-05-02 |
EP3672993A4 (en) | 2021-10-27 |
BR112020003654A2 (pt) | 2020-11-17 |
CN111315778A (zh) | 2020-06-19 |
CA3072919A1 (en) | 2019-02-28 |
RU2020111554A (ru) | 2021-09-23 |
RU2020111554A3 (zh) | 2022-01-19 |
KR20200038530A (ko) | 2020-04-13 |
AU2018322178A1 (en) | 2020-02-20 |
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