SG11201907496RA - Cyclic di-nucleotides compounds for the treatment of cancer - Google Patents
Cyclic di-nucleotides compounds for the treatment of cancerInfo
- Publication number
- SG11201907496RA SG11201907496RA SG11201907496RA SG11201907496RA SG11201907496RA SG 11201907496R A SG11201907496R A SG 11201907496RA SG 11201907496R A SG11201907496R A SG 11201907496RA SG 11201907496R A SG11201907496R A SG 11201907496RA SG 11201907496R A SG11201907496R A SG 11201907496RA
- Authority
- SG
- Singapore
- Prior art keywords
- massachusetts
- international
- andover
- august
- cancer
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title abstract 3
- 125000004122 cyclic group Chemical group 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102220240796 rs553605556 Human genes 0.000 abstract 2
- 241001333452 Bridelia insulana Species 0.000 abstract 1
- 241000721662 Juniperus Species 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6587—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having two phosphorus atoms as ring hetero atoms in the same ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762460562P | 2017-02-17 | 2017-02-17 | |
US201762479169P | 2017-03-30 | 2017-03-30 | |
US201762551647P | 2017-08-29 | 2017-08-29 | |
US201762551668P | 2017-08-29 | 2017-08-29 | |
US201762551645P | 2017-08-29 | 2017-08-29 | |
PCT/US2018/018556 WO2018152450A1 (fr) | 2017-02-17 | 2018-02-17 | Composés dinucléotidiques cycliques pour le traitement du cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201907496RA true SG11201907496RA (en) | 2019-09-27 |
Family
ID=61521844
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201907496RA SG11201907496RA (en) | 2017-02-17 | 2018-02-17 | Cyclic di-nucleotides compounds for the treatment of cancer |
Country Status (31)
Country | Link |
---|---|
US (4) | US20200055883A1 (fr) |
EP (3) | EP4008403A1 (fr) |
JP (2) | JP6672532B2 (fr) |
KR (1) | KR102645790B1 (fr) |
CN (3) | CN110536719A (fr) |
AU (1) | AU2018221170B2 (fr) |
BR (1) | BR112019017084A2 (fr) |
CA (1) | CA3053932A1 (fr) |
CL (1) | CL2019002304A1 (fr) |
CO (1) | CO2019008783A2 (fr) |
DK (1) | DK3582853T3 (fr) |
ES (1) | ES2906299T3 (fr) |
HR (1) | HRP20220110T1 (fr) |
HU (1) | HUE057665T2 (fr) |
IL (1) | IL268721B (fr) |
JO (1) | JOP20190194B1 (fr) |
LT (1) | LT3582853T (fr) |
MA (1) | MA47501A (fr) |
MD (1) | MD3582853T2 (fr) |
MX (1) | MX2019009796A (fr) |
PE (1) | PE20191686A1 (fr) |
PH (1) | PH12019501914A1 (fr) |
PL (1) | PL3582853T3 (fr) |
PT (1) | PT3582853T (fr) |
RS (1) | RS62842B1 (fr) |
SG (1) | SG11201907496RA (fr) |
SI (1) | SI3582853T1 (fr) |
TW (1) | TWI766948B (fr) |
UA (1) | UA125310C2 (fr) |
WO (2) | WO2018152453A1 (fr) |
ZA (1) | ZA201906111B (fr) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
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JOP20170192A1 (ar) | 2016-12-01 | 2019-01-30 | Takeda Pharmaceuticals Co | داي نوكليوتيد حلقي |
EP4310082A3 (fr) | 2017-01-20 | 2024-04-10 | Arcus Biosciences, Inc. | Azolopyrimidine pour le traitement de troubles liés au cancer |
WO2019084060A1 (fr) | 2017-10-24 | 2019-05-02 | Silverback Therapeutics, Inc. | Conjugués et leurs procédés d'utilisation pour l'administration sélective d'agents immunomodulateurs |
CN111566119A (zh) | 2017-11-10 | 2020-08-21 | 武田药品工业有限公司 | Sting调节剂化合物以及制备和使用方法 |
CN111511754B (zh) | 2017-12-20 | 2023-09-12 | 捷克共和国有机化学与生物化学研究所 | 活化sting转接蛋白的具有膦酸酯键的2’3’环状二核苷酸 |
EP3728283B1 (fr) | 2017-12-20 | 2023-11-22 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | Dinucléotides 3'3' cycliques ayant une liaison phosphonate activant la protéine adaptatrice de sting |
CA3090922A1 (fr) | 2018-02-16 | 2019-08-22 | Arcus Biosciences, Inc. | Dosage avec un compose azolopyrimidine |
TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
KR20200140867A (ko) | 2018-04-06 | 2020-12-16 | 인스티튜트 오브 오가닉 케미스트리 앤드 바이오케미스트리 에이에스 씨알 브이.브이.아이. | 3'3'-사이클릭 다이뉴클레오티드 |
KR20210015937A (ko) * | 2018-06-01 | 2021-02-10 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 방광암을 치료하기 위한 방법 |
US11691990B2 (en) | 2018-08-16 | 2023-07-04 | Eisai R&D Management Co., Ltd | Salts of compounds and crystals thereof |
US20200113912A1 (en) | 2018-09-12 | 2020-04-16 | Silverback Therapeutics, Inc. | Methods and Compositions for the Treatment of Disease with Immune Stimulatory Conjugates |
WO2020135715A1 (fr) * | 2018-12-29 | 2020-07-02 | 上海济煜医药科技有限公司 | Composé pour immunité tumorale et son application |
EP3966222A4 (fr) | 2019-05-09 | 2023-10-04 | Aligos Therapeutics, Inc. | Composés di-nucléosidiques cycliques modifiés servant de modulateurs sting |
TWI826690B (zh) * | 2019-05-23 | 2023-12-21 | 美商基利科學股份有限公司 | 經取代之烯吲哚酮化物及其用途 |
MX2022000052A (es) * | 2019-07-01 | 2022-04-06 | Eisai R&D Man Co Ltd | Sistema para aumentar el cumplimiento terapéutico del compuesto antineoplásico e7766. |
AU2020358726A1 (en) | 2019-10-01 | 2022-04-07 | Silverback Therapeutics, Inc. | Combination therapy with immune stimulatory conjugates |
JP2022177332A (ja) * | 2019-10-24 | 2022-12-01 | 日東電工株式会社 | オリゴヌクレオチドを製造する方法 |
WO2021168274A1 (fr) | 2020-02-21 | 2021-08-26 | Silverback Therapeutics, Inc. | Conjugués d'anticorps de nectine-4 et leurs utilisations |
WO2021206158A1 (fr) | 2020-04-10 | 2021-10-14 | 小野薬品工業株式会社 | Méthode de cancérothérapie |
WO2021252904A1 (fr) | 2020-06-11 | 2021-12-16 | Massachusetts Institute Of Technology | Approche ribonucléoprotéinique pour amplifier la signalisation sting pour une immunothérapie anticancéreuse |
TW202216211A (zh) | 2020-07-01 | 2022-05-01 | 美商希沃爾拜克治療公司 | 抗asgr1抗體共軛物及其用途 |
CN111909223A (zh) * | 2020-07-17 | 2020-11-10 | 清华大学 | 环二核苷酸共价修饰物及其制备方法和应用 |
JP2023545178A (ja) | 2020-10-14 | 2023-10-26 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Stingアゴニストと、細胞透過性ペプチド、カーゴ、及びtlrペプチドアゴニストを含む複合体との組合せ |
US20220168330A1 (en) | 2020-11-09 | 2022-06-02 | Takeda Pharmaceutical Company Limited | Antibody drug conjugates |
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GB2257704B (en) | 1991-07-18 | 1995-03-01 | Erba Carlo Spa | Cyclic oligonucleotides phosphorothioates |
US7592326B2 (en) | 2004-03-15 | 2009-09-22 | Karaolis David K R | Method for stimulating the immune, inflammatory or neuroprotective response |
AU2005222626B2 (en) | 2004-03-15 | 2010-05-20 | Karagen Pharmaceuticals, Inc. | A method for inhibiting cancer cell proliferation or increasing cancer cell apoptosis |
US8076303B2 (en) | 2005-12-13 | 2011-12-13 | Spring Bank Pharmaceuticals, Inc. | Nucleotide and oligonucleotide prodrugs |
GB0607950D0 (en) | 2006-04-21 | 2006-05-31 | Novartis Ag | Organic compounds |
WO2009133560A1 (fr) | 2008-04-29 | 2009-11-05 | Smart Assays | Dérivés de bis-(nucléotide monophosphate) cycliques non hydrolysables et perméables et leurs utilisations |
CN102199183B (zh) | 2010-03-26 | 2013-12-18 | 北京大学 | 环二鸟苷酸及其类似物和制备方法 |
JP6257607B2 (ja) * | 2012-06-08 | 2018-01-10 | アデュロ バイオテック,インコーポレイテッド | 癌免疫療法のための組成物および方法 |
AU2013358892B2 (en) * | 2012-12-13 | 2018-06-21 | Aduro Biotech, Inc. | Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use |
TN2015000457A1 (en) * | 2013-04-29 | 2017-04-06 | Memorial Sloan Kettering Cancer Center | Compositions and methods for altering second messenger signaling |
US20140329889A1 (en) | 2013-05-03 | 2014-11-06 | The Regents Of The University Of California | Cyclic di-nucleotide induction of type i interferon |
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AU2014268836B2 (en) | 2013-05-18 | 2018-08-02 | Aduro Biotech, Inc. | Compositions and methods for activating "stimulator of interferon gene"-dependent signalling |
EP3071209A4 (fr) | 2013-11-19 | 2017-08-16 | The University of Chicago | Utilisation d'un agoniste de sting en tant que traitement anti-cancéreux |
WO2015074145A1 (fr) | 2013-11-22 | 2015-05-28 | Brock University | Utilisation de dinucléotides cycliques fluorés comme adjuvants de vaccin oral |
KR20170015353A (ko) | 2014-06-04 | 2017-02-08 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | Sting의 조절제로서 사이클릭 디뉴클레오타이드 |
JP6762030B2 (ja) * | 2014-11-20 | 2020-09-30 | 国立研究開発法人医薬基盤・健康・栄養研究所 | 異なる核酸アジュバントの組み合わせによる、新規Th1誘導性アジュバントおよびその用途 |
WO2016096577A1 (fr) * | 2014-12-16 | 2016-06-23 | Invivogen | Utilisation combinée d'un agent chimiothérapeutique et d'un dinucléotide cyclique pour le traitement du cancer |
PL3233882T3 (pl) | 2014-12-16 | 2020-04-30 | Kayla Therapeutics | Fluorowane cykliczne dinukleotydy do indukcji cytokin |
CN107106589A (zh) | 2014-12-17 | 2017-08-29 | 立博美华基因科技有限责任公司 | 用cGAMP或cGAsMP治疗癌症的方法 |
GB201501462D0 (en) | 2015-01-29 | 2015-03-18 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
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TW201717968A (zh) | 2015-07-14 | 2017-06-01 | 春季銀行製藥公司 | 誘導rig-i和其他模式辨識受體之化合物及組成物 |
US10844051B2 (en) | 2015-07-22 | 2020-11-24 | The Royal Institution For The Advancement Of Learning/Mcgill University | Substituted oxazoles for the treatment of cancer |
UA123701C2 (uk) | 2015-08-13 | 2021-05-19 | Мерк Шарп І Доум Корп. | Циклічні динуклеотидні сполуки як агоністи sting |
US9809597B2 (en) | 2015-08-20 | 2017-11-07 | The Board Of Trustees Of The Leland Stanford Junior University | Ganciclovir derivatives for modulating innate and adaptive immunity and for use in immunotherapy |
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RU2722019C2 (ru) | 2015-12-03 | 2020-05-26 | Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Циклические пуриновые динуклеотиды в качестве модуляторов sting |
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WO2017123657A1 (fr) | 2016-01-11 | 2017-07-20 | Gary Glick | Dinucléotides cycliques pour traiter des affections associées à l'activité sting comme le cancer |
US10604542B2 (en) | 2016-01-11 | 2020-03-31 | Innate Tumor Immunity, Inc. | Cyclic dinucleotides for treating conditions associated with sting activity such as cancer |
CA3017524A1 (fr) | 2016-03-18 | 2017-09-21 | Immune Sensor, Llc | Composes di-nucleotides cycliques et leurs procedes d'utilisation |
RU2018137389A (ru) | 2016-04-07 | 2020-05-12 | Глаксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Гетероциклические амиды, полезные в качестве модуляторов |
US10537590B2 (en) | 2016-09-30 | 2020-01-21 | Boehringer Ingelheim International Gmbh | Cyclic dinucleotide compounds |
JOP20170188A1 (ar) | 2016-11-25 | 2019-01-30 | Janssen Biotech Inc | ثنائي النوكليوتيدات الحلقية كمنبهات ستينغ (sting) |
US20190336615A1 (en) | 2017-01-27 | 2019-11-07 | Silverback Therapeutics, Inc. | Tumor targeting conjugates and methods of use thereof |
WO2018198084A1 (fr) | 2017-04-27 | 2018-11-01 | Lupin Limited | Composés di-nucléotidiques cycliques avec des nucléobases tricycliques |
UY37695A (es) | 2017-04-28 | 2018-11-30 | Novartis Ag | Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo |
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2018
- 2018-02-16 US US16/486,954 patent/US20200055883A1/en not_active Abandoned
- 2018-02-17 LT LTEPPCT/US2018/018556T patent/LT3582853T/lt unknown
- 2018-02-17 MX MX2019009796A patent/MX2019009796A/es unknown
- 2018-02-17 JP JP2019544817A patent/JP6672532B2/ja active Active
- 2018-02-17 RS RS20220079A patent/RS62842B1/sr unknown
- 2018-02-17 CN CN201880025317.7A patent/CN110536719A/zh active Pending
- 2018-02-17 PL PL18708032T patent/PL3582853T3/pl unknown
- 2018-02-17 CN CN202410024195.7A patent/CN117866030A/zh active Pending
- 2018-02-17 CN CN201880021349.XA patent/CN110461416B/zh active Active
- 2018-02-17 HR HRP20220110TT patent/HRP20220110T1/hr unknown
- 2018-02-17 EP EP21208462.8A patent/EP4008403A1/fr not_active Withdrawn
- 2018-02-17 UA UAA201909860A patent/UA125310C2/uk unknown
- 2018-02-17 PE PE2019001715A patent/PE20191686A1/es unknown
- 2018-02-17 KR KR1020197027073A patent/KR102645790B1/ko active IP Right Grant
- 2018-02-17 JP JP2019544725A patent/JP2020510638A/ja active Pending
- 2018-02-17 JO JOP/2019/0194A patent/JOP20190194B1/ar active
- 2018-02-17 US US15/898,533 patent/US10246480B2/en active Active
- 2018-02-17 DK DK18708032.0T patent/DK3582853T3/da active
- 2018-02-17 HU HUE18708032A patent/HUE057665T2/hu unknown
- 2018-02-17 SI SI201830553T patent/SI3582853T1/sl unknown
- 2018-02-17 MA MA047501A patent/MA47501A/fr unknown
- 2018-02-17 AU AU2018221170A patent/AU2018221170B2/en active Active
- 2018-02-17 EP EP18708032.0A patent/EP3582853B1/fr active Active
- 2018-02-17 PT PT187080320T patent/PT3582853T/pt unknown
- 2018-02-17 CA CA3053932A patent/CA3053932A1/fr active Pending
- 2018-02-17 WO PCT/US2018/018561 patent/WO2018152453A1/fr unknown
- 2018-02-17 ES ES18708032T patent/ES2906299T3/es active Active
- 2018-02-17 EP EP18709835.5A patent/EP3582854A1/fr not_active Withdrawn
- 2018-02-17 WO PCT/US2018/018556 patent/WO2018152450A1/fr unknown
- 2018-02-17 MD MDE20200009T patent/MD3582853T2/ro unknown
- 2018-02-17 BR BR112019017084A patent/BR112019017084A2/pt unknown
- 2018-02-17 SG SG11201907496RA patent/SG11201907496RA/en unknown
- 2018-02-21 TW TW107105846A patent/TWI766948B/zh active
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2019
- 2019-02-15 US US16/277,522 patent/US10618930B2/en active Active
- 2019-08-13 CO CONC2019/0008783A patent/CO2019008783A2/es unknown
- 2019-08-14 CL CL2019002304A patent/CL2019002304A1/es unknown
- 2019-08-15 IL IL268721A patent/IL268721B/en unknown
- 2019-08-16 PH PH12019501914A patent/PH12019501914A1/en unknown
- 2019-09-16 ZA ZA2019/06111A patent/ZA201906111B/en unknown
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2020
- 2020-02-04 US US16/781,352 patent/US11339188B2/en active Active
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SG11201909963YA (en) | Methods for treating dravet syndrome | |
SG11201407268SA (en) | Nuclear transport modulators and uses thereof | |
SG11201908171TA (en) | Compounds and compositions for treating hematological disorders | |
SG11201407486PA (en) | Compositions and methods for modulating utrn expression | |
SG11201907650RA (en) | Personal therapy and exercise monitoring and oversight devices, systems, and related methods | |
SG11201806133UA (en) | Intermediates in the synthesis of eribulin and related methods of synthesis | |
SG11201408054RA (en) | Pegylated oxm variants | |
SG11201903076QA (en) | Carbamoyl phenylalaninol compounds and uses therof | |
SG11201408251SA (en) | A pharmaceutical composition containing nicotinic acid and/or nicotinamide and/or tryptophan for positively influencing the intestinal microbiota | |
SG11201407200TA (en) | Liquid formulation | |
SG11201810177VA (en) | Pet-imaging immunomodulators | |
SG11201804220SA (en) | Activated stem cells and systemic treatment methods for infected wounds | |
SG11201811671XA (en) | Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof | |
SG11201406787TA (en) | Rnai-based therapies for cardiomyopathies, muscular dystrophies and laminopathies | |
SG11201806544XA (en) | Compounds and methods of treating rna-mediated diseases | |
SG11201804095YA (en) | Rim brake system and a tire | |
SG11201408509PA (en) | Racecadotril lipid compositions | |
SG11201903427UA (en) | Deodorizing agent comprising zinc neodecanoate | |
SG11201803816RA (en) | Targeting of the formyl-peptide receptor 2/lipoxin a4 receptor (fpr2/alx) for treatment of heart disease |