SG11201906804UA - Zwitterionically modified polymers and hydrogels - Google Patents

Zwitterionically modified polymers and hydrogels

Info

Publication number
SG11201906804UA
SG11201906804UA SG11201906804UA SG11201906804UA SG11201906804UA SG 11201906804U A SG11201906804U A SG 11201906804UA SG 11201906804U A SG11201906804U A SG 11201906804UA SG 11201906804U A SG11201906804U A SG 11201906804UA SG 11201906804U A SG11201906804U A SG 11201906804UA
Authority
SG
Singapore
Prior art keywords
international
cornell university
ithaca
pct
present
Prior art date
Application number
SG11201906804UA
Other languages
English (en)
Inventor
Minglin Ma
Qingsheng Liu
Original Assignee
Univ Cornell
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Cornell filed Critical Univ Cornell
Publication of SG11201906804UA publication Critical patent/SG11201906804UA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0084—Guluromannuronans, e.g. alginic acid, i.e. D-mannuronic acid and D-guluronic acid units linked with alternating alpha- and beta-1,4-glycosidic bonds; Derivatives thereof, e.g. alginates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/39—Pancreas; Islets of Langerhans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/08—Polyoxyalkylene derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/02—Acyclic radicals
    • C07H7/033—Uronic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F116/00—Homopolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical
    • C08F116/02—Homopolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical by an alcohol radical
    • C08F116/04—Acyclic compounds
    • C08F116/06—Polyvinyl alcohol ; Vinyl alcohol
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F16/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical
    • C08F16/02—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical by an alcohol radical
    • C08F16/04—Acyclic compounds
    • C08F16/06—Polyvinyl alcohol ; Vinyl alcohol
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C08F220/60—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing nitrogen in addition to the carbonamido nitrogen
    • C08F220/603—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing nitrogen in addition to the carbonamido nitrogen and containing oxygen in addition to the carbonamido oxygen and nitrogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C08F220/60—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing nitrogen in addition to the carbonamido nitrogen
    • C08F220/606—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing nitrogen in addition to the carbonamido nitrogen and containing other heteroatoms
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L29/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers
    • C08L29/02—Homopolymers or copolymers of unsaturated alcohols
    • C08L29/04—Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/04—Alginic acid; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Materials Engineering (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Genetics & Genomics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
SG11201906804UA 2017-01-27 2018-01-27 Zwitterionically modified polymers and hydrogels SG11201906804UA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762451629P 2017-01-27 2017-01-27
PCT/US2018/015613 WO2018140834A1 (en) 2017-01-27 2018-01-27 Zwitterionically modified polymers and hydrogels

Publications (1)

Publication Number Publication Date
SG11201906804UA true SG11201906804UA (en) 2019-08-27

Family

ID=62978825

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201906804UA SG11201906804UA (en) 2017-01-27 2018-01-27 Zwitterionically modified polymers and hydrogels

Country Status (14)

Country Link
US (2) US11634512B2 (enExample)
EP (1) EP3573624B1 (enExample)
JP (1) JP7198210B2 (enExample)
KR (1) KR102618302B1 (enExample)
CN (2) CN118108677A (enExample)
AU (1) AU2018212895B2 (enExample)
BR (1) BR112019015141A2 (enExample)
CA (1) CA3051142A1 (enExample)
IL (1) IL267991A (enExample)
MX (1) MX2019008388A (enExample)
RU (1) RU2019126801A (enExample)
SG (1) SG11201906804UA (enExample)
WO (1) WO2018140834A1 (enExample)
ZA (1) ZA201904624B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118108677A (zh) 2017-01-27 2024-05-31 康奈尔大学 两性离子修饰的聚合物和水凝胶
US20220127421A1 (en) * 2019-03-05 2022-04-28 University Of Florida Research Foundation, Inc. Polyurethane copolymers and blends, methods of manufacture thereof and articles containing the same
WO2021202945A1 (en) * 2020-04-02 2021-10-07 Cornell University Nanofiber-enabled encapsulation devices and uses thereof
US12359026B2 (en) * 2020-05-28 2025-07-15 Mcmaster University In situ gelling zwitterionic hydrogel compositions, and methods of use thereof
KR102413336B1 (ko) * 2020-07-10 2022-06-27 부경대학교 산학협력단 다공성 알지네이트 기반 하이드로겔, 이의 제조방법 및 이를 이용한 약물 전달체
CN113563267B (zh) * 2021-07-08 2023-05-30 深圳华源再生医学有限公司 一种磺酸甜菜碱的制备方法及应用
CN113667141B (zh) * 2021-07-09 2023-10-03 深圳华源再生医学有限公司 抗蛋白粘附的海藻酸盐水凝胶及其制备方法和应用
JP7694952B2 (ja) * 2021-11-17 2025-06-18 国立大学法人 奈良先端科学技術大学院大学 ポリブチレンサクシネート系共重合体
CN114702606A (zh) * 2022-02-18 2022-07-05 深圳华源再生医学有限公司 一种两性离子修饰的多糖类聚合物及其制备方法与应用
EP4531879A1 (en) 2022-05-25 2025-04-09 Flagship Pioneering Innovations VI, LLC Compositions of secretory and/or catalytic cells and methods using the same
JP2025520113A (ja) 2022-06-03 2025-07-01 フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー 組成物及び方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2744130A (en) * 1952-04-11 1956-05-01 Du Pont Quaternary ammonium monomers and polymers thereof
US4868121A (en) 1985-02-07 1989-09-19 Mcdonnell Douglas Corporation Islet isolation process
US5821121A (en) 1991-06-24 1998-10-13 Pacific Biomedical Research, Inc. Hormone-secreting cells maintained in long-term culture
JPH05148288A (ja) * 1991-11-29 1993-06-15 Kao Corp 新規ベタイン化糖化合物
US5273904A (en) 1992-03-18 1993-12-28 Cobe Laboratories, Inc. Apparatus for purifying islets of Langerhans
DE69739085D1 (de) 1996-09-19 2008-12-18 Univ Michigan Polymere enthaltend polysaccharide wie alginate oder modifizierte alginate
CA2297025A1 (en) * 1997-07-25 1999-02-04 Sdg, Inc. Polymer based pharmaceutical compositions for targeted delivery of biologically active agents
GB0119665D0 (en) * 2001-08-10 2001-10-03 Isis Innovation Conjugates
WO2003068357A2 (en) 2002-02-12 2003-08-21 Cornell Research Foundation, Inc. Identification and high-yield isolation of human pancreatic islet progenitor and stem cells
US20090105238A1 (en) * 2005-10-17 2009-04-23 Isagro Ricerca S.R.L Compounds and Relative use for the Control of Phytopathogens
EP2496550B1 (en) 2009-11-06 2015-08-05 University Of Washington Through Its Center For Commercialization Crosslinked zwitterionic hydrogels
WO2011160066A1 (en) 2010-06-17 2011-12-22 Regents Of The University Of Minnesota Production of insulin producing cells
JP5690671B2 (ja) * 2010-06-30 2015-03-25 富士フイルム株式会社 新規な重合性組成物及びそれに用いる重合性化合物、並びに新規な重合性組成物を用いた画像形成材料及び平版印刷版原版
EP2714747B1 (en) 2011-06-02 2020-08-05 Massachusetts Institute of Technology Modified alginates for cell encapsulation and cell therapy
CZ2012136A3 (cs) 2012-02-28 2013-06-05 Contipro Biotech S.R.O. Deriváty na bázi kyseliny hyaluronové schopné tvorit hydrogely, zpusob jejich prípravy, hydrogely na bázi techto derivátu, zpusob jejich prípravy a pouzití
US10494538B2 (en) * 2013-05-30 2019-12-03 The University Of Akron Switchable antimicrobial and antifouling carboxybetaine-based hydrogels and elastomers with enhanced mechanical properties
WO2015057645A1 (en) * 2013-10-14 2015-04-23 The University Of Akron Zwitterionic polysaccharide polymers having antifouling, antimicrobial and optical transparency properties
CN111892589A (zh) * 2014-01-06 2020-11-06 理森制药股份公司 谷氨酰胺酶抑制剂
KR20240157103A (ko) 2014-08-01 2024-10-31 메사추세츠 인스티튜트 오브 테크놀로지 항-섬유 물질 및 응용을 위한 변형된 알기네이트
CN107530295A (zh) 2015-02-27 2018-01-02 韦恩州立大学 与生物相容性植入物相关的方法和组合物
EP3368085B1 (en) 2015-11-01 2024-01-03 Massachusetts Institute Of Technology Modified alginates for anti-fibrotic materials and applications
CA3027856A1 (en) * 2016-06-13 2017-12-21 Massachusetts Institute Of Technology Surface-coated continuous glucose monitors
US20190185867A1 (en) 2016-06-16 2019-06-20 Pioneer Hi-Bred International, Inc. Compositions and methods to control insect pests
CN118108677A (zh) 2017-01-27 2024-05-31 康奈尔大学 两性离子修饰的聚合物和水凝胶

Also Published As

Publication number Publication date
WO2018140834A1 (en) 2018-08-02
RU2019126801A3 (enExample) 2021-05-24
ZA201904624B (en) 2024-11-27
CN110381956A (zh) 2019-10-25
KR102618302B1 (ko) 2023-12-28
EP3573624B1 (en) 2025-03-19
CA3051142A1 (en) 2018-08-02
EP3573624A4 (en) 2020-10-21
IL267991A (en) 2019-09-26
US20240018276A1 (en) 2024-01-18
US12378329B2 (en) 2025-08-05
RU2019126801A (ru) 2021-03-02
EP3573624A1 (en) 2019-12-04
MX2019008388A (es) 2019-12-02
US11634512B2 (en) 2023-04-25
BR112019015141A2 (pt) 2020-03-24
CN118108677A (zh) 2024-05-31
JP7198210B2 (ja) 2022-12-28
CN110381956B (zh) 2024-02-02
AU2018212895B2 (en) 2024-02-22
JP2020506919A (ja) 2020-03-05
US20190389979A1 (en) 2019-12-26
KR20190109446A (ko) 2019-09-25
AU2018212895A1 (en) 2019-08-15

Similar Documents

Publication Publication Date Title
SG11201906804UA (en) Zwitterionically modified polymers and hydrogels
SG11201906763RA (en) Pyrrolo [1,2-b] pyridazine derivatives
SG11201811338VA (en) A novel botulinum neurotoxin and its derivatives
SG11201907650RA (en) Personal therapy and exercise monitoring and oversight devices, systems, and related methods
SG11201903604PA (en) Iot security service
SG11201809064QA (en) Chimeric neurotoxins
SG11201901390TA (en) Tetracycline compounds and methods of treatment
SG11201901063SA (en) Therapeutic agents for neurodegenerative diseases
SG11201805120YA (en) Zika virus vaccine
SG11201804180XA (en) High density rotomolding resin
SG11201408303WA (en) Adhesive compositions of propylene-based and ethylene-based polymers
SG11201901868VA (en) Breathable films with microbial barrier properties
SG11201809277SA (en) Random copolymers of acrylates as polymeric friction modifiers, and lubricants containing same
SG11201408251SA (en) A pharmaceutical composition containing nicotinic acid and/or nicotinamide and/or tryptophan for positively influencing the intestinal microbiota
SG11201810470XA (en) Lysine conjugated immunoglobulins
SG11201404696VA (en) Methods for making catalyst compositions and polymer products produced therefrom
SG11201909680UA (en) Phenyl-2-hydroxy-acetylamino-2-methyl-phenyl compounds
SG11201807720TA (en) Methods and systems for determining antibiotic susceptibility
SG11201805001UA (en) Method of treating influenza a
SG11201811212SA (en) Silane-mediated enhancement of rubber storage stability
SG11201900238UA (en) Compounds and methods for modulation of smn2
SG11201809679SA (en) Molecular modification of polyethylene resin
SG11201906436VA (en) Novel heterocyclic compound, its preparation method, and pharmaceutical composition comprising the same
SG11201901409YA (en) Polymerizing composition, method of manufacture thereof and articles comprising the same
SG11201803148SA (en) Contact lens packaging solutions