SG11201903346QA - Gestational age assessment by methylation and size profiling of maternal plasma dna - Google Patents
Gestational age assessment by methylation and size profiling of maternal plasma dnaInfo
- Publication number
- SG11201903346QA SG11201903346QA SG11201903346QA SG11201903346QA SG11201903346QA SG 11201903346Q A SG11201903346Q A SG 11201903346QA SG 11201903346Q A SG11201903346Q A SG 11201903346QA SG 11201903346Q A SG11201903346Q A SG 11201903346QA SG 11201903346Q A SG11201903346Q A SG 11201903346QA
- Authority
- SG
- Singapore
- Prior art keywords
- cell
- international
- free dna
- gestational age
- shatin
- Prior art date
Links
- 230000011987 methylation Effects 0.000 title abstract 5
- 238000007069 methylation reaction Methods 0.000 title abstract 5
- 230000008774 maternal effect Effects 0.000 title abstract 2
- 108020004414 DNA Proteins 0.000 abstract 11
- 239000012634 fragment Substances 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 210000003754 fetus Anatomy 0.000 abstract 2
- 102000053602 DNA Human genes 0.000 abstract 1
- 241000404883 Pisa Species 0.000 abstract 1
- 230000001605 fetal effect Effects 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 230000002123 temporal effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6858—Allele-specific amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662410108P | 2016-10-19 | 2016-10-19 | |
| PCT/CN2017/106663 WO2018072705A1 (en) | 2016-10-19 | 2017-10-18 | Gestational age assessment by methylation and size profiling of maternal plasma dna |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201903346QA true SG11201903346QA (en) | 2019-05-30 |
Family
ID=61903724
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201903346QA SG11201903346QA (en) | 2016-10-19 | 2017-10-18 | Gestational age assessment by methylation and size profiling of maternal plasma dna |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US11512306B2 (de) |
| EP (2) | EP4209598A1 (de) |
| CN (1) | CN109890984B (de) |
| IL (1) | IL265769B2 (de) |
| SG (1) | SG11201903346QA (de) |
| WO (1) | WO2018072705A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| WO2012108920A1 (en) | 2011-02-09 | 2012-08-16 | Natera, Inc | Methods for non-invasive prenatal ploidy calling |
| WO2016183106A1 (en) | 2015-05-11 | 2016-11-17 | Natera, Inc. | Methods and compositions for determining ploidy |
| JP2021520816A (ja) | 2018-04-14 | 2021-08-26 | ナテラ， インコーポレイテッド | 循環腫瘍ｄｎａの個別化された検出を用いる癌検出およびモニタリングの方法 |
| CN108765371B (zh) * | 2018-04-25 | 2020-07-07 | 浙江大学 | 一种病理切片中非常规细胞的分割方法 |
| CN109241628B (zh) * | 2018-09-08 | 2022-07-19 | 西北工业大学 | 基于图谱理论和聚类的三维cad模型分割方法 |
| WO2021108525A1 (en) * | 2019-11-27 | 2021-06-03 | Bioscreening & Diagnostics Llc | Detecting congenital heart defects |
| US20210265007A1 (en) * | 2020-02-05 | 2021-08-26 | The Chinese University Of Hong Kong | Molecular analyses using long cell-free fragments in pregnancy |
| CN114592074A (zh) * | 2022-04-12 | 2022-06-07 | 苏州市立医院 | 一种与胎龄相关的靶标基因组合及其应用 |
| CN114898802B (zh) * | 2022-07-14 | 2022-09-30 | 臻和(北京)生物科技有限公司 | 基于血浆游离dna甲基化测序数据的末端序列频率分布特征确定方法、评价方法及装置 |
| CN117766028A (zh) * | 2022-09-16 | 2024-03-26 | 深圳吉因加医学检验实验室 | 一种基于甲基化差异预测样本来源的方法及装置 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8476013B2 (en) | 2008-09-16 | 2013-07-02 | Sequenom, Inc. | Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses |
| EA034241B1 (ru) | 2009-11-06 | 2020-01-21 | Те Чайниз Юниверсити Ов Гонконг | Способ пренатальной диагностики дисбаланса последовательности |
| US8845539B2 (en) * | 2010-12-22 | 2014-09-30 | General Electric Company | Methods and systems for estimating gestation age of a fetus |
| US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
| KR102390711B1 (ko) * | 2012-09-20 | 2022-04-26 | 더 차이니즈 유니버시티 오브 홍콩 | 혈장으로부터 태아 또는 종양 메틸롬의 비침습적 결정 |
| US9732390B2 (en) * | 2012-09-20 | 2017-08-15 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
| KR102441391B1 (ko) | 2014-07-25 | 2022-09-07 | 유니버시티 오브 워싱톤 | 무세포 dna를 생성하는 조직 및/또는 세포 유형을 결정하는 방법 및 이를 사용하여 질환 또는 장애를 확인하는 방법 |
| US10319463B2 (en) | 2015-01-23 | 2019-06-11 | The Chinese University Of Hong Kong | Combined size- and count-based analysis of maternal plasma for detection of fetal subchromosomal aberrations |
-
2017
- 2017-10-18 EP EP23155767.9A patent/EP4209598A1/de active Pending
- 2017-10-18 CN CN201780064607.8A patent/CN109890984B/zh active Active
- 2017-10-18 US US15/787,050 patent/US11512306B2/en active Active
- 2017-10-18 IL IL265769A patent/IL265769B2/en unknown
- 2017-10-18 SG SG11201903346QA patent/SG11201903346QA/en unknown
- 2017-10-18 WO PCT/CN2017/106663 patent/WO2018072705A1/en unknown
- 2017-10-18 EP EP17861749.4A patent/EP3529377B1/de active Active
-
2022
- 2022-10-31 US US17/977,508 patent/US20230047963A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3529377A4 (de) | 2020-05-27 |
| CN109890984A (zh) | 2019-06-14 |
| WO2018072705A1 (en) | 2018-04-26 |
| IL265769B1 (en) | 2023-08-01 |
| EP3529377A1 (de) | 2019-08-28 |
| US20180105807A1 (en) | 2018-04-19 |
| IL265769B2 (en) | 2023-12-01 |
| EP3529377B1 (de) | 2023-04-05 |
| IL265769A (en) | 2019-06-30 |
| US11512306B2 (en) | 2022-11-29 |
| US20230047963A1 (en) | 2023-02-16 |
| EP4209598A1 (de) | 2023-07-12 |
| CN109890984B (zh) | 2024-03-29 |
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