SG11201902938TA - Compounds, devices, and uses thereof - Google Patents

Compounds, devices, and uses thereof

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Publication number
SG11201902938TA
SG11201902938TA SG11201902938TA SG11201902938TA SG11201902938TA SG 11201902938T A SG11201902938T A SG 11201902938TA SG 11201902938T A SG11201902938T A SG 11201902938TA SG 11201902938T A SG11201902938T A SG 11201902938TA SG 11201902938T A SG11201902938T A SG 11201902938TA
Authority
SG
Singapore
Prior art keywords
co7d
october
international
compounds
pct
Prior art date
Application number
SG11201902938TA
Inventor
Omid Veiseh
Richard Heidebrecht
Paul Wotton
Matthias Oberli
Robert Miller
Original Assignee
Sigilon Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigilon Therapeutics Inc filed Critical Sigilon Therapeutics Inc
Publication of SG11201902938TA publication Critical patent/SG11201902938TA/en

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    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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    • C12N9/2465—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1) acting on alpha-galactose-glycoside bonds, e.g. alpha-galactosidase (3.2.1.22)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01022—Alpha-galactosidase (3.2.1.22)

Abstract

International Patent Classification: C07D 401/14 (2006.01) C07D 409/14 (2006.01) C07D 405/14 (2006.01) C07D 413/04 (2006.01) C07D 401/04 (2006.01) C07D 401/10 (2006.01) C07D 401/12 (2006.01) C07D 403/04 (2006.01) C07D 405/04 (2006.01) C07D 405/06 (2006.01) CO7D 405/12 (2006.01) CO7D 409/06 (2006.01) CO7D 417/06 (2006.01) CO7D 417/14 (2006.01) CO7D 249/04 (2006.01) CO7D 249/06 (2006.01) CO7D 471/04 (2006.01) CO7D 487/04 (2006.01) A61K 31/4192 (2006.01) A61P 37/00 (2006.01) (21) International Application Number: PCT/US2017/055001 (22) International Filing Date: (25) Filing Language: (26) Publication Language: (30) Priority Data: 62/403,554 62/403,548 62/403,532 62/403,559 62/403,543 62/403,556 62/403,538 62/436,832 03 October 2017 (03.10.2017) English English 03 October 2016 (03.10.2016) US 03 October 2016 (03.10.2016) US 03 October 2016 (03.10.2016) US 03 October 2016 (03.10.2016) US 03 October 2016 (03.10.2016) US 03 October 2016 (03.10.2016) US 03 October 2016 (03.10.2016) US 20 December 2016 (20.12.2016) US (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 12 April 2018 (12.04.2018) Hu omits I iolo ol !MEM H 111110#1111 (10) International Publication Number WO 2018/067615 Al WIPO I PCT OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: with international search report (Art. 21(3)) W O 20 18/067 6 15 Al (71) Applicant: SIGILON THERAPEUTICS, INC. [US/US]; 161 First Street, Suite 2c, Cambridge, MA 02142 (US). (72) Inventors: VEISEH, Omid; 4903 Palmetto St., Bellaire, TX 77401 (US). HEIDEBRECHT, Richard; 222 Wil- low Ave #2, Somerville, MA 02144 (US). WOTTON, Paul, Kevin; 221 Columbus Ave #602, Boston, MA 02116 (US). OBERLI, Matthias; 4 Rollins Court, Cambridge, MA 02139 (US). MILLER, Robert, James; 120 North- ridge Drive, East Bridgewater, MA 02333 (US). (74) Agent: LARKIN, Angelyn; Lando & Anastasi, LLP, Riverfront Office Park, One Main Street, Suite 1100, Cam- bridge, MA 02142 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (54) Title: COMPOUNDS, DEVICES, AND USES THEREOF (57) : The present invention provides compounds, e.g., compounds of Formula (I) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are implantable elements (e.g., devices and materials) comprising the same, as well as methods of use thereof, e.g., for treating or preventing a disease, disorder, or condition.
SG11201902938TA 2016-10-03 2017-10-03 Compounds, devices, and uses thereof SG11201902938TA (en)

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US201662403532P 2016-10-03 2016-10-03
US201662403554P 2016-10-03 2016-10-03
US201662403559P 2016-10-03 2016-10-03
US201662403548P 2016-10-03 2016-10-03
US201662403556P 2016-10-03 2016-10-03
US201662403538P 2016-10-03 2016-10-03
US201662403543P 2016-10-03 2016-10-03
US201662436832P 2016-12-20 2016-12-20
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KR20190092374A (en) 2019-08-07
MX2019003887A (en) 2019-11-18
BR112019006712A2 (en) 2019-06-25
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CN110036008A (en) 2019-07-19
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