SG11201901059QA - Methods for purifying antibodies - Google Patents

Methods for purifying antibodies

Info

Publication number
SG11201901059QA
SG11201901059QA SG11201901059QA SG11201901059QA SG11201901059QA SG 11201901059Q A SG11201901059Q A SG 11201901059QA SG 11201901059Q A SG11201901059Q A SG 11201901059QA SG 11201901059Q A SG11201901059Q A SG 11201901059QA SG 11201901059Q A SG11201901059Q A SG 11201901059QA
Authority
SG
Singapore
Prior art keywords
international
prussia
king
road
rule
Prior art date
Application number
SG11201901059QA
Other languages
English (en)
Inventor
Andre C Dumetz
Kent E Goklen
Nicholas E Levy
Jessica Rachel Molek
Andrew S Thomson
Kenneth G Yancey
Original Assignee
Glaxosmithkline Ip Dev Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Ip Dev Ltd filed Critical Glaxosmithkline Ip Dev Ltd
Publication of SG11201901059QA publication Critical patent/SG11201901059QA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G, L chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/424—Elution mode
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Enzymes And Modification Thereof (AREA)
SG11201901059QA 2016-09-07 2017-09-06 Methods for purifying antibodies SG11201901059QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662384240P 2016-09-07 2016-09-07
PCT/IB2017/055374 WO2018047080A1 (en) 2016-09-07 2017-09-06 Methods for purifying antibodies

Publications (1)

Publication Number Publication Date
SG11201901059QA true SG11201901059QA (en) 2019-03-28

Family

ID=60138654

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201901059QA SG11201901059QA (en) 2016-09-07 2017-09-06 Methods for purifying antibodies

Country Status (13)

Country Link
US (2) US11530238B2 (ko)
EP (2) EP3510042B1 (ko)
JP (3) JP7058272B2 (ko)
KR (1) KR102489451B1 (ko)
CN (1) CN109689675A (ko)
AU (1) AU2017323583A1 (ko)
BR (1) BR112019004459A2 (ko)
CA (1) CA3035853A1 (ko)
DK (1) DK3510042T3 (ko)
IL (1) IL265016B (ko)
RU (1) RU2759909C2 (ko)
SG (1) SG11201901059QA (ko)
WO (1) WO2018047080A1 (ko)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3035853A1 (en) * 2016-09-07 2018-03-15 Glaxosmithkline Intellectual Property Development Limited Methods for purifying antibodies
TW202003555A (zh) * 2018-03-07 2020-01-16 英商葛蘭素史克智慧財產發展有限公司 用於純化重組多肽之方法
TW202000891A (zh) * 2018-03-07 2020-01-01 英商葛蘭素史克智慧財產發展有限公司 純化抗體之方法
EP3788151A4 (en) * 2018-05-04 2022-01-12 Sigma-Aldrich Co. LLC ALTERED CELLS WITH ALTERED HOST CELL PROTEIN PROFILES
GB201904741D0 (en) * 2019-04-04 2019-05-22 Glaxosmithkline Ip Dev Ltd Novel process
US20230143163A1 (en) * 2020-04-27 2023-05-11 Alexion Pharmaceuticals, Inc. Protein a chromatography purification of an antibody
CN113281430A (zh) * 2021-05-11 2021-08-20 苏州君盟生物医药科技有限公司 一种双特异性抗体的分离鉴定方法
CN115161308A (zh) * 2022-06-13 2022-10-11 江苏丰华生物制药有限公司 一种注射用替奈普酶上清液的纯化方法

Family Cites Families (22)

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JPS57106673A (en) 1980-12-24 1982-07-02 Chugai Pharmaceut Co Ltd Dibenzo(b,f)(1,4)oxazepin derivative
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5429746A (en) 1994-02-22 1995-07-04 Smith Kline Beecham Corporation Antibody purification
US6955917B2 (en) 1997-06-20 2005-10-18 Bayer Healthcare Llc Chromatographic method for high yield purification and viral inactivation of antibodies
IL127127A0 (en) 1998-11-18 1999-09-22 Peptor Ltd Small functional units of antibody heavy chain variable regions
EP1584242B1 (en) 2001-06-01 2010-01-20 Upfront Chromatography A/S Fractionation of protein containing mixtures
EP1419179B1 (en) 2001-08-10 2010-03-03 Aberdeen University Antigen binding domains from fish
CN100403028C (zh) 2002-05-31 2008-07-16 印度农业研究委员会 Bt-cry毒素的迅速检测
BRPI0508096B8 (pt) 2004-02-27 2021-05-25 Octapharma Ag método de preparação de um preparado de anticorpo seguro purificado contra vírus e vírus inativado
EP1786827A4 (en) 2004-05-14 2008-10-29 Kirin Holdings Kk PROCESS FOR IMMUNOGLOBULINE CLEANING
EP1974215B1 (en) 2006-01-06 2017-12-27 EMD Millipore Corporation Affinity chromatography matrices and methods of making and using the same
US8263750B2 (en) 2006-03-16 2012-09-11 Amgen Inc. Method for purifying a protein using protein-A affinity chromatography using an intermediate wash step
CA2911000A1 (en) * 2006-04-05 2007-10-18 Min W. Wan Antibody purification
JP5386354B2 (ja) * 2006-09-08 2014-01-15 ワイス・エルエルシー アフィニティークロマトグラフィーを使用するタンパク質精製におけるアルギニン洗浄
US20080167450A1 (en) 2007-01-05 2008-07-10 Hai Pan Methods of purifying proteins
EP3604324B1 (en) * 2008-08-14 2024-02-28 Genentech, Inc. Methods for removing a contaminant using indigenous protein displacement ion exchange membrane chromatography
CN107915769A (zh) 2011-03-29 2018-04-17 葛兰素史密斯克莱有限责任公司 用于蛋白纯化的缓冲液体系
TWI625335B (zh) 2013-03-15 2018-06-01 Glaxosmithkline Intellectual Property (No. 2) Limited 純化抗體的方法
WO2014186350A1 (en) 2013-05-15 2014-11-20 Medimmune Limited Purification of recombinantly produced polypeptides
CA3184564A1 (en) * 2013-09-13 2015-03-19 Genentech, Inc. Methods and compositions comprising an anti-il13 antibody and residual hamster phospholipase b-like 2
KR102332302B1 (ko) 2013-09-13 2021-12-01 제넨테크, 인크. 세포주에서 숙주 세포 단백질 및 재조합 폴리펩티드 생성물을 검출 및 정량화하기 위한 조성물 및 방법
CA3035853A1 (en) * 2016-09-07 2018-03-15 Glaxosmithkline Intellectual Property Development Limited Methods for purifying antibodies

Also Published As

Publication number Publication date
US11530238B2 (en) 2022-12-20
KR102489451B1 (ko) 2023-01-16
RU2019109975A3 (ko) 2020-12-17
JP7058272B2 (ja) 2022-04-21
EP3510042B1 (en) 2024-05-22
JP2024037787A (ja) 2024-03-19
US20210284686A1 (en) 2021-09-16
WO2018047080A1 (en) 2018-03-15
BR112019004459A2 (pt) 2019-05-28
US20230046182A1 (en) 2023-02-16
CN109689675A (zh) 2019-04-26
EP4389757A2 (en) 2024-06-26
JP2022058441A (ja) 2022-04-12
AU2017323583A1 (en) 2019-03-14
EP3510042A1 (en) 2019-07-17
RU2019109975A (ru) 2020-10-08
IL265016B (en) 2021-10-31
JP2019530744A (ja) 2019-10-24
RU2759909C2 (ru) 2021-11-18
CA3035853A1 (en) 2018-03-15
DK3510042T3 (da) 2024-06-10
KR20190043601A (ko) 2019-04-26

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