SG11201810967VA - Radio-pharmaceutical complexes - Google Patents

Radio-pharmaceutical complexes

Info

Publication number
SG11201810967VA
SG11201810967VA SG11201810967VA SG11201810967VA SG11201810967VA SG 11201810967V A SG11201810967V A SG 11201810967VA SG 11201810967V A SG11201810967V A SG 11201810967VA SG 11201810967V A SG11201810967V A SG 11201810967VA SG 11201810967V A SG11201810967V A SG 11201810967VA
Authority
SG
Singapore
Prior art keywords
international
targeting
tissue
oslo
pct
Prior art date
Application number
SG11201810967VA
Other languages
English (en)
Inventor
Alan Cuthbertson
Mark Trautwein
Ernst Weber
Jenny Karlsson
Stefanie Hammer
Original Assignee
Bayer Pharma AG
Bayer As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG, Bayer As filed Critical Bayer Pharma AG
Publication of SG11201810967VA publication Critical patent/SG11201810967VA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0474Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0474Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1075Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being against an enzyme
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81Amides; Imides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SG11201810967VA 2016-06-10 2017-06-06 Radio-pharmaceutical complexes SG11201810967VA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16173874 2016-06-10
PCT/EP2017/063689 WO2017211809A1 (en) 2016-06-10 2017-06-06 Radio-pharmaceutical complexes

Publications (1)

Publication Number Publication Date
SG11201810967VA true SG11201810967VA (en) 2019-01-30

Family

ID=56132786

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201810967VA SG11201810967VA (en) 2016-06-10 2017-06-06 Radio-pharmaceutical complexes

Country Status (26)

Country Link
US (1) US20190298865A1 (ja)
EP (1) EP3468619A1 (ja)
JP (1) JP2019517547A (ja)
KR (1) KR20190016544A (ja)
CN (1) CN109689115A (ja)
AR (1) AR110466A1 (ja)
AU (1) AU2017277463A1 (ja)
BR (1) BR112018075554A2 (ja)
CA (1) CA3026900A1 (ja)
CL (1) CL2018003550A1 (ja)
CO (1) CO2018013359A2 (ja)
CR (1) CR20180581A (ja)
CU (1) CU20180149A7 (ja)
DO (1) DOP2018000277A (ja)
EA (1) EA201892814A1 (ja)
EC (1) ECSP18091468A (ja)
IL (1) IL263538A (ja)
MA (1) MA45225A (ja)
MX (1) MX2018015340A (ja)
NI (1) NI201800136A (ja)
PE (1) PE20190327A1 (ja)
PH (1) PH12018502605A1 (ja)
SG (1) SG11201810967VA (ja)
TW (1) TW201805025A (ja)
UY (1) UY37286A (ja)
WO (1) WO2017211809A1 (ja)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016183266A1 (en) 2015-05-13 2016-11-17 Enanta Pharmaceuticals, Inc. Ehpatitis b antiviral agents
KR102398439B1 (ko) 2016-03-07 2022-05-16 이난타 파마슈티칼스, 인코포레이티드 B형 간염 항바이러스제
TWI811236B (zh) 2017-08-28 2023-08-11 美商因那塔製藥公司 B型肝炎抗病毒試劑
WO2019143902A2 (en) 2018-01-22 2019-07-25 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
UY38383A (es) 2018-09-21 2020-04-30 Enanta Pharm Inc Heterociclos funcionalizados como agentes antivirales
KR20210093951A (ko) 2018-11-21 2021-07-28 이난타 파마슈티칼스, 인코포레이티드 항바이러스제로서의 작용화된 헤테로사이클
WO2020247444A1 (en) 2019-06-03 2020-12-10 Enanta Pharmaceuticals, Inc, Hepatitis b antiviral agents
US11472808B2 (en) 2019-06-04 2022-10-18 Enanta Pharmaceuticals, Inc. Substituted pyrrolo[1,2-c]pyrimidines as hepatitis B antiviral agents
US11760755B2 (en) 2019-06-04 2023-09-19 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
MX2022000252A (es) 2019-07-08 2022-02-21 3B Pharmaceuticals Gmbh Compuestos que comprenden un ligando de proteina de activacion de fibroblasto y uso del mismo.
EP3763726A1 (en) 2019-07-08 2021-01-13 3B Pharmaceuticals GmbH Compounds comprising a fibroblast activation protein ligand and use thereof
US20220315554A1 (en) 2019-07-08 2022-10-06 3B Pharmaceuticals Gmbh Compounds comprising a fibroblast activation protein ligand and use thereof
US11738019B2 (en) 2019-07-11 2023-08-29 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
AR119479A1 (es) 2019-07-25 2021-12-22 Bayer As Radiofármacos dirigidos para diagnóstico y tratamiento de cáncer
WO2021055425A2 (en) 2019-09-17 2021-03-25 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
US11802125B2 (en) 2020-03-16 2023-10-31 Enanta Pharmaceuticals, Inc. Functionalized heterocyclic compounds as antiviral agents
KR20230093251A (ko) 2020-09-10 2023-06-27 프리시릭스 엔.브이. Fap에 대한 항체 단편
AU2022205523A1 (en) 2021-01-07 2023-07-13 3B Pharmaceuticals Gmbh Compounds comprising a fibroblast activation protein ligand and use thereof
EP4050018A1 (en) 2021-01-07 2022-08-31 3B Pharmaceuticals GmbH Compounds comprising a fibroblast activation protein ligand and use thereof
WO2023203135A1 (en) 2022-04-22 2023-10-26 Precirix N.V. Improved radiolabelled antibody
WO2023213801A1 (en) 2022-05-02 2023-11-09 Precirix N.V. Pre-targeting

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5179017A (en) 1980-02-25 1993-01-12 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4634665A (en) 1980-02-25 1987-01-06 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4510245A (en) 1982-11-18 1985-04-09 Chiron Corporation Adenovirus promoter system
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
US4968615A (en) 1985-12-18 1990-11-06 Ciba-Geigy Corporation Deoxyribonucleic acid segment from a virus
US4880615A (en) 1988-11-25 1989-11-14 Merck & Co., Inc. Stabilized radiopharmaceutical compositions
US5624901A (en) 1994-04-15 1997-04-29 The Regents Of The University Of California 3-hydroxy-2(1H)-pyridinone chelating agents
NO312708B1 (no) 2000-02-21 2002-06-24 Anticancer Therapeutic Inv Sa Radioaktive liposomer til terapi
NO313180B1 (no) 2000-07-04 2002-08-26 Anticancer Therapeutic Inv Sa Bensökende alfapartikkel emitterende radiofarmasöytika
GB0308731D0 (en) 2003-04-15 2003-05-21 Anticancer Therapeutic Inv Sa Method of radiotherapy
EP2423201B1 (en) 2006-08-15 2017-10-04 The Regents of the University of California Luminescent macrocyclic lanthanide complexes
WO2011040972A1 (en) 2009-10-02 2011-04-07 Ludwig Institute For Cancer Research Ltd. Anti-fibroblast activation protein antibodies and methods and uses thereof
WO2011079291A1 (en) * 2009-12-24 2011-06-30 Lumiphore, Inc. Radiopharmaceutical complexes
GB201002508D0 (en) 2010-02-12 2010-03-31 Algeta As Product
GB201208309D0 (en) 2012-05-11 2012-06-27 Algeta As Complexes
NL2009131C2 (en) * 2012-07-05 2014-01-07 Stichting Vu Vumc Compound and use of compound to prepare a radiollabelled compound.
MA41176A (fr) * 2014-12-17 2017-10-24 Bayer As Complexes radio-pharmaceutiques

Also Published As

Publication number Publication date
CL2018003550A1 (es) 2019-02-01
JP2019517547A (ja) 2019-06-24
EP3468619A1 (en) 2019-04-17
PE20190327A1 (es) 2019-03-05
MX2018015340A (es) 2019-03-28
US20190298865A1 (en) 2019-10-03
AR110466A1 (es) 2019-04-03
CO2018013359A2 (es) 2018-12-14
NI201800136A (es) 2019-04-29
PH12018502605A1 (en) 2019-10-21
IL263538A (en) 2019-01-31
CN109689115A (zh) 2019-04-26
DOP2018000277A (es) 2018-12-31
EA201892814A1 (ru) 2019-06-28
TW201805025A (zh) 2018-02-16
WO2017211809A1 (en) 2017-12-14
ECSP18091468A (es) 2018-12-31
MA45225A (fr) 2019-04-17
UY37286A (es) 2018-01-31
CA3026900A1 (en) 2017-12-14
KR20190016544A (ko) 2019-02-18
BR112018075554A2 (pt) 2019-10-01
AU2017277463A1 (en) 2019-01-03
CU20180149A7 (es) 2019-07-04
CR20180581A (es) 2019-02-11

Similar Documents

Publication Publication Date Title
SG11201810967VA (en) Radio-pharmaceutical complexes
SG11201908131RA (en) Benzazepine compounds, conjugates, and uses thereof
SG11201807187XA (en) Binding members to pd-l1
SG11201809344QA (en) Process for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde
SG11201811338VA (en) A novel botulinum neurotoxin and its derivatives
SG11201810600WA (en) Fxr (nr1h4) modulating compounds
SG11201807784SA (en) 3-desoxy derivative and pharmaceutical compositions thereof
SG11201909949XA (en) Targeted immunotolerance
SG11201808237UA (en) Substituted indole compound derivatives as dengue viral replication inhibitors
SG11201810628XA (en) Nasal pharmaceutical compositions with a porous excipient
SG11201808125RA (en) Methods for solid tumor treatment
SG11201907889YA (en) Glycan-interacting compounds and methods of use
SG11201811363YA (en) Anti-zika virus antibodies and methods of use
SG11201900163PA (en) Macrocycle kinase inhibitors
SG11201903287PA (en) Anti-respiratory syncytial virus antibodies, and methods of their generation and use
SG11201811442UA (en) Formulation of a peptide vaccine
SG11201909011PA (en) Niraparib compositions
SG11201808270PA (en) Substituted indoline derivatives as dengue viral replication inhibitors
SG11201808108XA (en) Synthesis of indazoles
SG11201811706RA (en) Process for the preparation of microcapsules
SG11201808138YA (en) Substituted indole derivatives as dengue viral replication inhibitors
SG11201809830WA (en) Selective reduction of cysteine-engineered antibodies
SG11201908465QA (en) Substituted indoline derivatives as dengue viral replication inhibitors
SG11201805680SA (en) Methods and compositions for the treatment of neurologic disease
SG11201809497RA (en) Processes for preparing phosphorodiamidate morpholino oligomers