AR110466A1 - Complejos radio-farmacéuticos - Google Patents

Complejos radio-farmacéuticos

Info

Publication number
AR110466A1
AR110466A1 ARP170101585A ARP170101585A AR110466A1 AR 110466 A1 AR110466 A1 AR 110466A1 AR P170101585 A ARP170101585 A AR P170101585A AR P170101585 A ARP170101585 A AR P170101585A AR 110466 A1 AR110466 A1 AR 110466A1
Authority
AR
Argentina
Prior art keywords
tissue
chelating agent
directed
complex
thorium
Prior art date
Application number
ARP170101585A
Other languages
English (en)
Inventor
Hammer Stefanie Dr
Jenny Karlsson
Weber Ernst Dr
Trautwein Mark Dr
Alan Cuthbertson
Original Assignee
Bayer Pharma AG
Bayer As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG, Bayer As filed Critical Bayer Pharma AG
Publication of AR110466A1 publication Critical patent/AR110466A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0474Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0474Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1075Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being against an enzyme
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81Amides; Imides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Se utiliza en el tratamiento de una enfermedad neoplásica o hiperplásica en el cual se aplica un complejo de torio que se dirige al tejido de ese tipo, así como también se provee el complejo y formulaciones farmacéuticas correspondientes. Reivindicación 1: Un método para la formación de un complejo de torio que se dirige al tejido, caracterizado porque dicho método comprende: a) formar un agente quelante octadentado de fórmula (1) ó (2), donde RC es un resto ligante que termina en un resto ácido carboxílico, tal como [-CH₂-Ph-N(H)-C(=O)-CH₂-CH₂-C(=O)OH], [-CH₂-CH₂-N(H)-C(=O)-(CH₂-CH₂-O)₁₋₃-CH₂-CH₂-C(=O)OH] o [-(CH₂)₁₋₃-Ph-N(H)-C(=O)-(CH₂)₁₋₅-C(=O)OH], donde Ph es un grupo fenileno, preferentemente un grupo para-fenileno, b) acoplar dicho agente quelante octadentado a un resto que se dirige al tejido que comprende una cadena peptídica con identidad o similitud de secuencia con una de las secuencias 1, 11 ó 21; y una cadena peptídica con identidad o similitud de secuencia con una de las secuencias 5, 15 ó 25; generando de ese modo un agente quelante que se dirige al tejido; y c) contactar dicho agente quelante que se dirige al tejido con una solución acuosa que comprende 4⁺ iones del isótopo del torio emisor a ²²⁷Th.
ARP170101585A 2016-06-10 2017-06-09 Complejos radio-farmacéuticos AR110466A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP16173874 2016-06-10

Publications (1)

Publication Number Publication Date
AR110466A1 true AR110466A1 (es) 2019-04-03

Family

ID=56132786

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP170101585A AR110466A1 (es) 2016-06-10 2017-06-09 Complejos radio-farmacéuticos

Country Status (26)

Country Link
US (1) US20190298865A1 (es)
EP (1) EP3468619A1 (es)
JP (1) JP2019517547A (es)
KR (1) KR20190016544A (es)
CN (1) CN109689115A (es)
AR (1) AR110466A1 (es)
AU (1) AU2017277463A1 (es)
BR (1) BR112018075554A2 (es)
CA (1) CA3026900A1 (es)
CL (1) CL2018003550A1 (es)
CO (1) CO2018013359A2 (es)
CR (1) CR20180581A (es)
CU (1) CU20180149A7 (es)
DO (1) DOP2018000277A (es)
EA (1) EA201892814A1 (es)
EC (1) ECSP18091468A (es)
IL (1) IL263538A (es)
MA (1) MA45225A (es)
MX (1) MX2018015340A (es)
NI (1) NI201800136A (es)
PE (1) PE20190327A1 (es)
PH (1) PH12018502605A1 (es)
SG (1) SG11201810967VA (es)
TW (1) TW201805025A (es)
UY (1) UY37286A (es)
WO (1) WO2017211809A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016183266A1 (en) 2015-05-13 2016-11-17 Enanta Pharmaceuticals, Inc. Ehpatitis b antiviral agents
ES2938341T3 (es) 2016-03-07 2023-04-10 Enanta Pharm Inc Agentes antivirales contra la hepatitis B
CA3073986A1 (en) 2017-08-28 2019-03-07 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
US11058678B2 (en) 2018-01-22 2021-07-13 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
CN112955142A (zh) 2018-09-21 2021-06-11 英安塔制药有限公司 官能化杂环化合物作为抗病毒剂
UY38483A (es) 2018-11-21 2020-06-30 Enanta Pharm Inc Heterociclos funcionalizados como agentes antivirales
US11236111B2 (en) 2019-06-03 2022-02-01 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
WO2020247575A1 (en) 2019-06-04 2020-12-10 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
WO2020247561A1 (en) 2019-06-04 2020-12-10 Enanta Pharmaceuticals, Inc, Hepatitis b antiviral agents
EP3763726A1 (en) 2019-07-08 2021-01-13 3B Pharmaceuticals GmbH Compounds comprising a fibroblast activation protein ligand and use thereof
CN118406106A (zh) 2019-07-08 2024-07-30 3B制药有限公司 包含成纤维细胞活化蛋白配体的化合物及其用途
CN114341158B (zh) 2019-07-08 2024-08-06 3B制药有限公司 包含成纤维细胞活化蛋白配体的化合物及其用途
WO2021007488A1 (en) 2019-07-11 2021-01-14 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
TW202116733A (zh) 2019-07-25 2021-05-01 挪威商拜耳公司 用於癌症診斷及治療之靶向放射性藥品
WO2021055425A2 (en) 2019-09-17 2021-03-25 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
US11802125B2 (en) 2020-03-16 2023-10-31 Enanta Pharmaceuticals, Inc. Functionalized heterocyclic compounds as antiviral agents
KR20230093251A (ko) 2020-09-10 2023-06-27 프리시릭스 엔.브이. Fap에 대한 항체 단편
IL303925A (en) 2021-01-07 2023-08-01 3B Pharmaceuticals Gmbh Compounds comprising a protein ligand for fibroblast activation and its use
EP4050018A1 (en) 2021-01-07 2022-08-31 3B Pharmaceuticals GmbH Compounds comprising a fibroblast activation protein ligand and use thereof
WO2023203135A1 (en) 2022-04-22 2023-10-26 Precirix N.V. Improved radiolabelled antibody
WO2023213801A1 (en) 2022-05-02 2023-11-09 Precirix N.V. Pre-targeting

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4634665A (en) 1980-02-25 1987-01-06 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US5179017A (en) 1980-02-25 1993-01-12 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4510245A (en) 1982-11-18 1985-04-09 Chiron Corporation Adenovirus promoter system
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
US4968615A (en) 1985-12-18 1990-11-06 Ciba-Geigy Corporation Deoxyribonucleic acid segment from a virus
US4880615A (en) 1988-11-25 1989-11-14 Merck & Co., Inc. Stabilized radiopharmaceutical compositions
US5624901A (en) 1994-04-15 1997-04-29 The Regents Of The University Of California 3-hydroxy-2(1H)-pyridinone chelating agents
NO312708B1 (no) 2000-02-21 2002-06-24 Anticancer Therapeutic Inv Sa Radioaktive liposomer til terapi
NO313180B1 (no) 2000-07-04 2002-08-26 Anticancer Therapeutic Inv Sa Bensökende alfapartikkel emitterende radiofarmasöytika
GB0308731D0 (en) 2003-04-15 2003-05-21 Anticancer Therapeutic Inv Sa Method of radiotherapy
EP2423201B1 (en) 2006-08-15 2017-10-04 The Regents of the University of California Luminescent macrocyclic lanthanide complexes
AU2010301105A1 (en) 2009-10-02 2012-04-19 Ludwig Institute For Cancer Research Ltd. Anti-fibroblast activation protein antibodies and methods and uses thereof
WO2011079291A1 (en) * 2009-12-24 2011-06-30 Lumiphore, Inc. Radiopharmaceutical complexes
GB201002508D0 (en) 2010-02-12 2010-03-31 Algeta As Product
GB201208309D0 (en) 2012-05-11 2012-06-27 Algeta As Complexes
NL2009131C2 (en) * 2012-07-05 2014-01-07 Stichting Vu Vumc Compound and use of compound to prepare a radiollabelled compound.
MA41176A (fr) * 2014-12-17 2017-10-24 Bayer As Complexes radio-pharmaceutiques

Also Published As

Publication number Publication date
EP3468619A1 (en) 2019-04-17
CR20180581A (es) 2019-02-11
US20190298865A1 (en) 2019-10-03
SG11201810967VA (en) 2019-01-30
ECSP18091468A (es) 2018-12-31
DOP2018000277A (es) 2018-12-31
IL263538A (en) 2019-01-31
MA45225A (fr) 2019-04-17
NI201800136A (es) 2019-04-29
KR20190016544A (ko) 2019-02-18
CO2018013359A2 (es) 2018-12-14
CU20180149A7 (es) 2019-07-04
AU2017277463A1 (en) 2019-01-03
EA201892814A1 (ru) 2019-06-28
CA3026900A1 (en) 2017-12-14
MX2018015340A (es) 2019-03-28
PE20190327A1 (es) 2019-03-05
BR112018075554A2 (pt) 2019-10-01
TW201805025A (zh) 2018-02-16
WO2017211809A1 (en) 2017-12-14
CL2018003550A1 (es) 2019-02-01
UY37286A (es) 2018-01-31
PH12018502605A1 (en) 2019-10-21
JP2019517547A (ja) 2019-06-24
CN109689115A (zh) 2019-04-26

Similar Documents

Publication Publication Date Title
AR110466A1 (es) Complejos radio-farmacéuticos
ECSP17038089A (es) Complejos radiofarmacéuticos
DOP2015000110A (es) Anticuerpos anti-ceacam5 y usos de estos
AR104350A1 (es) Celulosa o derivado celulósico que incluye grupos de acrilamida o ácido acrílico injertados para tratar formaciones subterráneas
PE20120586A1 (es) Proteinas de union a il-1
CO2018010024A2 (es) Complejos radiofarmacéuticos
AR107298A1 (es) Método de purificación
AR107300A1 (es) Método para la preparación de isótopos
BR112017023145A2 (pt) Método para produzir um conjugado de proteína- peg
AR102149A1 (es) Anticuerpos dirigidos contra ticagrelor y métodos para su uso
UA99242U (ru) Способ лечения доброкачественной гиперплазии предстательной железы больших размеров, осложненной кровотечением
TH1701003363A (th) สารเชิงซ้อนเภสัชรังสี

Legal Events

Date Code Title Description
FB Suspension of granting procedure