SG11201810031RA - Microorganism with modified aldehyde:ferredoxin oxidoreductase activity and related methods - Google Patents
Microorganism with modified aldehyde:ferredoxin oxidoreductase activity and related methodsInfo
- Publication number
- SG11201810031RA SG11201810031RA SG11201810031RA SG11201810031RA SG11201810031RA SG 11201810031R A SG11201810031R A SG 11201810031RA SG 11201810031R A SG11201810031R A SG 11201810031RA SG 11201810031R A SG11201810031R A SG 11201810031RA SG 11201810031R A SG11201810031R A SG 11201810031RA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- aldehyde
- lamon
- skokie
- avenue
- Prior art date
Links
- 230000000694 effects Effects 0.000 title abstract 4
- 108010074122 Ferredoxins Proteins 0.000 title abstract 3
- 108090000854 Oxidoreductases Proteins 0.000 title abstract 3
- 102000004316 Oxidoreductases Human genes 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 244000005700 microbiome Species 0.000 title abstract 2
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 title 1
- 102000007698 Alcohol dehydrogenase Human genes 0.000 abstract 3
- 241000894006 Bacteria Species 0.000 abstract 3
- 150000001299 aldehydes Chemical class 0.000 abstract 3
- ROWKJAVDOGWPAT-UHFFFAOYSA-N Acetoin Chemical compound CC(O)C(C)=O ROWKJAVDOGWPAT-UHFFFAOYSA-N 0.000 abstract 2
- 108010021809 Alcohol dehydrogenase Proteins 0.000 abstract 2
- 102000005369 Aldehyde Dehydrogenase Human genes 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 230000003247 decreasing effect Effects 0.000 abstract 2
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 abstract 2
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 abstract 2
- NMDWGEGFJUBKLB-UHFFFAOYSA-M 2-acetyllactate Chemical compound CC(=O)C(C)(O)C([O-])=O NMDWGEGFJUBKLB-UHFFFAOYSA-M 0.000 abstract 1
- 108020002663 Aldehyde Dehydrogenase Proteins 0.000 abstract 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 abstract 1
- XJLXINKUBYWONI-NNYOXOHSSA-O NADP(+) Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-NNYOXOHSSA-O 0.000 abstract 1
- 101710181816 Pyruvate-formate-lyase deactivase Proteins 0.000 abstract 1
- LIPOUNRJVLNBCD-UHFFFAOYSA-N acetyl dihydrogen phosphate Chemical compound CC(=O)OP(O)(O)=O LIPOUNRJVLNBCD-UHFFFAOYSA-N 0.000 abstract 1
- 230000001588 bifunctional effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- OWBTYPJTUOEWEK-UHFFFAOYSA-N butane-2,3-diol Chemical compound CC(O)C(C)O OWBTYPJTUOEWEK-UHFFFAOYSA-N 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- GFAZHVHNLUBROE-UHFFFAOYSA-N hydroxymethyl propionaldehyde Natural products CCC(=O)CO GFAZHVHNLUBROE-UHFFFAOYSA-N 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
- C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
- C12P5/02—Preparation of hydrocarbons or halogenated hydrocarbons acyclic
- C12P5/026—Unsaturated compounds, i.e. alkenes, alkynes or allenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/06—Ethanol, i.e. non-beverage
- C12P7/065—Ethanol, i.e. non-beverage with microorganisms other than yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/16—Butanols
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
- C12Y102/0101—Acetaldehyde dehydrogenase (acetylating) (1.2.1.10)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/07—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with an iron-sulfur protein as acceptor (1.2.7)
- C12Y102/07005—Aldehyde ferredoxin oxidoreductase (1.2.7.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01001—Alcohol dehydrogenase (1.1.1.1)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662336639P | 2016-05-14 | 2016-05-14 | |
| PCT/US2017/032564 WO2017200884A1 (en) | 2016-05-14 | 2017-05-12 | Microorganism with modified aldehyde:ferredoxin oxidoreductase activity and related methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201810031RA true SG11201810031RA (en) | 2018-12-28 |
Family
ID=60295016
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201810031RA SG11201810031RA (en) | 2016-05-14 | 2017-05-12 | Microorganism with modified aldehyde:ferredoxin oxidoreductase activity and related methods |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10294498B2 (ko) |
| EP (1) | EP3464559A4 (ko) |
| JP (2) | JP2019514441A (ko) |
| KR (2) | KR20230044031A (ko) |
| CN (1) | CN109477063A (ko) |
| CA (1) | CA3024114C (ko) |
| EA (1) | EA201892627A1 (ko) |
| SG (1) | SG11201810031RA (ko) |
| WO (1) | WO2017200884A1 (ko) |
| ZA (1) | ZA201807617B (ko) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA201892627A1 (ru) * | 2016-05-14 | 2019-04-30 | Ланцатек, Инк. | Микроорганизм с модифицированной активностью альдегид:ферредоксин оксидоредуктазы и связанные способы |
| US11976314B2 (en) * | 2017-08-29 | 2024-05-07 | Gwangju Institute Of Science And Technology | Method for converting non-ethanol producing, acetogenic strain to ethanol-producing strain and method for producing ethanol from same ethanol-producing strain by using carbon monoxide |
| CN109929862B (zh) * | 2019-03-14 | 2022-09-16 | 云南农业大学 | 一种从反刍动物瘤胃宏转录组数据筛选纤维素酶基因进行克隆的方法 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5593886A (en) | 1992-10-30 | 1997-01-14 | Gaddy; James L. | Clostridium stain which produces acetic acid from waste gases |
| UA72220C2 (uk) | 1998-09-08 | 2005-02-15 | Байоенджініерінг Рісорсиз, Інк. | Незмішувана з водою суміш розчинник/співрозчинник для екстрагування оцтової кислоти, спосіб одержання оцтової кислоти (варіанти), спосіб анаеробного мікробного бродіння для одержання оцтової кислоти (варіанти), модифікований розчинник та спосіб його одержання |
| NZ546496A (en) | 2006-04-07 | 2008-09-26 | Lanzatech New Zealand Ltd | Gas treatment process |
| US7704723B2 (en) | 2006-08-31 | 2010-04-27 | The Board Of Regents For Oklahoma State University | Isolation and characterization of novel clostridial species |
| NZ553984A (en) | 2007-03-19 | 2009-07-31 | Lanzatech New Zealand Ltd | Alcohol production process |
| EP2217696B1 (en) | 2007-11-13 | 2015-09-16 | Lanzatech New Zealand Limited | Novel bacteria and methods of use thereof |
| WO2009151342A1 (en) | 2008-06-09 | 2009-12-17 | Lanzatech New Zealand Limited | Production of butanediol by anaerobic microbial fermentation |
| US8039239B2 (en) | 2008-12-16 | 2011-10-18 | Coskata, Inc. | Recombinant microorganisms having modified production of alcohols and acids |
| EP2545178A4 (en) | 2010-03-10 | 2014-06-11 | Lanzatech New Zealand Ltd | ACIDIFICATION BY FERMENTATION |
| WO2011114238A2 (en) * | 2010-03-18 | 2011-09-22 | Universität Regensburg | Shuttle vector based transformation system for pyrococcus furiosus |
| WO2012024522A2 (en) | 2010-08-19 | 2012-02-23 | Lanzatech New Zealand Limited | A process for producing chemicals using microbial fermentation of substrates comprising carbon monoxide |
| CN103282505A (zh) | 2010-08-26 | 2013-09-04 | 新西兰郎泽科技公司 | 通过发酵产生乙醇和乙烯的方法 |
| US20110236941A1 (en) | 2010-10-22 | 2011-09-29 | Lanzatech New Zealand Limited | Recombinant microorganism and methods of production thereof |
| KR102015672B1 (ko) | 2011-02-25 | 2019-08-29 | 란자테크 뉴질랜드 리미티드 | 재조합 미생물 및 이의 용도 |
| CN103582703A (zh) * | 2011-03-31 | 2014-02-12 | 新西兰郎泽科技公司 | 一种用于控制丁二醇生产的发酵方法 |
| KR101989641B1 (ko) | 2011-09-08 | 2019-06-14 | 란자테크 뉴질랜드 리미티드 | 발효 공정 |
| US9994878B2 (en) | 2012-05-30 | 2018-06-12 | Lanzatech New Zealand Limited | Recombinant microorganisms and uses therefor |
| US20130323820A1 (en) | 2012-06-01 | 2013-12-05 | Lanzatech New Zealand Limited | Recombinant microorganisms and uses therefor |
| CN113186144A (zh) | 2012-06-08 | 2021-07-30 | 朗泽科技新西兰有限公司 | 重组微生物和其用途 |
| US9347076B2 (en) | 2012-06-21 | 2016-05-24 | Lanzatech New Zealand Limited | Recombinant microorganisms that make biodiesel |
| IN2015DN01365A (ko) | 2012-08-28 | 2015-07-03 | Lanzatech New Zealand Ltd | |
| US20140273115A1 (en) * | 2013-03-15 | 2014-09-18 | Lanzatech New Zealand Limited | System and method for controlling metabolite production in a microbial fermentation |
| EP3004362A4 (en) * | 2013-06-05 | 2017-01-11 | Lanzatech New Zealand Limited | Recombinant microorganisms exhibiting increased flux through a fermentation pathway |
| US20150275238A1 (en) * | 2014-03-28 | 2015-10-01 | University Of Georgia Research Foundation, Inc. | Genetically engineered microbes and methods for converting organic acids to alcohols |
| CN110066718B (zh) * | 2014-10-22 | 2022-09-20 | 朗泽科技新西兰有限公司 | 多阶段系统和用于将co转化成乙醇的多阶段生物学方法 |
| BR122023023164A2 (pt) | 2015-05-27 | 2024-03-05 | Lanzatech Nz, Inc. | Bactéria geneticamente modificada fixadora de c1 capaz de produzir pelo menos um produto derivado de corismato, e, método de fabricação de um produto de fermentação |
| KR20210037002A (ko) | 2015-10-13 | 2021-04-05 | 란자테크 뉴질랜드 리미티드 | 에너지-생성 발효 경로를 포함하는 유전자 조작된 박테리아 |
| EA201892627A1 (ru) * | 2016-05-14 | 2019-04-30 | Ланцатек, Инк. | Микроорганизм с модифицированной активностью альдегид:ферредоксин оксидоредуктазы и связанные способы |
-
2017
- 2017-05-12 EA EA201892627A patent/EA201892627A1/ru unknown
- 2017-05-12 EP EP17799922.4A patent/EP3464559A4/en active Pending
- 2017-05-12 SG SG11201810031RA patent/SG11201810031RA/en unknown
- 2017-05-12 CN CN201780029930.1A patent/CN109477063A/zh active Pending
- 2017-05-12 CA CA3024114A patent/CA3024114C/en active Active
- 2017-05-12 KR KR1020237009707A patent/KR20230044031A/ko not_active Application Discontinuation
- 2017-05-12 JP JP2019512182A patent/JP2019514441A/ja active Pending
- 2017-05-12 WO PCT/US2017/032564 patent/WO2017200884A1/en unknown
- 2017-05-12 US US15/594,252 patent/US10294498B2/en active Active
- 2017-05-12 KR KR1020187035923A patent/KR102514023B1/ko active IP Right Grant
-
2018
- 2018-11-13 ZA ZA2018/07617A patent/ZA201807617B/en unknown
-
2022
- 2022-07-19 JP JP2022115092A patent/JP2022163046A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20170327849A1 (en) | 2017-11-16 |
| KR102514023B1 (ko) | 2023-03-23 |
| EP3464559A4 (en) | 2020-02-12 |
| EP3464559A1 (en) | 2019-04-10 |
| WO2017200884A1 (en) | 2017-11-23 |
| EA201892627A1 (ru) | 2019-04-30 |
| ZA201807617B (en) | 2021-04-28 |
| CN109477063A (zh) | 2019-03-15 |
| KR20230044031A (ko) | 2023-03-31 |
| JP2019514441A (ja) | 2019-06-06 |
| US10294498B2 (en) | 2019-05-21 |
| CA3024114A1 (en) | 2017-11-23 |
| JP2022163046A (ja) | 2022-10-25 |
| KR20190017790A (ko) | 2019-02-20 |
| CA3024114C (en) | 2020-02-04 |
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