SG11201809279YA - Method for producing dopamine-producing neural precursor cells - Google Patents
Method for producing dopamine-producing neural precursor cellsInfo
- Publication number
- SG11201809279YA SG11201809279YA SG11201809279YA SG11201809279YA SG11201809279YA SG 11201809279Y A SG11201809279Y A SG 11201809279YA SG 11201809279Y A SG11201809279Y A SG 11201809279YA SG 11201809279Y A SG11201809279Y A SG 11201809279YA SG 11201809279Y A SG11201809279Y A SG 11201809279YA
- Authority
- SG
- Singapore
- Prior art keywords
- cells
- producing
- lrtm1
- corin
- positive
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 230000001537 neural effect Effects 0.000 title abstract 2
- 239000002243 precursor Substances 0.000 title abstract 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 title 2
- 229960003638 dopamine Drugs 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 7
- 102100037293 Atrial natriuretic peptide-converting enzyme Human genes 0.000 abstract 3
- 101710133555 Atrial natriuretic peptide-converting enzyme Proteins 0.000 abstract 3
- 102000003693 Hedgehog Proteins Human genes 0.000 abstract 2
- 108090000031 Hedgehog Proteins Proteins 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 abstract 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 210000005064 dopaminergic neuron Anatomy 0.000 abstract 1
- 210000002744 extracellular matrix Anatomy 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 235000003170 nutritional factors Nutrition 0.000 abstract 1
- 210000001778 pluripotent stem cell Anatomy 0.000 abstract 1
- 210000000130 stem cell Anatomy 0.000 abstract 1
- 238000004114 suspension culture Methods 0.000 abstract 1
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0619—Neurons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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- C12N2501/10—Growth factors
- C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
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- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Neurosurgery (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Developmental Biology & Embryology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
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- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Transplantation (AREA)
- Emergency Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2016086499 | 2016-04-22 | ||
PCT/JP2017/016246 WO2017183736A1 (fr) | 2016-04-22 | 2017-04-24 | Procédé de production de cellules précurseurs neurales produisant de la dopamine |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201809279YA true SG11201809279YA (en) | 2018-11-29 |
Family
ID=60116215
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201809279YA SG11201809279YA (en) | 2016-04-22 | 2017-04-24 | Method for producing dopamine-producing neural precursor cells |
Country Status (10)
Country | Link |
---|---|
US (2) | US11898163B2 (fr) |
EP (1) | EP3447130A4 (fr) |
JP (2) | JP7011260B2 (fr) |
KR (1) | KR102312123B1 (fr) |
CN (1) | CN109072198B (fr) |
AU (1) | AU2017254268B2 (fr) |
CA (1) | CA3021628A1 (fr) |
IL (1) | IL262475B2 (fr) |
SG (1) | SG11201809279YA (fr) |
WO (1) | WO2017183736A1 (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
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JPWO2018193949A1 (ja) * | 2017-04-19 | 2020-02-27 | 国立大学法人名古屋大学 | ドパミン神経細胞の調製方法 |
WO2019160148A1 (fr) | 2018-02-19 | 2019-08-22 | 大日本住友製薬株式会社 | Agrégat cellulaire, mélange d'agrégats cellulaires et sa méthode de préparation |
CN112011510B (zh) * | 2019-05-30 | 2023-01-03 | 中国科学院上海有机化学研究所 | 一种由人多能干细胞制备多巴胺神经元的方法 |
US20230000923A1 (en) * | 2019-09-20 | 2023-01-05 | Korea Research Institute Of Bioscience And Biotechnology | Production method for induced dopaminergic neuronal progenitors, using direct reprogramming |
AU2020202273B2 (en) * | 2019-09-25 | 2022-06-30 | S-Biomedics | Method for inducing differentiation of stem cell into dopaminergic neural precursor cell |
KR102392133B1 (ko) * | 2019-09-25 | 2022-04-29 | (주) 에스바이오메딕스 | 줄기세포로부터 도파민 신경전구세포 분화 유도 방법 |
EP4090734A1 (fr) * | 2020-01-13 | 2022-11-23 | Aspen Neuroscience, Inc. | Procédé de différenciation de cellules nerveuses et compositions associées et méthodes d'utilisation |
WO2021216622A1 (fr) * | 2020-04-21 | 2021-10-28 | Aspen Neuroscience, Inc. | Édition génique de gba1 dans des cellules souches et procédé d'utilisation de cellules différenciées à partir de celles-ci |
WO2021216623A1 (fr) * | 2020-04-21 | 2021-10-28 | Aspen Neuroscience, Inc. | Édition génique de lrrk2 dans des cellules souches et procédé d'utilisation de cellules différenciées à partir de celles-ci |
WO2022020798A1 (fr) * | 2020-07-24 | 2022-01-27 | The Scripps Research Institute | Procédés de différenciation de neurones et d'identification de phénotypes de maladie associés |
CN112626023B (zh) * | 2021-01-12 | 2023-08-04 | 中国人民解放军海军军医大学 | 脊髓olig2+神经祖细胞诱导及自我更新培养体系、诱导方法及应用 |
CN113403262A (zh) * | 2021-06-23 | 2021-09-17 | 昆明理工大学 | 一种对食蟹猴干细胞的无饲养层培养方法 |
CN113481160B (zh) * | 2021-08-20 | 2022-04-29 | 北京太东生物科技有限公司 | 视网膜色素上皮细胞诱导培养基及其应用 |
WO2023153464A1 (fr) * | 2022-02-09 | 2023-08-17 | 住友ファーマ株式会社 | Procédé d'évaluation du potentiel de différenciation de cellules dans un bouillon de culture dans la différenciation de cellules souches pluripotentes en cellules neurales de la région de plaque de plancher mésencéphale |
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2017
- 2017-04-24 KR KR1020187032370A patent/KR102312123B1/ko active IP Right Grant
- 2017-04-24 EP EP17786067.3A patent/EP3447130A4/fr active Pending
- 2017-04-24 CA CA3021628A patent/CA3021628A1/fr active Pending
- 2017-04-24 JP JP2018513238A patent/JP7011260B2/ja active Active
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- 2017-04-24 WO PCT/JP2017/016246 patent/WO2017183736A1/fr active Application Filing
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JPWO2017183736A1 (ja) | 2019-02-28 |
US20240117304A1 (en) | 2024-04-11 |
JP7356658B2 (ja) | 2023-10-05 |
AU2017254268B2 (en) | 2023-03-16 |
AU2017254268A1 (en) | 2018-11-29 |
EP3447130A1 (fr) | 2019-02-27 |
CA3021628A1 (fr) | 2017-10-26 |
EP3447130A4 (fr) | 2019-11-13 |
KR20180135918A (ko) | 2018-12-21 |
IL262475A (en) | 2018-12-31 |
IL262475B1 (en) | 2023-07-01 |
IL262475B2 (en) | 2023-11-01 |
JP7011260B2 (ja) | 2022-02-10 |
US11898163B2 (en) | 2024-02-13 |
CN109072198B (zh) | 2022-08-26 |
CN109072198A (zh) | 2018-12-21 |
US20190112575A1 (en) | 2019-04-18 |
KR102312123B1 (ko) | 2021-10-13 |
WO2017183736A1 (fr) | 2017-10-26 |
JP2022037232A (ja) | 2022-03-08 |
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