SG11201808909WA - Ex vivo bite-activated t cells - Google Patents
Ex vivo bite-activated t cellsInfo
- Publication number
- SG11201808909WA SG11201808909WA SG11201808909WA SG11201808909WA SG11201808909WA SG 11201808909W A SG11201808909W A SG 11201808909WA SG 11201808909W A SG11201808909W A SG 11201808909WA SG 11201808909W A SG11201808909W A SG 11201808909WA SG 11201808909W A SG11201808909W A SG 11201808909WA
- Authority
- SG
- Singapore
- Prior art keywords
- madrid
- calle
- parque
- santiago
- pcm
- Prior art date
Links
- 210000001744 T-lymphocyte Anatomy 0.000 title abstract 4
- 206010028980 Neoplasm Diseases 0.000 abstract 5
- 238000000034 method Methods 0.000 abstract 5
- 210000004027 cell Anatomy 0.000 abstract 4
- 201000011510 cancer Diseases 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 230000022534 cell killing Effects 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 210000002865 immune cell Anatomy 0.000 abstract 2
- 239000012642 immune effector Substances 0.000 abstract 2
- 229940121354 immunomodulator Drugs 0.000 abstract 2
- 241000585705 Alicia <angiosperm> Species 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 230000002489 hematologic effect Effects 0.000 abstract 1
- 230000001394 metastastic effect Effects 0.000 abstract 1
- 206010061289 metastatic neoplasm Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000011275 oncology therapy Methods 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 230000004043 responsiveness Effects 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- A61K39/001103—Receptors for growth factors
- A61K39/001106—Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ErbB4
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- A61K39/001103—Receptors for growth factors
- A61K39/001109—Vascular endothelial growth factor receptors [VEGFR]
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- A61K39/00111—Hepatocyte growth factor receptor [HGFR or c-met]
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- A61K39/001111—Immunoglobulin superfamily
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- A61K39/001166—Adhesion molecules, e.g. NRCAM, EpCAM or cadherins
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- A61K39/001195—Prostate specific membrane antigen [PSMA]
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- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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- A61K39/4643—Vertebrate antigens
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- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464411—Immunoglobulin superfamily
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- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
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- A61K39/4644—Cancer antigens
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- A61K39/464416—Receptors for cytokines
- A61K39/464419—Receptors for interleukins [IL]
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
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- C12N5/0636—T lymphocytes
- C12N5/0637—Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
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- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
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- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/505—CD4; CD8
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/515—CD3, T-cell receptor complex
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Developmental Biology & Embryology (AREA)
- Vascular Medicine (AREA)
- Toxicology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662321964P | 2016-04-13 | 2016-04-13 | |
PCT/EP2017/058891 WO2017178572A1 (en) | 2016-04-13 | 2017-04-12 | Ex vivo bite-activated t cells |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201808909WA true SG11201808909WA (en) | 2018-11-29 |
Family
ID=58669776
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201808909WA SG11201808909WA (en) | 2016-04-13 | 2017-04-12 | Ex vivo bite-activated t cells |
Country Status (11)
Country | Link |
---|---|
US (1) | US20190218515A1 (es) |
EP (1) | EP3445391A1 (es) |
JP (2) | JP7038353B2 (es) |
KR (1) | KR20180133442A (es) |
CN (2) | CN109789195A (es) |
AU (2) | AU2017249698B2 (es) |
CA (1) | CA3020830A1 (es) |
IL (2) | IL295538B2 (es) |
MX (2) | MX2018012488A (es) |
SG (1) | SG11201808909WA (es) |
WO (1) | WO2017178572A1 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11576932B2 (en) * | 2016-03-31 | 2023-02-14 | Lion Tcr Pte. Ltd. | Non-activated t cells expressing exogenous virus-specific T cell receptor (TCR) |
MY200973A (en) * | 2017-04-11 | 2024-01-26 | Inhibrx Inc | Multispecific Polypeptide Constructs Having Constrained Cd3 Binding And Methods Of Using The Same |
WO2019077062A1 (en) * | 2017-10-18 | 2019-04-25 | Vivia Biotech, S.L. | C-CELLS ACTIVATED BY BIT |
EP3716991A4 (en) * | 2017-12-01 | 2021-09-08 | Soricimed Biopharma Inc. | TRPV6 INHIBITORS AND POLYTHERAPIES FOR THE TREATMENT OF CANCERS |
JP2021511790A (ja) * | 2018-02-02 | 2021-05-13 | ウェイク・フォレスト・ユニバーシティ・ヘルス・サイエンシーズWake Forest University Health Sciences | 免疫療法に関するオルガノイドならびにそれを調製および使用する方法 |
EP3765094A4 (en) | 2018-03-15 | 2021-12-22 | KSQ Therapeutics, Inc. | GENE REGULATION COMPOSITIONS AND METHODS FOR IMPROVING IMMUNOTHERAPY |
JP2021519072A (ja) * | 2018-03-27 | 2021-08-10 | システィミューン, インク.Systimmune, Inc. | ガイダンス及びナビゲーションコントロール蛋白質並びにその生産及び使用方法 |
EA202190424A1 (ru) * | 2018-08-31 | 2021-07-08 | Инвектис Са | Способ оценки функционального состояния химерного антигенного рецептора (car) |
CN115916818A (zh) * | 2019-12-11 | 2023-04-04 | 库利南肿瘤股份有限公司 | 抗cd19抗体和多特异性结合蛋白 |
JP2023506834A (ja) * | 2019-12-11 | 2023-02-20 | カリナン オンコロジー インコーポレイテッド | 抗血清アルブミン抗体 |
WO2022109611A1 (en) | 2020-11-20 | 2022-05-27 | Simcere Innovation, Inc. | Armed dual car-t compositions and methods for cancer immunotherapy |
WO2022220412A1 (ko) | 2021-04-12 | 2022-10-20 | 메디젠 테라퓨틱스, 인코포레이티드 | 항원에 노출된 cd8 t 세포의 활성화 및 증식 방법 그리고 그에 의해 제조된 항암 활성이 강화된 cd8 t 세포 및 그의 용도 |
US20230313140A1 (en) * | 2022-04-04 | 2023-10-05 | St. Jude Children's Research Hospital, Inc. | Method for preparing t cells for adoptive t cell therapy |
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Publication number | Priority date | Publication date | Assignee | Title |
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US5811097A (en) | 1995-07-25 | 1998-09-22 | The Regents Of The University Of California | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
WO1998056915A2 (en) | 1997-06-12 | 1998-12-17 | Research Corporation Technologies, Inc. | Artificial antibody polypeptides |
AUPP221098A0 (en) | 1998-03-06 | 1998-04-02 | Diatech Pty Ltd | V-like domain binding molecules |
US7112324B1 (en) | 1998-04-21 | 2006-09-26 | Micromet Ag | CD 19×CD3 specific polypeptides and uses thereof |
US6818418B1 (en) | 1998-12-10 | 2004-11-16 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
CA2351346C (en) | 1998-12-10 | 2015-09-01 | Phylos, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
EP1163339A1 (en) | 1999-04-01 | 2001-12-19 | Innogenetics N.V. | A polypeptide structure for use as a scaffold |
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-
2017
- 2017-04-12 JP JP2018554093A patent/JP7038353B2/ja active Active
- 2017-04-12 SG SG11201808909WA patent/SG11201808909WA/en unknown
- 2017-04-12 AU AU2017249698A patent/AU2017249698B2/en active Active
- 2017-04-12 WO PCT/EP2017/058891 patent/WO2017178572A1/en active Application Filing
- 2017-04-12 US US16/093,867 patent/US20190218515A1/en active Pending
- 2017-04-12 KR KR1020187031631A patent/KR20180133442A/ko unknown
- 2017-04-12 IL IL295538A patent/IL295538B2/en unknown
- 2017-04-12 CN CN201780035722.2A patent/CN109789195A/zh active Pending
- 2017-04-12 CA CA3020830A patent/CA3020830A1/en active Pending
- 2017-04-12 CN CN202311188005.7A patent/CN117327650A/zh active Pending
- 2017-04-12 EP EP17721339.4A patent/EP3445391A1/en active Pending
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- 2017-04-12 MX MX2018012488A patent/MX2018012488A/es unknown
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2022
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IL262359A (en) | 2018-11-29 |
KR20180133442A (ko) | 2018-12-14 |
JP2022081509A (ja) | 2022-05-31 |
EP3445391A1 (en) | 2019-02-27 |
JP2019513400A (ja) | 2019-05-30 |
IL295538B2 (en) | 2024-02-01 |
CA3020830A1 (en) | 2017-10-19 |
JP7038353B2 (ja) | 2022-03-18 |
IL262359B (en) | 2022-09-01 |
AU2017249698A1 (en) | 2018-11-08 |
CN109789195A (zh) | 2019-05-21 |
MX2018012488A (es) | 2019-06-06 |
IL295538A (en) | 2022-10-01 |
US20190218515A1 (en) | 2019-07-18 |
AU2017249698B2 (en) | 2023-03-09 |
WO2017178572A1 (en) | 2017-10-19 |
MX2022006444A (es) | 2022-06-22 |
CN117327650A (zh) | 2024-01-02 |
IL295538B1 (en) | 2023-10-01 |
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