SG11201808592PA - Method for selection of high m6p recombinant proteins - Google Patents
Method for selection of high m6p recombinant proteinsInfo
- Publication number
- SG11201808592PA SG11201808592PA SG11201808592PA SG11201808592PA SG11201808592PA SG 11201808592P A SG11201808592P A SG 11201808592PA SG 11201808592P A SG11201808592P A SG 11201808592PA SG 11201808592P A SG11201808592P A SG 11201808592PA SG 11201808592P A SG11201808592P A SG 11201808592PA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- new jersey
- human lysosomal
- cranbury
- march
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/0102—Alpha-glucosidase (3.2.1.20)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Water Supply & Treatment (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662315400P | 2016-03-30 | 2016-03-30 | |
| US201762457584P | 2017-02-10 | 2017-02-10 | |
| US15/473,994 US10227577B2 (en) | 2016-03-30 | 2017-03-30 | Method for selection of high M6P recombinant proteins |
| PCT/US2017/024981 WO2017173059A1 (en) | 2016-03-30 | 2017-03-30 | Method for selection of high m6p recombinant proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201808592PA true SG11201808592PA (en) | 2018-10-30 |
Family
ID=58640993
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201808592PA SG11201808592PA (en) | 2016-03-30 | 2017-03-30 | Method for selection of high m6p recombinant proteins |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US10227577B2 (es) |
| JP (3) | JP7046003B2 (es) |
| KR (3) | KR102455821B1 (es) |
| AU (2) | AU2017239640B2 (es) |
| BR (1) | BR112018070189A2 (es) |
| CA (1) | CA3019354A1 (es) |
| CL (1) | CL2018002767A1 (es) |
| IL (2) | IL295551A (es) |
| MX (3) | MX2018011951A (es) |
| PE (1) | PE20190127A1 (es) |
| SG (1) | SG11201808592PA (es) |
| WO (1) | WO2017173059A1 (es) |
| ZA (2) | ZA201807184B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2018011951A (es) * | 2016-03-30 | 2019-02-13 | Amicus Therapeutics Inc | Metodo para seleccionar proteinas recombinantes ricas en m6p. |
| KR102444612B1 (ko) * | 2016-03-30 | 2022-09-21 | 아미쿠스 세라퓨틱스, 인코포레이티드 | 재조합 산 알파-글루코시다제를 포함하는 제형 |
| JP2020503900A (ja) | 2017-01-10 | 2020-02-06 | アミカス セラピューティックス インコーポレイテッド | ファブリー病の処置のための組換えアルファ−ガラクトシダーゼａ |
| JP7193476B2 (ja) * | 2017-05-15 | 2022-12-20 | アミカス セラピューティックス インコーポレイテッド | 組換えヒト酸性アルファグリコシダーゼ |
| CA3149955A1 (en) * | 2019-09-06 | 2021-03-11 | Kumar DHANASEKHARAN | Method for capturing and purification of biologics |
| EP3871687A1 (en) * | 2020-02-27 | 2021-09-01 | eleva GmbH | Enzyme replacement therapy for treating pompe disease |
| WO2023150387A1 (en) * | 2022-02-07 | 2023-08-10 | M6P Therapeutics, Inc. | Compositions comprising acid alpha glucosidase and methods of use thereof |
| WO2023215865A1 (en) | 2022-05-05 | 2023-11-09 | Amicus Therapeutics, Inc. | Methods for treating pompe disease |
| WO2024119070A1 (en) | 2022-12-02 | 2024-06-06 | Amicus Therapeutics, Inc. | Methods for treating late onset pompe disease in pediatric patients |
| WO2024119091A1 (en) | 2022-12-02 | 2024-06-06 | Amicus Therapeutics, Inc. | Fexamethods for treating infantile-onset pompe disease in pediatric patients |
Family Cites Families (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4837237A (en) | 1985-07-09 | 1989-06-06 | Fred Hutchinson Cancer Research Center | Therapy using glucosidase processing inhibitors |
| US5879680A (en) | 1987-12-23 | 1999-03-09 | The United States Of America As Represented By The Department Of Health And Human Services | Cloned DNA for synthesizing unique glucocerebrosidase |
| US4985445A (en) | 1988-02-12 | 1991-01-15 | Meiji Seika Kaisha, Ltd. | Cancer cell metastasis inhibitors and novel compounds |
| US6451600B1 (en) | 1989-12-22 | 2002-09-17 | Genzyme Corporation | Enzymatically active recombinant glucocerebrosidase |
| US5236838A (en) | 1988-12-23 | 1993-08-17 | Genzyme Corporation | Enzymatically active recombinant glucocerebrosidase |
| US5179023A (en) | 1989-03-24 | 1993-01-12 | Research Corporation Technologies, Inc. | Recombinant α-galactosidase a therapy for Fabry disease |
| US5011829A (en) | 1989-06-02 | 1991-04-30 | G. D. Searle & Co. | Pharmaceutical composition and method of inhibiting virus |
| US5103008A (en) | 1989-08-17 | 1992-04-07 | Monsanto Company | Compound, N-butyl-deoxynojirimycin-6-phosphate |
| US5401650A (en) | 1990-10-24 | 1995-03-28 | The Mount Sinai School Of Medicine Of The City University Of New York | Cloning and expression of biologically active α-galactosidase A |
| US5399567A (en) | 1993-05-13 | 1995-03-21 | Monsanto Company | Method of treating cholera |
| US20020013953A1 (en) * | 1995-08-02 | 2002-01-31 | Reuser Arnold J. | Compositions and methods for treating enzyme deficiency |
| US20020073438A1 (en) * | 1995-08-02 | 2002-06-13 | Reuser Arnold J. | Methods of purifying human acid alpha-glucosidase |
| US6118045A (en) | 1995-08-02 | 2000-09-12 | Pharming B.V. | Lysosomal proteins produced in the milk of transgenic animals |
| US6458574B1 (en) * | 1996-09-12 | 2002-10-01 | Transkaryotic Therapies, Inc. | Treatment of a α-galactosidase a deficiency |
| US6083725A (en) | 1996-09-13 | 2000-07-04 | Transkaryotic Therapies, Inc. | Tranfected human cells expressing human α-galactosidase A protein |
| US6210666B1 (en) | 1997-10-21 | 2001-04-03 | Orphan Medical, Inc. | Truncated α-galactosidase A to treat fabry disease |
| EP1030839B1 (en) | 1997-11-10 | 2004-02-04 | G.D. SEARLE & CO. | Use of alkylated iminosugars to treat multidrug resistance |
| US6465488B1 (en) | 1997-12-11 | 2002-10-15 | Chancellor, Masters & Scholars Of The University Of Oxford | Inhibition of glycolipid biosynthesis |
| US6274597B1 (en) | 1998-06-01 | 2001-08-14 | Mount Sinai School Of Medicine Of New York University | Method of enhancing lysosomal α-Galactosidase A |
| ATE410506T1 (de) | 1998-12-07 | 2008-10-15 | Genzyme Corp | Behandlung der pompeschen krankheit |
| US6545021B1 (en) | 1999-02-12 | 2003-04-08 | G.D. Searle & Co. | Use of substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds for treating hepatitis virus infections |
| JP2003505430A (ja) | 1999-07-26 | 2003-02-12 | ジー・ディー・サール・アンド・カンパニー | デオキシノジリマイシンの長鎖ｎ−アルキル誘導体およびグルコセレブロシダーゼ酵素の糖脂質異常蓄積疾患の治療用の薬剤の製造のための使用 |
| US6537785B1 (en) | 1999-09-14 | 2003-03-25 | Genzyme Glycobiology Research Institute, Inc. | Methods of treating lysosomal storage diseases |
| US20020095135A1 (en) | 2000-06-19 | 2002-07-18 | David Meeker | Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases |
| US20040204379A1 (en) | 2000-06-19 | 2004-10-14 | Cheng Seng H. | Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases |
| DK3108895T3 (en) | 2000-07-18 | 2018-11-26 | Univ Duke | Treatment of glycogen storage disease type II |
| CN1638739A (zh) | 2000-08-18 | 2005-07-13 | 法玛西雅厄普约翰美国公司 | 治疗成瘾性障碍的化合物 |
| US7723296B2 (en) | 2001-01-18 | 2010-05-25 | Genzyme Corporation | Methods for introducing mannose-6-phosphate and other oligosaccharides onto glycoproteins and its application thereof |
| US7560424B2 (en) | 2001-04-30 | 2009-07-14 | Zystor Therapeutics, Inc. | Targeted therapeutic proteins |
| EP1974752B1 (en) | 2001-04-30 | 2012-09-26 | BioMarin Pharmaceutical Inc. | Subcellular targeting of therapeutic proteins |
| US20030072761A1 (en) | 2001-10-16 | 2003-04-17 | Lebowitz Jonathan | Methods and compositions for targeting proteins across the blood brain barrier |
| MXPA04003640A (es) | 2001-10-16 | 2005-04-11 | Rxkinetix Inc | Formulaciones de proteina de alta concentracion y metodo de fabricacion. |
| US7658916B2 (en) | 2002-04-05 | 2010-02-09 | Genzyme Corporation | Methods of enhancing lysosomal storage disease therapy by modulation of cell surface receptor density |
| CA2814774C (en) | 2003-01-31 | 2016-03-22 | Mount Sinai School Of Medicine Of New York University | Combination therapy for treating protein deficiency disorders |
| FR2861991B1 (fr) | 2003-11-07 | 2008-01-18 | Centre Nat Rech Scient | Utilisation d'inhibiteurs de glucosidase pour une therapie de la mucoviscidose |
| CA2556245A1 (en) | 2004-02-06 | 2005-08-25 | Biomarin Pharmaceutical Inc. | Manufacture of highly phosphorylated lysosomal enzymes and uses thereof |
| ATE465250T1 (de) | 2004-02-10 | 2010-05-15 | Zystor Therapeutics Inc | Saure alpha-glukosidase und fragmente davon |
| US20060142234A1 (en) | 2004-12-23 | 2006-06-29 | Guohua Chen | Injectable non-aqueous suspension |
| EP3782655A1 (en) | 2005-05-17 | 2021-02-24 | Amicus Therapeutics, Inc. | A method for the treatment of pompe disease using 1-deoxynojirimycin and derivatives |
| AU2007322123A1 (en) | 2006-11-13 | 2008-05-29 | Biomarin Pharmaceutical Inc. | Methods for treating Pompe disease |
| WO2008112525A2 (en) | 2007-03-09 | 2008-09-18 | Link Medicine Corporation | Treatment of lysosomal storage diseases |
| WO2008134628A2 (en) | 2007-04-26 | 2008-11-06 | Amicus Therapeutics, Inc. | Dosing regimens for the treatment of lysosomal storage diseases using pharmacological chaperones |
| EP2252288A1 (en) | 2007-11-21 | 2010-11-24 | Summit Corporation Plc | Treatment of protein folding disorders |
| WO2009075815A1 (en) | 2007-12-07 | 2009-06-18 | Duke University | Immunomodulating gene therapy |
| PT3470077T (pt) | 2008-02-12 | 2020-11-30 | Amicus Therapeutics Inc | Método para previsão da resposta ao tratamento farmacológico de doenças com chaperonas |
| JP2011517556A (ja) | 2008-03-12 | 2011-06-16 | アミカス セラピューティックス インコーポレイテッド | ポンペ病のための治療選択肢を診断し評価するための検定 |
| JP2011512876A (ja) | 2008-03-12 | 2011-04-28 | アミカス セラピューティックス インコーポレイテッド | 特異的薬理シャペロンを用いたポンペ病の治療および代理マーカーを用いた治療の監視 |
| WO2010015816A2 (en) | 2008-08-06 | 2010-02-11 | Summit Corporation Plc | Treatment of lysosomal storage disorders and other proteostatic diseases |
| WO2010056746A1 (en) | 2008-11-11 | 2010-05-20 | Amicus Therapeutics, Inc. | Therapy regimens, dosing regimens and stable medicaments for the treatment of pompe disease |
| CN105879047A (zh) | 2008-12-16 | 2016-08-24 | 建新公司 | 寡糖-蛋白缀合物 |
| WO2010118283A1 (en) | 2009-04-09 | 2010-10-14 | Amicus Therapeutics, Inc. | Methods for preventing and/or treating lysosomal storage disorders |
| ES2569514T3 (es) | 2009-06-17 | 2016-05-11 | Biomarin Pharmaceutical Inc. | Formulaciones para enzimas lisosómicas |
| CA2775938C (en) * | 2009-09-29 | 2021-08-10 | Oxyrane Uk Limited | Hydrolysis of mannose-1-phospho-6-mannose linkage to phospho-6-mannose |
| WO2011109600A1 (en) | 2010-03-05 | 2011-09-09 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for modifying the glycosylation pattern of a polypeptide |
| EP2622088A2 (en) | 2010-09-29 | 2013-08-07 | Oxyrane UK Limited | Mannosidases capable of uncapping mannose-1-phospho-6-mannose linkages and demannosylating phosphorylated n-glycans and methods of facilitating mammalian cellular uptake of glycoproteins |
| US20140186326A1 (en) | 2011-04-22 | 2014-07-03 | William Canfield | Modified acid alpha glucosidase with accelerated processing |
| WO2013013017A2 (en) | 2011-07-21 | 2013-01-24 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for modifying the glycosylation of lysosomal storage disorder therapeutics |
| JP6320931B2 (ja) | 2011-12-22 | 2018-05-09 | セントジーン アイピー ゲーエムベーハー | リソソーム酵素を再構成する能力を有する化合物ならびにアンブロキソールおよび／またはアンブロキソールの誘導体の組み合わせ |
| KR20140135222A (ko) | 2012-03-07 | 2014-11-25 | 아미쿠스 세라퓨틱스, 인코포레이티드 | 폼페병의 치료를 위한 고농도 알파-글루코시다제 조성물 |
| KR20190114003A (ko) | 2012-03-15 | 2019-10-08 | 옥시레인 유케이 리미티드 | 폼페병의 치료를 위한 방법 및 물질 |
| PT2844279T (pt) | 2012-05-03 | 2021-03-11 | Amicus Therapeutics Inc | Esquema posológico para o tratamento da doença de pompe |
| CA2915127A1 (en) | 2012-06-06 | 2013-12-12 | Giancarlo PARENTI | Allosteric chaperones and uses thereof |
| PT3201320T (pt) | 2014-09-30 | 2024-01-12 | Amicus Therapeutics Inc | Alfa-glucosidase ácida altamente potente com hidratos de carbono intensificados |
| MX2018011951A (es) * | 2016-03-30 | 2019-02-13 | Amicus Therapeutics Inc | Metodo para seleccionar proteinas recombinantes ricas en m6p. |
-
2017
- 2017-03-30 MX MX2018011951A patent/MX2018011951A/es unknown
- 2017-03-30 KR KR1020217041615A patent/KR102455821B1/ko active IP Right Grant
- 2017-03-30 JP JP2018551350A patent/JP7046003B2/ja active Active
- 2017-03-30 CA CA3019354A patent/CA3019354A1/en active Pending
- 2017-03-30 KR KR1020187030848A patent/KR102343162B1/ko active IP Right Grant
- 2017-03-30 IL IL295551A patent/IL295551A/en unknown
- 2017-03-30 SG SG11201808592PA patent/SG11201808592PA/en unknown
- 2017-03-30 BR BR112018070189-0A patent/BR112018070189A2/pt unknown
- 2017-03-30 AU AU2017239640A patent/AU2017239640B2/en active Active
- 2017-03-30 WO PCT/US2017/024981 patent/WO2017173059A1/en active Application Filing
- 2017-03-30 IL IL262060A patent/IL262060B/en unknown
- 2017-03-30 US US15/473,994 patent/US10227577B2/en active Active
- 2017-03-30 KR KR1020227035616A patent/KR20220145918A/ko not_active Application Discontinuation
- 2017-03-30 PE PE2018001915A patent/PE20190127A1/es unknown
-
2018
- 2018-09-28 MX MX2022014532A patent/MX2022014532A/es unknown
- 2018-09-28 CL CL2018002767A patent/CL2018002767A1/es unknown
- 2018-09-28 MX MX2022014533A patent/MX2022014533A/es unknown
- 2018-10-26 ZA ZA2018/07184A patent/ZA201807184B/en unknown
-
2019
- 2019-01-18 US US16/252,519 patent/US11441138B2/en active Active
-
2020
- 2020-10-23 ZA ZA2020/06604A patent/ZA202006604B/en unknown
-
2022
- 2022-03-22 JP JP2022044814A patent/JP7436545B2/ja active Active
- 2022-09-12 US US17/931,351 patent/US20230079225A1/en active Pending
- 2022-10-27 AU AU2022259797A patent/AU2022259797B2/en active Active
-
2024
- 2024-02-08 JP JP2024017546A patent/JP2024063015A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20230079225A1 (en) | 2023-03-16 |
| JP7046003B2 (ja) | 2022-04-01 |
| IL295551A (en) | 2022-10-01 |
| AU2022259797B2 (en) | 2024-08-08 |
| ZA202006604B (en) | 2023-04-26 |
| MX2022014533A (es) | 2022-12-13 |
| ZA201807184B (en) | 2021-02-24 |
| US20170335301A1 (en) | 2017-11-23 |
| KR102343162B1 (ko) | 2021-12-23 |
| AU2017239640A1 (en) | 2018-10-25 |
| MX2022014532A (es) | 2022-12-13 |
| CA3019354A1 (en) | 2017-10-05 |
| JP2024063015A (ja) | 2024-05-10 |
| US11441138B2 (en) | 2022-09-13 |
| KR20180128945A (ko) | 2018-12-04 |
| JP2019509754A (ja) | 2019-04-11 |
| WO2017173059A1 (en) | 2017-10-05 |
| JP2022101545A (ja) | 2022-07-06 |
| AU2022259797A1 (en) | 2022-12-01 |
| KR20220145918A (ko) | 2022-10-31 |
| KR20210157477A (ko) | 2021-12-28 |
| US10227577B2 (en) | 2019-03-12 |
| AU2017239640B2 (en) | 2022-07-28 |
| CL2018002767A1 (es) | 2019-01-11 |
| KR102455821B1 (ko) | 2022-10-18 |
| US20190382742A1 (en) | 2019-12-19 |
| JP7436545B2 (ja) | 2024-02-21 |
| MX2018011951A (es) | 2019-02-13 |
| PE20190127A1 (es) | 2019-01-17 |
| IL262060B (en) | 2022-09-01 |
| BR112018070189A2 (pt) | 2019-02-19 |
| IL262060A (en) | 2018-11-29 |
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| SG11201805320XA (en) | Materials and methods for treatment of amyotrophic lateral sclerosis and/or frontal temporal lobular degeneration | |
| SG11201906297QA (en) | Nucleic acids encoding crispr-associated proteins and uses thereof | |
| SG11201811432WA (en) | Rna for cancer therapy | |
| SG11201903454VA (en) | Immunologically discernible cell surface variants for use in cell therapy | |
| SG11201903882VA (en) | Il-2 variants for the treatment of autoimmune diseases | |
| SG11201804373VA (en) | Compositions and methods for immunooncology | |
| SG11201807912SA (en) | Vaccine against rsv | |
| SG11201806002SA (en) | Methods for extending the replicative capacity of somatic cells during an ex vivo cultivation process | |
| SG11201811232XA (en) | Treatment of amd using aav2 variant with aflibercept | |
| SG11201900349VA (en) | Somatostatin modulators and uses thereof | |
| SG11201809700YA (en) | Gdf15 fusion proteins and uses thereof | |
| SG11201807827VA (en) | Process for the preparation of pegylated drug-linkers and intermediates thereof | |
| SG11201805162VA (en) | Plasmid constructs for heterologous protein expression and methods of use | |
| SG11201803958WA (en) | Nucleic acids encoding repetitive amino acid sequences rich in proline and alanine residues that have low repetitive nucleotide sequences | |
| SG11201804510PA (en) | Biparatopic polypeptides antagonizing wnt signaling in tumor cells | |
| SG11201908325PA (en) | Process for the preparation of glucuronide drug-linkers and intermediates thereof | |
| SG11201807809XA (en) | A transient commensal microorganism for improving gut health | |
| SG11201408459VA (en) | Purification of virus like particles | |
| SG11201807134RA (en) | Transposon system and methods of use | |
| SG11201805001UA (en) | Method of treating influenza a | |
| SG11201804704PA (en) | Compositions and methods for decreasing tau expression | |
| SG11201901986SA (en) | Process for the manufacture of a solid pharmaceutical adminstration form |