SG11201807963WA - Compositions useful in the prevention and/or treatment of disorders of the oral cavity, upper airways and esophagus - Google Patents
Compositions useful in the prevention and/or treatment of disorders of the oral cavity, upper airways and esophagusInfo
- Publication number
- SG11201807963WA SG11201807963WA SG11201807963WA SG11201807963WA SG11201807963WA SG 11201807963W A SG11201807963W A SG 11201807963WA SG 11201807963W A SG11201807963W A SG 11201807963WA SG 11201807963W A SG11201807963W A SG 11201807963WA SG 11201807963W A SG11201807963W A SG 11201807963WA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- esophagus
- disorders
- prevention
- treatment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Mycology (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Otolaryngology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Toxicology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITUA2016A001822A ITUA20161822A1 (it) | 2016-03-18 | 2016-03-18 | Composizioni utili nella prevenzione e/o nel trattamento di patologie del cavo orale, delle prime vie aeree e dell’esofago |
| PCT/EP2017/056148 WO2017158041A1 (en) | 2016-03-18 | 2017-03-15 | Compositions useful in the prevention and/or treatment of disorders of the oral cavity, upper airways and esophagus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201807963WA true SG11201807963WA (en) | 2018-10-30 |
Family
ID=56203816
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201807963WA SG11201807963WA (en) | 2016-03-18 | 2017-03-15 | Compositions useful in the prevention and/or treatment of disorders of the oral cavity, upper airways and esophagus |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US20190083392A1 (da) |
| EP (1) | EP3429607B1 (da) |
| JP (1) | JP2019508470A (da) |
| KR (1) | KR20180123042A (da) |
| CN (1) | CN108778304A (da) |
| AU (1) | AU2017234987A1 (da) |
| BR (1) | BR112018068642A2 (da) |
| CA (1) | CA3017791A1 (da) |
| DK (1) | DK3429607T3 (da) |
| ES (1) | ES2906803T3 (da) |
| HU (1) | HUE058136T2 (da) |
| IL (1) | IL261737A (da) |
| IT (1) | ITUA20161822A1 (da) |
| MX (1) | MX2018011205A (da) |
| PL (1) | PL3429607T3 (da) |
| PT (1) | PT3429607T (da) |
| RU (1) | RU2018132775A (da) |
| SG (1) | SG11201807963WA (da) |
| SI (1) | SI3429607T1 (da) |
| WO (1) | WO2017158041A1 (da) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102110568B1 (ko) * | 2018-12-31 | 2020-05-13 | 정동희 | 수용성 탄닌산을 함유하는 구강용 조성물 및 그 제조방법 |
| KR102225151B1 (ko) * | 2019-06-25 | 2021-03-10 | 주식회사 제이비케이랩 | A형 인플루엔자 바이러스 감염의 예방 또는 치료를 위한 안토시아닌-음전하성 다당류 복합체의 용도 |
| JP7495744B2 (ja) * | 2019-06-27 | 2024-06-05 | ジェービーケーラボ カンパニー リミテッド | 有効成分としてアントシアニン－負帯電多糖複合体を含む胃炎又は消化性潰瘍を予防、改善又は治療するための組成物 |
| IT202000003092A1 (it) * | 2020-02-17 | 2021-08-17 | Neilos S R L | Composizione per la protezione della mucosa gastro-intestinale e per la prevenzione e il trattamento di patologie ad essa associate |
| CN111234322B (zh) * | 2020-02-17 | 2021-11-05 | 天津大学 | 一种高抗氧化性可食用包装薄膜及其制备方法 |
| IT202000026566A1 (it) * | 2020-11-06 | 2022-05-06 | Herbal E Antioxidant Derivatives Srl Ed In Forma Abbreviata H&Ad Srl | Combinazioni di antivirali e antimicrobici naturali, loro uso e formulazioni che le contengono |
| IT202100021992A1 (it) * | 2021-08-27 | 2023-02-27 | Neilos S R L | Composizione per la prevenzione e/o il trattamento delle patologie gastriche ed esofagee |
| CN113559234A (zh) * | 2021-09-01 | 2021-10-29 | 四川省医学科学院·四川省人民医院 | 一种防治粘膜炎的中药及其使用方法 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1238043A (en) * | 1983-12-15 | 1988-06-14 | Endre A. Balazs | Water insoluble preparations of hyaluronic acid and processes therefor |
| US4716224A (en) * | 1984-05-04 | 1987-12-29 | Seikagaku Kogyo Co. Ltd. | Crosslinked hyaluronic acid and its use |
| EP0464298B1 (en) | 1990-07-05 | 1995-06-21 | INDENA S.p.A. | Echinacea extracts, a process for the preparation thereof and formulations containing them |
| JP4177900B2 (ja) * | 1997-04-04 | 2008-11-05 | 株式会社クラレ | 歯周病治療用材料 |
| GB9902652D0 (en) * | 1999-02-05 | 1999-03-31 | Fermentech Med Ltd | Process |
| IT1318649B1 (it) * | 2000-07-28 | 2003-08-27 | Propharma S R L Ora Sinclair P | Composizioni farmaceutiche per il trattamento di mucositi e stomatiti. |
| EP1236466B1 (en) * | 2001-02-28 | 2011-09-21 | Axiomedic Ltd. | Solid self-adhesive compositions for topical treatment of oral mucosal disorders |
| US7166435B2 (en) * | 2001-08-06 | 2007-01-23 | The Quigley Corporation | Compositions and methods for reducing the transmissivity of illnesses |
| JP2005508919A (ja) * | 2001-09-29 | 2005-04-07 | バイヤースドルフ・アクチエンゲゼルシヤフト | 化粧用および皮膚科学用スティック |
| ITMI20032287A1 (it) * | 2003-11-24 | 2005-05-25 | Indena Spa | Composizioni per il trattamento delle affezioni del cavo orale e delle prime vie respiratorie |
| US7785619B2 (en) * | 2004-04-08 | 2010-08-31 | Micro Nutrient, Llc | Pharmanutrient composition(s) and system(s) for individualized, responsive dosing regimens |
| ITMI20042414A1 (it) * | 2004-12-17 | 2005-03-17 | Indena Spa | Formulazione per il trattamento di affezioni delle prime vie respiratorie |
| US20090264392A1 (en) * | 2008-04-21 | 2009-10-22 | Meritage Pharma, Inc. | Treating eosinophilic esophagitis |
| JPWO2010092941A1 (ja) * | 2009-02-16 | 2012-08-16 | 株式会社ブルボン | 血管拡張作用を有する組成物、製造法および用途 |
| WO2010146601A1 (en) * | 2009-06-15 | 2010-12-23 | Unijules Life Sciences Ltd | Rapid dissolvable oral film for delivering herbal extract/s with or without other pharmaceutically active agents |
| WO2011048479A2 (en) * | 2009-10-21 | 2011-04-28 | Maqui New Life S.A. | Compositions that include anthocyanidins and methods of use |
| CN101787214B (zh) * | 2010-03-08 | 2012-04-25 | 四川大学 | 一种原花青素交联胶原为基质的可食用膜及其制备方法 |
| GB201007290D0 (en) * | 2010-04-30 | 2010-06-16 | R5 Pharmaceuticals Ltd | Pharmaceutical powder compositions |
| IT1401141B1 (it) * | 2010-07-26 | 2013-07-12 | Indena Spa | Formulazioni contenenti estratti di echinacea angustifolia e di zingiber officinale utili nella riduzione dell'infiammazione e del dolore periferico |
| BE1018740A3 (nl) * | 2010-08-10 | 2011-07-05 | Oystershell Nv | Samenstelling voor de behandeling van vochtige epitheliale oppervlakken. |
| IT1402018B1 (it) * | 2010-10-11 | 2013-08-28 | Indena Spa | Formulazioni per il trattamento delle affezioni delle prime vie respiratorie. |
| IT1402749B1 (it) * | 2010-10-28 | 2013-09-18 | Indena Spa | Composizioni per il trattamento di ulcere periferiche di varia origine |
| ITMI20110033A1 (it) * | 2011-01-17 | 2012-07-18 | Biofarmitalia Spa | Composizione terapeutica mucoadesiva a base di acido ialuronico per la prevenzione e terapia di lesioni epiteliali, delle mucose del corpo umano |
| JP5752958B2 (ja) * | 2011-03-10 | 2015-07-22 | 花王株式会社 | 口腔用組成物 |
| FR2972327B1 (fr) * | 2011-03-11 | 2017-08-11 | Laboratoires Le Stum | Composition nutraceutique mucoadhesive comprenant une association d'antioxydants |
| US10426761B2 (en) * | 2011-04-19 | 2019-10-01 | Arms Pharmaceutical, Llc | Method for treatment of disease caused or aggravated by microorganisms or relieving symptoms thereof |
| CA2915358A1 (en) * | 2012-06-14 | 2013-12-19 | Entrega, Inc. | Mucoadhesive devices for delivery of active agents |
| WO2015017316A2 (en) * | 2013-08-01 | 2015-02-05 | Abbott Nicholas L | Methods and compositions for modifying mucous membranes |
| EP3166563B1 (en) * | 2014-07-08 | 2020-12-16 | Fertin Pharma A/S | Oral delivery system comprising two compartments |
| US11623008B2 (en) * | 2014-08-20 | 2023-04-11 | Professional Compounding Centers Of America | Excipient compositions for mucoadhesive pharmaceutical compositions including a synergistic combination of amylopectin, pullulan, hyaluronic acid, and xyloglucan |
| CN104840958B (zh) * | 2015-05-28 | 2018-03-30 | 广州帝奇医药技术有限公司 | 人工粘膜组合物及其制备方法和应用 |
-
2016
- 2016-03-18 IT ITUA2016A001822A patent/ITUA20161822A1/it unknown
-
2017
- 2017-03-15 PL PL17714160T patent/PL3429607T3/pl unknown
- 2017-03-15 WO PCT/EP2017/056148 patent/WO2017158041A1/en active Application Filing
- 2017-03-15 HU HUE17714160A patent/HUE058136T2/hu unknown
- 2017-03-15 PT PT177141603T patent/PT3429607T/pt unknown
- 2017-03-15 CA CA3017791A patent/CA3017791A1/en not_active Abandoned
- 2017-03-15 BR BR112018068642A patent/BR112018068642A2/pt not_active IP Right Cessation
- 2017-03-15 KR KR1020187026774A patent/KR20180123042A/ko not_active IP Right Cessation
- 2017-03-15 MX MX2018011205A patent/MX2018011205A/es unknown
- 2017-03-15 AU AU2017234987A patent/AU2017234987A1/en not_active Abandoned
- 2017-03-15 ES ES17714160T patent/ES2906803T3/es active Active
- 2017-03-15 SI SI201731059T patent/SI3429607T1/sl unknown
- 2017-03-15 RU RU2018132775A patent/RU2018132775A/ru not_active Application Discontinuation
- 2017-03-15 SG SG11201807963WA patent/SG11201807963WA/en unknown
- 2017-03-15 CN CN201780017366.1A patent/CN108778304A/zh active Pending
- 2017-03-15 JP JP2018548812A patent/JP2019508470A/ja active Pending
- 2017-03-15 EP EP17714160.3A patent/EP3429607B1/en active Active
- 2017-03-15 US US16/084,989 patent/US20190083392A1/en not_active Abandoned
- 2017-03-15 DK DK17714160.3T patent/DK3429607T3/da active
-
2018
- 2018-09-13 IL IL261737A patent/IL261737A/en unknown
-
2020
- 2020-05-27 US US16/884,245 patent/US20200289413A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| RU2018132775A3 (da) | 2020-04-20 |
| PL3429607T3 (pl) | 2022-04-04 |
| WO2017158041A1 (en) | 2017-09-21 |
| BR112018068642A2 (pt) | 2019-02-05 |
| AU2017234987A1 (en) | 2018-10-04 |
| HUE058136T2 (hu) | 2022-07-28 |
| EP3429607B1 (en) | 2021-12-15 |
| PT3429607T (pt) | 2022-02-22 |
| ITUA20161822A1 (it) | 2017-09-18 |
| SI3429607T1 (sl) | 2022-04-29 |
| IL261737A (en) | 2018-10-31 |
| MX2018011205A (es) | 2018-11-22 |
| US20200289413A1 (en) | 2020-09-17 |
| RU2018132775A (ru) | 2020-04-20 |
| KR20180123042A (ko) | 2018-11-14 |
| ES2906803T3 (es) | 2022-04-20 |
| US20190083392A1 (en) | 2019-03-21 |
| CA3017791A1 (en) | 2017-09-21 |
| EP3429607A1 (en) | 2019-01-23 |
| DK3429607T3 (da) | 2022-01-10 |
| JP2019508470A (ja) | 2019-03-28 |
| CN108778304A (zh) | 2018-11-09 |
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