SG11201807526SA - Combination therapy using a liv1-adc and a chemotherapeutic - Google Patents
Combination therapy using a liv1-adc and a chemotherapeuticInfo
- Publication number
- SG11201807526SA SG11201807526SA SG11201807526SA SG11201807526SA SG11201807526SA SG 11201807526S A SG11201807526S A SG 11201807526SA SG 11201807526S A SG11201807526S A SG 11201807526SA SG 11201807526S A SG11201807526S A SG 11201807526SA SG 11201807526S A SG11201807526S A SG 11201807526SA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- hliv22
- bothell
- abraxane
- washington
- Prior art date
Links
- 230000000973 chemotherapeutic effect Effects 0.000 title abstract 3
- 238000002648 combination therapy Methods 0.000 title abstract 2
- 108010012934 Albumin-Bound Paclitaxel Proteins 0.000 abstract 5
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 abstract 5
- 229940028652 abraxane Drugs 0.000 abstract 5
- 229960004679 doxorubicin Drugs 0.000 abstract 3
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 3
- 241000211815 Livia Species 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 239000007943 implant Substances 0.000 abstract 2
- 102100040414 Heat shock transcription factor, X-linked Human genes 0.000 abstract 1
- 101001037907 Homo sapiens Heat shock transcription factor, X-linked Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
Classifications
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
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- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
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- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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- A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3015—Breast
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Pulmonology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662308639P | 2016-03-15 | 2016-03-15 | |
US201662317792P | 2016-04-04 | 2016-04-04 | |
US201662367510P | 2016-07-27 | 2016-07-27 | |
PCT/US2017/022541 WO2017161007A1 (en) | 2016-03-15 | 2017-03-15 | Combination therapy using a liv1-adc and a chemotherapeutic |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201807526SA true SG11201807526SA (en) | 2018-09-27 |
Family
ID=59852409
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201807526SA SG11201807526SA (en) | 2016-03-15 | 2017-03-15 | Combination therapy using a liv1-adc and a chemotherapeutic |
SG10201912908QA SG10201912908QA (en) | 2016-03-15 | 2017-03-15 | Combination therapy using a liv1-adc and a chemotherapeutic |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201912908QA SG10201912908QA (en) | 2016-03-15 | 2017-03-15 | Combination therapy using a liv1-adc and a chemotherapeutic |
Country Status (14)
Country | Link |
---|---|
US (2) | US11325980B2 (pt) |
EP (1) | EP3429626A4 (pt) |
JP (3) | JP2019508433A (pt) |
KR (3) | KR20220157515A (pt) |
CN (1) | CN108697801A (pt) |
AU (2) | AU2017235545A1 (pt) |
BR (1) | BR112018068129A2 (pt) |
CA (1) | CA3016485A1 (pt) |
EA (1) | EA201891968A1 (pt) |
IL (1) | IL261505A (pt) |
MA (1) | MA45324A (pt) |
MX (2) | MX2018010847A (pt) |
SG (2) | SG11201807526SA (pt) |
WO (1) | WO2017161007A1 (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20200145867A (ko) | 2010-12-06 | 2020-12-30 | 시애틀 지네틱스, 인크. | Liv-1에 대한 인간화 항체 및 이의 암을 치료하기 위한 용도 |
EP3717518A1 (en) * | 2017-12-01 | 2020-10-07 | Seattle Genetics, Inc. | Humanized anti-liv1 antibodies for the treatment of breast cancer |
US20210292429A1 (en) * | 2018-11-07 | 2021-09-23 | Crispr Therapeutics Ag | Anti-liv1 immune cell cancer therapy |
TW202133887A (zh) | 2019-12-09 | 2021-09-16 | 美商西健公司 | 使用liv1-adc及pd-1拮抗劑之組合療法 |
Family Cites Families (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4880935A (en) | 1986-07-11 | 1989-11-14 | Icrf (Patents) Limited | Heterobifunctional linking agents derived from N-succinimido-dithio-alpha methyl-methylene-benzoates |
IL106992A (en) | 1988-02-11 | 1994-06-24 | Bristol Myers Squibb Co | Noble hydrazonic history of anthracycline and methods for their preparation |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
EP0656367A1 (en) | 1991-08-22 | 1995-06-07 | Becton, Dickinson and Company | Method and composition for cancer therapy and for prognosticating responses to cancer theraphy |
US5622929A (en) | 1992-01-23 | 1997-04-22 | Bristol-Myers Squibb Company | Thioether conjugates |
US6214345B1 (en) | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
CA2132500A1 (en) | 1994-09-20 | 1996-03-21 | David Lockwood Manning | Methods for predicting the behaviour of breast tumours |
WO1997023243A1 (en) | 1995-12-22 | 1997-07-03 | Bristol-Myers Squibb Company | Branched hydrazone linkers |
US6130237A (en) | 1996-09-12 | 2000-10-10 | Cancer Research Campaign Technology Limited | Condensed N-aclyindoles as antitumor agents |
EP0939824B1 (en) | 1996-10-31 | 2007-06-06 | Abbott Laboratories | Reagents and methods useful for detecting diseases of the breast |
US6066778A (en) | 1996-11-06 | 2000-05-23 | The Regents Of The University Of Michigan | Transgenic mice expressing APC resistant factor V |
WO1998034118A1 (en) | 1997-01-30 | 1998-08-06 | Yale University | Diagnostic methods and compositions based on the distribution of rad51 |
JP2001521744A (ja) | 1997-10-31 | 2001-11-13 | アボット・ラボラトリーズ | 乳房の疾患の検出に有用な試薬および方法 |
JP2001523472A (ja) | 1997-11-18 | 2001-11-27 | アボット・ラボラトリーズ | 乳房の疾患の検出に有用な試薬および方法 |
AU2010699A (en) | 1997-12-24 | 1999-07-19 | Corixa Corporation | Compounds for immunotherapy and diagnosis of breast cancer and methods for theiruse |
CA2347906A1 (en) | 1998-08-04 | 2000-02-17 | Diadexus, Inc. | A novel method of diagnosing, monitoring, staging, imaging and treating breast cancer |
AU1316200A (en) | 1998-10-15 | 2000-05-01 | Chiron Corporation | Metastatic breast and colon cancer regulated genes |
AU3395900A (en) | 1999-03-12 | 2000-10-04 | Human Genome Sciences, Inc. | Human lung cancer associated gene sequences and polypeptides |
US6762020B1 (en) | 1999-03-15 | 2004-07-13 | Protein Design Labs, Inc. | Methods of diagnosing breast cancer |
US20040141983A1 (en) | 1999-03-15 | 2004-07-22 | Protein Design Labs, Inc. | Compositions against cancer antigen LIV-1 and uses thereof |
EP1263780A2 (en) | 2000-01-25 | 2002-12-11 | Genentech, Inc. | Liv-1 related protein, polynulceotides encoding the same and use thereof for treatment of cancer |
AU2001264099A1 (en) | 2000-06-13 | 2001-12-24 | University College Cardiff Consultants Ltd. | Zinc transporters |
US6964849B2 (en) | 2001-01-11 | 2005-11-15 | Curagen Corporation | Proteins and nucleic acids encoding same |
US6884869B2 (en) | 2001-04-30 | 2005-04-26 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
AU2002322280A1 (en) | 2001-06-21 | 2003-01-21 | Millennium Pharmaceuticals, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer |
AU2002324451A1 (en) | 2001-06-21 | 2003-01-08 | Millennium Pharmaceuticals, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast and ovarian cancer |
US7091186B2 (en) | 2001-09-24 | 2006-08-15 | Seattle Genetics, Inc. | p-Amidobenzylethers in drug delivery agents |
IL163902A0 (en) | 2002-03-08 | 2005-12-18 | Protein Design Labs Inc | Antibodies against cancer antigen tmeff2 and uses thereof |
AU2003263964C1 (en) | 2002-07-31 | 2010-08-19 | Seagen Inc. | Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease |
MXPA05007940A (es) | 2003-01-27 | 2007-06-14 | Biogen Idec Inc | Composiciones y metodos para el tratamiento del cancer usando igsf9 y liv-1. |
WO2004067564A2 (en) | 2003-01-29 | 2004-08-12 | Protein Design Labs, Inc. | Compositions against cancer antigen liv-1 and uses thereof |
SI1725249T1 (sl) | 2003-11-06 | 2014-04-30 | Seattle Genetics, Inc. | Spojine monometilvalina, sposobne konjugacije na ligande |
US7371381B2 (en) | 2003-12-12 | 2008-05-13 | Amgen Inc. | Anti-galanin antibodies and uses thereof |
US7501121B2 (en) | 2004-06-17 | 2009-03-10 | Wyeth | IL-13 binding agents |
US20060222653A1 (en) | 2004-11-12 | 2006-10-05 | Xencor, Inc. | Antibodies operably linked to selected chemoattractants |
WO2006124269A2 (en) | 2005-05-16 | 2006-11-23 | Amgen Fremont Inc. | Human monoclonal antibodies that bind to very late antigen-1 for the treatment of inflammation and other disorders |
JP2009506790A (ja) * | 2005-09-07 | 2009-02-19 | メディミューン,エルエルシー | 毒素とコンジュゲートしたeph受容体抗体 |
CN101309933A (zh) | 2005-09-07 | 2008-11-19 | 米迪缪尼有限公司 | 毒素偶联的Eph受体抗体 |
TW200813231A (en) | 2006-04-13 | 2008-03-16 | Novartis Vaccines & Diagnostic | Methods of treating, diagnosing or detecting cancer |
PL2099823T5 (pl) | 2006-12-01 | 2023-02-20 | Seagen Inc. | Wariant środków wiążących cel i jego zastosowania |
EP2137215A2 (en) | 2007-04-23 | 2009-12-30 | Wyeth | Methods and compositions for treating and monitoring treatment of il-13-associated disorders |
KR101710472B1 (ko) | 2007-11-30 | 2017-02-27 | 글락소 그룹 리미티드 | 항원-결합 작제물 |
WO2010003773A1 (en) | 2008-06-16 | 2010-01-14 | Siemens Medical Solutions Diagnostics Gmbh | Algorithms for outcome prediction in patients with node-positive chemotherapy-treated breast cancer |
WO2010045234A1 (en) | 2008-10-14 | 2010-04-22 | University Of Louisville Research Foundation, Inc. | Methods of optimizing treatment of estrogen-receptor positive breast cancers |
WO2010069858A1 (en) | 2008-12-19 | 2010-06-24 | F. Hoffmann-La Roche Ag | Pharmaceutical composition |
US8642270B2 (en) | 2009-02-09 | 2014-02-04 | Vm Institute Of Research | Prognostic biomarkers to predict overall survival and metastatic disease in patients with triple negative breast cancer |
US20110165566A1 (en) | 2009-07-09 | 2011-07-07 | Wittliff James L | Methods of optimizing treatment of breast cancer |
EP3211094A3 (en) | 2009-09-03 | 2017-11-01 | F. Hoffmann-La Roche AG | Methods for treating, diagnosing, and monitoring rheumatoid arthritis |
KR20200145867A (ko) | 2010-12-06 | 2020-12-30 | 시애틀 지네틱스, 인크. | Liv-1에 대한 인간화 항체 및 이의 암을 치료하기 위한 용도 |
WO2012125712A2 (en) | 2011-03-14 | 2012-09-20 | Respira Health, Llc | Lung tumor classifier for current and former smokers |
CN104334189A (zh) | 2011-10-14 | 2015-02-04 | 霍夫曼-拉罗奇有限公司 | Her2二聚化抑制剂帕妥珠单抗的用途和包含her2二聚化抑制剂帕妥珠单抗的制品 |
CN104755497A (zh) | 2012-05-11 | 2015-07-01 | 梅里麦克制药股份有限公司 | 结合抗癌治疗剂的双特异性scfv轭合物的剂量和给药 |
DE202012006349U1 (de) | 2012-07-03 | 2013-07-05 | Schuster Engineering Gmbh | Schiffsladeanordnung |
PL2766048T3 (pl) | 2012-10-12 | 2015-05-29 | Medimmune Ltd | Pirolobenzodiazepiny i ich koniugaty |
US10898555B2 (en) | 2013-07-02 | 2021-01-26 | Japanese Foundation For Cancer Research | Cellular immunity inducing vaccine |
US11185594B2 (en) | 2014-04-10 | 2021-11-30 | Daiichi Sankyo Company, Limited | (Anti-HER2 antibody)-drug conjugate |
EP3717518A1 (en) | 2017-12-01 | 2020-10-07 | Seattle Genetics, Inc. | Humanized anti-liv1 antibodies for the treatment of breast cancer |
US20210292429A1 (en) | 2018-11-07 | 2021-09-23 | Crispr Therapeutics Ag | Anti-liv1 immune cell cancer therapy |
GB201908208D0 (en) | 2019-06-10 | 2019-07-24 | Univ College Cardiff Consultants Ltd | An anti-mitotic agent |
TW202133887A (zh) | 2019-12-09 | 2021-09-16 | 美商西健公司 | 使用liv1-adc及pd-1拮抗劑之組合療法 |
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2017
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- 2017-03-15 EP EP17767448.8A patent/EP3429626A4/en active Pending
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- 2017-03-15 KR KR1020187028273A patent/KR20180121571A/ko active Application Filing
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- 2017-03-15 MX MX2018010847A patent/MX2018010847A/es unknown
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US11325980B2 (en) | 2022-05-10 |
IL261505A (en) | 2018-10-31 |
KR20180121571A (ko) | 2018-11-07 |
JP2024075639A (ja) | 2024-06-04 |
SG10201912908QA (en) | 2020-02-27 |
MA45324A (fr) | 2019-01-23 |
WO2017161007A1 (en) | 2017-09-21 |
US20190085091A1 (en) | 2019-03-21 |
EP3429626A4 (en) | 2020-05-06 |
MX2023008849A (es) | 2023-08-15 |
KR20220157515A (ko) | 2022-11-29 |
AU2017235545A1 (en) | 2018-10-25 |
BR112018068129A2 (pt) | 2019-01-15 |
KR20230169462A (ko) | 2023-12-15 |
CN108697801A (zh) | 2018-10-23 |
JP2019508433A (ja) | 2019-03-28 |
US20230235083A1 (en) | 2023-07-27 |
EA201891968A1 (ru) | 2019-02-28 |
MX2018010847A (es) | 2019-07-04 |
EP3429626A1 (en) | 2019-01-23 |
CA3016485A1 (en) | 2017-09-21 |
JP2022058676A (ja) | 2022-04-12 |
AU2024201856A1 (en) | 2024-04-11 |
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