SG11201806493PA - Determination of mtrnr1 gene mutation - Google Patents

Determination of mtrnr1 gene mutation

Info

Publication number
SG11201806493PA
SG11201806493PA SG11201806493PA SG11201806493PA SG11201806493PA SG 11201806493P A SG11201806493P A SG 11201806493PA SG 11201806493P A SG11201806493P A SG 11201806493PA SG 11201806493P A SG11201806493P A SG 11201806493PA SG 11201806493P A SG11201806493P A SG 11201806493PA
Authority
SG
Singapore
Prior art keywords
international
mtrnr1
singapore
pct
target
Prior art date
Application number
SG11201806493PA
Inventor
Yanbing Zu
Jackie Y Ying
Original Assignee
Agency Science Tech & Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agency Science Tech & Res filed Critical Agency Science Tech & Res
Publication of SG11201806493PA publication Critical patent/SG11201806493PA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/142478 Al 24 August 2017 (24.08.2017) WIPO I PCT 111111111111110111011111111111010111110111010111110101111111111110111111111110111111 (51) International Patent Classification: C12Q 1/68 (2006.01) (21) International Application Number: PCT/SG2017/050057 (22) International Filing Date: 9 February 2017 (09.02.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 10201601165V 17 February 2016 (17.02.2016) SG (71) Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH [SG/SG]; 1 Fusionopolis Way, #20-10 Connexis, Singapore 138632 (SG). (72) Inventors: ZU, Yanbing; c/o Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, Singapore 138669 (SG). YING, Jackie Y.; c/o Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, Singapore 138669 (SG). (74) Agent: VIERING, JENTSCHURA & PARTNER LLP; P.O. Box 1088, Rochor Post Office, Rochor Road, Singa- pore 911833 (SG). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, [Continued on next page] (54) Title: DETERMINATION OF MTRNR1 GENE MUTATION W O 20 1714247 / 8 Al Figure 1 (a) 60 WT probe n n 55 • n • • E 50 n A A • 45 n WT target ¨ MUT target 40 10 100 1000 [Target] (nM) (57) : The invention relates to methods and kits for determining the presence of a mutation selected from the group consisting of 1555A>G and 1494C>T in human Mito - chondrially Encoded 12S RNA (MTRNR1 ) gene in a sample from a subject, comprising, inter alia, amplifying at least part of the MTRNR1 gene and detecting the amplified DNA with a plasmonic gold nanoparticle covalently coupled to a mor- pholino oligonucleotide probe. The claimed method may be used for determining the risk of a subject to Aminoglycos - ide-induced hearing loss. WO 2017/142478 Al 1#11101M01101DEIROIDEOM01011111010111111111101110110111111 LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, Published: SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a))
SG11201806493PA 2016-02-17 2017-02-09 Determination of mtrnr1 gene mutation SG11201806493PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SG10201601165V 2016-02-17
PCT/SG2017/050057 WO2017142478A1 (en) 2016-02-17 2017-02-09 Determination of mtrnr1 gene mutation

Publications (1)

Publication Number Publication Date
SG11201806493PA true SG11201806493PA (en) 2018-08-30

Family

ID=59626248

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201806493PA SG11201806493PA (en) 2016-02-17 2017-02-09 Determination of mtrnr1 gene mutation
SG10201912789UA SG10201912789UA (en) 2016-02-17 2017-02-09 Determination of mtrnr1 gene mutation

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10201912789UA SG10201912789UA (en) 2016-02-17 2017-02-09 Determination of mtrnr1 gene mutation

Country Status (5)

Country Link
US (1) US20200165672A1 (en)
JP (1) JP2019506870A (en)
CN (1) CN109072301A (en)
SG (2) SG11201806493PA (en)
WO (1) WO2017142478A1 (en)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003048769A1 (en) * 2001-11-30 2003-06-12 Nanosphere, Inc. Real-time monitoring of pcr amplification using nanoparticle probes
CN102884204B (en) * 2010-01-12 2015-03-25 新加坡科技研究局 Sequence-selective recognition of nucleic acids using nanoparticle probes
CN102154481B (en) * 2011-02-11 2013-01-02 智海生物工程（北京）有限公司 Method for detecting mitochondrial mutations and kit thereof
EP2984183B1 (en) * 2013-04-11 2020-03-25 Agency For Science, Technology And Research Nanoprobe-based genetic testing
WO2015041603A1 (en) * 2013-09-17 2015-03-26 Agency For Science, Technology And Research Method for detection of a genetic variant
CN103937875A (en) * 2014-01-21 2014-07-23 芮宝生物医药科技（厦门）有限公司 Primers and probes used for human drug-induced deafness gene mutation screening, and application methods thereof
CN104263848B (en) * 2014-10-24 2016-06-15 厦门大学 A kind of deaf susceptibility gene mutation detection kit and preparation method thereof and application
CN104357569B (en) * 2014-11-07 2016-09-21 成都正德奥生物科技有限公司 A kind of detection method of the deaf mutant gene clamping down on polymerase chain reaction (PCR) based on peptide nucleic acid(PNA) (PNA)
CN105255999A (en) * 2015-07-22 2016-01-20 广州市达瑞生物技术股份有限公司 Method for detecting 20 mutation sites of deaf genes

Also Published As

Publication number Publication date
CN109072301A (en) 2018-12-21
SG10201912789UA (en) 2020-02-27
US20200165672A1 (en) 2020-05-28
JP2019506870A (en) 2019-03-14
WO2017142478A1 (en) 2017-08-24

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