SG11201805788WA - Combining electronic monitoring with inhaled pharmacological therapy to manage cardiac arrhythmias including atrial fibrillation - Google Patents

Combining electronic monitoring with inhaled pharmacological therapy to manage cardiac arrhythmias including atrial fibrillation

Info

Publication number
SG11201805788WA
SG11201805788WA SG11201805788WA SG11201805788WA SG11201805788WA SG 11201805788W A SG11201805788W A SG 11201805788WA SG 11201805788W A SG11201805788W A SG 11201805788WA SG 11201805788W A SG11201805788W A SG 11201805788WA SG 11201805788W A SG11201805788W A SG 11201805788WA
Authority
SG
Singapore
Prior art keywords
international
california
electronic monitoring
pct
atrial fibrillation
Prior art date
Application number
SG11201805788WA
Other languages
English (en)
Inventor
Rangachari Narasimhan
Luiz Belardinelli
Carlos A Schuler
Original Assignee
Incarda Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incarda Therapeutics Inc filed Critical Incarda Therapeutics Inc
Publication of SG11201805788WA publication Critical patent/SG11201805788WA/en

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    • A61B5/0004Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by the type of physiological signal transmitted
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SG11201805788WA 2016-02-01 2017-02-01 Combining electronic monitoring with inhaled pharmacological therapy to manage cardiac arrhythmias including atrial fibrillation SG11201805788WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662289473P 2016-02-01 2016-02-01
PCT/US2017/016018 WO2017136421A1 (en) 2016-02-01 2017-02-01 Combining electronic monitoring with inhaled pharmacological therapy to manage cardiac arrhythmias including atrial fibrillation

Publications (1)

Publication Number Publication Date
SG11201805788WA true SG11201805788WA (en) 2018-08-30

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Application Number Title Priority Date Filing Date
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SG10202012584UA SG10202012584UA (en) 2016-02-01 2017-02-01 Combining electronic monitoring with inhaled pharmacological therapy to manage cardiac arrhythmias including atrial fibrillation

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Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180102201A (ko) 2016-02-01 2018-09-14 인카다 테라퓨틱스, 인크. 심방 세동을 포함한 심장 부정맥을 관리하기 위한 전자 모니터링과 흡입 약리 치료의 조합
WO2018209107A1 (en) 2017-05-10 2018-11-15 Incarda Therapeutics, Inc. Unit doses, aerosols, kits, and methods for treating heart conditions by pulmonary administration
WO2019183470A2 (en) 2018-03-22 2019-09-26 Incarda Therapeutics, Inc. A novel method to slow ventricular rate
JP2021526900A (ja) * 2018-06-05 2021-10-11 インカーダ セラピューティクス, インコーポレイテッド エアロゾルを用いるブルガダ症候群の診断方法
JP7504115B2 (ja) * 2018-11-27 2024-06-21 イプセン バイオファーム リミテッド 痙縮のための投与計算器
US11007185B2 (en) 2019-08-01 2021-05-18 Incarda Therapeutics, Inc. Antiarrhythmic formulation
WO2021022058A2 (en) * 2019-08-01 2021-02-04 Incarda Therapeutics, Inc. Antiarrhythmic formulation

Family Cites Families (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1004593A (en) 1911-03-25 1911-10-03 Catherine Ryan Measuring device for cutting garments.
US4069819A (en) 1973-04-13 1978-01-24 Societa Farmaceutici S.P.A. Inhalation device
IT1016489B (it) 1974-03-18 1977-05-30 Isf Spa Inalatore
SE408265B (sv) 1975-12-12 1979-06-05 Draco Ab Anordning for koldioxiddriven endosaerosol, avsedd for inhalering
US4247066A (en) 1978-02-21 1981-01-27 General Dynamics Corporation Airfoil variable cambering device and method
IT1116047B (it) 1979-04-27 1986-02-10 Sigma Tau Ind Farmaceuti Dispositivo per la rapida inalazione di farmaci in polvere da parte di persone sofferenti di asma
DE3634952A1 (de) 1986-10-14 1988-04-21 Bayer Ag Imidazo-pyrrolo-pyridin-derivate
US4930518A (en) * 1988-09-26 1990-06-05 Hrushesky William J M Sinus arrhythmia monitor
US4962095A (en) 1989-02-15 1990-10-09 E. R. Squibb & Sons, Inc. Method of reducing pre-and post-ischemic myocardial arrhythmias and fibrillation
IT1228459B (it) 1989-02-23 1991-06-19 Phidea S R L Inalatore con svuotamento regolare e completo della capsula.
DE69233690T2 (de) 1991-07-02 2008-01-24 Nektar Therapeutics, San Carlos Abgabevorrichtung für nebelförmige Medikamente
US5785049A (en) 1994-09-21 1998-07-28 Inhale Therapeutic Systems Method and apparatus for dispersion of dry powder medicaments
US6582728B1 (en) 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
KR100419037B1 (ko) 1994-03-07 2004-06-12 넥타르 테라퓨틱스 폐를통한인슐린의전달방법및그조성물
US6051256A (en) 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
CN1073119C (zh) 1994-05-18 2001-10-17 吸入治疗系统公司 干扰素干粉配方的方法及组合物
JP3388896B2 (ja) 1994-08-08 2003-03-24 株式会社日立ユニシアオートモティブ 吸入式投薬器
US5693609A (en) 1994-11-17 1997-12-02 Eli Lilly And Company Acylated insulin analogs
CA2218074C (en) 1995-04-14 2002-10-08 Mohammed Eljamal Powdered pharmaceutical formulations having improved dispersibility
US5874064A (en) 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US5985309A (en) 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation
US6503480B1 (en) 1997-05-23 2003-01-07 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US5855913A (en) 1997-01-16 1999-01-05 Massachusetts Instite Of Technology Particles incorporating surfactants for pulmonary drug delivery
US5976574A (en) 1996-12-31 1999-11-02 Inhale Therapeutic Systems Processes for spray drying hydrophobic drugs in organic solvent suspensions
EP1019020A1 (en) 1997-09-29 2000-07-19 Inhale Therapeutic Systems, Inc. Stabilized bioactive preparations and methods of use
US20020017295A1 (en) 2000-07-07 2002-02-14 Weers Jeffry G. Phospholipid-based powders for inhalation
WO1999016420A1 (en) * 1997-09-29 1999-04-08 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in nebulizers
US6541479B1 (en) 1997-12-02 2003-04-01 Massachusetts College Of Pharmacy Calcium channel blockers
US7308894B2 (en) * 1998-06-03 2007-12-18 Scott Laboratories, Inc. Apparatuses and methods for providing a conscious patient relief from pain and anxiety associated with medical or surgical procedures according to appropriate clinical heuristics
US6257233B1 (en) 1998-06-04 2001-07-10 Inhale Therapeutic Systems Dry powder dispersing apparatus and methods for their use
DE19835346A1 (de) 1998-08-05 2000-02-10 Boehringer Ingelheim Pharma Zweiteilige Kapsel zur Aufnahme von pharmazeutischen Zubereitungen für Pulverinhalatoren
CZ20011581A3 (cs) 1998-11-12 2001-12-12 Frank G. Pilkiewicz Systém pro podávání bioaktivní sloučeniny inhalací
DE60029099T2 (de) 1999-05-28 2007-01-11 Nektar Therapeutics, San Carlos Gerät und verfahren zur aerosolisierung einer pharmazeutischen pulverzusammensetzung
US8002700B2 (en) * 1999-12-30 2011-08-23 Medtronic, Inc. Communications system for an implantable medical device and a delivery device
JP2004500424A (ja) 2000-04-17 2004-01-08 ヴェクトゥラ リミテッド 吸入器で使用するための製剤
US7442388B2 (en) 2000-05-10 2008-10-28 Weers Jeffry G Phospholipid-based powders for drug delivery
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US6357490B1 (en) 2000-08-22 2002-03-19 Advanced Inhalation Research, Inc. System, method and apparatus for filling containers
SE517229C2 (sv) * 2000-09-25 2002-05-14 Microdrug Ag Kontinuerlig inhalator för torrt pulver
FI20002215A0 (fi) * 2000-10-06 2000-10-06 Orion Yhtymae Oyj Yhdistelmäpartikkelit
CA2430172A1 (en) * 2000-11-28 2002-07-25 Medtronic, Inc. Method and apparatus for discrimination of atrial fibrillation using ventricular rate detection
CA2432319A1 (en) 2000-12-21 2002-07-18 Nektar Therapeutics Pulmonary delivery of polyene antifungal agents
IL157580A0 (en) 2001-03-20 2004-03-28 Glaxo Group Ltd Inhalation drug combination
US6766799B2 (en) 2001-04-16 2004-07-27 Advanced Inhalation Research, Inc. Inhalation device
US7090830B2 (en) 2001-05-24 2006-08-15 Alexza Pharmaceuticals, Inc. Drug condensation aerosols and kits
EP1392262A1 (en) 2001-05-24 2004-03-03 Alexza Molecular Delivery Corporation Delivery of drug esters through an inhalation route
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US20080038363A1 (en) 2001-05-24 2008-02-14 Zaffaroni Alejandro C Aerosol delivery system and uses thereof
EP1450885B1 (en) 2001-09-28 2015-04-22 Kurve Technology, Inc. Nasal nebulizer
US6968226B2 (en) * 2002-01-30 2005-11-22 Medtronic, Inc. Method and system for terminating an atrial arrhythmia
JP2005530736A (ja) 2002-04-18 2005-10-13 シーブイ・セラピューティクス・インコーポレイテッド ベーターブロッカー、カルシウムチャネルブロッカー、または心臓のグリコシドと共にa1アデノシンアゴニストを投与することを含む不整脈の処置方法
EP1356762A1 (de) * 2002-04-22 2003-10-29 UbiCom Gesellschaft für Telekommunikation mbH Geräteanordnung zur Fernüberwachung von Körperfunktionen
US7607436B2 (en) 2002-05-06 2009-10-27 The Research Foundation Of State University Of New York Methods, devices and formulations for targeted endobronchial therapy
US8245708B2 (en) 2002-05-07 2012-08-21 The Research Foundation Of State University Of New York Methods, devices and formulations for targeted endobronchial therapy
EP2647400A1 (en) 2002-05-07 2013-10-09 The State University of New York at Stony Brook Devices for targeted endobronchial therapy
US6871089B2 (en) * 2002-06-05 2005-03-22 Card Guard Technologies, Inc. Portable ECG monitor and method for atrial fibrillation detection
US20040045546A1 (en) 2002-09-05 2004-03-11 Peirce Management, Llc Pharmaceutical delivery system for oral inhalation through nebulization consisting of inert substrate impregnated with substance (S) to be solubilized or suspended prior to use
RU38570U1 (ru) 2002-12-19 2004-07-10 Главный военный клинический госпиталь им. акад. Н.Н. Бурденко Комплекс лечения нарушений сердечного ритма
EP1589947B2 (en) 2002-12-31 2019-01-30 Novartis AG Pharmaceutical formulation with an insoluble active agent for pulmonary administration
EP1633371A1 (en) 2003-04-24 2006-03-15 Aderis Pharmaceuticals, Inc. Method of treating atrial fibrillation or atrial flutter
WO2005018635A2 (en) 2003-08-07 2005-03-03 Cardiome Pharma Corp. Ion channel modulating activity i
US7967756B2 (en) * 2003-09-18 2011-06-28 Cardiac Pacemakers, Inc. Respiratory therapy control based on cardiac cycle
US20050142070A1 (en) * 2003-09-18 2005-06-30 Hartley Jesse W. Methods and systems for assessing pulmonary disease with drug therapy control
US8403865B2 (en) * 2004-02-05 2013-03-26 Earlysense Ltd. Prediction and monitoring of clinical episodes
US20070118054A1 (en) * 2005-11-01 2007-05-24 Earlysense Ltd. Methods and systems for monitoring patients for clinical episodes
EP2388036A3 (en) * 2004-02-25 2013-03-13 ResMed Ltd. Cardiac monitoring and therapy using a device for providing pressure treatment of sleep disordered breathing
CA2464029A1 (en) 2004-04-08 2005-10-08 Valery Telfort Non-invasive ventilation monitor
AU2005245018A1 (en) 2004-05-21 2005-12-01 Transave, Inc. Treatment of lung diseases and pre-lung disease conditions
US8569277B2 (en) 2004-08-11 2013-10-29 Palo Alto Investors Methods of treating a subject for a condition
EP1809240A4 (en) 2004-10-12 2010-06-16 Alexza Pharmaceuticals Inc ADMINISTRATION OF A DRUG-FREE DRUG WITHOUT DANGER TO THE CARDIOVASCULAR SYSTEM
TWI396541B (zh) 2005-10-10 2013-05-21 Boehringer Ingelheim Int 用於治療呼吸疾病之新穎藥物組合
ITMI20051999A1 (it) 2005-10-21 2007-04-22 Eratech S R L Formulazioni inalatorie di farmaci in fora di polvere secca per somministrazione come tale o con nebulizzatore e dotate di elevata erogabilita' respirabilita' e stabilita'
EP1951672B1 (en) 2005-10-21 2011-05-25 Merck Sharp & Dohme Corp. Potassium channel inhibitors
CL2007002689A1 (es) 2006-09-18 2008-04-18 Vitae Pharmaceuticals Inc Compuestos derivados de piperidin-1-carboxamida, inhibidores de la renina; compuestos intermediarios; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como hipertension, insuficiencia cardiaca, fibrosis cardiaca, entre otras.
EP2069009A1 (en) * 2006-09-28 2009-06-17 Medtronic, Inc. Implantable medical device with sensor self-test feature
US8573197B2 (en) 2006-10-25 2013-11-05 Novartis Ag Powder dispersion apparatus, method of making and using the apparatus, and components that can be used on the apparatus and other devices
EP2099295A4 (en) 2006-11-22 2010-02-24 Reliant Pharmaceuticals Inc PROPHYLAXIS AND TREATMENT OF AURICULAR FIBRILLATION WITH OMEGA-3 FATTY ACIDS
TW200840578A (en) 2006-12-15 2008-10-16 Procter & Gamble Compositions of azimilide dihydrochloride
WO2008134630A1 (en) 2007-04-30 2008-11-06 Apt Pharmaceuticals Dexrazoxane compounds for cardioprotection
US20080275036A1 (en) 2007-05-02 2008-11-06 Apt Pharmaceuticals, Inc. Prevention and treatment of cardiac conditions
US9320448B2 (en) * 2008-04-18 2016-04-26 Pacesetter, Inc. Systems and methods for improved atrial fibrillation (AF) monitoring
US20110144125A1 (en) 2008-08-14 2011-06-16 The Uab Research Foundation Anti-Arrhythmia Agents, Methods of Their Use, Methods of Their Identification and Kits Therefore
WO2010022259A1 (en) 2008-08-22 2010-02-25 Milestone Pharmaceuticals Inc. Short acting benzothiazepine calcium channel blockers and uses thereof
EA027992B1 (ru) 2008-09-23 2017-09-29 Лаборэтори Скин Кэа, Инк. Способ получения однородных, жестких, сферических, нанопористых частиц фосфата кальция, содержащих активное вещество
WO2010042658A1 (en) 2008-10-07 2010-04-15 Bioparadox, Llc Use of platelet rich plasma composition in the treatment of cardiac conduction abnormalities
AU2013248242B2 (en) * 2009-03-18 2016-08-18 Incarda Therapeutics, Inc Unit doses, aerosols, kits, and methods for treating heart conditions by pulmonary administration
CA2835771C (en) * 2009-03-18 2017-01-24 Incarda Therapeutics, Inc. Unit doses, aerosols, kits, and methods for treating heart conditions by pulmonary administration
US10137245B2 (en) * 2010-08-17 2018-11-27 University Of Florida Research Foundation, Inc. Central site photoplethysmography, medication administration, and safety
ITRM20110390A1 (it) 2011-07-21 2013-01-22 Eramo Alessandra D Prodotto per stimolare la produzione endogena di mediatori dell'infiammazione.
CN104955508A (zh) * 2012-11-28 2015-09-30 艾尼科提恩科技公司 用于化合物递送的方法和设备
CA2946253C (en) * 2013-05-06 2022-08-09 University Health Network Methods of administering dantrolene for the acute treatment of cardiac arrhythmias
GB2522727B (en) * 2013-11-26 2017-01-25 Purity Health Pharma Ltd Pulmonary delivery devices
KR20180102201A (ko) 2016-02-01 2018-09-14 인카다 테라퓨틱스, 인크. 심방 세동을 포함한 심장 부정맥을 관리하기 위한 전자 모니터링과 흡입 약리 치료의 조합
WO2018209107A1 (en) 2017-05-10 2018-11-15 Incarda Therapeutics, Inc. Unit doses, aerosols, kits, and methods for treating heart conditions by pulmonary administration

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US10660578B2 (en) 2020-05-26
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