SG11201805352QA - Method and system for determining network connections - Google Patents

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 13 July 2017 (13.07.2017) WIPOIPCT (10) International Publication Number WO 2017/118733 A1 (51) International Patent Classification: A61B 5/0476 (2006.01) A61B 5/00 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/EP2017/050269 6 January 2017 (06.01.2017) English English (30) Priority Data: PI2016000032 8 January 2016 (08.01.2016) MY (71) Applicant: GENTING TAURX DIAGNOSTIC CENTRE SDN BHD [MY/MY]; 24th Floor, Wisma Gent- ing, Jalan Sultan Ismail, Kuala Lumpur, 50250 (MY). (72) Inventors: SOMMERLADE, Linda; University of Aber­ deen, Institute for Complex Systems and Mathematical Biology, Meston Walk, Aberdeen Aberdeenshire AB24 3UE (GB). SCHELTER, Bjorn Olaf; University of Aber­ deen, Institute for Complex Systems and Mathematical Biology, Meston Walk, Aberdeen Aberdeenshire AB24 3UE (GB). WISCHIK, Claude Michel; Institute of Med­ ical Sciences, Forresterhill, Aberdeen Aberdeenshire AB25 2ZD (GB). (74) Agents: HODSDON, Stephen et al.; Mewburn Ellis LLP, City Tower, 40 Basinghall Street, London Greater London EC2V 5DE (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, [Continued on next page] (54) Title: METHOD AND SYSTEM FOR DETERMINING NETWORK CONNECTIONS Measure data from network nodes Calculate coherence and partial coherence of all possible connections Set coefficients of connections for which coherence or partial coherence is below threshold to zero Estimate auto-regressive coefficients for non-zero coefficients (57) : This invention relates to methods and systems for de­ termining network connections. It is particularly, but not exclusively, related to methods and systems for determining network connections in sparse networks, and has particular application to EEG data. An aspect of the invention provides a method for identifying, in a network of in­ teracting nodes simultaneously producing signals,connections between said nodes andof estimating connection coefficients between nodesid- entified as connected which includes the steps of setting to zero con­ nection coefficients where the calculated coherence or partial coher­ ence is below a first predetermined thresholdand subsequently setting to zero connection coefficients where the estimated connection coeffi­ cients are below a second predetermined threshold, and then re-estim- atingthe connection coefficients for the combinations of nodes for which the connection coefficients have not already been set to zero. Cluster estimated coefficients according to squared Euclidean distances and set coefficients in smaller value cluster to zero Estimate auto-regressive coefficients for all remaining non-zero connections m i> oo o CJ O & WO 2017/118733 A11 lllll llllllll II llllll III lllll III llll III III lllll lllll lllll lllll lllll llll lllllll llll llll llll TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3))