SG11201805028RA - Controlled-release cnp agonists with increased nep stability - Google Patents
Controlled-release cnp agonists with increased nep stabilityInfo
- Publication number
- SG11201805028RA SG11201805028RA SG11201805028RA SG11201805028RA SG11201805028RA SG 11201805028R A SG11201805028R A SG 11201805028RA SG 11201805028R A SG11201805028R A SG 11201805028RA SG 11201805028R A SG11201805028R A SG 11201805028RA SG 11201805028R A SG11201805028R A SG 11201805028RA
- Authority
- SG
- Singapore
- Prior art keywords
- controlled
- release cnp
- cnp agonists
- increased nep
- stability
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/593—Polyesters, e.g. PLGA or polylactide-co-glycolide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Computer And Data Communications (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16150628 | 2016-01-08 | ||
EP16179289 | 2016-07-13 | ||
EP16191461 | 2016-09-29 | ||
PCT/EP2017/050213 WO2017118700A1 (fr) | 2016-01-08 | 2017-01-05 | Agonistes cnp à libération contrôlée présentant une meilleure stabilité à nep |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201805028RA true SG11201805028RA (en) | 2018-07-30 |
Family
ID=57851047
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201805028RA SG11201805028RA (en) | 2016-01-08 | 2017-01-05 | Controlled-release cnp agonists with increased nep stability |
Country Status (16)
Country | Link |
---|---|
US (2) | US11224661B2 (fr) |
EP (1) | EP3400018A1 (fr) |
JP (2) | JP7076371B2 (fr) |
KR (1) | KR20180100624A (fr) |
CN (2) | CN114306629B (fr) |
AU (3) | AU2017205690B2 (fr) |
BR (1) | BR112018011152A2 (fr) |
CA (1) | CA3008015A1 (fr) |
HK (1) | HK1259384A1 (fr) |
IL (2) | IL293979B1 (fr) |
MX (1) | MX2018008050A (fr) |
MY (1) | MY195190A (fr) |
NZ (1) | NZ743487A (fr) |
SG (1) | SG11201805028RA (fr) |
WO (1) | WO2017118700A1 (fr) |
ZA (1) | ZA201804413B (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3400018A1 (fr) | 2016-01-08 | 2018-11-14 | Ascendis Pharma Growth Disorders A/S | Agonistes cnp à libération contrôlée présentant une meilleure stabilité à nep |
CN115177720A (zh) | 2016-01-08 | 2022-10-14 | 阿森迪斯药物生长障碍股份有限公司 | 具有低npr-c结合的控制释放cnp激动剂 |
EP3400065A1 (fr) | 2016-01-08 | 2018-11-14 | Ascendis Pharma Growth Disorders A/S | Agonistes de cnp à libération contrôlée présentant des effets secondaires réduits |
CA3007976C (fr) * | 2016-01-08 | 2023-09-26 | Ascendis Pharma Growth Disorders A/S | Promedicaments du cnp possedant de grands fragments a role de transporteur |
AU2017205693B2 (en) | 2016-01-08 | 2022-03-31 | Ascendis Pharma Growth Disorders A/S | Controlled-release CNP agonists with low initial NPR-B activity |
EP3400019B1 (fr) | 2016-01-08 | 2022-09-28 | Ascendis Pharma Growth Disorders A/S | Promédicaments du cnp ayant le transporteur fixé sur la partie cyclique du peptide |
KR102531327B1 (ko) | 2016-09-29 | 2023-05-11 | 아센디스 파마 그로우쓰 디스오더스 에이/에스 | 조절 방출 cnp 아고니스트를 사용한 병용 요법 |
MX2021008708A (es) | 2019-02-11 | 2021-09-21 | Ascendis Pharma Growth Disorders As | Formulaciones farmaceuticas secas de conjugados de peptido natriuretico tipo c (cnp). |
CN110006724B (zh) * | 2019-04-17 | 2021-06-04 | 郑州安图生物工程股份有限公司 | 采用巴氏和革兰氏染色方法检测滴虫用试剂 |
WO2020254612A1 (fr) * | 2019-06-21 | 2020-12-24 | Ascendis Pharma Oncology Division A/S | Composés inhibiteurs de tyrosine kinases à libération contrôlée présentant des propriétés pharmacodynamiques localisées |
WO2020254609A1 (fr) * | 2019-06-21 | 2020-12-24 | Ascendis Pharma Oncology Division A/S | Conjugués inhibiteur de tyrosine kinase |
WO2020254613A1 (fr) * | 2019-06-21 | 2020-12-24 | Ascendis Pharma Oncology Division A/S | Composés inhibiteurs de tyrosine kinase à libération contrôlée présentant des propriétés pharmacocinétiques localisées |
CN114026080A (zh) * | 2019-06-21 | 2022-02-08 | 阿森迪斯药物股份有限公司 | 含有提供π-电子对的杂芳族氮的化合物的缀合物 |
WO2023227505A1 (fr) | 2022-05-23 | 2023-11-30 | Ascendis Pharma Growth Disorders A/S | Formulations pharmaceutiques liquides de composés cnp |
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WO2016110577A1 (fr) | 2015-01-09 | 2016-07-14 | Ascendis Pharma A/S | Promédicaments de cnp |
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CA3007976C (fr) | 2016-01-08 | 2023-09-26 | Ascendis Pharma Growth Disorders A/S | Promedicaments du cnp possedant de grands fragments a role de transporteur |
EP3400018A1 (fr) | 2016-01-08 | 2018-11-14 | Ascendis Pharma Growth Disorders A/S | Agonistes cnp à libération contrôlée présentant une meilleure stabilité à nep |
EP3400019B1 (fr) | 2016-01-08 | 2022-09-28 | Ascendis Pharma Growth Disorders A/S | Promédicaments du cnp ayant le transporteur fixé sur la partie cyclique du peptide |
EP3400065A1 (fr) | 2016-01-08 | 2018-11-14 | Ascendis Pharma Growth Disorders A/S | Agonistes de cnp à libération contrôlée présentant des effets secondaires réduits |
AU2017205693B2 (en) | 2016-01-08 | 2022-03-31 | Ascendis Pharma Growth Disorders A/S | Controlled-release CNP agonists with low initial NPR-B activity |
KR20210047309A (ko) | 2018-08-16 | 2021-04-29 | 비욘드스프링 파마수티컬스, 인코포레이티드. | 면역 반응을 자극하기 위한 방법 및 조성물 |
MX2021008708A (es) | 2019-02-11 | 2021-09-21 | Ascendis Pharma Growth Disorders As | Formulaciones farmaceuticas secas de conjugados de peptido natriuretico tipo c (cnp). |
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2017
- 2017-01-05 EP EP17700782.0A patent/EP3400018A1/fr active Pending
- 2017-01-05 WO PCT/EP2017/050213 patent/WO2017118700A1/fr active Application Filing
- 2017-01-05 MY MYPI2018001004A patent/MY195190A/en unknown
- 2017-01-05 AU AU2017205690A patent/AU2017205690B2/en active Active
- 2017-01-05 US US16/067,111 patent/US11224661B2/en active Active
- 2017-01-05 IL IL293979A patent/IL293979B1/en unknown
- 2017-01-05 JP JP2018535377A patent/JP7076371B2/ja active Active
- 2017-01-05 SG SG11201805028RA patent/SG11201805028RA/en unknown
- 2017-01-05 BR BR112018011152A patent/BR112018011152A2/pt active Search and Examination
- 2017-01-05 KR KR1020187022488A patent/KR20180100624A/ko not_active Application Discontinuation
- 2017-01-05 IL IL259659A patent/IL259659B/en unknown
- 2017-01-05 CN CN202210108310.XA patent/CN114306629B/zh active Active
- 2017-01-05 CA CA3008015A patent/CA3008015A1/fr active Pending
- 2017-01-05 MX MX2018008050A patent/MX2018008050A/es unknown
- 2017-01-05 NZ NZ743487A patent/NZ743487A/en unknown
- 2017-01-05 CN CN201780006097.9A patent/CN108472380B/zh active Active
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2018
- 2018-07-02 ZA ZA2018/04413A patent/ZA201804413B/en unknown
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2019
- 2019-01-31 HK HK19101752.5A patent/HK1259384A1/zh unknown
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2021
- 2021-11-30 US US17/538,971 patent/US20220088206A1/en active Pending
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2022
- 2022-05-17 JP JP2022080588A patent/JP7499807B2/ja active Active
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2024
- 2024-02-02 AU AU2024200659A patent/AU2024200659A1/en active Pending
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AU2022209221A1 (en) | 2022-09-29 |
BR112018011152A2 (pt) | 2018-11-21 |
KR20180100624A (ko) | 2018-09-11 |
JP7499807B2 (ja) | 2024-06-14 |
CN114306629A (zh) | 2022-04-12 |
HK1259384A1 (zh) | 2019-11-29 |
AU2022209221B2 (en) | 2023-12-14 |
EP3400018A1 (fr) | 2018-11-14 |
ZA201804413B (en) | 2019-03-27 |
CN114306629B (zh) | 2023-11-10 |
CN108472380A (zh) | 2018-08-31 |
US11224661B2 (en) | 2022-01-18 |
AU2017205690A1 (en) | 2018-06-07 |
IL259659B (en) | 2022-08-01 |
US20220088206A1 (en) | 2022-03-24 |
AU2024200659A1 (en) | 2024-02-22 |
IL293979A (en) | 2022-08-01 |
JP2022110084A (ja) | 2022-07-28 |
MY195190A (en) | 2023-01-11 |
IL259659A (en) | 2018-07-31 |
MX2018008050A (es) | 2018-08-23 |
JP2019507725A (ja) | 2019-03-22 |
JP7076371B2 (ja) | 2022-05-27 |
NZ743487A (en) | 2023-02-24 |
CN108472380B (zh) | 2022-03-01 |
WO2017118700A1 (fr) | 2017-07-13 |
CA3008015A1 (fr) | 2017-07-13 |
AU2017205690B2 (en) | 2022-04-28 |
IL293979B1 (en) | 2024-04-01 |
US20190022237A1 (en) | 2019-01-24 |
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