SG11201800394WA - Novel endos mutant enzyme - Google Patents

Novel endos mutant enzyme

Info

Publication number
SG11201800394WA
SG11201800394WA SG11201800394WA SG11201800394WA SG11201800394WA SG 11201800394W A SG11201800394W A SG 11201800394WA SG 11201800394W A SG11201800394W A SG 11201800394WA SG 11201800394W A SG11201800394W A SG 11201800394WA SG 11201800394W A SG11201800394W A SG 11201800394WA
Authority
SG
Singapore
Prior art keywords
novel
mutant enzyme
endos mutant
endos
enzyme
Prior art date
Application number
SG11201800394WA
Other languages
English (en)
Inventor
Yoshirou KAWAGUCHI
Kensuke Nakamura
Yukiko Sekiguchi
Mitsuhiro Iwamoto
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of SG11201800394WA publication Critical patent/SG11201800394WA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/24Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/02Preparation of hybrid cells by fusion of two or more cells, e.g. protoplast fusion
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/02Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41Glycosylation, sialylation, or fucosylation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01096Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase (3.2.1.96)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG11201800394WA 2015-07-16 2016-07-15 Novel endos mutant enzyme SG11201800394WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2015141901 2015-07-16
PCT/JP2016/070921 WO2017010559A1 (fr) 2015-07-16 2016-07-15 Nouvelle enzyme endos mutée

Publications (1)

Publication Number Publication Date
SG11201800394WA true SG11201800394WA (en) 2018-02-27

Family

ID=57757160

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201800394WA SG11201800394WA (en) 2015-07-16 2016-07-15 Novel endos mutant enzyme
SG10201914047RA SG10201914047RA (en) 2015-07-16 2016-07-15 Novel endos mutant enzyme

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10201914047RA SG10201914047RA (en) 2015-07-16 2016-07-15 Novel endos mutant enzyme

Country Status (11)

Country Link
US (1) US11001819B2 (fr)
EP (1) EP3323886B1 (fr)
JP (1) JP6752203B2 (fr)
KR (1) KR102546854B1 (fr)
CN (1) CN108026518B (fr)
AU (1) AU2016294206B9 (fr)
ES (1) ES2848861T3 (fr)
HK (1) HK1248271A1 (fr)
SG (2) SG11201800394WA (fr)
TW (1) TWI730972B (fr)
WO (1) WO2017010559A1 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108350605A (zh) 2015-09-04 2018-07-31 台湾浩鼎生技股份有限公司 聚糖阵列以及使用方法
US10980894B2 (en) 2016-03-29 2021-04-20 Obi Pharma, Inc. Antibodies, pharmaceutical compositions and methods
BR112018070097A2 (pt) 2016-03-29 2019-02-12 Obi Pharma, Inc. anticorpo, hibridoma, composição farmacêutica, método para tratar câncer em um indivíduo, método para inibir a proliferação de células cancerígenas, método para diagnosticar o câncer em um indivíduo, método para tratar um paciente humano, método para fazer imagens de um indivíduo, conjugado de fármaco-anticorpo (adc), método para tratar câncer, anticorpo biespecífico e método para preparar uma população de anticorpos homogêneos
SG11201809024UA (en) 2016-04-22 2018-11-29 Obi Pharma Inc Cancer immunotherapy by immune activation or immune modulation via globo series antigens
KR102493562B1 (ko) * 2016-07-01 2023-01-30 다이이찌 산쿄 가부시키가이샤 hANP-Fc 함유 분자 콘주게이트
KR102528998B1 (ko) 2016-07-29 2023-05-03 오비아이 파머 인코퍼레이티드 인간 항체, 제약 조성물 및 방법
ES2911522T3 (es) 2016-12-02 2022-05-19 Daiichi Sankyo Co Ltd Novedosa endo-ß-n-acetilglucosaminidasa
CN117003875A (zh) 2017-09-29 2023-11-07 第一三共株式会社 抗体或其功能性片段、多核苷酸、表达载体、宿主细胞、糖链重构抗体、药物组合物、应用
TW202035444A (zh) 2018-06-27 2020-10-01 台灣浩鼎生技股份有限公司 用於糖蛋白工程的糖苷合成酶變體及其使用方法
JP7401456B2 (ja) 2018-11-14 2023-12-19 第一三共株式会社 抗cdh6抗体-ピロロベンゾジアゼピン誘導体コンジュゲート
TW202102225A (zh) 2019-03-25 2021-01-16 日商第一三共股份有限公司 抗her2抗體-吡咯并苯二氮呯衍生物結合物
TW202102228A (zh) 2019-03-25 2021-01-16 日商第一三共股份有限公司 抗體-吡咯并苯二氮呯衍生物結合物
WO2020196712A1 (fr) 2019-03-27 2020-10-01 第一三共株式会社 Combinaison d'un conjugué anticorps-dérivé de pyrrolobenzodiazépine et d'un inhibiteur de parp
CA3143262A1 (fr) 2019-08-05 2021-02-11 Cho Pharma, Inc. Proteine de fusion pour le remodelage de la glycoforme d'anticorps
US20230039189A1 (en) 2020-01-10 2023-02-09 Riken Population of antibodies comprising homogeneous antibodies each having left-right asymmetric sugar chains, and method for producing same
JP2023532219A (ja) * 2020-06-18 2023-07-27 上海宝済薬業有限公司 免疫グロブリン分解酵素IdeEの突然変異体
KR20230061360A (ko) 2020-09-02 2023-05-08 다이이찌 산쿄 가부시키가이샤 신규 엔도-β-N-아세틸글루코사미니다아제
WO2022211075A1 (fr) * 2021-03-31 2022-10-06 日本マイクロバイオファーマ株式会社 Procédé de fabrication d'un conjugué anticorps-médicament et enzyme utilisée dans ledit procédé

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8323908B2 (en) * 2007-09-14 2012-12-04 Genovis Ab Method of assessing glycosylation state or functional quality of an IgG containing sample
JP5795067B2 (ja) * 2011-07-21 2015-10-14 京セラ株式会社 照明装置、イメージセンサヘッドおよびこれを備える読取装置
GB201201314D0 (en) * 2012-01-26 2012-03-07 Isis Innovation Composition
EP2812442B9 (fr) 2012-02-10 2023-02-15 University of Maryland, Baltimore Glyco-ingénierie chimio-enzymatique d'anticorps et de leurs fragments fc

Also Published As

Publication number Publication date
TWI730972B (zh) 2021-06-21
AU2016294206A1 (en) 2018-02-08
WO2017010559A1 (fr) 2017-01-19
JPWO2017010559A1 (ja) 2018-04-26
CN108026518B (zh) 2022-09-06
EP3323886B1 (fr) 2020-10-21
AU2016294206B2 (en) 2021-12-02
TW201708540A (zh) 2017-03-01
KR102546854B1 (ko) 2023-06-22
KR20180030536A (ko) 2018-03-23
CN108026518A (zh) 2018-05-11
US20180208915A1 (en) 2018-07-26
JP6752203B2 (ja) 2020-09-09
EP3323886A1 (fr) 2018-05-23
HK1248271A1 (zh) 2018-10-12
ES2848861T3 (es) 2021-08-12
SG10201914047RA (en) 2020-03-30
EP3323886A4 (fr) 2019-02-27
US11001819B2 (en) 2021-05-11
AU2016294206B9 (en) 2021-12-23

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