SG11201708359TA - Generation of functional cells from stem cells - Google Patents

Generation of functional cells from stem cells

Info

Publication number
SG11201708359TA
SG11201708359TA SG11201708359TA SG11201708359TA SG11201708359TA SG 11201708359T A SG11201708359T A SG 11201708359TA SG 11201708359T A SG11201708359T A SG 11201708359TA SG 11201708359T A SG11201708359T A SG 11201708359TA SG 11201708359T A SG11201708359T A SG 11201708359TA
Authority
SG
Singapore
Prior art keywords
cells
generation
functional
stem cells
stem
Prior art date
Application number
SG11201708359TA
Other languages
English (en)
Inventor
Xuyang Sun
Bing Lim
Original Assignee
Agency Science Tech & Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agency Science Tech & Res filed Critical Agency Science Tech & Res
Publication of SG11201708359TA publication Critical patent/SG11201708359TA/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5073—Stem cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/65—MicroRNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/08—Coculture with; Conditioned medium produced by cells of the nervous system
    • C12N2502/086—Coculture with; Conditioned medium produced by cells of the nervous system glial cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Toxicology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
SG11201708359TA 2015-04-10 2016-04-11 Generation of functional cells from stem cells SG11201708359TA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SG10201502869T 2015-04-10
PCT/SG2016/050176 WO2016163958A1 (fr) 2015-04-10 2016-04-11 Génération de cellules fonctionnelles à partir de cellules souches

Publications (1)

Publication Number Publication Date
SG11201708359TA true SG11201708359TA (en) 2017-11-29

Family

ID=57071959

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201708359TA SG11201708359TA (en) 2015-04-10 2016-04-11 Generation of functional cells from stem cells

Country Status (6)

Country Link
US (1) US20180072988A1 (fr)
EP (1) EP3280797A4 (fr)
JP (1) JP2018513686A (fr)
CN (1) CN107709549A (fr)
SG (1) SG11201708359TA (fr)
WO (1) WO2016163958A1 (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
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US11396644B2 (en) * 2016-01-31 2022-07-26 Keio University Method for promoting differentiation of pluripotent stem cells by reducing undifferentiated state thereof
CN109689860A (zh) 2016-09-12 2019-04-26 哈佛学院院长及董事 转录因子控制干细胞的分化
GB201619876D0 (en) 2016-11-24 2017-01-11 Cambridge Entpr Ltd Controllable transcription
CA3054120A1 (fr) * 2017-02-24 2018-08-30 Koji Tanabe Methode de production de cellules nerveuses par l'ajout d'un arn a facteur d'induction
US11136555B2 (en) * 2017-03-01 2021-10-05 Elixirgen Scientific, Inc. Compositions and methods for differentiation of human pluripotent stem cells into desired cell types
US20200377885A1 (en) * 2017-08-07 2020-12-03 Washington University Compositions and methods for the generation of neurons and uses thereof
JP6783954B2 (ja) * 2017-11-30 2020-11-11 アイ ピース，インコーポレイテッド 神経系細胞の作製方法
EP3717654A4 (fr) * 2017-12-01 2021-11-10 President And Fellows Of Harvard College Procédés et compositions pour la production de cellules progénitrices d'oligodendrocytes
WO2019195675A1 (fr) 2018-04-06 2019-10-10 President And Fellows Of Harvard College Procédés d'identification d'associations de facteurs de transcription
WO2020010249A1 (fr) * 2018-07-06 2020-01-09 The Regents Of The University Of California Nouveau procédé d'ingénierie de tissus humains translantables
CN108998453A (zh) * 2018-07-18 2018-12-14 暨南大学 一种靶向OC-2基因的siRNA及其应用
CN110857436B (zh) * 2018-08-24 2021-06-29 中山大学中山眼科中心 体外重编程制备视网膜节细胞的方法
IT201800009133A1 (it) * 2018-10-03 2020-04-03 Università Cattolica del Sacro Cuore Identificazione di biomarcatori molecolari predittivi di risposta al trattamento radiochemoterapico nel carcinoma della cervice
AU2019368519B2 (en) * 2018-10-26 2022-11-03 Shandong University System and method for real-time screening and measurement of cellular specific photosensitive effect
JPWO2020209137A1 (fr) * 2019-04-09 2020-10-15
KR102183208B1 (ko) * 2019-07-25 2020-11-25 한국과학기술연구원 Ngn2(neurogenin-2)를 이용하여 척수 손상 모델에서 반응성 성상세포를 신경세포로 리프로그래밍하는 방법
US20220282210A1 (en) * 2019-08-29 2022-09-08 Keio University Method for producing parvalbumin-positive nerve cells, cell, and differentiation inducer
CN112704567A (zh) * 2019-10-25 2021-04-27 复旦大学附属华山医院 一种确定动物脑桥被盖背外侧下核（sld）解剖功能学边界的实验方法
KR102249776B1 (ko) * 2019-11-25 2021-05-10 연세대학교 산학협력단 개선된 생체 내 리프로그래밍 시스템 및 이를 이용한 세포 전환 방법
EP4081035A4 (fr) 2019-12-23 2024-03-27 Boston Medical Center Corporation Dérivation à base d'ipsc humaines de cellules nk et t en utilisant l'induction notch précoce
JP2023516484A (ja) 2020-03-11 2023-04-19 ビット バイオ リミテッド 肝細胞作製方法
WO2022055239A1 (fr) * 2020-09-10 2022-03-17 고려대학교 산학협력단 Procédé de différenciation rapide et efficace de cellules gliales fonctionnelles
KR102534488B1 (ko) * 2020-09-10 2023-05-22 고려대학교 산학협력단 기능성 신경교세포를 단기간에 효율적으로 분화시키는 방법
CN111961650B (zh) * 2020-10-20 2023-06-13 士泽生物医药（苏州）有限公司 一种体外获得神经胶质细胞的方法及其应用
CN112305209B (zh) * 2020-10-26 2021-11-23 南开大学 一种无接触贴壁细胞三维形态测量方法及细胞封接方法
KR102710574B1 (ko) * 2022-03-28 2024-09-27 주식회사 비엔에이치리서치 약물의 전기생리학적 스크리닝 방법
WO2023192939A2 (fr) * 2022-04-01 2023-10-05 President And Fellows Of Harvard College Procédés et compositions de production de cellules de type ovogonie
CN114958747B (zh) * 2022-06-08 2024-08-20 中国科学院动物研究所 一种多能干细胞诱导产生兴奋性和抑制性神经元的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6602680B2 (en) * 2000-07-14 2003-08-05 The Regents Of The University Of California Production of gabaergic cells
US20070087437A1 (en) * 2005-10-14 2007-04-19 Jifan Hu Methods for rejuvenating cells in vitro and in vivo
US9365821B2 (en) * 2009-09-01 2016-06-14 Mcmaster University Transformed human pluripotent stem cells and associated methods
JP5968871B2 (ja) * 2010-04-13 2016-08-10 セルラー ダイナミクス インターナショナル， インコーポレイテッド フォワードプログラミングによる肝細胞の産生
KR20140121317A (ko) * 2013-04-06 2014-10-15 서울대학교산학협력단 비신경 세포로부터 유도 신경 줄기 세포의 생산 방법 및 이에 의하여 생산되는 유도 신경 줄기 세포

Also Published As

Publication number Publication date
EP3280797A1 (fr) 2018-02-14
US20180072988A1 (en) 2018-03-15
CN107709549A (zh) 2018-02-16
WO2016163958A1 (fr) 2016-10-13
JP2018513686A (ja) 2018-05-31
EP3280797A4 (fr) 2019-01-16

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