SG11201708336YA - Polypeptide-based shuttle agents for improving the transduction efficiency of polypeptide cargos to the cytosol of target eukaryotic cells, uses thereof, methods and kits relating to same - Google Patents
Polypeptide-based shuttle agents for improving the transduction efficiency of polypeptide cargos to the cytosol of target eukaryotic cells, uses thereof, methods and kits relating to sameInfo
- Publication number
- SG11201708336YA SG11201708336YA SG11201708336YA SG11201708336YA SG11201708336YA SG 11201708336Y A SG11201708336Y A SG 11201708336YA SG 11201708336Y A SG11201708336Y A SG 11201708336YA SG 11201708336Y A SG11201708336Y A SG 11201708336YA SG 11201708336Y A SG11201708336Y A SG 11201708336YA
- Authority
- SG
- Singapore
- Prior art keywords
- polypeptide
- cytosol
- improving
- methods
- eukaryotic cells
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562145760P | 2015-04-10 | 2015-04-10 | |
| US201562246892P | 2015-10-27 | 2015-10-27 | |
| PCT/CA2016/050403 WO2016161516A1 (en) | 2015-04-10 | 2016-04-08 | Polypeptide-based shuttle agents for improving the transduction efficiency of polypeptide cargos to the cytosol of target eukaryotic cells, uses thereof, methods and kits relating to same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201708336YA true SG11201708336YA (en) | 2017-11-29 |
Family
ID=57071637
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201708336YA SG11201708336YA (en) | 2015-04-10 | 2016-04-08 | Polypeptide-based shuttle agents for improving the transduction efficiency of polypeptide cargos to the cytosol of target eukaryotic cells, uses thereof, methods and kits relating to same |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US9738687B2 (zh) |
| EP (1) | EP3280739B1 (zh) |
| JP (2) | JP6956705B2 (zh) |
| KR (2) | KR20210124536A (zh) |
| CN (1) | CN107636017B (zh) |
| AU (1) | AU2016245347B2 (zh) |
| CA (2) | CA3149413A1 (zh) |
| ES (1) | ES2864758T3 (zh) |
| IL (1) | IL254919B (zh) |
| SG (1) | SG11201708336YA (zh) |
| WO (1) | WO2016161516A1 (zh) |
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| CA3149413A1 (en) * | 2015-04-10 | 2016-10-13 | Feldan Bio Inc. | Polypeptide-based shuttle agents for improving the transduction efficiency of polypeptide cargos to the cytosol of target eukaryotic cells, uses thereof, methods and kits relating to same |
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| WO2017175072A1 (en) * | 2016-04-08 | 2017-10-12 | Feldan Bio Inc. | Peptide shuttle based gene disruption |
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| WO2017207589A1 (en) | 2016-06-01 | 2017-12-07 | Kws Saat Se | Hybrid nucleic acid sequences for genome engineering |
| EP3478845A4 (en) | 2016-06-30 | 2019-07-31 | Zymergen, Inc. | METHODS OF PRODUCING A GLUCOSE PERMEASE BANK AND USES THEREOF |
| US10544390B2 (en) | 2016-06-30 | 2020-01-28 | Zymergen Inc. | Methods for generating a bacterial hemoglobin library and uses thereof |
| US20200283743A1 (en) | 2016-08-17 | 2020-09-10 | The Broad Institute, Inc. | Novel crispr enzymes and systems |
| WO2018035388A1 (en) | 2016-08-17 | 2018-02-22 | The Broad Institute, Inc. | Novel crispr enzymes and systems |
| US9982267B2 (en) | 2016-10-12 | 2018-05-29 | Feldan Bio Inc. | Rationally-designed synthetic peptide shuttle agents for delivering polypeptide cargos from an extracellular space to the cytosol and/or nucleus of a target eukaryotic cell, uses thereof, methods and kits relating to same |
| US11629170B2 (en) | 2016-10-12 | 2023-04-18 | Feldan Bio Inc. | Rationally-designed synthetic peptide shuttle agents for delivering polypeptide cargos from an extracellular space to the cytosol and/or nucleus of a target eukaryotic cell, uses thereof, methods and kits relating to same |
| KR102626671B1 (ko) * | 2016-10-12 | 2024-01-18 | 펠단 바이오 인코포레이티드 | 세포외 공간으로부터 표적 진핵 세포의 세포질 및/또는 핵으로 폴리펩타이드 카고를 전달하기 위한 합리적으로-설계된 합성 펩타이드 셔틀제, 이의 용도, 이와 관련된 방법 및 키트 |
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| RU2707542C1 (ru) | 2019-03-28 | 2019-11-27 | Федеральное бюджетное учреждение науки "Центральный научно-исследовательский институт эпидемиологии" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ЦНИИ Эпидемиологии Роспотребнадзора) | Способ получения препарата рекомбинантной нуклеазы CAS, по существу, свободного от бактериальных эндотоксинов, полученный данным способом препарат и содержащий его набор для использования в системе CRISPR/Cas |
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| WO2021034418A2 (en) * | 2019-07-02 | 2021-02-25 | Trustees Of Tufts College | Novel peptide, compositions and method for delivery of agents into cells and tissues |
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| CN115998894A (zh) * | 2021-10-21 | 2023-04-25 | 福州大学 | 一种硫属元素杂环化合物和胰岛素组装形成的团聚体及其制备方法和胰岛素口服制剂 |
| GB202116307D0 (en) | 2021-11-12 | 2021-12-29 | Syngenta Crop Protection Ag | Herbicide resistance |
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| CN116578092B (zh) * | 2023-05-29 | 2023-11-14 | 汕头大学 | 一种基于基因调控网络的智能体集群运动控制方法及系统 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1958606A (zh) * | 2005-10-31 | 2007-05-09 | 中国人民解放军军事医学科学院基础医学研究所 | 一种重组肝癌复合表位抗原,其制备方法及在制备肝癌特异免疫治疗药物中的应用 |
| EP2054079A4 (en) * | 2006-07-19 | 2009-12-23 | Univ Florida | COMPOSITIONS FOR THE PROGRAMMING OF A CELL AND APPLICATIONS THEREOF |
| JP6659546B2 (ja) * | 2013-09-10 | 2020-03-04 | ザ テキサス エー アンド エム ユニバーシティ システム | 生細胞内への分子の送達のための組成物および方法 |
| MX2016007328A (es) | 2013-12-12 | 2017-07-19 | Broad Inst Inc | Suministro, uso y aplicaciones terapeuticas de sistemas y composiciones crispr-cas para edicion del genoma. |
| CA3149413A1 (en) | 2015-04-10 | 2016-10-13 | Feldan Bio Inc. | Polypeptide-based shuttle agents for improving the transduction efficiency of polypeptide cargos to the cytosol of target eukaryotic cells, uses thereof, methods and kits relating to same |
| US9982267B2 (en) | 2016-10-12 | 2018-05-29 | Feldan Bio Inc. | Rationally-designed synthetic peptide shuttle agents for delivering polypeptide cargos from an extracellular space to the cytosol and/or nucleus of a target eukaryotic cell, uses thereof, methods and kits relating to same |
| US11629170B2 (en) * | 2016-10-12 | 2023-04-18 | Feldan Bio Inc. | Rationally-designed synthetic peptide shuttle agents for delivering polypeptide cargos from an extracellular space to the cytosol and/or nucleus of a target eukaryotic cell, uses thereof, methods and kits relating to same |
-
2016
- 2016-04-08 CA CA3149413A patent/CA3149413A1/en active Pending
- 2016-04-08 CN CN201680033851.3A patent/CN107636017B/zh active Active
- 2016-04-08 WO PCT/CA2016/050403 patent/WO2016161516A1/en active Application Filing
- 2016-04-08 ES ES16775984T patent/ES2864758T3/es active Active
- 2016-04-08 AU AU2016245347A patent/AU2016245347B2/en active Active
- 2016-04-08 SG SG11201708336YA patent/SG11201708336YA/en unknown
- 2016-04-08 US US15/094,365 patent/US9738687B2/en active Active
- 2016-04-08 KR KR1020217032040A patent/KR20210124536A/ko active IP Right Grant
- 2016-04-08 KR KR1020177032555A patent/KR20170135957A/ko active Application Filing
- 2016-04-08 CA CA2981716A patent/CA2981716C/en active Active
- 2016-04-08 JP JP2018503698A patent/JP6956705B2/ja active Active
- 2016-04-08 EP EP16775984.4A patent/EP3280739B1/en active Active
-
2017
- 2017-04-12 US US15/486,155 patent/US10633421B2/en active Active
- 2017-10-08 IL IL254919A patent/IL254919B/en unknown
-
2020
- 2020-02-21 US US16/797,867 patent/US20200181202A1/en active Pending
-
2021
- 2021-06-01 JP JP2021092230A patent/JP2021121224A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20160298078A1 (en) | 2016-10-13 |
| CN107636017A (zh) | 2018-01-26 |
| JP6956705B2 (ja) | 2021-11-02 |
| CA3149413A1 (en) | 2016-10-13 |
| US10633421B2 (en) | 2020-04-28 |
| EP3280739A1 (en) | 2018-02-14 |
| US20200181202A1 (en) | 2020-06-11 |
| AU2016245347A1 (en) | 2017-11-09 |
| KR20210124536A (ko) | 2021-10-14 |
| JP2018512891A (ja) | 2018-05-24 |
| EP3280739B1 (en) | 2020-12-30 |
| KR20170135957A (ko) | 2017-12-08 |
| AU2016245347B2 (en) | 2021-01-28 |
| CA2981716A1 (en) | 2016-10-13 |
| IL254919B (en) | 2022-04-01 |
| US20170267728A1 (en) | 2017-09-21 |
| CN107636017B (zh) | 2022-05-31 |
| EP3280739A4 (en) | 2018-12-26 |
| US9738687B2 (en) | 2017-08-22 |
| IL254919A0 (en) | 2017-12-31 |
| ES2864758T3 (es) | 2021-10-14 |
| CA2981716C (en) | 2022-04-12 |
| WO2016161516A1 (en) | 2016-10-13 |
| JP2021121224A (ja) | 2021-08-26 |
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