SG11201605408RA - Indazole compounds as irak4 inhibitors - Google Patents
Indazole compounds as irak4 inhibitorsInfo
- Publication number
- SG11201605408RA SG11201605408RA SG11201605408RA SG11201605408RA SG11201605408RA SG 11201605408R A SG11201605408R A SG 11201605408RA SG 11201605408R A SG11201605408R A SG 11201605408RA SG 11201605408R A SG11201605408R A SG 11201605408RA SG 11201605408R A SG11201605408R A SG 11201605408RA
- Authority
- SG
- Singapore
- Prior art keywords
- indazole compounds
- irak4 inhibitors
- irak4
- inhibitors
- indazole
- Prior art date
Links
- 229940127590 IRAK4 inhibitor Drugs 0.000 title 1
- 125000003453 indazolyl group Chemical class N1N=C(C2=C1C=CC=C2)* 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/11—Esters of phosphoric acids with hydroxyalkyl compounds without further substituents on alkyl
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN146CH2014 | 2014-01-10 | ||
IN3018CH2014 | 2014-06-20 | ||
PCT/IB2015/050119 WO2015104662A1 (en) | 2014-01-10 | 2015-01-07 | Indazole compounds as irak4 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201605408RA true SG11201605408RA (en) | 2016-07-28 |
Family
ID=52462359
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201605408RA SG11201605408RA (en) | 2014-01-10 | 2015-01-07 | Indazole compounds as irak4 inhibitors |
Country Status (16)
Country | Link |
---|---|
US (1) | US10160753B2 (ja) |
EP (1) | EP3092226B1 (ja) |
JP (1) | JP2017505337A (ja) |
KR (1) | KR20160115933A (ja) |
CN (1) | CN106458982A (ja) |
AU (1) | AU2015205348A1 (ja) |
BR (1) | BR112016015983A2 (ja) |
CA (1) | CA2935880A1 (ja) |
CU (1) | CU20160109A7 (ja) |
EA (1) | EA201691401A1 (ja) |
HK (1) | HK1231480A1 (ja) |
IL (1) | IL246555A0 (ja) |
MX (1) | MX2016009011A (ja) |
PH (1) | PH12016501338A1 (ja) |
SG (1) | SG11201605408RA (ja) |
WO (1) | WO2015104662A1 (ja) |
Families Citing this family (66)
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GB201311891D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
GB201311888D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
BR112016015983A2 (pt) | 2014-01-10 | 2017-08-08 | Aurigene Discovery Tech Ltd | Compostos de indazol como inibidores de irak4, seus usos, e composição farmacêutica |
CU24389B1 (es) | 2014-01-13 | 2019-04-04 | Aurigene Discovery Tech Ltd | Compuestos de heterociclilo bicíclico como inhibidores de irak4 |
MX2016017147A (es) * | 2014-06-20 | 2017-06-07 | Aurigene Discovery Tech Ltd | Compuestos de indazole substituidos como inhibidores de irak4. |
JO3705B1 (ar) | 2014-11-26 | 2021-01-31 | Bayer Pharma AG | إندازولات مستبدلة جديدة، عمليات لتحضيرها، مستحضرات دوائية تحتوي عليها واستخدامها في إنتاج أدوية |
EP3233840B1 (en) | 2014-12-16 | 2018-11-21 | Eudendron S.r.l. | Heterocyclic derivatives modulating activity of certain protein kinases |
WO2016174183A1 (en) | 2015-04-30 | 2016-11-03 | Bayer Pharma Aktiengesellschaft | Combinations of inhibitors of irak4 with inhibitors of btk |
EP3195865A1 (de) | 2016-01-25 | 2017-07-26 | Bayer Pharma Aktiengesellschaft | Kombinationen von irak4 inhibitoren und btk inhibitoren |
BR112018000624A2 (pt) * | 2015-07-15 | 2018-09-18 | Aurigene Discovery Technologies Limited | compostos de indazol e azaindazol como inibidores de irak-4 |
JP6994454B2 (ja) * | 2015-08-04 | 2022-01-14 | ライジェル ファーマシューティカルズ, インコーポレイテッド | ベンズアゾール化合物ならびに該化合物の作製方法および使用方法 |
EP3347353B1 (en) * | 2015-09-11 | 2019-07-17 | Boehringer Ingelheim International GmbH | Pyrazolyl-substituted heteroaryls and their use as medicaments |
WO2017108744A1 (de) * | 2015-12-22 | 2017-06-29 | Bayer Pharma Aktiengesellschaft | Neue substituierte indazole, verfahren zu ihrer herstellung, pharmazeutische präparate die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln |
CN109153665B (zh) * | 2016-03-03 | 2021-10-15 | 拜耳医药股份有限公司 | 新的2-取代的吲唑、其制备方法、包含其的药物制剂及其用于制备药物的用途 |
BR112018072242A2 (pt) * | 2016-04-29 | 2019-04-09 | Bayer Pharma Aktiengesellschaft | forma polimórfica de n-{6-(2-hidróxipropan-2-il)-2-[2-(metilsulfonil)etil]-2h-indazol-5-il}-6-(trifluorometil)piridina-2-carboxamida |
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WO2017207385A1 (de) | 2016-05-31 | 2017-12-07 | Bayer Pharma Aktiengesellschaft | Substituierte 3-methylindazole, verfahren zu ihrer herstellung, pharmazeutische präparate, die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln |
US20190125736A1 (en) * | 2016-06-01 | 2019-05-02 | Bayer Pharma Aktiengesellschaft | Use of 2-substituted indazoles for the treatment and prophylaxis of autoimmune diseases |
RU2743170C2 (ru) * | 2016-06-01 | 2021-02-15 | Байер Энимал Хелс Гмбх | Замещенные индазолы, пригодные для лечения и предупреждения аллергических и/или воспалительных заболеваний у животных |
US11254667B2 (en) | 2016-08-17 | 2022-02-22 | Children's Hospital Medical Center | Substituted imidazo[1,2-A]pyridines as IRAK 1/4 and flt3 inhibitors |
US11542261B2 (en) | 2016-08-17 | 2023-01-03 | Children's Hospital Medical Center | Substituted Imidazo[1,2-a]-pyridines as IRAK 1/4 and FLT3 inhibitors |
AU2017322427B2 (en) | 2016-09-09 | 2021-12-23 | Incyte Corporation | Pyrazolopyridine derivatives as HPK1 modulators and uses thereof for the treatment of cancer |
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KR102633530B1 (ko) | 2017-03-31 | 2024-02-02 | 오리진 온콜로지 리미티드 | 혈액 장애를 치료하기 위한 화합물 및 조성물 |
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- 2015-01-07 EP EP15703102.2A patent/EP3092226B1/en not_active Revoked
- 2015-01-07 CA CA2935880A patent/CA2935880A1/en not_active Abandoned
- 2015-01-07 MX MX2016009011A patent/MX2016009011A/es unknown
- 2015-01-07 JP JP2016563277A patent/JP2017505337A/ja not_active Ceased
- 2015-01-07 WO PCT/IB2015/050119 patent/WO2015104662A1/en active Application Filing
- 2015-01-07 SG SG11201605408RA patent/SG11201605408RA/en unknown
- 2015-01-07 KR KR1020167021614A patent/KR20160115933A/ko not_active Application Discontinuation
- 2015-01-07 AU AU2015205348A patent/AU2015205348A1/en not_active Abandoned
- 2015-01-07 US US15/110,309 patent/US10160753B2/en not_active Expired - Fee Related
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EP3092226B1 (en) | 2019-03-13 |
US20160326151A1 (en) | 2016-11-10 |
HK1231480A1 (zh) | 2017-12-22 |
KR20160115933A (ko) | 2016-10-06 |
MX2016009011A (es) | 2017-01-23 |
WO2015104662A1 (en) | 2015-07-16 |
BR112016015983A2 (pt) | 2017-08-08 |
CA2935880A1 (en) | 2015-07-16 |
US10160753B2 (en) | 2018-12-25 |
JP2017505337A (ja) | 2017-02-16 |
IL246555A0 (en) | 2016-08-31 |
EA201691401A1 (ru) | 2016-11-30 |
EP3092226A1 (en) | 2016-11-16 |
CN106458982A (zh) | 2017-02-22 |
PH12016501338A1 (en) | 2016-08-15 |
AU2015205348A1 (en) | 2016-07-28 |
CU20160109A7 (es) | 2017-02-02 |
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