SG11201509650YA - Slc2a transporter inhibitors - Google Patents

Slc2a transporter inhibitors

Info

Publication number
SG11201509650YA
SG11201509650YA SG11201509650YA SG11201509650YA SG11201509650YA SG 11201509650Y A SG11201509650Y A SG 11201509650YA SG 11201509650Y A SG11201509650Y A SG 11201509650YA SG 11201509650Y A SG11201509650Y A SG 11201509650YA SG 11201509650Y A SG11201509650Y A SG 11201509650YA
Authority
SG
Singapore
Prior art keywords
slc2a
transporter inhibitors
transporter
inhibitors
slc2a transporter
Prior art date
Application number
SG11201509650YA
Other languages
English (en)
Inventor
Phillip Martin Cowley
Alan Wise
Thomas James Brown
Matthew Isherwood
Anjan Chakrabarti
Original Assignee
Iomet Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB201309405A external-priority patent/GB201309405D0/en
Priority claimed from GB201402341A external-priority patent/GB201402341D0/en
Application filed by Iomet Pharma Ltd filed Critical Iomet Pharma Ltd
Publication of SG11201509650YA publication Critical patent/SG11201509650YA/en

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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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SG11201509650YA 2013-05-24 2014-05-22 Slc2a transporter inhibitors SG11201509650YA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB201309405A GB201309405D0 (en) 2013-05-24 2013-05-24 Pharmaceutical compound
GB201402341A GB201402341D0 (en) 2014-02-11 2014-02-11 Pharmaceutical compound
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Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2874089T3 (es) * 2015-09-29 2021-11-04 Oncotherapy Science Inc Compuesto bicíclico y su uso para inhibir SUV39H2
EP3386993A1 (de) * 2015-12-10 2018-10-17 Bayer Pharma Aktiengesellschaft Substituierte perhydropyrrolo[3,4-c]pyrrol-derivate und ihre verwendung
US10759794B2 (en) * 2015-12-10 2020-09-01 Bayer Pharma Aktiengesellschaft 2-phenyl-3-(piperazinomethyl)imidazo[1,2-A]pyridine derivatives as blockers of task-1 and task-2 channels, for the treatment of sleep-related breathing disorders
JOP20190005A1 (ar) 2016-07-20 2019-01-20 Bayer Ag مركبات ديازاهيترو ثنائية الحلقة مستبدلة واستخداماتها
WO2018227427A1 (en) * 2017-06-14 2018-12-20 Bayer Aktiengesellschaft Substituted bridged diazepane derivatives and use thereof
JOP20190284A1 (ar) * 2017-06-14 2019-12-11 Bayer Pharma AG مركبات إيميدازوبيريميدين مستبدلة بديازا ثنائي الحلقة واستخدامها للمعالجة من اضطرابات التنفس
RS65335B1 (sr) 2018-10-05 2024-04-30 Annapurna Bio Inc Jedinjenja i kompozicije za lečenje stanja povezanih sa aktivnošću receptora apj
US20240034729A9 (en) * 2018-12-29 2024-02-01 Wuhan Ll Science And Technology Development Co., Ltd. Heterocyclic compound, intermediate, preparation method therefor and application thereof
JP2022108114A (ja) * 2021-01-12 2022-07-25 株式会社スタイルアンドバリュージャパン オートファジー誘導剤
US20240252454A1 (en) 2021-05-03 2024-08-01 Lead Discovery Center Gmbh Composition comprising an inhibitor of mitochondrial transcription
CN114457045B (zh) * 2022-02-25 2023-07-14 中国人民解放军军事科学院军事医学研究院 抑制Slc2a1的RNAi腺相关病毒及其制备和应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3318880A (en) * 1963-04-30 1967-05-09 Selvi & C Lab Bioterapico Novel[1, 2-alpha]imidazopyridines and a process for the manufacture thereof
FR1536351A (fr) * 1967-07-03 1968-08-27 Pyridylimidazopyridines
GB8305245D0 (en) * 1983-02-25 1983-03-30 Fujisawa Pharmaceutical Co Imidazo-heterocyclic compounds
FR2568880B1 (fr) 1984-08-07 1986-12-12 Synthelabo Derives d'acylaminomethyl-3 imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique
JP2775282B2 (ja) * 1989-03-14 1998-07-16 日清製粉株式会社 紅麹の製造法
JP2003095942A (ja) * 2001-09-21 2003-04-03 Ito En Ltd 脂肪細胞におけるグルコース取込阻害剤及びｇｌｕｔ４トランスロケーション抑制剤、筋肉細胞におけるグルコース取込活性化剤並びに脂肪軽減飲食物
FR2857966A1 (fr) * 2003-07-24 2005-01-28 Aventis Pharma Sa Produits aryl-heteroaromatiques, compositions les contenant et utilisation
JP5242885B2 (ja) * 2004-05-20 2013-07-24 株式会社 伊藤園 筋肉内ａｍｐｋ活性化剤
WO2006101455A1 (en) * 2005-03-21 2006-09-28 S*Bio Pte Ltd Imidazo[1,2-a]pyridine derivatives: preparation and pharmaceutical applications
ES2397275T3 (es) * 2005-08-04 2013-03-05 Sirtris Pharmaceuticals, Inc. Derivados de imidazopiridina como agentes moduladores de la sirtuína
JP2009518409A (ja) * 2005-12-06 2009-05-07 メルク エンド カムパニー インコーポレーテッド モルホリンカルボキサミドプロキネチシン受容体アンタゴニスト
US20100298314A1 (en) * 2006-12-20 2010-11-25 Schering Corporation Novel jnk inhibitors
EP1974729A1 (en) 2007-03-28 2008-10-01 Santhera Pharmaceuticals (Schweiz) AG Substituted imidazopyridine derivates as melanocortin- 4 receptor antagonists
CA2724842A1 (en) 2008-05-19 2009-11-26 Sunovion Pharmaceuticals Inc. Imidazo[1,2-a]pyridine compounds
JP2014509616A (ja) * 2011-03-31 2014-04-21 エーエムベーエルエーエム テクノロジー トランスファー ゲーエムベーハー 治療用イミダゾ［１，２−ａ］ピリジン化合物

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