SG11201508598YA - Engineered phenylalanine ammonia lyase polypeptides - Google Patents

Engineered phenylalanine ammonia lyase polypeptides

Info

Publication number
SG11201508598YA
SG11201508598YA SG11201508598YA SG11201508598YA SG11201508598YA SG 11201508598Y A SG11201508598Y A SG 11201508598YA SG 11201508598Y A SG11201508598Y A SG 11201508598YA SG 11201508598Y A SG11201508598Y A SG 11201508598YA SG 11201508598Y A SG11201508598Y A SG 11201508598YA
Authority
SG
Singapore
Prior art keywords
ammonia lyase
phenylalanine ammonia
engineered phenylalanine
lyase polypeptides
polypeptides
Prior art date
Application number
SG11201508598YA
Other languages
English (en)
Inventor
Gjalt W Huisman
Nicholas J Agard
Benjamin Mijts
Jonathan Vroom
Xiyun Zhang
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Publication of SG11201508598YA publication Critical patent/SG11201508598YA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y403/00—Carbon-nitrogen lyases (4.3)
    • C12Y403/01—Ammonia-lyases (4.3.1)
    • C12Y403/01005—Phenylalanine ammonia-lyase (4.3.1.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y403/00—Carbon-nitrogen lyases (4.3)
    • C12Y403/01—Ammonia-lyases (4.3.1)
    • C12Y403/01024—Phenylalanine ammonia-lyase (4.3.1.24)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
SG11201508598YA 2013-04-18 2014-04-17 Engineered phenylalanine ammonia lyase polypeptides SG11201508598YA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361813586P 2013-04-18 2013-04-18
US201361897932P 2013-10-31 2013-10-31
PCT/US2014/034500 WO2014172541A2 (fr) 2013-04-18 2014-04-17 Polypeptides de phénylalanine ammoniac-lyase modifiés

Publications (1)

Publication Number Publication Date
SG11201508598YA true SG11201508598YA (en) 2015-11-27

Family

ID=51729192

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201508598YA SG11201508598YA (en) 2013-04-18 2014-04-17 Engineered phenylalanine ammonia lyase polypeptides

Country Status (26)

Country Link
US (17) US9611468B2 (fr)
EP (3) EP2986722B1 (fr)
JP (5) JP6637410B2 (fr)
KR (1) KR102218930B1 (fr)
CN (2) CN105324483B (fr)
AU (2) AU2014253900C1 (fr)
CA (1) CA2909719C (fr)
CY (1) CY1121891T1 (fr)
DK (2) DK3521423T3 (fr)
EA (1) EA034034B1 (fr)
ES (2) ES2890955T3 (fr)
HR (1) HRP20190928T1 (fr)
HU (2) HUE055899T2 (fr)
IL (1) IL242067B (fr)
LT (1) LT2986722T (fr)
MX (1) MX366196B (fr)
MY (1) MY193198A (fr)
NZ (1) NZ713396A (fr)
PE (1) PE20151775A1 (fr)
PH (1) PH12015502412A1 (fr)
PL (1) PL2986722T3 (fr)
PT (1) PT2986722T (fr)
RS (1) RS58802B1 (fr)
SG (1) SG11201508598YA (fr)
SI (1) SI2986722T1 (fr)
WO (1) WO2014172541A2 (fr)

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EP3145536B1 (fr) * 2014-04-16 2021-10-27 Codexis, Inc. Tyrosine ammonia-lyase génétiquement modifiée
CN106636048A (zh) * 2016-12-14 2017-05-10 江南大学 一株酶活提高的苯丙氨酸脱氨酶突变体
CN106755160B (zh) * 2017-01-17 2019-08-02 湖州颐辉生物科技有限公司 一种组氨酸解氨酶及其用途
CN110573175A (zh) * 2017-02-13 2019-12-13 科德克希思公司 工程化苯丙氨酸氨裂合酶多肽
JP7320495B2 (ja) * 2017-05-27 2023-08-03 エンズィマスター（ニンボー）バイオ－エンジニアリング カンパニー リミテッド 操作されたアルドラーゼポリペプチドおよびその使用
WO2019241132A1 (fr) * 2018-06-12 2019-12-19 Codexis, Inc. Tyrosine ammonia-lyase modifiée
US11198861B2 (en) 2018-07-12 2021-12-14 Codexis, Inc. Engineered phenylalanine ammonia lyase polypeptides
CA3116590A1 (fr) * 2018-10-29 2020-05-07 Codexis, Inc. Variants d'adn polymerase ingenierises
SG11202105668PA (en) * 2018-12-14 2021-06-29 Codexis Inc Engineered tyrosine ammonia lyase
EP4121525A1 (fr) 2020-03-20 2023-01-25 Synlogic Operating Company, Inc. Micro-organismes modifiés pour réduire l'hyperphénylalaninémie
EP4271806A1 (fr) * 2020-12-31 2023-11-08 Synlogic Operating Company, Inc. Micro-organismes modifiés pour réduire l'hyperphénylalaninémie
CN114015636B (zh) * 2021-12-08 2023-09-29 天地壹号饮料股份有限公司 重组醋酸菌及其制备方法和应用
CN114457151A (zh) * 2022-01-27 2022-05-10 宁夏医科大学总医院 一种用于检测苯丙氨酸羟化酶基因突变的检测试剂盒及其检测方法
CN117417925A (zh) * 2022-07-18 2024-01-19 浙江泽科塔生物医药有限公司 Pal变体、包含该pal变体的药物组合物以及用于制备该pal变体的方法
CN115518691B (zh) * 2022-10-14 2023-11-21 天津大学 一种具有类漆酶活性的人工酶及制备方法和应用
CN116478975B (zh) * 2023-06-16 2023-09-01 苏州优信合生技术有限公司 高活性苯丙氨酸解氨酶突变体及其表达菌株

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Also Published As

Publication number Publication date
JP2020185017A (ja) 2020-11-19
CN109486803A (zh) 2019-03-19
WO2014172541A3 (fr) 2015-02-19
HRP20190928T1 (hr) 2019-07-26
US20200032236A1 (en) 2020-01-30
US20200199566A1 (en) 2020-06-25
WO2014172541A2 (fr) 2014-10-23
US20190241882A1 (en) 2019-08-08
US20180037880A1 (en) 2018-02-08
AU2014253900B2 (en) 2019-09-19
MX2015014662A (es) 2016-03-03
US20210222146A1 (en) 2021-07-22
US20200040325A1 (en) 2020-02-06
JP7129715B2 (ja) 2022-09-02
EP3521423B1 (fr) 2021-07-21
PH12015502412B1 (en) 2016-02-22
CA2909719C (fr) 2022-09-27
KR102218930B1 (ko) 2021-02-23
US20200399627A1 (en) 2020-12-24
PT2986722T (pt) 2019-06-21
PH12015502412A1 (en) 2016-02-22
RS58802B1 (sr) 2019-07-31
AU2019272057A1 (en) 2019-12-19
US10144924B2 (en) 2018-12-04
HUE055899T2 (hu) 2022-01-28
JP2022183356A (ja) 2022-12-08
US10494623B2 (en) 2019-12-03
US11401515B2 (en) 2022-08-02
HUE043549T2 (hu) 2019-08-28
US10487319B2 (en) 2019-11-26
AU2014253900C1 (en) 2020-04-02
US10941391B2 (en) 2021-03-09
US10870843B2 (en) 2020-12-22
US20140314843A1 (en) 2014-10-23
DK2986722T3 (da) 2019-05-13
EP2986722B1 (fr) 2019-04-03
MX366196B (es) 2019-07-01
US20200032235A1 (en) 2020-01-30
EP3521423A1 (fr) 2019-08-07
AU2014253900A1 (en) 2015-11-12
IL242067B (en) 2018-03-29
US20190055535A1 (en) 2019-02-21
JP2018166524A (ja) 2018-11-01
US10160963B2 (en) 2018-12-25
US20200231959A1 (en) 2020-07-23
DK3521423T3 (da) 2021-09-06
US20200032233A1 (en) 2020-01-30
CN109486803B (zh) 2022-10-25
US10358639B2 (en) 2019-07-23
US20190055536A1 (en) 2019-02-21
US10294468B2 (en) 2019-05-21
EP2986722A4 (fr) 2017-02-22
US20170191050A1 (en) 2017-07-06
PE20151775A1 (es) 2015-12-02
ES2890955T3 (es) 2022-01-25
US11130947B2 (en) 2021-09-28
EP3971288A1 (fr) 2022-03-23
US20200032234A1 (en) 2020-01-30
SI2986722T1 (sl) 2019-07-31
US10640759B2 (en) 2020-05-05
KR20150143816A (ko) 2015-12-23
MY193198A (en) 2022-09-26
EP2986722A2 (fr) 2016-02-24
EA201591995A1 (ru) 2016-04-29
US11136571B2 (en) 2021-10-05
JP2016516428A (ja) 2016-06-09
AU2019272057B2 (en) 2021-05-27
EA034034B1 (ru) 2019-12-20
NZ713396A (en) 2020-06-26
CA2909719A1 (fr) 2014-10-23
US10975367B2 (en) 2021-04-13
PL2986722T3 (pl) 2019-10-31
CN105324483A (zh) 2016-02-10
US9611468B2 (en) 2017-04-04
US10717974B2 (en) 2020-07-21
BR112015026160A2 (pt) 2017-10-10
US20180016568A1 (en) 2018-01-18
US20190040377A1 (en) 2019-02-07
CY1121891T1 (el) 2020-10-14
CN105324483B (zh) 2018-11-30
JP2020185016A (ja) 2020-11-19
JP6637410B2 (ja) 2020-01-29
US11913045B2 (en) 2024-02-27
ES2729048T3 (es) 2019-10-30
LT2986722T (lt) 2019-09-10

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