SG11201508108YA - Covalently closed non-coding immunomodulatory dna construct - Google Patents
Covalently closed non-coding immunomodulatory dna constructInfo
- Publication number
- SG11201508108YA SG11201508108YA SG11201508108YA SG11201508108YA SG11201508108YA SG 11201508108Y A SG11201508108Y A SG 11201508108YA SG 11201508108Y A SG11201508108Y A SG 11201508108YA SG 11201508108Y A SG11201508108Y A SG 11201508108YA SG 11201508108Y A SG11201508108Y A SG 11201508108YA
- Authority
- SG
- Singapore
- Prior art keywords
- dna construct
- covalently closed
- closed non
- immunomodulatory dna
- coding
- Prior art date
Links
- 230000002519 immonomodulatory effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6804—Nucleic acid analysis using immunogens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/17—Immunomodulatory nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/532—Closed or circular
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/31—Combination therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Plant Pathology (AREA)
- Pulmonology (AREA)
- Mycology (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pathology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1402847.6A GB2523187A (en) | 2014-02-18 | 2014-02-18 | Covalently closed non-coding immunomodulatory DNA construct |
| PCT/EP2015/053396 WO2015124614A1 (en) | 2014-02-18 | 2015-02-18 | Covalently closed non-coding immunomodulatory dna construct |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201508108YA true SG11201508108YA (en) | 2015-10-29 |
Family
ID=50440342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201508108YA SG11201508108YA (en) | 2014-02-18 | 2015-02-18 | Covalently closed non-coding immunomodulatory dna construct |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US10280424B2 (es) |
| EP (1) | EP2999787B1 (es) |
| JP (1) | JP6067893B2 (es) |
| KR (1) | KR101831713B1 (es) |
| CN (1) | CN105264074A (es) |
| AU (1) | AU2015220911B2 (es) |
| BR (1) | BR112015025748A2 (es) |
| CA (1) | CA2908522A1 (es) |
| DK (1) | DK2999787T3 (es) |
| ES (1) | ES2634002T3 (es) |
| GB (1) | GB2523187A (es) |
| HK (1) | HK1216758A1 (es) |
| MX (1) | MX2015014190A (es) |
| RU (1) | RU2668387C2 (es) |
| SG (1) | SG11201508108YA (es) |
| WO (1) | WO2015124614A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10894963B2 (en) | 2013-07-25 | 2021-01-19 | Exicure, Inc. | Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use |
| US10568898B2 (en) | 2013-08-13 | 2020-02-25 | Northwestern University | Lipophilic nanoparticles for drug delivery |
| GB2523187A (en) * | 2014-02-18 | 2015-08-19 | Mologen Ag | Covalently closed non-coding immunomodulatory DNA construct |
| CN106535876B (zh) | 2014-06-04 | 2020-09-11 | 埃克西奎雷股份有限公司 | 免疫调节剂通过脂质体球形核酸的多价递送以用于预防或治疗应用 |
| JP2017537619A (ja) | 2014-11-21 | 2017-12-21 | ノースウェスタン ユニバーシティ | 球状核酸ナノ粒子複合体の配列特異的細胞内取込 |
| LU92821B1 (en) * | 2015-09-09 | 2017-03-20 | Mologen Ag | Combination comprising immunostimulatory oligonucleotides |
| GB2542425A (en) * | 2015-09-21 | 2017-03-22 | Mologen Ag | Means for the treatment of HIV |
| WO2018039629A2 (en) | 2016-08-25 | 2018-03-01 | Northwestern University | Micellar spherical nucleic acids from thermoresponsive, traceless templates |
| US11433131B2 (en) | 2017-05-11 | 2022-09-06 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (SNAs) |
| CN111278510A (zh) | 2017-08-31 | 2020-06-12 | 莫洛根股份公司 | 用于调节肿瘤微环境的tlr-9激动剂 |
| CN115003829A (zh) * | 2020-01-31 | 2022-09-02 | 泰瑞斯疗法公司 | 带有修饰的核苷酸的闭合线性dna |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US20030050263A1 (en) * | 1994-07-15 | 2003-03-13 | The University Of Iowa Research Foundation | Methods and products for treating HIV infection |
| DE19935756A1 (de) * | 1999-07-27 | 2001-02-08 | Mologen Forschungs Entwicklung | Kovalent geschlossenes Nukleinsäuremolekül zur Immunstimulation |
| JP2005535627A (ja) * | 2002-06-25 | 2005-11-24 | シティ・オブ・ホープ | アジュバント不含ペプチド・ワクチン |
| RU2351362C2 (ru) * | 2003-03-26 | 2009-04-10 | Цитос Байотекнолоджи Аг | КОНЪЮГАТЫ ПЕПТИДА Melan-A, АНАЛОГА ВИРУСОПОДОБНОЙ ЧАСТИЦЫ |
| UA88457C2 (ru) | 2003-10-30 | 2009-10-26 | Коли Фармасьютикал Гмбх | Иммуностимулирующая нуклеиновая кислота с улучшенной иммуностимулирующей эффективностью |
| BRPI0418157A (pt) * | 2003-12-30 | 2007-04-17 | Mologen Ag | terapêutica de tumores alogênicos |
| EP1716234B1 (de) | 2004-02-20 | 2013-10-02 | Mologen AG | Substituiertes, nicht-kodierendes nukleinsäuremolekül zur therapeutischen und prophylaktischen immunstimulation in menschen und höheren tieren |
| WO2006015560A1 (de) * | 2004-08-09 | 2006-02-16 | Mologen Ag | Immunmodulierendes mittel in verbindung mit chemotherapeutischen massnahmen |
| MX2008014380A (es) | 2006-05-11 | 2009-03-02 | Mologen Ag | Multimero para inmunoestimulacion. |
| WO2010039137A1 (en) | 2008-10-02 | 2010-04-08 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response |
| EP2246433A1 (de) | 2009-04-30 | 2010-11-03 | Mologen AG | Concatemere zur Immunmodulation |
| GB2523187A (en) * | 2014-02-18 | 2015-08-19 | Mologen Ag | Covalently closed non-coding immunomodulatory DNA construct |
-
2014
- 2014-02-18 GB GB1402847.6A patent/GB2523187A/en not_active Withdrawn
-
2015
- 2015-02-18 EP EP15706416.3A patent/EP2999787B1/en not_active Not-in-force
- 2015-02-18 RU RU2015140720A patent/RU2668387C2/ru not_active IP Right Cessation
- 2015-02-18 WO PCT/EP2015/053396 patent/WO2015124614A1/en active Application Filing
- 2015-02-18 SG SG11201508108YA patent/SG11201508108YA/en unknown
- 2015-02-18 AU AU2015220911A patent/AU2015220911B2/en not_active Ceased
- 2015-02-18 US US14/899,601 patent/US10280424B2/en active Active
- 2015-02-18 CN CN201580000576.0A patent/CN105264074A/zh active Pending
- 2015-02-18 JP JP2015563141A patent/JP6067893B2/ja not_active Expired - Fee Related
- 2015-02-18 CA CA2908522A patent/CA2908522A1/en not_active Abandoned
- 2015-02-18 ES ES15706416.3T patent/ES2634002T3/es active Active
- 2015-02-18 MX MX2015014190A patent/MX2015014190A/es unknown
- 2015-02-18 BR BR112015025748A patent/BR112015025748A2/pt not_active IP Right Cessation
- 2015-02-18 KR KR1020157028152A patent/KR101831713B1/ko active IP Right Grant
- 2015-02-18 DK DK15706416.3T patent/DK2999787T3/en active
-
2016
- 2016-04-20 HK HK16104520.3A patent/HK1216758A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2015220911B2 (en) | 2017-02-02 |
| CN105264074A (zh) | 2016-01-20 |
| US20160348114A1 (en) | 2016-12-01 |
| HK1216758A1 (zh) | 2016-12-02 |
| MX2015014190A (es) | 2015-12-11 |
| DK2999787T3 (en) | 2017-08-07 |
| EP2999787A1 (en) | 2016-03-30 |
| KR20150130425A (ko) | 2015-11-23 |
| JP6067893B2 (ja) | 2017-01-25 |
| CA2908522A1 (en) | 2015-08-27 |
| WO2015124614A1 (en) | 2015-08-27 |
| GB2523187A (en) | 2015-08-19 |
| US10280424B2 (en) | 2019-05-07 |
| RU2015140720A (ru) | 2017-03-29 |
| KR101831713B1 (ko) | 2018-02-23 |
| RU2668387C2 (ru) | 2018-09-28 |
| AU2015220911A1 (en) | 2015-10-15 |
| BR112015025748A2 (pt) | 2017-10-10 |
| GB201402847D0 (en) | 2014-04-02 |
| ES2634002T3 (es) | 2017-09-26 |
| EP2999787B1 (en) | 2017-04-19 |
| JP2016526373A (ja) | 2016-09-05 |
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