SG11201506357RA - Macrocyclic lrrk2 kinase inhibitors - Google Patents
Macrocyclic lrrk2 kinase inhibitorsInfo
- Publication number
- SG11201506357RA SG11201506357RA SG11201506357RA SG11201506357RA SG11201506357RA SG 11201506357R A SG11201506357R A SG 11201506357RA SG 11201506357R A SG11201506357R A SG 11201506357RA SG 11201506357R A SG11201506357R A SG 11201506357RA SG 11201506357R A SG11201506357R A SG 11201506357RA
- Authority
- SG
- Singapore
- Prior art keywords
- kinase inhibitors
- lrrk2 kinase
- macrocyclic
- macrocyclic lrrk2
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13305314 | 2013-03-15 | ||
| EP13305311 | 2013-03-15 | ||
| PCT/EP2014/055049 WO2014140235A1 (fr) | 2013-03-15 | 2014-03-14 | Inhibiteurs macrocycliques de la kinase lrrk2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201506357RA true SG11201506357RA (en) | 2015-09-29 |
Family
ID=50277239
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201506357RA SG11201506357RA (en) | 2013-03-15 | 2014-03-14 | Macrocyclic lrrk2 kinase inhibitors |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20160031905A1 (fr) |
| EP (1) | EP2970333B1 (fr) |
| JP (1) | JP2016510793A (fr) |
| KR (1) | KR20150129016A (fr) |
| CN (1) | CN105143232A (fr) |
| AU (1) | AU2014230485A1 (fr) |
| BR (1) | BR112015019873A2 (fr) |
| CA (1) | CA2904462A1 (fr) |
| DK (1) | DK2970333T3 (fr) |
| EA (1) | EA201591698A1 (fr) |
| ES (1) | ES2635021T3 (fr) |
| HK (1) | HK1219481A1 (fr) |
| MX (1) | MX2015011359A (fr) |
| PL (1) | PL2970333T3 (fr) |
| PT (1) | PT2970333T (fr) |
| SG (1) | SG11201506357RA (fr) |
| TW (1) | TW201444850A (fr) |
| WO (1) | WO2014140235A1 (fr) |
| ZA (1) | ZA201506327B (fr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20150133765A (ko) * | 2013-03-15 | 2015-11-30 | 온코디자인 에스.에이. | 거대고리 rip2 키나제 억제제 |
| WO2016146651A1 (fr) | 2015-03-16 | 2016-09-22 | Oncodesign Sa | Inhibiteurs macrocycliques de récepteur kinase de type activine |
| CN113956269A (zh) * | 2018-04-16 | 2022-01-21 | 深圳市塔吉瑞生物医药有限公司 | 用于抑制蛋白激酶活性的二(杂)芳基大环化合物 |
| AU2021214866A1 (en) * | 2020-01-31 | 2022-09-22 | Oncodesign Precision Medicine (OPM) | Macrocyclic RIP2-kinase inhibitors |
| US11858940B2 (en) * | 2020-03-21 | 2024-01-02 | Arvinas Operations, Inc. | Selective modulators of mutant LRRK2 proteolysis and associated methods of use |
| US11780851B2 (en) | 2021-10-27 | 2023-10-10 | H. Lundbeck A/S | LRRK2 inhibitors |
| CN117425660A (zh) * | 2022-05-18 | 2024-01-19 | 上海翊石医药科技有限公司 | 一种芳杂环类化合物及其中间体、药物组合物和用途 |
| CN117659043A (zh) * | 2022-09-07 | 2024-03-08 | 苏州朗睿生物医药有限公司 | 一种大环咪唑并[1,2-b]哒嗪衍生物及其制备方法和用途 |
| WO2024056775A1 (fr) * | 2022-09-15 | 2024-03-21 | H. Lundbeck A/S | Inhibiteurs macrocycliques de kinase 2 à répétition riche en leucine (lrrk2) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201008134D0 (en) * | 2010-05-14 | 2010-06-30 | Medical Res Council Technology | Compounds |
| GB201015949D0 (en) * | 2010-09-22 | 2010-11-03 | Medical Res Council Technology | Compounds |
| PE20140927A1 (es) * | 2011-04-21 | 2014-08-24 | Origenis Gmbh | Compuestos heterociclicos como inhibidores de cinasas |
| WO2013001310A1 (fr) * | 2011-06-30 | 2013-01-03 | Centro Nacional De Investigaciones Oncológicas (Cnio) | Composés macrocycliques et leur utilisation en tant qu'inhibiteurs de cdk8 |
| PL2760453T3 (pl) * | 2011-09-30 | 2016-11-30 | Makrocykliczne Inhibitory kinazy LRRK2 | |
| JP6046728B2 (ja) * | 2011-09-30 | 2016-12-21 | オンコデザイン エス．ア． | 大環状ｆｌｔ３キナーゼ阻害剤 |
-
2014
- 2014-03-14 SG SG11201506357RA patent/SG11201506357RA/en unknown
- 2014-03-14 JP JP2015562173A patent/JP2016510793A/ja not_active Abandoned
- 2014-03-14 US US14/777,495 patent/US20160031905A1/en not_active Abandoned
- 2014-03-14 WO PCT/EP2014/055049 patent/WO2014140235A1/fr active Application Filing
- 2014-03-14 ES ES14709962.6T patent/ES2635021T3/es active Active
- 2014-03-14 KR KR1020157029380A patent/KR20150129016A/ko not_active Application Discontinuation
- 2014-03-14 EP EP14709962.6A patent/EP2970333B1/fr active Active
- 2014-03-14 MX MX2015011359A patent/MX2015011359A/es unknown
- 2014-03-14 BR BR112015019873A patent/BR112015019873A2/pt not_active IP Right Cessation
- 2014-03-14 TW TW103109451A patent/TW201444850A/zh unknown
- 2014-03-14 DK DK14709962.6T patent/DK2970333T3/en active
- 2014-03-14 EA EA201591698A patent/EA201591698A1/ru unknown
- 2014-03-14 CA CA2904462A patent/CA2904462A1/fr not_active Abandoned
- 2014-03-14 PL PL14709962T patent/PL2970333T3/pl unknown
- 2014-03-14 PT PT147099626T patent/PT2970333T/pt unknown
- 2014-03-14 CN CN201480014168.6A patent/CN105143232A/zh active Pending
- 2014-03-14 AU AU2014230485A patent/AU2014230485A1/en not_active Abandoned
-
2015
- 2015-08-28 ZA ZA2015/06327A patent/ZA201506327B/en unknown
-
2016
- 2016-06-28 HK HK16107521.5A patent/HK1219481A1/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2016510793A (ja) | 2016-04-11 |
| CA2904462A1 (fr) | 2014-09-18 |
| CN105143232A (zh) | 2015-12-09 |
| HK1219481A1 (zh) | 2017-04-07 |
| EP2970333B1 (fr) | 2017-05-03 |
| EA201591698A1 (ru) | 2016-02-29 |
| PT2970333T (pt) | 2017-08-01 |
| PL2970333T3 (pl) | 2017-12-29 |
| ES2635021T3 (es) | 2017-10-02 |
| ZA201506327B (en) | 2017-02-22 |
| TW201444850A (zh) | 2014-12-01 |
| BR112015019873A2 (pt) | 2017-07-18 |
| KR20150129016A (ko) | 2015-11-18 |
| WO2014140235A1 (fr) | 2014-09-18 |
| AU2014230485A1 (en) | 2015-09-24 |
| DK2970333T3 (en) | 2017-08-21 |
| US20160031905A1 (en) | 2016-02-04 |
| MX2015011359A (es) | 2015-12-16 |
| EP2970333A1 (fr) | 2016-01-20 |
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