SG11201505937SA - Spiro-lactam nmda receptor modulators and uses thereof - Google Patents

Spiro-lactam nmda receptor modulators and uses thereof

Info

Publication number
SG11201505937SA
SG11201505937SA SG11201505937SA SG11201505937SA SG11201505937SA SG 11201505937S A SG11201505937S A SG 11201505937SA SG 11201505937S A SG11201505937S A SG 11201505937SA SG 11201505937S A SG11201505937S A SG 11201505937SA SG 11201505937S A SG11201505937S A SG 11201505937SA
Authority
SG
Singapore
Prior art keywords
spiro
nmda receptor
receptor modulators
lactam nmda
lactam
Prior art date
Application number
SG11201505937SA
Other languages
English (en)
Inventor
John A Lowe Iii
M Amin Khan
Original Assignee
Naurex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50097881&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201505937S(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Naurex Inc filed Critical Naurex Inc
Publication of SG11201505937SA publication Critical patent/SG11201505937SA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SG11201505937SA 2013-01-29 2014-01-29 Spiro-lactam nmda receptor modulators and uses thereof SG11201505937SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361757939P 2013-01-29 2013-01-29
PCT/US2014/013626 WO2014120789A1 (en) 2013-01-29 2014-01-29 Spiro-lactam nmda receptor modulators and uses thereof

Publications (1)

Publication Number Publication Date
SG11201505937SA true SG11201505937SA (en) 2015-09-29

Family

ID=50097881

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201505937SA SG11201505937SA (en) 2013-01-29 2014-01-29 Spiro-lactam nmda receptor modulators and uses thereof

Country Status (16)

Country Link
US (2) US9738650B2 (enrdf_load_stackoverflow)
EP (1) EP2951186B1 (enrdf_load_stackoverflow)
JP (1) JP2016506961A (enrdf_load_stackoverflow)
KR (1) KR20150110586A (enrdf_load_stackoverflow)
CN (1) CN105026401A (enrdf_load_stackoverflow)
AU (1) AU2014212490A1 (enrdf_load_stackoverflow)
BR (1) BR112015018095A2 (enrdf_load_stackoverflow)
CA (1) CA2899010A1 (enrdf_load_stackoverflow)
CL (1) CL2015002124A1 (enrdf_load_stackoverflow)
EA (1) EA201591404A1 (enrdf_load_stackoverflow)
IL (1) IL240165A0 (enrdf_load_stackoverflow)
MX (1) MX2015009778A (enrdf_load_stackoverflow)
PE (1) PE20151438A1 (enrdf_load_stackoverflow)
PH (1) PH12015501600A1 (enrdf_load_stackoverflow)
SG (1) SG11201505937SA (enrdf_load_stackoverflow)
WO (1) WO2014120789A1 (enrdf_load_stackoverflow)

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MX2015009785A (es) 2013-01-29 2016-04-04 Aptinyx Inc Moduladores de receptores nmda de espiro-lactama y sus usos.
PH12015501596B1 (en) 2013-01-29 2023-12-06 Aptinyx Inc Spiro-lactam nmda receptor modulators and uses thereof
EA201591404A1 (ru) 2013-01-29 2016-01-29 Аптиникс Инк. Спиролактамные модуляторы рецептора nmda и их применение
MX2015009773A (es) 2013-01-29 2016-08-05 Aptinyx Inc Moduladores de receptores nmda de espiro-lactama y sus usos.
HUE043843T2 (hu) 2013-01-29 2019-09-30 Aptinyx Inc Spiro-laktám NMDA receptor modulátorok és azok alkalmazása
BR112018073663A2 (pt) 2016-05-19 2019-04-30 Aptinyx Inc. moduladores de receptores nmda spiro-lactâmicos e seus usos
WO2017201285A1 (en) 2016-05-19 2017-11-23 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
JP2019527232A (ja) 2016-08-01 2019-09-26 アプティニックス インコーポレイテッド スピロ−ラクタムｎｍｄａ修飾因子及びこれを用いた方法
SG11201900546UA (en) * 2016-08-01 2019-02-27 Aptinyx Inc Spiro-lactam and bis-spiro-lactam nmda receptor modulators and uses thereof
CN109890825B (zh) * 2016-08-01 2022-03-11 阿普廷伊克斯股份有限公司 螺-内酰胺nmda受体调节剂及其用途
EA201990424A1 (ru) * 2016-08-01 2019-08-30 Аптиникс Инк. Спиролактамовые модуляторы nmda-рецептора и их применение
CA3031534C (en) 2016-08-01 2023-10-17 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
US11578072B2 (en) * 2018-01-31 2023-02-14 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
WO2019152685A1 (en) * 2018-01-31 2019-08-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and methods of using same
CA3089559A1 (en) * 2018-01-31 2019-08-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
WO2019152696A1 (en) * 2018-01-31 2019-08-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
CN109485598A (zh) * 2018-11-29 2019-03-19 河南师范大学 一种去除氨基上喹啉保护基的新方法
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PH12015501596B1 (en) 2013-01-29 2023-12-06 Aptinyx Inc Spiro-lactam nmda receptor modulators and uses thereof
MX2015009785A (es) 2013-01-29 2016-04-04 Aptinyx Inc Moduladores de receptores nmda de espiro-lactama y sus usos.
HUE043843T2 (hu) 2013-01-29 2019-09-30 Aptinyx Inc Spiro-laktám NMDA receptor modulátorok és azok alkalmazása
EA201591404A1 (ru) 2013-01-29 2016-01-29 Аптиникс Инк. Спиролактамные модуляторы рецептора nmda и их применение

Also Published As

Publication number Publication date
KR20150110586A (ko) 2015-10-02
CA2899010A1 (en) 2014-08-07
JP2016506961A (ja) 2016-03-07
EA201591404A1 (ru) 2016-01-29
PH12015501600A1 (en) 2015-10-19
AU2014212490A1 (en) 2015-07-30
EP2951186A1 (en) 2015-12-09
WO2014120789A1 (en) 2014-08-07
CN105026401A (zh) 2015-11-04
US9738650B2 (en) 2017-08-22
EP2951186B1 (en) 2018-07-25
US20150376195A1 (en) 2015-12-31
US20180155354A1 (en) 2018-06-07
MX2015009778A (es) 2016-02-09
US10253032B2 (en) 2019-04-09
IL240165A0 (en) 2015-09-24
PE20151438A1 (es) 2015-10-10
BR112015018095A2 (pt) 2017-07-18
CL2015002124A1 (es) 2015-12-04

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