SG11201503773SA - Gemcitabine prodrugs and uses thereof - Google Patents
Gemcitabine prodrugs and uses thereofInfo
- Publication number
- SG11201503773SA SG11201503773SA SG11201503773SA SG11201503773SA SG11201503773SA SG 11201503773S A SG11201503773S A SG 11201503773SA SG 11201503773S A SG11201503773S A SG 11201503773SA SG 11201503773S A SG11201503773S A SG 11201503773SA SG 11201503773S A SG11201503773S A SG 11201503773SA
- Authority
- SG
- Singapore
- Prior art keywords
- gemcitabine prodrugs
- gemcitabine
- prodrugs
- Prior art date
Links
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 title 1
- 229960005277 gemcitabine Drugs 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261725643P | 2012-11-13 | 2012-11-13 | |
| PCT/US2013/069640 WO2014078295A1 (en) | 2012-11-13 | 2013-11-12 | Gemcitabine prodrugs and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201503773SA true SG11201503773SA (en) | 2015-06-29 |
Family
ID=50681903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201503773SA SG11201503773SA (en) | 2012-11-13 | 2013-11-12 | Gemcitabine prodrugs and uses thereof |
Country Status (10)
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2919790B1 (en) | 2012-11-13 | 2018-04-04 | Boyen Therapeutics, Inc. | Gemcitabine prodrugs and uses thereof |
| JP6783224B2 (ja) | 2014-04-04 | 2020-11-11 | デル マー ファーマシューティカルズ | 肺の非小細胞癌腫及び卵巣癌を処置するためのジアンヒドロガラクチトール及びその類縁体又は誘導体の使用 |
| WO2016078399A1 (zh) * | 2014-11-17 | 2016-05-26 | 常州方圆制药有限公司 | 新型胞苷衍生物二聚体及其应用 |
| WO2016078397A1 (zh) * | 2014-11-17 | 2016-05-26 | 常州方圆制药有限公司 | 新型胞苷衍生物及其应用 |
| WO2016078160A1 (zh) * | 2014-11-17 | 2016-05-26 | 常州方圆制药有限公司 | 胞苷衍生物及其应用 |
| WO2016078163A1 (zh) | 2014-11-17 | 2016-05-26 | 常州方圆制药有限公司 | 新型胞苷衍生物二聚体及其应用 |
| ITUB20159671A1 (it) * | 2015-12-22 | 2017-06-22 | Maurizio Ceruti | Carbammati lipidici di farmaci antitumorali |
| KR20180096698A (ko) * | 2015-12-23 | 2018-08-29 | 뉴카나 피엘씨 | 조합 요법 |
| CN106946960A (zh) * | 2017-03-29 | 2017-07-14 | 郑州泰基鸿诺医药股份有限公司 | 一种吉西他滨前药的晶型、制备方法、用途和药物组合物 |
| CN110831605A (zh) | 2017-04-26 | 2020-02-21 | 托马斯·I.·卡尔曼 | 多靶标的核苷衍生物 |
| CN108329371B (zh) * | 2018-03-06 | 2021-04-09 | 沈阳药科大学 | 白蛋白结合型吉西他滨前药及其合成和应用 |
| US20210238214A1 (en) * | 2018-04-26 | 2021-08-05 | NanoMed Holdings Pty Ltd | Gemcitabine amphiphile prodrugs |
| GR1009958B (el) * | 2019-04-24 | 2021-03-18 | ΕΝΟΡΑΣΙΣ ΑΝΩΝΥΜΗ ΕΜΠΟΡΙΚΗ ΕΤΑΙΡΕΙΑ ΦΑΡΜΑΚΕΥΤΙΚΩΝ ΚΑΙ ΙΑΤΡΙΚΩΝ ΥΛΙΚΩΝ ΚΑΙ ΜΗΧΑΝΗΜΑΤΩΝ με δ.τ. "ΕΝΟΡΑΣΙΣ Α.Ε." | Παραγωγα γεμσιταβινης και μεθοδοι δημιουργιας παραγωγων γεμσιταβινης |
| GB201906210D0 (en) | 2019-05-02 | 2019-06-19 | Econic Tech Limited | A polyol block copolymer, compositions and processes therefor |
| GB201906214D0 (en) | 2019-05-02 | 2019-06-19 | Econic Tech Ltd | A polyol block copolymer, compositions and processes therefor |
| CN114011581B (zh) * | 2021-11-09 | 2023-03-24 | 昆明理工大学 | 一种弱酸性条件下铜硫分离的抑制剂制备方法及其应用 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4814438A (en) | 1986-12-24 | 1989-03-21 | Eli Lilly And Company | Immunoglobulin conjugates of 2',2'-difluronucleosides |
| US4994558A (en) | 1986-12-24 | 1991-02-19 | Eli Lilly And Company | Immunoglobulin conjugates |
| GB2321454A (en) | 1997-01-24 | 1998-07-29 | Norsk Hydro As | Gemcitabine esters and amides |
| NZ336676A (en) | 1997-01-24 | 2000-01-28 | Norsk Hydro As | Gemcitabine esters or amides useful as anti-cancer and anti-viral agents |
| US6376470B1 (en) | 1999-09-23 | 2002-04-23 | Enzon, Inc. | Polymer conjugates of ara-C and ara-C derivatives |
| AU2003291726A1 (en) | 2002-11-04 | 2004-06-07 | Xenoport, Inc. | Gemcitabine prodrugs, pharmaceutical compositions and uses thereof |
| GB0321613D0 (en) | 2003-09-15 | 2003-10-15 | Drug Discovery Lab As | Compounds |
| FR2874016B1 (fr) | 2004-06-30 | 2006-11-24 | Centre Nat Rech Scient Cnrse | Nanoparticules de derives de la gemcitabine |
| WO2006029081A2 (en) | 2004-09-02 | 2006-03-16 | Neopharm, Inc. | Nucleoside-lipid conjugates, their method of preparation and uses thereof |
| WO2006030217A2 (en) | 2004-09-15 | 2006-03-23 | Drug Discovery Laboratory As | Drug conjugates of long chain fatty acid or ester moieties as protein binding prodrugs |
| MX2007007228A (es) | 2004-12-17 | 2007-08-14 | Lilly Co Eli | Profarmaco de amida de gemcitabina, composiciones y uso del mismo. |
| NO322682B1 (no) | 2005-03-18 | 2006-11-27 | Clavis Pharma Asa | Anvendelse av gemcitabinderivater for fremstilling av orale doseringsformer ved kreftbehandling, samt slike orale doseringsformer |
| AT502221A1 (de) | 2005-07-20 | 2007-02-15 | Pharmacon Forschung & Beratung Gmbh | Homogemcitabine, verfahren zu ihrer herstellung sowie deren verwendung |
| MX2009000198A (es) | 2006-06-21 | 2009-01-22 | Lilly Co Eli | Formas cristalinas de profarmaco amida de gemcitabina, composiciones y usos del mismo. |
| CN101209350B (zh) | 2006-12-30 | 2011-09-07 | 中国人民解放军军事医学科学院毒物药物研究所 | 以氨基酸为连接子的多聚谷氨酸-药物偶合物 |
| WO2010039039A1 (en) | 2008-10-03 | 2010-04-08 | Clavis Pharma Asa | Oral formulations of gemcitabine derivatives |
| JP2012505228A (ja) | 2008-10-07 | 2012-03-01 | レクサン ファーマシューティカルズ インコーポレイテッド | Ｈｐｍａ−ドセタキセルまたはゲムシタビンコンジュゲートおよびその使用 |
| CN101525361B (zh) | 2009-04-21 | 2010-11-17 | 济南圣鲁金药物技术开发有限公司 | 基于吉西他滨结构的前药及其合成方法及应用 |
| US8871780B2 (en) * | 2009-07-02 | 2014-10-28 | Kempharm, Inc. | Phenylethanoic acid, phenylpropanoic acid and phenylpropenoic acid conjugates and prodrugs of hydrocodone, method of making and use thereof |
| CN102740833A (zh) | 2009-11-20 | 2012-10-17 | 克拉维斯制药公司 | 吉西他滨衍生物的肠胃外制剂 |
| GB201016855D0 (en) | 2010-10-06 | 2010-11-17 | Nucana Biomed Ltd | Chemical compounds |
| WO2012098557A1 (en) | 2011-01-20 | 2012-07-26 | Institute Of Life Sciences | Pegylated gemcitabine derivative and process for preparing the same |
| EP2739290A4 (en) | 2011-08-02 | 2015-04-15 | Clovis Oncology Inc | METHOD FOR SELECTION OF CHEMOTHERAPEUTICS AGAINST ADENOCARCINOMAS |
| CN102432654A (zh) | 2011-09-26 | 2012-05-02 | 宋云龙 | 吉西他滨酰胺衍生物及其制备方法和用途 |
| EP2919790B1 (en) | 2012-11-13 | 2018-04-04 | Boyen Therapeutics, Inc. | Gemcitabine prodrugs and uses thereof |
| CN103130854A (zh) | 2013-01-31 | 2013-06-05 | 华东师范大学 | 维生素e琥珀酸酯化吉西他滨前药及应用 |
-
2013
- 2013-11-12 EP EP13855096.7A patent/EP2919790B1/en active Active
- 2013-11-12 SG SG11201503773SA patent/SG11201503773SA/en unknown
- 2013-11-12 CN CN201380059144.8A patent/CN104968353B/zh active Active
- 2013-11-12 US US14/077,778 patent/US8956613B2/en not_active Expired - Fee Related
- 2013-11-12 BR BR112015010941A patent/BR112015010941A2/pt not_active IP Right Cessation
- 2013-11-12 AU AU2013345007A patent/AU2013345007B2/en active Active
- 2013-11-12 WO PCT/US2013/069640 patent/WO2014078295A1/en active Application Filing
- 2013-11-12 KR KR1020157015453A patent/KR20150082606A/ko not_active Ceased
- 2013-11-12 CA CA2891124A patent/CA2891124A1/en not_active Abandoned
- 2013-11-12 JP JP2015542007A patent/JP6420247B2/ja active Active
-
2015
- 2015-01-16 US US14/599,166 patent/US9540410B2/en not_active Expired - Fee Related
-
2016
- 2016-12-05 US US15/369,187 patent/US9890189B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2016503414A (ja) | 2016-02-04 |
| EP2919790A1 (en) | 2015-09-23 |
| WO2014078295A1 (en) | 2014-05-22 |
| BR112015010941A2 (pt) | 2017-07-11 |
| US20140134160A1 (en) | 2014-05-15 |
| CN104968353A (zh) | 2015-10-07 |
| EP2919790B1 (en) | 2018-04-04 |
| EP2919790A4 (en) | 2016-04-06 |
| WO2014078295A8 (en) | 2015-05-21 |
| CA2891124A1 (en) | 2014-05-22 |
| CN104968353B (zh) | 2017-12-22 |
| AU2013345007A1 (en) | 2015-05-21 |
| AU2013345007B2 (en) | 2018-08-30 |
| US8956613B2 (en) | 2015-02-17 |
| US9540410B2 (en) | 2017-01-10 |
| US9890189B2 (en) | 2018-02-13 |
| KR20150082606A (ko) | 2015-07-15 |
| US20170107245A1 (en) | 2017-04-20 |
| US20150132298A1 (en) | 2015-05-14 |
| JP6420247B2 (ja) | 2018-11-07 |
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