SG11201408042YA - Improved antagonist antibodies against gdf-8 and uses therefor - Google Patents
Improved antagonist antibodies against gdf-8 and uses thereforInfo
- Publication number
- SG11201408042YA SG11201408042YA SG11201408042YA SG11201408042YA SG11201408042YA SG 11201408042Y A SG11201408042Y A SG 11201408042YA SG 11201408042Y A SG11201408042Y A SG 11201408042YA SG 11201408042Y A SG11201408042Y A SG 11201408042YA SG 11201408042Y A SG11201408042Y A SG 11201408042YA
- Authority
- SG
- Singapore
- Prior art keywords
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- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
- A61K2039/622—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier non-covalent binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261660232P | 2012-06-15 | 2012-06-15 | |
PCT/IB2013/054810 WO2013186719A1 (fr) | 2012-06-15 | 2013-06-12 | Anticorps antagonistes améliorés dirigés contre gdf-8 et leurs utilisations |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201408042YA true SG11201408042YA (en) | 2015-01-29 |
Family
ID=48914383
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201408042YA SG11201408042YA (en) | 2012-06-15 | 2013-06-12 | Improved antagonist antibodies against gdf-8 and uses therefor |
Country Status (21)
Country | Link |
---|---|
US (4) | US8992913B2 (fr) |
EP (1) | EP2861617A1 (fr) |
JP (3) | JP6433889B2 (fr) |
KR (1) | KR101704893B1 (fr) |
CN (1) | CN104487453B (fr) |
AR (1) | AR093217A1 (fr) |
AU (1) | AU2013276131B2 (fr) |
CA (1) | CA2876397C (fr) |
CO (1) | CO7151524A2 (fr) |
HK (1) | HK1208471A1 (fr) |
IL (1) | IL236289A0 (fr) |
MX (1) | MX364738B (fr) |
MY (1) | MY177331A (fr) |
NZ (1) | NZ702269A (fr) |
PE (1) | PE20150223A1 (fr) |
PH (1) | PH12014502698A1 (fr) |
RU (1) | RU2630634C2 (fr) |
SA (1) | SA113340642B1 (fr) |
SG (1) | SG11201408042YA (fr) |
TW (1) | TWI495643B (fr) |
WO (1) | WO2013186719A1 (fr) |
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ES2568436T3 (es) | 2006-03-31 | 2016-04-29 | Chugai Seiyaku Kabushiki Kaisha | Procedimiento para controlar la farmacocinética en sangre de anticuerpos |
EP3689912A1 (fr) | 2007-09-26 | 2020-08-05 | Chugai Seiyaku Kabushiki Kaisha | Procédé de modification d'un anticorps par point isoélectrique par substitution d'acide aminé dans cdr |
EP4238993A3 (fr) | 2008-04-11 | 2023-11-29 | Chugai Seiyaku Kabushiki Kaisha | Molécule de liaison à l'antigène capable de se lier à deux ou plusieurs molécules d'antigène de manière répétée |
SG190727A1 (en) | 2010-11-30 | 2013-07-31 | Chugai Pharmaceutical Co Ltd | Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly |
WO2013074557A1 (fr) | 2011-11-14 | 2013-05-23 | Regeneron Pharmaceuticals, Inc. | Compositions et méthodes permettant d'augmenter la masse et la force musculaires par un effet antagoniste spécifiquement dirigé contre la myostatine et/ou l'activine a |
EP2861617A1 (fr) * | 2012-06-15 | 2015-04-22 | Pfizer Inc. | Anticorps antagonistes améliorés dirigés contre gdf-8 et leurs utilisations |
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TWI697501B (zh) | 2012-08-24 | 2020-07-01 | 日商中外製藥股份有限公司 | FcγRIIb特異性Fc區域變異體 |
CN104768969B (zh) | 2012-09-13 | 2021-04-16 | 百时美施贵宝公司 | 结合至肌生成抑制素的基于纤连蛋白的支架结构域蛋白 |
ES2715710T3 (es) | 2013-01-25 | 2019-06-05 | Shire Human Genetic Therapies | Folistatina en el tratamiento de la distrofía muscular de Duchenne |
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EA038146B1 (ru) | 2015-09-15 | 2021-07-13 | Сколар Рок, Инк. | Антитела к про-/латентному миостатину и их применения |
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2013
- 2013-06-12 EP EP13744828.8A patent/EP2861617A1/fr not_active Withdrawn
- 2013-06-12 NZ NZ702269A patent/NZ702269A/en not_active IP Right Cessation
- 2013-06-12 RU RU2014150433A patent/RU2630634C2/ru active
- 2013-06-12 WO PCT/IB2013/054810 patent/WO2013186719A1/fr active Application Filing
- 2013-06-12 CN CN201380030753.0A patent/CN104487453B/zh not_active Expired - Fee Related
- 2013-06-12 MY MYPI2014703762A patent/MY177331A/en unknown
- 2013-06-12 MX MX2014014995A patent/MX364738B/es active IP Right Grant
- 2013-06-12 AU AU2013276131A patent/AU2013276131B2/en not_active Ceased
- 2013-06-12 SA SA113340642A patent/SA113340642B1/ar unknown
- 2013-06-12 PE PE2014002435A patent/PE20150223A1/es active IP Right Grant
- 2013-06-12 SG SG11201408042YA patent/SG11201408042YA/en unknown
- 2013-06-12 KR KR1020147034989A patent/KR101704893B1/ko active IP Right Grant
- 2013-06-12 JP JP2015516728A patent/JP6433889B2/ja not_active Expired - Fee Related
- 2013-06-12 US US13/916,379 patent/US8992913B2/en not_active Expired - Fee Related
- 2013-06-12 CA CA2876397A patent/CA2876397C/fr not_active Expired - Fee Related
- 2013-06-14 TW TW102121200A patent/TWI495643B/zh not_active IP Right Cessation
- 2013-06-14 AR ARP130102122A patent/AR093217A1/es unknown
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- 2014-12-03 PH PH12014502698A patent/PH12014502698A1/en unknown
- 2014-12-15 IL IL236289A patent/IL236289A0/en active IP Right Grant
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2015
- 2015-02-19 US US14/626,321 patent/US9751937B2/en active Active
- 2015-09-11 HK HK15108889.0A patent/HK1208471A1/xx not_active IP Right Cessation
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2017
- 2017-08-01 US US15/666,317 patent/US20180057579A1/en not_active Abandoned
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2018
- 2018-11-07 JP JP2018209932A patent/JP2019059738A/ja active Pending
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2019
- 2019-11-13 US US16/682,437 patent/US20200277365A1/en not_active Abandoned
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- 2020-07-21 JP JP2020124373A patent/JP2021001170A/ja not_active Withdrawn
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