SG11201407809QA - Chromatographic purification of immunoglobulin g preparations with particles having multimodal functionalities - Google Patents

Chromatographic purification of immunoglobulin g preparations with particles having multimodal functionalities

Info

Publication number
SG11201407809QA
SG11201407809QA SG11201407809QA SG11201407809QA SG11201407809QA SG 11201407809Q A SG11201407809Q A SG 11201407809QA SG 11201407809Q A SG11201407809Q A SG 11201407809QA SG 11201407809Q A SG11201407809Q A SG 11201407809QA SG 11201407809Q A SG11201407809Q A SG 11201407809QA
Authority
SG
Singapore
Prior art keywords
international
chromatographic column
packed
sample
protein
Prior art date
Application number
SG11201407809QA
Other languages
English (en)
Inventor
Peter Stanley Gagnon
Original Assignee
Agency Science Tech & Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agency Science Tech & Res filed Critical Agency Science Tech & Res
Publication of SG11201407809QA publication Critical patent/SG11201407809QA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
SG11201407809QA 2012-05-31 2013-01-21 Chromatographic purification of immunoglobulin g preparations with particles having multimodal functionalities SG11201407809QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261653913P 2012-05-31 2012-05-31
PCT/SG2013/000031 WO2013180647A1 (en) 2012-05-31 2013-01-21 Chromatographic purification of immunoglobulin g preparations with particles having multimodal functionalities

Publications (1)

Publication Number Publication Date
SG11201407809QA true SG11201407809QA (en) 2014-12-30

Family

ID=49673718

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201407809QA SG11201407809QA (en) 2012-05-31 2013-01-21 Chromatographic purification of immunoglobulin g preparations with particles having multimodal functionalities

Country Status (8)

Country Link
US (1) US9890205B2 (ja)
EP (1) EP2855504B1 (ja)
JP (1) JP6297029B2 (ja)
KR (1) KR20150027060A (ja)
CN (1) CN104507955A (ja)
IN (1) IN2014DN09962A (ja)
SG (1) SG11201407809QA (ja)
WO (1) WO2013180647A1 (ja)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104507953B (zh) * 2012-05-31 2018-05-18 新加坡科技研究局 通过用正电性有机添加剂处理来降低蛋白质制剂中蛋白质-污染物复合物和聚集物水平的方法
KR20150118120A (ko) 2013-02-22 2015-10-21 에이전시 포 사이언스, 테크놀로지 앤드 리서치 단백질 제제들로부터 엔도톡신들을 제거하기 위한 물질들 및 방법들
JP2016509069A (ja) * 2013-02-28 2016-03-24 エイジェンシー・フォー・サイエンス，テクノロジー・アンド・リサーチ 非イオン性有機ポリマー存在下、高導電率でのタンパク質精製
CN105980397A (zh) * 2014-02-19 2016-09-28 新加坡科技研究局 分级分离方法
CN106061992A (zh) * 2014-02-27 2016-10-26 新加坡科技研究局 通过用烷基阳离子处理来降低蛋白质制剂中的染色质含量的方法
WO2015130222A1 (en) 2014-02-27 2015-09-03 Agency For Science, Technology And Research Antibody purification process
EP3674310A1 (en) * 2014-03-10 2020-07-01 Richter Gedeon Nyrt. Immunoglobulin purification using pre-cleaning steps
SG11201609815QA (en) * 2014-05-29 2016-12-29 Agency Science Tech & Res Protein Extraction Methods
CN104356211B (zh) * 2014-09-22 2017-08-29 山东信得科技股份有限公司 一种应用Triton X‑114和尿囊素去除重组蛋白质溶液中内毒素的方法
EP3277397A1 (en) 2015-03-31 2018-02-07 GE Healthcare Bio-Sciences AB A liquid chromatograhy system, a device, and a method
US11697800B2 (en) 2015-11-05 2023-07-11 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. Method for the separation of virus compositions including depletion and purification thereof
US20190039046A1 (en) * 2016-02-25 2019-02-07 Hitachi, Ltd. Adsorbent material and purification method
WO2018092691A1 (ja) * 2016-11-18 2018-05-24 Jnc株式会社 抗体の精製方法
JPWO2018147393A1 (ja) * 2017-02-10 2019-11-21 三菱ケミカル株式会社 ヒトインスリン精製用分離剤及びヒトインスリンの精製方法
WO2019192877A1 (en) * 2018-04-03 2019-10-10 Merck Patent Gmbh Cex chromatography media and low salt elution of target proteins from biopharmaceutical feeds
CN114341152A (zh) 2019-09-06 2022-04-12 比亚分离公司 用于降低生物制品的染色质含量的组合物和方法

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0666793A (ja) * 1984-09-14 1994-03-11 Medekusu:Kk リウマチ疾患のみに特異的に発現する蛋白質に対して特異な抗体
US5429746A (en) * 1994-02-22 1995-07-04 Smith Kline Beecham Corporation Antibody purification
US5691132A (en) 1994-11-14 1997-11-25 Cerus Corporation Method for inactivating pathogens in red cell compositions using quinacrine mustard
EP2270044B1 (en) * 1998-06-09 2014-11-05 CSL Behring AG Liquid immunoglobulin G (lgG) product
EP1200179B8 (en) 1999-07-30 2007-02-21 Genentech, Inc. Charged filtration membranes and uses therefor
GB0216002D0 (en) * 2002-07-10 2002-08-21 Nat Blood Authority Process and composition
CA2548220A1 (en) * 2003-12-01 2005-09-09 Introgen Therapeutics, Inc. Use of mda-7 to inhibit infection by pathogenic organisms
JP2008500959A (ja) * 2004-01-30 2008-01-17 スオメン プナイネン リスティ ヴェリパルヴェル ウイルスについて安全な免疫グロブリンの製造方法
WO2005082937A2 (en) * 2004-02-27 2005-09-09 Octapharma Ag A method of providing a purified, virus safe antibody preparation
RU2007118954A (ru) * 2004-10-22 2008-11-27 Эмджен Инк. (Us) Способ рефолдинга рекомбинантных антител
PT1841863E (pt) * 2005-01-14 2010-10-25 Bayer Healthcare Llc Método para a purificação de factor vii
KR101482791B1 (ko) * 2005-03-11 2015-01-21 와이어쓰 엘엘씨 약한 분배성 크로마토그래피법
NZ571479A (en) 2006-04-05 2012-10-26 Abbott Biotech Ltd Antibody purification
WO2007136327A1 (en) * 2006-05-22 2007-11-29 Ge Healthcare Bio-Sciences Ab A method of producing igg
WO2009017491A1 (en) * 2006-06-14 2009-02-05 Smithkline Beecham Corporation Methods for purifying antibodies using ceramic hydroxyapatite
JP5361738B2 (ja) * 2007-01-22 2013-12-04 ジェネンテック， インコーポレイテッド 多価電解質沈殿物及びタンパク質の精製
CN101306200B (zh) * 2008-07-04 2011-04-06 四川远大蜀阳药业股份有限公司 静脉注射用乙型肝炎人免疫球蛋白的制备方法
EP2321338A1 (en) * 2008-08-14 2011-05-18 Merck Sharp & Dohme Corp. Methods for purifying antibodies using protein a affinity chromatography
EP2346901A1 (en) * 2008-10-20 2011-07-27 Abbott Laboratories Antibodies that bind to il-18 and methods of purifying the same
US20120282654A1 (en) * 2009-04-29 2012-11-08 Schering Corporation Antibody purification
IT1397061B1 (it) * 2009-12-28 2012-12-28 Kedrion Spa Nuovo processo di purificazione su scala industriale di gammaglobuline da plasma umano per uso industriale.
US20130023436A1 (en) * 2010-01-15 2013-01-24 Bryan William Jones Disease diagnosis and treatment using computational molecular phenotyping
GB201012599D0 (en) * 2010-07-27 2010-09-08 Ucb Pharma Sa Process for purifying proteins
SG10201506030RA (en) * 2010-07-30 2015-09-29 Medimmune Llc Method for purifying active polypeptides or immunoconjugates
CA2815342A1 (en) * 2010-10-20 2012-04-26 Medimmune, Llc Methods for processing inclusion bodies
CN102286099B (zh) * 2011-08-05 2014-04-09 深圳市卫光生物制品股份有限公司 静注巨细胞病毒人免疫球蛋白及其制备方法
KR20150118120A (ko) * 2013-02-22 2015-10-21 에이전시 포 사이언스, 테크놀로지 앤드 리서치 단백질 제제들로부터 엔도톡신들을 제거하기 위한 물질들 및 방법들
WO2014133459A1 (en) * 2013-02-28 2014-09-04 Agency For Science, Technology And Research Chromatographic purification of antibodies from chromatin-deficient cell culture harvests
WO2014196926A1 (en) * 2013-06-04 2014-12-11 Agency For Science, Technology And Research Protein purification process

Also Published As

Publication number Publication date
EP2855504A1 (en) 2015-04-08
EP2855504B1 (en) 2018-10-24
US9890205B2 (en) 2018-02-13
WO2013180647A1 (en) 2013-12-05
JP2015519360A (ja) 2015-07-09
KR20150027060A (ko) 2015-03-11
US20150183852A1 (en) 2015-07-02
EP2855504A4 (en) 2015-07-29
CN104507955A (zh) 2015-04-08
IN2014DN09962A (ja) 2015-08-14
JP6297029B2 (ja) 2018-03-20

Similar Documents

Publication Publication Date Title
SG11201407809QA (en) Chromatographic purification of immunoglobulin g preparations with particles having multimodal functionalities
SG11201900201YA (en) Methods for quantitating individual antibodies from a mixture
SG11201407800SA (en) Selective binding of biological targets to solid phase ureides
SG11201407233RA (en) Ethylene oligomerization process
SG11201408536WA (en) METHOD FOR PRODUCING SOLUBLE FcR AS Fc-FUSION WITH INERT IMMUNOGLOBULIN Fc-REGION AND USES THEREOF
SG11201408780XA (en) Optimization of antibodies that bind lymphocyte activation gene-3 (lag-3), and uses thereof
SG11201407901PA (en) Single-particle analysis of particle populations
SG11201407579QA (en) Interleukin-2 fusion proteins and uses thereof
SG11201408821SA (en) Selective pi3k delta inhibitors
SG11201901307VA (en) Heterodimeric immunoglobulin constructs and preparation methods thereof
SG11201809685XA (en) A method of enhancing the performance of chromatography methods for purification of proteins
SG11201907671XA (en) Systems and methods for cracking hydrocarbon streams such as crude oils utilizing catalysts which include zeolite mixtures
SG11201407898WA (en) Electrode testing apparatus
SG11201901140QA (en) Compounds and methods for reducing tau expression
SG11201809374VA (en) Cd40l-fc fusion polypeptides and methods of use thereof
SG11201408502XA (en) Method of purifying an antibody
SG11201810987TA (en) A thermoplastic optical device
SG11201900573UA (en) Methods of purifying fc-containing proteins
SG11201406767VA (en) Microfilter and apparatus for separating a biological entity from a sample volume
SG11201407294UA (en) Contamination identification system
SG11201902738PA (en) Vehicle collision avoidance
SG11201808869WA (en) Affinity chromatography devices
SG11201408163VA (en) Modified fibronectin fragments or variants and uses thereof
SG11201805204WA (en) Nicotine particle capsule
SG11201901188VA (en) Metal powder feedstocks for additive manufacturing, and system and methods for producing the same