SG11201406727QA - Apparatus and method for separating a biological entity from a sample volume - Google Patents

Apparatus and method for separating a biological entity from a sample volume

Info

Publication number
SG11201406727QA
SG11201406727QA SG11201406727QA SG11201406727QA SG11201406727QA SG 11201406727Q A SG11201406727Q A SG 11201406727QA SG 11201406727Q A SG11201406727Q A SG 11201406727QA SG 11201406727Q A SG11201406727Q A SG 11201406727QA SG 11201406727Q A SG11201406727Q A SG 11201406727QA
Authority
SG
Singapore
Prior art keywords
separating
sample volume
biological entity
entity
biological
Prior art date
Application number
SG11201406727QA
Other languages
English (en)
Inventor
Abdur Rub Abdur Rahman
Chandran Jegatha
Lakshmi Shankar
Chee Chung Wong
Original Assignee
Agency Science Tech & Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agency Science Tech & Res filed Critical Agency Science Tech & Res
Priority to SG11201406727QA priority Critical patent/SG11201406727QA/en
Publication of SG11201406727QA publication Critical patent/SG11201406727QA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N13/00Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326Magnetic particles
    • G01N33/54333Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00Magnetic separation
    • B03C1/02Magnetic separation acting directly on the substance being separated
    • B03C1/30Combinations with other devices, not otherwise provided for
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966Animal cells
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/06Auxiliary integrated devices, integrated components
    • B01L2300/0681Filter
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00Details of magnetic or electrostatic separation
    • B03C2201/22Details of magnetic or electrostatic separation characterised by the magnetic field, e.g. its shape or generation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
SG11201406727QA 2012-04-20 2013-04-19 Apparatus and method for separating a biological entity from a sample volume SG11201406727QA (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SG11201406727QA SG11201406727QA (en) 2012-04-20 2013-04-19 Apparatus and method for separating a biological entity from a sample volume

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SG2012029435 2012-04-20
SG11201406727QA SG11201406727QA (en) 2012-04-20 2013-04-19 Apparatus and method for separating a biological entity from a sample volume
PCT/SG2013/000156 WO2013158044A1 (fr) 2012-04-20 2013-04-19 Appareil et procédé pour séparer une entité biologique d'un volume d'échantillon

Publications (1)

Publication Number Publication Date
SG11201406727QA true SG11201406727QA (en) 2014-11-27

Family

ID=55131482

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201406727QA SG11201406727QA (en) 2012-04-20 2013-04-19 Apparatus and method for separating a biological entity from a sample volume

Country Status (4)

Country Link
US (1) US20150118728A1 (fr)
EP (1) EP2838581A4 (fr)
SG (1) SG11201406727QA (fr)
WO (1) WO2013158044A1 (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10151672B2 (en) 2014-02-11 2018-12-11 Wallac Oy Device and a method for managing a sample to be analyzed and a solid sample carrier and liquid sample carrier
CN106574290A (zh) * 2014-07-30 2017-04-19 日立化成株式会社 血中稀少细胞捕获方法
US20170269086A1 (en) * 2014-07-30 2017-09-21 Hitachi Chemical Company, Ltd. Method for capturing rare cells in blood
US9885699B2 (en) * 2014-07-31 2018-02-06 Becton, Dickinson And Company Methods for processing whole blood samples, and compositions for use in practicing the same
US10251990B2 (en) 2016-04-29 2019-04-09 Fenwal, Inc. System and method for processing, incubating, and/or selecting biological cells
US10449283B2 (en) 2016-04-29 2019-10-22 Fenwal, Inc. System and method for selecting and culturing cells
EP3499228A4 (fr) * 2016-08-12 2020-04-15 Hitachi Chemical Company, Ltd. Procédé de détection de cellules cancéreuses circulantes dans le sang, et procédé de prétraitement destiné à détecter des cellules cancéreuses circulantes dans le sang
WO2018052847A1 (fr) * 2016-09-13 2018-03-22 Gulamari Ltd. Dispositifs de filtre microfluidique et procédés
US20180100850A1 (en) * 2016-10-06 2018-04-12 Arkray, Inc. Method for Collecting Rare Cells
EP3338823B1 (fr) 2016-12-21 2021-06-16 Fenwal, Inc. Système et procédé pour séparer des cellules incorporant une séparation magnétique
CN107219360B (zh) * 2017-07-03 2018-04-03 南京岚煜生物科技有限公司 单通道化学发光微流控芯片及其检测方法
EP3801809B1 (fr) * 2018-05-30 2024-05-15 The Regents of University of California Dispositif de filtre microfluidique et procédé de dissociation de tissus et d'agrégats cellulaires et enrichissement de cellules individuelles
CN108795692B (zh) * 2018-06-26 2021-01-01 成都普瑞康生物科技有限公司 稀有细胞捕获系统及其应用
EP3837544A4 (fr) * 2018-08-16 2022-08-03 SiMPore Inc. Dispositifs, procédés, et kits pour l'analyse d'échantillon au moyen de filtres à microfente
CN112823202B (zh) * 2018-08-24 2023-12-19 深圳华大生命科学研究院 细胞及生物分子分离提取装置及测试系统
CN110180613B (zh) * 2019-06-27 2020-02-14 电子科技大学 一种基于表面电荷的移液枪
CN110540933B (zh) * 2019-08-30 2024-05-10 杭州华得森生物技术有限公司 一种循环稀有细胞集成微流控分离装置及方法
CN112779118A (zh) * 2019-11-07 2021-05-11 北京机械设备研究所 一种循环肿瘤细胞正向分离系统
US20210237064A1 (en) 2020-01-31 2021-08-05 Astrin Biosciences, Inc. Biological Fluid Filtration System
CN111979098A (zh) * 2020-09-11 2020-11-24 安徽贝铭生物科技有限公司 一种细胞过滤器
DE102020215567A1 (de) * 2020-12-09 2022-06-09 Robert Bosch Gesellschaft mit beschränkter Haftung Rückhaltevorrichtung und Verfahren zur Separierung von Zellen
CN113186098B (zh) * 2021-05-28 2024-03-26 宁波康程德诺生物医药有限公司 一种一体化下开口核酸快提试管、快提检测装置及方法
US20220410160A1 (en) * 2021-06-09 2022-12-29 Beijing Boe Technology Development Co., Ltd. Microfluidic chip and microfluidic device
DE102023204412A1 (de) * 2023-05-12 2024-11-14 Robert Bosch Gesellschaft mit beschränkter Haftung Mikrofluidische Vorrichtung und Verfahren zum Abreichern von Leukozyten in einer Probe

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5167812A (en) * 1984-11-28 1992-12-01 Trustees Of The Univ. Of Penna. Affinity chromatogry using dried calcium alginate-magnetite separation media in a magnetically stabilized fluidized bed
DE60000014T2 (de) * 2000-05-16 2002-05-02 Biochip Technologies Gmbh Linker-System zum Aktivieren von Oberflächen für die Biokonjugation und Verfahren zu ihrer Verwendung
EP1439897B1 (fr) * 2001-10-11 2010-09-01 Aviva Biosciences Corporation Methodes pour la separation des cellules rares provenant d'echantillons de fluides
WO2003049530A2 (fr) * 2001-12-07 2003-06-19 Dyax Corporation Procede et appareil de lavage de particules a reponse magnetique
WO2005028663A2 (fr) * 2003-09-18 2005-03-31 Immunivest Corporation Systeme d'analyse et de preparation d'echantillon programmable independamment de l'operateur
EP1691925A1 (fr) * 2003-12-17 2006-08-23 Inverness Medical Switzerland GmbH Systeme
US7846393B2 (en) * 2005-04-21 2010-12-07 California Institute Of Technology Membrane filter for capturing circulating tumor cells
JP4699840B2 (ja) * 2005-08-31 2011-06-15 ローム株式会社 バイオチップ及び免疫分析方法
EP2041299A4 (fr) * 2006-07-14 2010-01-13 Aviva Biosciences Corp Procedes et compositions servant a detecter des cellules rares dans un echantillon biologique
ES2977359T3 (es) * 2010-01-19 2024-08-22 Sirigen Ii Ltd Nuevos reactivos para la amplificación dirigida de la señal de un biomarcador

Also Published As

Publication number Publication date
US20150118728A1 (en) 2015-04-30
WO2013158044A1 (fr) 2013-10-24
EP2838581A4 (fr) 2016-03-02
EP2838581A1 (fr) 2015-02-25

Similar Documents

Publication Publication Date Title
SG11201406727QA (en) Apparatus and method for separating a biological entity from a sample volume
GB2490958B (en) Method and apparatus for mass analysis
GB2518795B (en) Apparatus and method for representative fluid sampling
ZA201605964B (en) Specimen collection apparatus
GB2486910B (en) Apparatus and method for fluid separation
SG11201402821VA (en) Method and device for sample processing
EP2946199A4 (fr) Procédé et appareil de mesure d'analytes
GB201312660D0 (en) Method and apparatus for analyzing a document
EP2833144A4 (fr) Procédé de détection d'une substance biologique
EP2908951A4 (fr) Appareil et procédés de traitement d'échantillons
EP3030908A4 (fr) Appareil de séparation numérique d'échantillon de fluide et procédés pour analyse d'échantillon quantitative en une étape
PL2630466T3 (pl) Urządzenie do pobierania próbki i sposób pobierania próbki
GB2486937B (en) Apparatus and method for sensing and identifying specimen slides
PL2901131T3 (pl) Układ i sposób do wytwarzania próbek analitycznych
EP2906924A4 (fr) Appareil et procédé d'extraction d'analyte
EP2909589A4 (fr) Appareil et procédés d'analyse ultrasonore d'échantillon biologique
EP2909625A4 (fr) Procédé et appareil de décantation automatisé d'échantillons en boulettes
GB2490764B (en) Tissue sample handling method and apparatus
ZA201401132B (en) Separation method and apparatus
GB201419816D0 (en) Methods, packaging and apparatus for collection of biological samples
ZA201307586B (en) Method and apparatus for particle separation
EP2906348A4 (fr) Dispositif et procédé améliorés pour la séparation d'un échantillon
GB2492233B (en) Apparatus for separating fluids and associated methods
GB2548295B (en) Sampling apparatus and method for sampling
GB2500845B (en) Apparatus and method for fluid separation