SG11201405956SA - Method to overcome dna chemical modifications sensitivity of engineered tale dna binding domains - Google Patents

Method to overcome dna chemical modifications sensitivity of engineered tale dna binding domains

Info

Publication number
SG11201405956SA
SG11201405956SA SG11201405956SA SG11201405956SA SG11201405956SA SG 11201405956S A SG11201405956S A SG 11201405956SA SG 11201405956S A SG11201405956S A SG 11201405956SA SG 11201405956S A SG11201405956S A SG 11201405956SA SG 11201405956S A SG11201405956S A SG 11201405956SA
Authority
SG
Singapore
Prior art keywords
sensitivity
binding domains
chemical modifications
overcome
dna
Prior art date
Application number
SG11201405956SA
Other languages
English (en)
Inventor
Philippe Duchateau
Julien Valton
Original Assignee
Cellectis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellectis filed Critical Cellectis
Publication of SG11201405956SA publication Critical patent/SG11201405956SA/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
SG11201405956SA 2012-03-23 2013-03-15 Method to overcome dna chemical modifications sensitivity of engineered tale dna binding domains SG11201405956SA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261615011P 2012-03-23 2012-03-23
US201261674083P 2012-07-20 2012-07-20
PCT/IB2013/000721 WO2013140250A1 (en) 2012-03-23 2013-03-15 Method to overcome dna chemical modifications sensitivity of engineered tale dna binding domains

Publications (1)

Publication Number Publication Date
SG11201405956SA true SG11201405956SA (en) 2014-11-27

Family

ID=48471035

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201405956SA SG11201405956SA (en) 2012-03-23 2013-03-15 Method to overcome dna chemical modifications sensitivity of engineered tale dna binding domains
SG10201607943RA SG10201607943RA (en) 2012-03-23 2013-03-15 Method to overcome dna chemical modifications sensitivity of engineered tale dna binding domains

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10201607943RA SG10201607943RA (en) 2012-03-23 2013-03-15 Method to overcome dna chemical modifications sensitivity of engineered tale dna binding domains

Country Status (10)

Country Link
US (2) US10301614B2 (ja)
EP (1) EP2828384B1 (ja)
JP (1) JP6212535B2 (ja)
CA (1) CA2868055C (ja)
DK (1) DK2828384T3 (ja)
ES (1) ES2683072T3 (ja)
HK (1) HK1201553A1 (ja)
IL (1) IL234797B (ja)
SG (2) SG11201405956SA (ja)
WO (1) WO2013140250A1 (ja)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2828384T3 (en) * 2012-03-23 2018-07-16 Cellectis PROCEDURE FOR SURVIVING SENSITIVITY TO CHEMICAL DNA MODIFICATIONS OF CONSTRUCTED SPEECH DNA BINDING DOMAINS
EP3613854A1 (en) 2014-03-05 2020-02-26 National University Corporation Kobe University Genomic sequence modification method for specifically converting nucleic acid bases of targeted dna sequence, and molecular complex for use in same
ES2938623T3 (es) * 2015-09-09 2023-04-13 Univ Kobe Nat Univ Corp Método para convertir una secuencia del genoma de una bacteria gram-positiva mediante una conversión específica de una base de ácido nucleico de una secuencia de ADN seleccionada como diana y el complejo molecular utilizado en el mismo
KR102061438B1 (ko) 2015-11-27 2019-12-31 고쿠리츠다이가쿠호진 고베다이가쿠 표적화 dna 서열 중의 핵산 염기가 특이적으로 전환되어 있는 단자엽식물 게놈 서열을 전환시키는 방법, 및 그것에 사용되는 분자 복합체
EP3214183B1 (en) * 2016-03-01 2018-11-21 Universität Konstanz Transcription activator-like effector (tale)-based decoding of cytosine nucleobases by selective modification response
EP3663310A4 (en) 2017-08-04 2021-08-11 Peking University TALE-RVD WITH SPECIFIC DETECTION OF A DNA BASE MODIFIED BY METHYLATION AND APPLICATION OF IT
JP7109009B2 (ja) 2017-08-08 2022-07-29 北京大学 遺伝子ノックアウト方法
EP4149252A2 (en) * 2020-05-12 2023-03-22 Factor Bioscience Inc. Engineered gene-editing proteins
WO2022178124A1 (en) * 2021-02-17 2022-08-25 The Curators Of The University Of Missouri Chloroplast cytosine base editors and mitochondria cytosine base editors in plants
IL311782A (en) * 2021-10-04 2024-05-01 Poseida Therapeutics Inc Transposases and their uses
EP4276174A1 (en) 2022-05-09 2023-11-15 Cellectis S.A. Gene therapy for the treatment of activated pi3kinase delta syndrome type 1 (apds1)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
JP4966006B2 (ja) 2003-01-28 2012-07-04 セレクティス カスタムメイドメガヌクレアーゼおよびその使用
US20110239315A1 (en) * 2009-01-12 2011-09-29 Ulla Bonas Modular dna-binding domains and methods of use
EP2206723A1 (en) * 2009-01-12 2010-07-14 Bonas, Ulla Modular DNA-binding domains
WO2011072246A2 (en) 2009-12-10 2011-06-16 Regents Of The University Of Minnesota Tal effector-mediated dna modification
WO2012158986A2 (en) * 2011-05-17 2012-11-22 Transposagen Biopharmaceuticals, Inc. Methods for site-specific genetic modification in stem cells using xanthomonas tal nucleases (xtn) for the creation of model organisms
DK2828384T3 (en) * 2012-03-23 2018-07-16 Cellectis PROCEDURE FOR SURVIVING SENSITIVITY TO CHEMICAL DNA MODIFICATIONS OF CONSTRUCTED SPEECH DNA BINDING DOMAINS

Also Published As

Publication number Publication date
DK2828384T3 (en) 2018-07-16
US10301614B2 (en) 2019-05-28
EP2828384B1 (en) 2018-05-09
CA2868055A1 (en) 2013-09-26
US20150037809A1 (en) 2015-02-05
JP2015510772A (ja) 2015-04-13
JP6212535B2 (ja) 2017-10-11
CA2868055C (en) 2020-06-30
US20190338273A1 (en) 2019-11-07
WO2013140250A8 (en) 2014-11-06
HK1201553A1 (en) 2015-09-04
SG10201607943RA (en) 2016-11-29
EP2828384A1 (en) 2015-01-28
ES2683072T3 (es) 2018-09-24
US11220683B2 (en) 2022-01-11
IL234797B (en) 2019-02-28
WO2013140250A1 (en) 2013-09-26

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