SG11201402734XA - 6-difluoromethyl-5,6-dihydro-2h-[1,4]oxazin-3-amine derivatives - Google Patents

6-difluoromethyl-5,6-dihydro-2h-[1,4]oxazin-3-amine derivatives

Info

Publication number
SG11201402734XA
SG11201402734XA SG11201402734XA SG11201402734XA SG11201402734XA SG 11201402734X A SG11201402734X A SG 11201402734XA SG 11201402734X A SG11201402734X A SG 11201402734XA SG 11201402734X A SG11201402734X A SG 11201402734XA SG 11201402734X A SG11201402734X A SG 11201402734XA
Authority
SG
Singapore
Prior art keywords
oxazin
difluoromethyl
dihydro
amine derivatives
amine
Prior art date
Application number
SG11201402734XA
Other languages
English (en)
Inventor
Andrés Avelino Trabanco-Suárez
Henricus Jacobus Maria Gijsen
Michel Surkyn
Hana Prokopcová
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of SG11201402734XA publication Critical patent/SG11201402734XA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SG11201402734XA 2011-12-05 2012-12-04 6-difluoromethyl-5,6-dihydro-2h-[1,4]oxazin-3-amine derivatives SG11201402734XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11191997 2011-12-05
PCT/EP2012/074351 WO2013083557A1 (en) 2011-12-05 2012-12-04 6-difluoromethyl-5,6-dihydro-2h-[1,4]oxazin-3-amine derivatives

Publications (1)

Publication Number Publication Date
SG11201402734XA true SG11201402734XA (en) 2014-06-27

Family

ID=47278317

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201402734XA SG11201402734XA (en) 2011-12-05 2012-12-04 6-difluoromethyl-5,6-dihydro-2h-[1,4]oxazin-3-amine derivatives

Country Status (19)

Country Link
US (1) US20140343048A1 (ko)
EP (1) EP2788346B1 (ko)
JP (1) JP6169095B2 (ko)
KR (1) KR102060379B1 (ko)
CN (1) CN103974951B (ko)
AU (1) AU2012347397B2 (ko)
BR (1) BR112014013310A2 (ko)
CA (1) CA2852366C (ko)
EA (1) EA023909B1 (ko)
ES (1) ES2558604T3 (ko)
HK (1) HK1198586A1 (ko)
IL (1) IL232916A (ko)
MX (1) MX357384B (ko)
MY (1) MY165209A (ko)
PH (1) PH12014501235B1 (ko)
SG (1) SG11201402734XA (ko)
UA (1) UA111749C2 (ko)
WO (1) WO2013083557A1 (ko)
ZA (1) ZA201404074B (ko)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101324426B1 (ko) 2008-06-13 2013-10-31 시오노기세야쿠 가부시키가이샤 β 세크레타제 저해 작용을 갖는 황 함유 복소환 유도체
CN102834384A (zh) 2009-12-11 2012-12-19 盐野义制药株式会社 *嗪衍生物
BR112012031094A2 (pt) 2010-06-09 2016-10-25 Janssen Pharmaceutica Nv derivados de 5,6-di-hidro-2h-[1,4]oxazin-3-il-maina úteis como inibidores de beta-secretase (bace)
JP5834091B2 (ja) 2010-12-22 2015-12-16 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプJanssen Pharmaceutica Naamloze Vennootschap ベータ−セクレターゼ(BACE)の阻害剤として有用な5,6−ジヒドロ−イミダゾ[1,2−a]ピラジン−8−イルアミン誘導体
CN103415521B (zh) 2011-03-09 2016-01-06 詹森药业有限公司 用作β分泌酶(BACE)抑制剂的3,4-二氢-吡咯并[1,2-a]吡嗪-1-基胺衍生物
WO2013083556A1 (en) * 2011-12-06 2013-06-13 Janssen Pharmaceutica Nv 5-(3-aminophenyl)-5-alkyl-5,6-dihydro-2h-[1,4]oxazin-3-amine derivatives
WO2014065434A1 (en) 2012-10-24 2014-05-01 Shionogi & Co., Ltd. Dihydrooxazine or oxazepine derivatives having bace1 inhibitory activity
KR102243135B1 (ko) 2013-06-12 2021-04-22 얀센 파마슈티카 엔.브이. 베타-세크레타제(bace) 저해제로서의 4-아미노-6-페닐-5,6-디하이드로이미다조[1,5-a]피라진-3(2h)-온 유도체
EA028775B1 (ru) 2013-06-12 2017-12-29 Янссен Фармацевтика Нв Производные 4-амино-6-фенил-6,7-дигидро[1,2,3]триазоло[1,5-a]пиразина в качестве ингибиторов бета-секретазы (bace)
CN105283457B (zh) 2013-06-12 2018-09-18 詹森药业有限公司 作为β-分泌酶(BACE)抑制剂的4-氨基-6-苯基-5,6-二氢咪唑并[1,5-A]吡嗪衍生物
ES2768823T3 (es) 2014-12-18 2020-06-23 Janssen Pharmaceutica Nv Derivados de 2,3,4,5-tetrahidropiridin-6-amina y 3,4-dihidro-2H-pirrol-5-amina útiles como inhibidores de beta-secretasa
WO2021154599A1 (en) * 2020-01-27 2021-08-05 Silcotek Corp. Biopharmaceutical manufacturing process and product

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR077328A1 (es) * 2009-07-24 2011-08-17 Novartis Ag Derivados de oxazina y su uso en el tratamiento de trastornos neurologicos
US8188079B2 (en) * 2009-08-19 2012-05-29 Hoffman-La Roche Inc. 3-amino-5-phenyl-5,6-dihydro-2H-[1,4]oxazines
UA103272C2 (uk) * 2009-12-11 2013-09-25 Ф. Хоффманн-Ля Рош Аг 2-аміно-5,5-дифтор-5,6-дигідро-4h-оксазини як інгібітори bace1 і/або bace2
BR112012031094A2 (pt) * 2010-06-09 2016-10-25 Janssen Pharmaceutica Nv derivados de 5,6-di-hidro-2h-[1,4]oxazin-3-il-maina úteis como inibidores de beta-secretase (bace)
BR112013017779A2 (pt) * 2011-01-12 2016-10-11 Novartis Ag derivados de oxazina e seu uso no tratamento de distúrbios neurológicos
JP2012147763A (ja) * 2011-01-17 2012-08-09 Toshitaka Kobayashi 乾物穿孔具
WO2013083556A1 (en) * 2011-12-06 2013-06-13 Janssen Pharmaceutica Nv 5-(3-aminophenyl)-5-alkyl-5,6-dihydro-2h-[1,4]oxazin-3-amine derivatives

Also Published As

Publication number Publication date
PH12014501235A1 (en) 2014-09-08
CN103974951A (zh) 2014-08-06
AU2012347397B2 (en) 2016-09-22
PH12014501235B1 (en) 2014-09-08
US20140343048A1 (en) 2014-11-20
BR112014013310A2 (pt) 2017-06-13
EP2788346A1 (en) 2014-10-15
ES2558604T3 (es) 2016-02-05
UA111749C2 (uk) 2016-06-10
JP6169095B2 (ja) 2017-07-26
KR102060379B1 (ko) 2019-12-30
EP2788346B1 (en) 2015-10-28
CA2852366C (en) 2020-02-18
NZ626662A (en) 2015-05-29
EA201491116A1 (ru) 2014-12-30
CN103974951B (zh) 2016-04-13
JP2015500223A (ja) 2015-01-05
ZA201404074B (en) 2016-10-26
IL232916A (en) 2016-07-31
AU2012347397A1 (en) 2014-04-24
MX2014006689A (es) 2014-09-04
WO2013083557A1 (en) 2013-06-13
IL232916A0 (en) 2014-08-03
MY165209A (en) 2018-03-05
EA023909B1 (ru) 2016-07-29
HK1198586A1 (zh) 2015-04-30
CA2852366A1 (en) 2013-06-13
KR20140107209A (ko) 2014-09-04
MX357384B (es) 2018-07-06

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