SG11201402351WA - Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or an anti-adm non-ig scaffold for use in therapy - Google Patents
Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or an anti-adm non-ig scaffold for use in therapyInfo
- Publication number
- SG11201402351WA SG11201402351WA SG11201402351WA SG11201402351WA SG11201402351WA SG 11201402351W A SG11201402351W A SG 11201402351WA SG 11201402351W A SG11201402351W A SG 11201402351WA SG 11201402351W A SG11201402351W A SG 11201402351WA SG 11201402351W A SG11201402351W A SG 11201402351WA
- Authority
- SG
- Singapore
- Prior art keywords
- adm
- antibody
- adrenomedullin
- scaffold
- therapy
- Prior art date
Links
- 102000008394 Immunoglobulin Fragments Human genes 0.000 title 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/70—Mechanisms involved in disease identification
- G01N2800/7095—Inflammation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11189448 | 2011-11-16 | ||
| EP12160018 | 2012-03-16 | ||
| PCT/EP2012/072931 WO2013072512A1 (fr) | 2011-11-16 | 2012-11-16 | Anticorps anti-adrénomédulline (adm) ou fragment d'anticorps anti-adm ou échafaudage non-ig anti-adm pour application thérapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201402351WA true SG11201402351WA (en) | 2014-06-27 |
Family
ID=48087103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201402351WA SG11201402351WA (en) | 2011-11-16 | 2012-11-16 | Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or an anti-adm non-ig scaffold for use in therapy |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP2594588B1 (fr) |
| JP (1) | JP6321545B2 (fr) |
| KR (3) | KR102249078B1 (fr) |
| CN (4) | CN110054690B (fr) |
| AU (1) | AU2012338732B2 (fr) |
| BR (2) | BR112014011670B1 (fr) |
| CA (1) | CA2856141C (fr) |
| DK (1) | DK2594588T3 (fr) |
| ES (1) | ES2494191T3 (fr) |
| HK (1) | HK1202127A1 (fr) |
| IL (2) | IL283215B2 (fr) |
| MX (1) | MX355482B (fr) |
| PL (1) | PL2594588T3 (fr) |
| PT (1) | PT2594588E (fr) |
| RU (1) | RU2662671C2 (fr) |
| SG (1) | SG11201402351WA (fr) |
| WO (1) | WO2013072512A1 (fr) |
| ZA (1) | ZA201403548B (fr) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2662671C2 (ru) * | 2011-11-16 | 2018-07-26 | Адреномед Аг | АНТИТЕЛО К АДРЕНОМЕДУЛЛИНУ (ADM) ИЛИ ФРАГМЕНТ АНТИ-ADM АНТИТЕЛА, ИЛИ АНТИ-ADM HE-Ig КАРКАС ДЛЯ ПРИМЕНЕНИЯ В ТЕРАПИИ |
| EP3380845A1 (fr) * | 2015-11-27 | 2018-10-03 | B.R.A.H.M.S GmbH | Mr-proadm utilisé comme marqueur pour l'état de volume extracellulaire d'un sujet |
| CN109716136B (zh) * | 2016-07-08 | 2023-09-22 | 斯弗因高泰克有限公司 | 肾上腺髓质素用于评估急性心力衰竭患者的充血 |
| KR20190120174A (ko) * | 2016-12-16 | 2019-10-23 | 아드레노메드 아게 | 울혈의 중재 및 치료가 필요한 환자에서 울혈의 중재 및 치료에 사용하기 위한 항-아드레노메둘린 (ADM) 항체 또는 항-ADM 항체 단편 또는 항-ADM 비-Ig 스캐폴드 |
| EP3339324A1 (fr) | 2016-12-22 | 2018-06-27 | sphingotec GmbH | Anticorps anti-adrénomedulline (adm) ou fragment d'anticorps anti-adm ou échafaudage anti-adm non-ig destiné à être utilisé dans l'intervention et la thérapie de congestion chez un patient ayantbesoin |
| EP3604538A4 (fr) * | 2017-03-29 | 2020-12-30 | University of Miyazaki | Dérivé d'adrénomédulline à durée d'action longue |
| EP4159229A1 (fr) * | 2017-09-25 | 2023-04-05 | AdrenoMed AG | Liant anti-adrénomédulline (adm) destiné à être utilisé dans la thérapie ou la prévention de symptômes de maladie |
| EP3698134A1 (fr) | 2017-10-18 | 2020-08-26 | AdrenoMed AG | Surveillance de thérapie sous traitement avec un liant anti-adrénomédulline (adm) |
| SG11202006686SA (en) * | 2018-02-08 | 2020-08-28 | Sphingotec Gmbh | Adrenomedullin (adm) for diagnosis and/or prediction of dementia and anti-adrenomedullin binder for use in therapy or prevention of dementia |
| WO2021038078A1 (fr) | 2019-08-30 | 2021-03-04 | 4TEEN4 Pharmaceuticals GmbH | Orientation de thérapie et/ou surveillance de thérapie permettant le traitement d'un choc |
| EP3871689A1 (fr) | 2020-02-26 | 2021-09-01 | sphingotec GmbH | Anticorps anti-adm se liant à l'extrémité n-terminale libre pour accélérer la transition de l'adm-gly vers la bio-adm chez les patients dont le rapport adm-gly/bio-adm est supérieur à un seuil et combinaison avec la vitamine c |
| JP2023515985A (ja) | 2020-02-27 | 2023-04-17 | アドレノメト アクチェンゲゼルシャフト | ショック状態の患者の治療において使用するための抗アドレノメデュリン（ａｄｍ）結合剤 |
| BR112022015215A2 (pt) | 2020-02-27 | 2022-10-11 | 4TEEN4 Pharmaceuticals GmbH | Dpp3 para orientação, monitoramento e estratificação de terapia de anticorpos nt-adm em pacientes com choque |
| AU2021227277A1 (en) | 2020-02-27 | 2022-10-20 | Adrenomed Ag | Anti-Adrenomedullin (ADM) antibody or anti-ADM antibody fragment or anti-ADM non-Ig scaffold for use in therapy or prevention of shock |
| MX2022011577A (es) | 2020-03-16 | 2022-10-18 | Sphingotec Gmbh | Proadrenomedulina o fragmento de la misma en pacientes infectados con coronavirus y tratamientos con aglutinante contra la adrenomedulina. |
| WO2023175035A1 (fr) | 2022-03-15 | 2023-09-21 | Adrenomed Ag | Formulation aqueuse stable d'un anticorps anti-adrénomédulline (adm) ou d'un fragment d'anticorps anti-adm |
| WO2024017331A1 (fr) * | 2022-07-20 | 2024-01-25 | 上海济煜医药科技有限公司 | Anticorps anti-adrénomédulin non neutralisant, son procédé de préparation et son utilisation |
| WO2024023369A1 (fr) | 2022-07-29 | 2024-02-01 | Adrenomed Ag | Anticorps anti-adrénomédulline (adm) ou fragment d'anticorps anti-adm ou échafaudage non-ig anti-adm destiné à être utilisé en thérapie ou prévention du choc |
| WO2024023368A1 (fr) | 2022-07-29 | 2024-02-01 | 4TEEN4 Pharmaceuticals GmbH | Prédiction d'augmentation de dpp3 chez un patient souffrant d'un choc septique |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| AU634716B2 (en) | 1988-08-01 | 1993-03-04 | Ciba Corning Diagnostics Corp. | Method for detection of an analyte using acridinium esters and liposomes |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| SG48759A1 (en) | 1990-01-12 | 2002-07-23 | Abgenix Inc | Generation of xenogenic antibodies |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| ATE185601T1 (de) | 1990-07-10 | 1999-10-15 | Cambridge Antibody Tech | Verfahren zur herstellung von spezifischen bindungspaargliedern |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| EP0746609A4 (fr) | 1991-12-17 | 1997-12-17 | Genpharm Int | Animaux transgeniques non humains capables de produire des anticorps heterologues |
| JP2774769B2 (ja) * | 1993-04-26 | 1998-07-09 | 賢治 寒川 | アドレノメデュリン |
| US6818418B1 (en) | 1998-12-10 | 2004-11-16 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
| AU774725B2 (en) * | 1999-09-10 | 2004-07-08 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Determination of adrenomedullin-binding proteins |
| JP2005508623A (ja) | 2001-08-30 | 2005-04-07 | バイオレクシス ファーマシューティカル コーポレイション | 改変されたトランスフェリン融合タンパク質 |
| PT1531791E (pt) | 2002-06-07 | 2010-12-16 | Dyax Corp | Prevenção e redução da isquémia |
| DE10316583A1 (de) * | 2003-04-10 | 2004-10-28 | B.R.A.H.M.S Aktiengesellschaft | Bestimmung eines midregionalen Proadrenomedullin-Teilpeptids in biologischen Flüssigkeiten zu diagnostischen Zwecken, sowie Immunoassays für die Durchführung einer solchen Bestimmung |
| EP1620734A1 (fr) | 2003-04-25 | 2006-02-01 | Genova Ltd. | Especes de polypeptides secretes reduites dans des troubles cardiovasculaires |
| AU2004284090A1 (en) | 2003-10-24 | 2005-05-06 | Avidia, Inc. | LDL receptor class A and EGF domain monomers and multimers |
| US20100028995A1 (en) | 2004-02-23 | 2010-02-04 | Anaphore, Inc. | Tetranectin Trimerizing Polypeptides |
| EP1800131A2 (fr) | 2004-09-09 | 2007-06-27 | Bayer HealthCare AG | Agents diagnostiques et therapeutiques destines a des maladies associees au recepteur d'adrenomedulline (amdr) |
| CA2477867A1 (fr) * | 2004-09-17 | 2006-03-17 | Oncorex, Inc. | Peptides, adn, arn et composes pour inhiber ou amorcer l'activite de l'adrenomedulline et leur utilisation |
| EP1793847A2 (fr) | 2004-09-21 | 2007-06-13 | NascaCell IP GmbH | Utilisation de microproteines en tant qu'inhibiteurs d'une tryptase |
| US9829494B2 (en) | 2005-12-01 | 2017-11-28 | Adrenomed Ag | Methods of treatment using ADM antibodies |
| CN101165067B (zh) * | 2006-10-19 | 2011-04-20 | 四川大学华西医院 | 肾上腺髓质素(27-52)的固相合成方法 |
| ATE527353T1 (de) | 2007-12-19 | 2011-10-15 | Affibody Ab | Pdgf-bindendes polypeptid aus protein a |
| MX2011004649A (es) | 2008-11-03 | 2011-05-30 | Molecular Partners Ag | Proteinas de union que inhiben la interaccion en el receptor de vegf-a. |
| JP5868318B2 (ja) | 2009-08-27 | 2016-02-24 | コヴァジェン アクチェン ゲゼルシャフト | 新規なｉｌ−１７結合化合物およびその医薬用途 |
| CA2778871C (fr) | 2009-12-14 | 2017-08-01 | Scil Proteins Gmbh | Proteines d'ubiquitine modifiee possedant une activite de liaison specifique pour l'extradomaine b de la fibronectine |
| EP2580236B1 (fr) | 2010-06-08 | 2019-04-03 | Pieris Pharmaceuticals GmbH | Mutéines de lipocaline des larmes se liant à il-4 r alpha |
| RU2662671C2 (ru) * | 2011-11-16 | 2018-07-26 | Адреномед Аг | АНТИТЕЛО К АДРЕНОМЕДУЛЛИНУ (ADM) ИЛИ ФРАГМЕНТ АНТИ-ADM АНТИТЕЛА, ИЛИ АНТИ-ADM HE-Ig КАРКАС ДЛЯ ПРИМЕНЕНИЯ В ТЕРАПИИ |
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2012
- 2012-11-16 RU RU2014123990A patent/RU2662671C2/ru active
- 2012-11-16 CA CA2856141A patent/CA2856141C/fr active Active
- 2012-11-16 KR KR1020207029323A patent/KR102249078B1/ko active IP Right Grant
- 2012-11-16 ES ES12193121.6T patent/ES2494191T3/es active Active
- 2012-11-16 CN CN201811275032.7A patent/CN110054690B/zh active Active
- 2012-11-16 IL IL283215A patent/IL283215B2/en unknown
- 2012-11-16 MX MX2014005996A patent/MX355482B/es active IP Right Grant
- 2012-11-16 BR BR112014011670-9A patent/BR112014011670B1/pt active IP Right Grant
- 2012-11-16 CN CN202111048028.9A patent/CN114044824A/zh active Pending
- 2012-11-16 PL PL12193121T patent/PL2594588T3/pl unknown
- 2012-11-16 AU AU2012338732A patent/AU2012338732B2/en active Active
- 2012-11-16 JP JP2014541696A patent/JP6321545B2/ja active Active
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- 2012-11-16 KR KR1020147015835A patent/KR102047443B1/ko active IP Right Grant
- 2012-11-16 EP EP12193121.6A patent/EP2594588B1/fr active Active
- 2012-11-16 SG SG11201402351WA patent/SG11201402351WA/en unknown
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- 2012-11-16 CN CN201280066575.2A patent/CN104144948B/zh active Active
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- 2012-11-16 CN CN202410037251.0A patent/CN118105479A/zh active Pending
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2014
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